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Here, in stark contrast to reports of other inorganic nanomaterials, we find that nickel-cobalt alloy magnetic nanocrystals (NiCo NCs) actually inhibit activation of NLRP3, NLRC4 and AIM2 inflammasomes. We show that NiCo NCs disrupt the canonical inflammasome ASC speck formation process by downregulating the lncRNA Neat1, and experimentally confirm that the entry of NiCo NCs into cells is required for the observed inhibition of inflammasome activation. Furthermore, we find that NiCo NCs inhibit neutrophil recruitment in an acute peritonitis mouse model and relieve symptoms in a colitis mouse model, again by inhibiting inflammasome activation. Beyond demonstrating a highly surprising and apparently therapeutic impact for an inorganic nanomaterial on inflammatory responses, our work suggests that nickel- and cobalt-containing nanomaterials may offer an opportunity to design anti-inflammatory nanomedicines for the therapeutics of macrophage-mediated diseases.<\/jats:p>","DOI":"10.1093\/nsr\/nwad179","type":"journal-article","created":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T03:59:55Z","timestamp":1687838395000},"source":"Crossref","is-referenced-by-count":31,"title":["Nickle-cobalt alloy nanocrystals inhibit activation of inflammasomes"],"prefix":"10.1093","volume":"10","author":[{"given":"Jun","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, The First Affiliated Hospital of USTC, School of Basic Medical Sciences, Division of Molecular Medicine, Department of Chemistry, Institute of Biomimetic Materials & Chemistry, Division of Nanomaterials & Chemistry, Hefei National Research 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