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The nucleus of the solitary tract (NTS) is important for initiating these responses. However, the molecular heterogeneities and cellular diversities of the NTS occlude a better understanding of these defensive responses. Here, we constructed the single-nucleus transcriptomic atlas of NTS cells and found multiple populations of NTS neurons that may be involved in these defensive responses. Among these, we identified Calbindin1-positive (Calb1+) NTS neurons that are molecularly distinct from Tac1+ neurons. These Calb1+ neurons are critical for nausea and retching induced by cereulide; an emetic toxin secreted by Bacillus Cereus. Strikingly, we found that cereulide can directly modulate vagal sensory neurons that innervate Calb1+ NTS neurons, a novel mechanism distinct from that for nausea and retching induced by Staphylococcal enterotoxin A. Together, our transcriptomic atlas of NTS neurons and the functional analyses revealed the neural mechanism for cereulide-induced retching-like behavior. These results demonstrate the molecular and cellular complexities in the brain that underlie defensive responses to the diversities of pathogens and toxins.<\/jats:p>","DOI":"10.1093\/nsr\/nwad256","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T05:14:08Z","timestamp":1695878048000},"source":"Crossref","is-referenced-by-count":10,"title":["Brain circuits for retching-like behavior"],"prefix":"10.1093","volume":"11","author":[{"given":"Lifang","family":"Huo","sequence":"first","affiliation":[{"name":"School of Basic Medical Sciences, Guangzhou National Laboratory, The Fifth Affiliated Hospital, Guangzhou Medical University , Guangzhou 510799 , China"},{"name":"Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory) , Guangzhou 510320 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimin","family":"Ye","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Guangzhou National Laboratory, The Fifth Affiliated Hospital, Guangzhou Medical University , Guangzhou 510799 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiling","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Guangzhou National Laboratory, The Fifth Affiliated Hospital, Guangzhou Medical University , Guangzhou 510799 , China"},{"name":"Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory) , Guangzhou 510320 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqing","family":"He","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Guangzhou National Laboratory, The Fifth Affiliated Hospital, Guangzhou Medical University , Guangzhou 510799 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meizhu","family":"Huang","sequence":"additional","affiliation":[{"name":"Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory) , Guangzhou 510320 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dapeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, School of Basic Medical Sciences, Beijing Key Laboratory of Neural Regeneration and Repair, Advanced Innovation Center for Human Brain Protection, Capital Medical University , Beijing 100069 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cognitive Neuroscience and Learning, IDG\/McGovern Institute for Brain Research, Beijing Normal University , Beijing 100875 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[{"name":"Changping Life Science Laboratory , Beijing 102299 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3440-2617","authenticated-orcid":false,"given":"Xiaoqun","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cognitive Neuroscience and Learning, IDG\/McGovern Institute for Brain Research, Beijing Normal University , Beijing 100875 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Cao","sequence":"additional","affiliation":[{"name":"National Institute of Biological Sciences , Beijing 102206 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Dong","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Guangzhou National Laboratory, The Fifth Affiliated Hospital, Guangzhou Medical University , Guangzhou 510799 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1042-4021","authenticated-orcid":false,"given":"Congping","family":"Shang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Guangzhou National Laboratory, The Fifth Affiliated Hospital, Guangzhou Medical University , Guangzhou 510799 , China"},{"name":"Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory) , Guangzhou 510320 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,9,27]]},"reference":[{"key":"2024012921351763100_bib1","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1007\/BF00987509","article-title":"Structure-activity relationship of stress-inducing odorants in the rat","volume":"10","author":"Vernet-Maury","year":"1984","journal-title":"J Chem Ecol"},{"key":"2024012921351763100_bib2","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.1126\/science.aaa8694","article-title":"BRAIN CIRCUITS. 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