{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T15:51:15Z","timestamp":1793807475012,"version":"4.6.1"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,3,23]],"date-time":"2024-03-23T00:00:00Z","timestamp":1711152000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272141"],"award-info":[{"award-number":["82272141"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002412","name":"Xi\u2019an Jiaotong University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province","doi-asserted-by":"publisher","award":["2022JZ-48"],"award-info":[{"award-number":["2022JZ-48"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2509104"],"award-info":[{"award-number":["2023YFC2509104"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Precise and efficient therapy of malignant tumors is always a challenge. Herein, gold nanoclusters co-modified by aggregation-induced-emission (AIE) molecules, copper ion chelator (acylthiourea) and tumor-targeting agent (folic acid) were fabricated to perform AIE-guided and tumor-specific synergistic therapy with great spatio-temporal controllability for the targeted elimination and metastasis inhibition of malignant tumors. During therapy, the functional gold nanoclusters (AuNTF) would rapidly accumulate in the tumor tissue due to the enhanced permeability and retention effect as well as folic acid-mediated tumor targeting, which was followed by endocytosis by tumor cells. After that, the overexpressed copper ions in the tumor cells would trigger the aggregation of these intracellular AuNTF via a chelation process that not only generated the photothermal agent in situ to perform the tumor-specific photothermal therapy damaging the primary tumor, but also led to the copper deficiency of tumor cells to inhibit its metastasis. Moreover, the copper ions were reduced to cuprous ions along with the chelation, which further catalysed the excess H2O2 in the tumor cells to produce cytotoxic reactive oxygen species, resulting in additional chemodynamic therapy for enhanced antitumor efficiency. The aggregation of AuNTF also activated the AIE molecules to present fluorescence, which not only imaged the therapeutic area for real-time monitoring of this tumor-specific synergistic therapy, but also allowed us to perform near-infrared radiation at the correct time point and location to achieve optimal photothermal therapy. Both in vitro and in vivo results revealed the strong tumor elimination, effective metastasis inhibition and high survival rate of tumor-bearing mice after treatment using the AuNTF nanoclusters, indicating that this AIE-guided and tumor-specific synergistic strategy could offer a promising approach for tumor therapy.<\/jats:p>","DOI":"10.1093\/nsr\/nwae113","type":"journal-article","created":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T14:54:47Z","timestamp":1711032887000},"source":"Crossref","is-referenced-by-count":24,"title":["Intelligent gold nanocluster for effective treatment of malignant tumor via tumor-specific photothermal\u2013chemodynamic therapy with AIE guidance"],"prefix":"10.1093","volume":"11","author":[{"given":"Feng","family":"Liu","sequence":"first","affiliation":[{"name":"School of Energy and Power Engineering, Xi'an Jiaotong University , Xi'an 710049 , China"},{"name":"Department of Chemical Engineering, Shaanxi Key Laboratory of Energy Chemical Process Intensification, Institute of Polymer Science in Chemical Engineering, School of Chemical Engineering and Technology, Xi'an Jiaotong University , Xi'an 710049 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianfeng","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Health Science Center, Xi'an Jiaotong University , Xi'an 710061 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Shaanxi Key Laboratory of Energy Chemical Process Intensification, Institute of Polymer Science in Chemical Engineering, School of Chemical Engineering and Technology, Xi'an Jiaotong University , Xi'an 710049 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Shaanxi Key Laboratory of Energy Chemical Process Intensification, Institute of Polymer Science in Chemical Engineering, School of Chemical Engineering and Technology, Xi'an Jiaotong University , Xi'an 710049 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Cheng","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Health Science Center, Xi'an Jiaotong University , Xi'an 710061 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuhong","family":"Peng","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Health Science Center, Xi'an Jiaotong University , Xi'an 710061 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haihu","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Energy and Power Engineering, Xi'an Jiaotong University , Xi'an 710049 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmin","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Health Science Center, Xi'an Jiaotong University , Xi'an 710061 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Shaanxi Key Laboratory of Energy Chemical Process Intensification, Institute of Polymer Science in Chemical Engineering, School of Chemical Engineering and Technology, Xi'an Jiaotong University , Xi'an 710049 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,3,22]]},"reference":[{"key":"2024050218275138600_bib1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"2024050218275138600_bib2","doi-asserted-by":"publisher","first-page":"409","DOI":"10.3322\/caac.21731","article-title":"Cancer treatment and survivorship statistics, 2022","volume":"72","author":"Miller","year":"2022","journal-title":"CA Cancer J Clin"},{"key":"2024050218275138600_bib3","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1038\/s41571-022-00685-3","article-title":"Mitigating acute chemotherapy-associated adverse events in patients with cancer","volume":"19","author":"Kuderer","year":"2022","journal-title":"Nat Rev Clin Oncol"},{"key":"2024050218275138600_bib4","doi-asserted-by":"publisher","first-page":"488","DOI":"10.3322\/caac.21498","article-title":"Local cancer recurrence: the realities, challenges, and opportunities for new therapies","volume":"68","author":"Mahvi","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"2024050218275138600_bib5","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1038\/s41575-022-00703-w","article-title":"Current developments in gastric cancer: from molecular profiling to treatment strategy","volume":"20","author":"Alsina","year":"2023","journal-title":"Nat Rev Gastro Hepat"},{"key":"2024050218275138600_bib6","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1038\/s41578-019-0108-1","article-title":"Cancer nanomedicine for combination cancer immunotherapy","volume":"4","author":"Nam","year":"2019","journal-title":"Nat Rev Mater"},{"key":"2024050218275138600_bib7","doi-asserted-by":"publisher","first-page":"2103868","DOI":"10.1002\/smll.202103868","article-title":"Chemodynamic therapy via Fenton and Fenton-like nanomaterials: strategies and recent advances","volume":"18","author":"Jia","year":"2022","journal-title":"Small"},{"key":"2024050218275138600_bib8","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1002\/anie.201805664","article-title":"Chemodynamic therapy: tumour microenvironment-mediated fenton and Fenton-like reactions","volume":"58","author":"Tang","year":"2019","journal-title":"Angew Chem Int Ed"},{"key":"2024050218275138600_bib9","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1038\/s41571-020-0410-2","article-title":"Clinical development and potential of photothermal and photodynamic therapies for cancer","volume":"17","author":"Li","year":"2020","journal-title":"Nat Rev Clin Oncol"},{"key":"2024050218275138600_bib10","doi-asserted-by":"publisher","first-page":"5890","DOI":"10.1002\/anie.201911477","article-title":"Two-dimensional nanomaterials for photothermal therapy","volume":"59","author":"Liu","year":"2020","journal-title":"Angew Chem Int Ed"},{"key":"2024050218275138600_bib11","doi-asserted-by":"publisher","first-page":"2003891","DOI":"10.1002\/adfm.202003891","article-title":"Emetine-loaded black phosphorus hydrogel sensitizes tumor to photothermal therapy through inhibition of stress granule formation","volume":"30","author":"Xie","year":"2020","journal-title":"Adv Funct Mater"},{"key":"2024050218275138600_bib12","doi-asserted-by":"publisher","first-page":"2004460","DOI":"10.1002\/adma.202004460","article-title":"Injectable and NIR-responsive DNA-inorganic hybrid hydrogels with outstanding photothermal therapy","volume":"32","author":"Liu","year":"2020","journal-title":"Adv Mater"},{"key":"2024050218275138600_bib13","doi-asserted-by":"publisher","first-page":"7744","DOI":"10.1073\/pnas.1817251116","article-title":"Photothermal-responsive nanosized hybrid polymersome as versatile therapeutics codelivery nanovehicle for effective tumor suppression","volume":"116","author":"Zhang","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"key":"2024050218275138600_bib14","doi-asserted-by":"publisher","first-page":"1904401","DOI":"10.1002\/adfm.201904401","article-title":"Stimuli-responsive scaffold for breast cancer treatment combining accurate photothermal therapy and adipose tissue regeneration","volume":"29","author":"Bai","year":"2019","journal-title":"Adv Funct Mater"},{"key":"2024050218275138600_bib15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.biomaterials.2018.01.026","article-title":"One-pot synthesis of albumin-gadolinium stabilized polypyrrole nanotheranostic agent for magnetic resonance imaging guided photothermal therapy","volume":"161","author":"Yang","year":"2018","journal-title":"Biomaterials"},{"key":"2024050218275138600_bib16","doi-asserted-by":"publisher","first-page":"2001212","DOI":"10.1002\/adhm.202001212","article-title":"Self-propelled micro\/nanomotors for tumor targeting delivery and therapy","volume":"10","author":"Lin","year":"2021","journal-title":"Adv Healthc Mater"},{"key":"2024050218275138600_bib17","doi-asserted-by":"publisher","first-page":"1901223","DOI":"10.1002\/adhm.201901223","article-title":"Size-dependent EPR effect of polymeric nanoparticles on tumor targeting","volume":"9","author":"Kang","year":"2020","journal-title":"Adv Healthc Mater"},{"key":"2024050218275138600_bib18","doi-asserted-by":"publisher","first-page":"1902409","DOI":"10.1002\/adma.201902409","article-title":"Tumor targeting strategies of smart fluorescent nanoparticles and their applications in cancer diagnosis and treatment","volume":"31","author":"He","year":"2019","journal-title":"Adv Mater"},{"key":"2024050218275138600_bib19","doi-asserted-by":"publisher","first-page":"1603275","DOI":"10.1002\/smll.201603275","article-title":"Cooperative strategies for enhancing performance of photothermal therapy (PTT) agent: optimizing its photothermal conversion and cell internalization ability","volume":"13","author":"Du","year":"2017","journal-title":"Small"},{"key":"2024050218275138600_bib20","doi-asserted-by":"publisher","first-page":"9494","DOI":"10.1039\/C4NR00708E","article-title":"Nanoparticles for photothermal therapies","volume":"6","author":"Jaque","year":"2014","journal-title":"Nanoscale"},{"key":"2024050218275138600_bib21","doi-asserted-by":"publisher","first-page":"1902926","DOI":"10.1002\/smll.201902926","article-title":"Tumor pH-responsive albumin\/polyaniline assemblies for amplified photoacoustic imaging and augmented photothermal therapy","volume":"15","author":"Tian","year":"2019","journal-title":"Small"},{"key":"2024050218275138600_bib22","doi-asserted-by":"publisher","first-page":"2110219","DOI":"10.1002\/adma.202110219","article-title":"Intelligent gold nanoparticles with oncogenic microRNA-dependent activities to manipulate tumorigenic environments for synergistic tumor therapy","volume":"34","author":"Wang","year":"2022","journal-title":"Adv Mater"},{"key":"2024050218275138600_bib23","doi-asserted-by":"publisher","first-page":"133850","DOI":"10.1016\/j.cej.2021.133850","article-title":"Intelligent gold nanoparticles for synergistic tumor treatment via intracellular Ca2+ regulation and resulting on-demand photothermal therapy","volume":"433","author":"Guo","year":"2022","journal-title":"Chem Eng J"},{"key":"2024050218275138600_bib24","doi-asserted-by":"publisher","first-page":"1801961","DOI":"10.1002\/adfm.201801961","article-title":"Core-satellite mesoporous silica-gold nanotheranostics for biological stimuli triggered multimodal cancer therapy","volume":"28","author":"Jin","year":"2018","journal-title":"Adv Funct Mater"},{"key":"2024050218275138600_bib25","doi-asserted-by":"publisher","first-page":"28621","DOI":"10.1021\/acsami.9b05943","article-title":"Intracellular enzyme-triggered assembly of amino acid-modified gold nanoparticles for accurate cancer therapy with multimode","volume":"11","author":"Liu","year":"2019","journal-title":"ACS Appl Mater Inter"},{"key":"2024050218275138600_bib26","first-page":"6","article-title":"EMT and tumor metastasis","volume":"4","author":"Heerboth","year":"2015","journal-title":"Clin Transl Oncol"},{"key":"2024050218275138600_bib27","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1038\/nm.3394","article-title":"Microenvironmental regulation of tumor progression and metastasis","volume":"19","author":"Quail","year":"2013","journal-title":"Nat Med"},{"key":"2024050218275138600_bib28","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1038\/nm1469","article-title":"Tumor metastasis: mechanistic insights and clinical challenges","volume":"12","author":"Steeg","year":"2006","journal-title":"Nat Med"},{"key":"2024050218275138600_bib29","doi-asserted-by":"publisher","first-page":"2003972","DOI":"10.1002\/advs.202003972","article-title":"Nanoprobes-assisted multichannel NIR-II fluorescence imaging-guided resection and photothermal ablation of lymph nodes","volume":"8","author":"Fan","year":"2021","journal-title":"Adv Sci"},{"key":"2024050218275138600_bib30","doi-asserted-by":"publisher","first-page":"2000170","DOI":"10.1002\/adtp.202000170","article-title":"Near-infrared fluorescence\/photoacoustic agent with an intensifying optical performance for imaging-guided effective photothermal therapy","volume":"3","author":"Ye","year":"2020","journal-title":"Adv Ther"},{"key":"2024050218275138600_bib31","doi-asserted-by":"publisher","first-page":"nwab039","DOI":"10.1093\/nsr\/nwab039","article-title":"Red blood cell membrane-camouflaged nanoparticles loaded with AIEgen and poly(I\u2009:\u2009C) for enhanced tumoral photodynamic-immunotherapy","volume":"8","author":"Dai","year":"2021","journal-title":"Natl Sci Rev"},{"key":"2024050218275138600_bib32","doi-asserted-by":"publisher","first-page":"1606167","DOI":"10.1002\/adma.201606167","article-title":"Mitochondrion-anchoring photosensitizer with aggregation-induced emission characteristics synergistically boosts the radiosensitivity of cancer cells to ionizing radiation","volume":"29","author":"Yu","year":"2017","journal-title":"Adv Mater"},{"key":"2024050218275138600_bib33","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1021\/ja206929s","article-title":"Synthesis and characterization of wurtzite-phase copper tin selenide nanocrystals","volume":"134","author":"Norako","year":"2012","journal-title":"J Am Chem Soc"},{"key":"2024050218275138600_bib34","doi-asserted-by":"publisher","first-page":"2100524","DOI":"10.1002\/advs.202100524","article-title":"Good steel used in the blade: well-tailored type-I photosensitizers with aggregation-induced emission characteristics for precise nuclear targeting photodynamic therapy","volume":"8","author":"Kang","year":"2021","journal-title":"Adv Sci"},{"key":"2024050218275138600_bib35","doi-asserted-by":"publisher","first-page":"2003210","DOI":"10.1002\/adma.202003210","article-title":"An all-round athlete on the track of phototheranostics: subtly regulating the balance between radiative and nonradiative decays for multimodal imaging-guided synergistic therapy","volume":"32","author":"Zhang","year":"2020","journal-title":"Adv Mater"},{"key":"2024050218275138600_bib36","doi-asserted-by":"publisher","first-page":"2205371","DOI":"10.1002\/adfm.202205371","article-title":"A versatile 980\u00a0nm absorbing aggregation-induced emission luminogen for NIR-II imaging-guided synergistic photo-immunotherapy against advanced pancreatic cancer","volume":"32","author":"Wang","year":"2022","journal-title":"Adv Funct Mater"},{"key":"2024050218275138600_bib37","doi-asserted-by":"publisher","first-page":"5121","DOI":"10.1021\/acsnano.0c02197","article-title":"Supramolecular aggregation-induced emission nanodots with programmed tumor microenvironment responsiveness for image-guided orthotopic pancreatic cancer therapy","volume":"14","author":"Chen","year":"2020","journal-title":"ACS Nano"},{"key":"2024050218275138600_bib38","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1038\/s41568-021-00417-2","article-title":"Connecting copper and cancer: from transition metal signalling to metalloplasia","volume":"22","author":"Ge","year":"2022","journal-title":"Nat Rev Cancer"},{"key":"2024050218275138600_bib39","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1038\/s41551-017-0130-9","article-title":"A non-cytotoxic dendrimer with innate and potent anticancer and anti-metastatic activities","volume":"1","author":"Shao","year":"2017","journal-title":"Nat Biomed Eng"},{"key":"2024050218275138600_bib40","doi-asserted-by":"publisher","first-page":"202210415","DOI":"10.1002\/anie.202210415","article-title":"A forward vision for chemodynamic therapy: issues and opportunities","volume":"62","author":"Zhao","year":"2023","journal-title":"Angew Chem Int Ed"},{"key":"2024050218275138600_bib41","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1021\/jacs.8b08714","article-title":"Self-assembled copper-amino acid nanoparticles for in situ glutathione \u2018AND\u2019 H2O2 sequentially triggered chemodynamic therapy","volume":"141","author":"Ma","year":"2019","journal-title":"J Am Chem Soc"},{"key":"2024050218275138600_bib42","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1038\/s41392-020-0115-0","article-title":"Targeting folate receptor beta positive tumor-associated macrophages in lung cancer with a folate-modified liposomal complex","volume":"5","author":"Tie","year":"2020","journal-title":"Sig Transduct Target Ther"},{"key":"2024050218275138600_bib43","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1002\/ejic.201601451","article-title":"Synthesis and characterization of copper complexes with the N-(2,6-diisopropylphenyl)-N\u2032-acylthiourea ligands","volume":"2017","author":"Wang","year":"2017","journal-title":"Eur J Inorg Chem"},{"key":"2024050218275138600_bib44","doi-asserted-by":"publisher","first-page":"1902137","DOI":"10.1002\/advs.201902137","article-title":"Self-supply of O2 and H2O2 by a nanocatalytic medicine to enhance combined chemo\/chemodynamic therapy","volume":"6","author":"Gao","year":"2019","journal-title":"Adv Sci"},{"key":"2024050218275138600_bib45","doi-asserted-by":"publisher","first-page":"2204733","DOI":"10.1002\/adma.202204733","article-title":"An Enzyme-engineered nonporous copper(I) coordination polymer nanoplatform for cuproptosis-based synergistic cancer therapy","volume":"34","author":"Xu","year":"2022","journal-title":"Adv Mater"},{"key":"2024050218275138600_bib46","doi-asserted-by":"publisher","first-page":"2104079","DOI":"10.1002\/advs.202104079","article-title":"Precise molecular engineering of type I photosensitizers with near-infrared aggregation-induced emission for image-guided photodynamic killing of multidrug-resistant bacteria","volume":"9","author":"Xiao","year":"2022","journal-title":"Adv Sci"},{"key":"2024050218275138600_bib47","doi-asserted-by":"publisher","first-page":"101477","DOI":"10.1016\/j.nantod.2022.101477","article-title":"Bonsai-inspired AIE nanohybrid photosensitizer based on vermiculite nanosheets for ferroptosis-assisted oxygen self-sufficient photodynamic cancer therapy","volume":"44","author":"Yu","year":"2022","journal-title":"Nano Today"},{"key":"2024050218275138600_bib48","doi-asserted-by":"publisher","first-page":"2100021","DOI":"10.1002\/adma.202100021","article-title":"Aggregation-induced emission-active gels: fabrications, functions, and applications","volume":"33","author":"Li","year":"2021","journal-title":"Adv Mater"},{"key":"2024050218275138600_bib49","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1006\/abbi.1995.1444","article-title":"Inhibition of the human immunodeficiency virus-1 protease and human immunodeficiency virus-1 replication by bathocuproine disulfonic acid Cu+","volume":"322","author":"Davis","year":"1995","journal-title":"Arch Biochem Biophys"},{"key":"2024050218275138600_bib50","doi-asserted-by":"publisher","first-page":"7275","DOI":"10.1039\/C5NR00706B","article-title":"Lysosome-controlled efficient ROS overproduction against cancer cells with a high pH-responsive catalytic nanosystem","volume":"7","author":"Fu","year":"2015","journal-title":"Nanoscale"},{"key":"2024050218275138600_bib51","doi-asserted-by":"publisher","first-page":"1834","DOI":"10.1039\/D0MH00105H","article-title":"Glucose-responsive cascaded nanocatalytic reactor with self-modulation of the tumor microenvironment for enhanced chemo-catalytic therapy","volume":"7","author":"Mei","year":"2020","journal-title":"Mater Horiz"},{"key":"2024050218275138600_bib52","doi-asserted-by":"publisher","first-page":"6202","DOI":"10.1021\/acs.nanolett.1c01950","article-title":"Binding-induced fibrillogenesis peptides recognize and block intracellular vimentin skeletonization against breast cancer","volume":"21","author":"Fan","year":"2021","journal-title":"Nano Lett"},{"key":"2024050218275138600_bib53","doi-asserted-by":"publisher","first-page":"2842","DOI":"10.1038\/s41467-022-30063-7","article-title":"Extracellular vimentin mimics VEGF and is a target for anti-angiogenic immunotherapy","volume":"13","author":"Beijnum","year":"2022","journal-title":"Nat Commun"},{"key":"2024050218275138600_bib54","doi-asserted-by":"publisher","first-page":"3800","DOI":"10.1038\/s41467-019-11716-6","article-title":"Rebalancing of actomyosin contractility enables mammary tumor formation upon loss of E-cadherin","volume":"10","author":"Schipper","year":"2019","journal-title":"Nat Commun"},{"key":"2024050218275138600_bib55","doi-asserted-by":"publisher","first-page":"13996","DOI":"10.1038\/ncomms13996","article-title":"Cell division orientation is coupled to cell-cell adhesion by the E-cadherin\/LGN complex","volume":"8","author":"Gloerich","year":"2017","journal-title":"Nat Commun"},{"key":"2024050218275138600_bib56","first-page":"354","article-title":"Intelligent nanoreactor coupling tumor microenvironment manipulation and H2O2-dependent photothermal-chemodynamic therapy for accurate treatment of primary and metastatic tumors","volume":"34","author":"Liu","year":"2024","journal-title":"Bioact Mater"},{"key":"2024050218275138600_bib57","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202307310","article-title":"Selective manipulation of the mitochondria oxidative stress in different cells using intelligent mesoporous silica nanoparticles to activate on-demand immunotherapy for cancer treatment","author":"Chang","year":"2023","journal-title":"Small"},{"key":"2024050218275138600_bib58","doi-asserted-by":"publisher","first-page":"12410","DOI":"10.1038\/srep12410","article-title":"Copper depletion inhibits CoCl2-induced aggressive phenotype of MCF-7 cells via downregulation of HIF-1 and inhibition of Snail\/Twist-mediated epithelial-mesenchymal transition","volume":"5","author":"Li","year":"2015","journal-title":"Sci Rep"},{"key":"2024050218275138600_bib59","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.actbio.2023.04.036","article-title":"Intelligent gold nanoparticles for malignant tumor treatment via spontaneous copper manipulation and on-demand photothermal therapy based on copper induced click chemistry","volume":"166","author":"Yin","year":"2023","journal-title":"Acta Biomater"},{"key":"2024050218275138600_bib60","doi-asserted-by":"publisher","first-page":"2304394","DOI":"10.1002\/adfm.202304394","article-title":"Integration of tumor elimination and tissue regeneration via selective manipulation of physiological microenvironments based on intelligent nanocomposite hydrogel for postoperative treatment of malignant melanoma","volume":"33","author":"Chen","year":"2023","journal-title":"Adv Funct Mater"},{"key":"2024050218275138600_bib61","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1007\/s12072-022-10460-2","article-title":"Identification and development of a novel risk model based on cuproptosis-associated RNA methylation regulators for predicting prognosis and characterizing immune status in hepatocellular carcinoma","volume":"17","author":"Li","year":"2023","journal-title":"Hepatol Int"}],"container-title":["National Science Review"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/nsr\/advance-article-pdf\/doi\/10.1093\/nsr\/nwae113\/57067956\/nwae113.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nsr\/article-pdf\/11\/5\/nwae113\/57389720\/nwae113.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nsr\/article-pdf\/11\/5\/nwae113\/57389720\/nwae113.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T19:00:16Z","timestamp":1714676416000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nsr\/article\/doi\/10.1093\/nsr\/nwae113\/7633981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,22]]},"references-count":61,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,4,3]]}},"URL":"https:\/\/doi.org\/10.1093\/nsr\/nwae113","relation":{},"ISSN":["2095-5138","2053-714X"],"issn-type":[{"value":"2095-5138","type":"print"},{"value":"2053-714X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,5]]},"published":{"date-parts":[[2024,3,22]]},"article-number":"nwae113"}}