{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:30:30Z","timestamp":1793298630869,"version":"4.5.0"},"reference-count":81,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,6,29]],"date-time":"2024-06-29T00:00:00Z","timestamp":1719619200000},"content-version":"vor","delay-in-days":16,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFA0709202"],"award-info":[{"award-number":["2019YFA0709202"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFF1200700"],"award-info":[{"award-number":["2021YFF1200700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA1205804"],"award-info":[{"award-number":["2022YFA1205804"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21820102009"],"award-info":[{"award-number":["21820102009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22237006"],"award-info":[{"award-number":["22237006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,13]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Alzheimer's disease (AD) is a devastating neurodegenerative disease that affects \u223c50 million people globally. The accumulation of amyloid-\u03b2 (A\u03b2) plaques, a predominant pathological feature of AD, plays a crucial role in AD pathogenesis. In this respect, A\u03b2 has been regarded as a highly promising therapeutic target for AD treatment. Polyoxometalates (POMs) are a novel class of metallodrugs being developed as modulators of A\u03b2 aggregation, owing to their negative charge, polarity, and three-dimensional structure. Unlike traditional discrete inorganic complexes, POMs contain tens to hundreds of metal atoms, showcasing remarkable tunability and diversity in nuclearities, sizes, and shapes. The easily adjustable and structurally variable nature of POMs allows for their favorable interactions with A\u03b2. This mini-review presents a balanced overview of recent progress in using POMs to mitigate amyloidosis. Clear correlations between anti-amyloid activities and structural features of POMs are also elaborated in detail. Finally, we discuss the current challenges and future prospects of POMs in combating AD.<\/jats:p>","DOI":"10.1093\/nsr\/nwae226","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:19:06Z","timestamp":1719533946000},"source":"Crossref","is-referenced-by-count":30,"title":["Polyoxometalates: metallodrug agents for combating amyloid aggregation"],"prefix":"10.1093","volume":"11","author":[{"given":"Mengmeng","family":"Ma","sequence":"first","affiliation":[{"name":"Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022 , China"},{"name":"School of Applied Chemistry and Engineering, University of Science and Technology of China , Hefei 230026 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenqi","family":"Liu","sequence":"additional","affiliation":[{"name":"Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022 , China"},{"name":"School of Applied Chemistry and Engineering, University of Science and Technology of China , Hefei 230026 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huisi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022 , China"},{"name":"School of Applied Chemistry and Engineering, University of Science and Technology of China , Hefei 230026 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haochen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022 , China"},{"name":"School of Applied Chemistry and Engineering, University of Science and Technology of China , Hefei 230026 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinsong","family":"Ren","sequence":"additional","affiliation":[{"name":"Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022 , China"},{"name":"School of Applied Chemistry and Engineering, University of Science and Technology of China , Hefei 230026 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2868-3205","authenticated-orcid":false,"given":"Xiaogang","family":"Qu","sequence":"additional","affiliation":[{"name":"Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022 , China"},{"name":"School of Applied Chemistry and Engineering, University of Science and Technology of China , Hefei 230026 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,6,28]]},"reference":[{"key":"2024073015475660600_bib1","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1038\/d41586-018-05718-5","article-title":"An age-old story of dementia","volume":"559","author":"Drew","year":"2018","journal-title":"Nature"},{"key":"2024073015475660600_bib2","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/978-981-32-9358-8_16","article-title":"Amyloid-\u03b2 and tau at the crossroads of Alzheimer's disease","volume":"1184","author":"Gallardo","year":"2019","journal-title":"Adv Exp Med Biol"},{"key":"2024073015475660600_bib3","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1038\/s41593-020-0687-6","article-title":"Synergy between amyloid-\u03b2 and tau in Alzheimer's disease","volume":"23","author":"Busche","year":"2020","journal-title":"Nat Neurosci"},{"key":"2024073015475660600_bib4","doi-asserted-by":"publisher","first-page":"2172","DOI":"10.1021\/acs.accounts.1c00055","article-title":"Current strategies for modulating A\u03b2 aggregation with multifunctional agents","volume":"54","author":"Du","year":"2021","journal-title":"Acc Chem Res"},{"key":"2024073015475660600_bib5","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1038\/s41573-022-00391-w","article-title":"The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics","volume":"21","author":"Karran","year":"2022","journal-title":"Nat Rev Drug Discov"},{"key":"2024073015475660600_bib6","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/s41582-022-00645-6","article-title":"Early-stage Alzheimer disease: getting trial-ready","volume":"18","author":"Aisen","year":"2022","journal-title":"Nat Rev Neurol"},{"key":"2024073015475660600_bib7","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1039\/C6CS00731G","article-title":"Towards an understanding of amyloid-\u03b2 oligomers: characterization, toxicity mechanisms, and inhibitors","volume":"46","author":"Lee","year":"2017","journal-title":"Chem Soc Rev"},{"key":"2024073015475660600_bib8","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1007\/s40265-023-01858-9","article-title":"Anti-amyloid monoclonal antibodies are transformative treatments that redefine Alzheimer's disease therapeutics","volume":"83","author":"Cummings","year":"2023","journal-title":"Drugs"},{"key":"2024073015475660600_bib9","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1002\/(SICI)1521-3773(19990601)38:11%3c1512::AID-ANIE1512%3e3.0.CO;2-Y","article-title":"Metals in medicine","volume":"38","author":"Guo","year":"1999","journal-title":"Angew Chem Int Ed"},{"key":"2024073015475660600_bib10","doi-asserted-by":"publisher","first-page":"2544","DOI":"10.1039\/D1CS00468A","article-title":"Metallodrugs in cancer nanomedicine","volume":"51","author":"Pena","year":"2022","journal-title":"Chem Soc Rev"},{"key":"2024073015475660600_bib11","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1039\/C4SC03094J","article-title":"Metal complexes as potential modulators of inflammatory and autoimmune responses","volume":"6","author":"Leung","year":"2015","journal-title":"Chem Sci"},{"key":"2024073015475660600_bib12","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1021\/acs.chemrev.8b00209","article-title":"Stimuli-responsive therapeutic metallodrugs","volume":"119","author":"Wang","year":"2019","journal-title":"Chem Rev"},{"key":"2024073015475660600_bib13","doi-asserted-by":"publisher","first-page":"679","DOI":"10.4155\/fmc-2017-0248","article-title":"Amyloid \u03b2-targeted metal complexes for potential applications in Alzheimer's disease","volume":"10","author":"Liu","year":"2018","journal-title":"Future Med Chem"},{"key":"2024073015475660600_bib14","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1021\/acs.inorgchem.3c03441","article-title":"A diruthenium metallodrug as a potent inhibitor of amyloid-beta aggregation: synergism of mechanisms of action","volume":"63","author":"La Manna","year":"2024","journal-title":"Inorg Chem"},{"key":"2024073015475660600_bib15","doi-asserted-by":"publisher","first-page":"12677","DOI":"10.1039\/D3DT02187D","article-title":"The inhibitory effects of platinum(II) complexes on amyloid aggregation: a theoretical and experimental approach","volume":"52","author":"La Manna","year":"2023","journal-title":"Dalton Trans"},{"key":"2024073015475660600_bib16","doi-asserted-by":"publisher","first-page":"10470","DOI":"10.1021\/acs.inorgchem.3c01522","article-title":"Metal-complexes bearing releasable CO differently modulate amyloid aggregation","volume":"62","author":"La Manna","year":"2023","journal-title":"Inorg Chem"},{"key":"2024073015475660600_bib17","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.3390\/ijms20081829","article-title":"Recent developments in metal-based drugs and chelating agents for neurodegenerative diseases treatments","volume":"20","author":"Sales","year":"2019","journal-title":"Int J Mol Sci"},{"key":"2024073015475660600_bib18","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1021\/acs.inorgchem.8b02813","article-title":"Strategies employing transition metal complexes to modulate amyloid-beta aggregation","volume":"58","author":"Suh","year":"2019","journal-title":"Inorg Chem"},{"key":"2024073015475660600_bib19","doi-asserted-by":"publisher","first-page":"110721","DOI":"10.1016\/j.jinorgbio.2019.110721","article-title":"Inhibitory effects of oxidovanadium complexes on the aggregation of human islet amyloid polypeptide and its fragments","volume":"197","author":"Xu","year":"2019","journal-title":"J Inorg Biochem"},{"key":"2024073015475660600_bib20","doi-asserted-by":"publisher","first-page":"213255","DOI":"10.1016\/j.ccr.2020.213255","article-title":"Metal complexes that bind to the amyloid-\u03b2 peptide of relevance to Alzheimer's disease","volume":"412","author":"Gomes","year":"2020","journal-title":"Coordin Chem Rev"},{"key":"2024073015475660600_bib21","doi-asserted-by":"publisher","first-page":"7403","DOI":"10.1039\/c2cs35190k","article-title":"Engineering polyoxometalates with emergent properties","volume":"41","author":"Miras","year":"2012","journal-title":"Chem Soc Rev"},{"key":"2024073015475660600_bib22","doi-asserted-by":"publisher","first-page":"9140011","DOI":"10.26599\/POM.2022.9140011","article-title":"Latest progress in covalently modified polyoxometalates-based molecular assemblies and advanced materials","volume":"1","author":"Zhang","year":"2022","journal-title":"Polyoxometalates"},{"key":"2024073015475660600_bib23","doi-asserted-by":"publisher","first-page":"e2005019","DOI":"10.1002\/adma.202005019","article-title":"The intrinsic charge carrier behaviors and applications of polyoxometalate clusters based materials","volume":"33","author":"Yang","year":"2021","journal-title":"Adv Mater"},{"key":"2024073015475660600_bib24","doi-asserted-by":"publisher","first-page":"4615","DOI":"10.1039\/C3CS60404G","article-title":"Recent advances in porous polyoxometalate-based metal-organic framework materials","volume":"43","author":"Du","year":"2014","journal-title":"Chem Soc Rev"},{"key":"2024073015475660600_bib25","doi-asserted-by":"publisher","first-page":"0112","DOI":"10.1038\/s41570-018-0112","article-title":"Synthesis, structures and applications of electron-rich polyoxometalates","volume":"2","author":"Gumerova","year":"2018","journal-title":"Nat Rev Chem"},{"key":"2024073015475660600_bib26","doi-asserted-by":"publisher","first-page":"5679","DOI":"10.1039\/C4CS00097H","article-title":"Polyoxometalate based open-frameworks (POM-OFs)","volume":"43","author":"Miras","year":"2014","journal-title":"Chem Soc Rev"},{"key":"2024073015475660600_bib27","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1515\/revic-2023-0008","article-title":"Polyoxometalates as next-generation of theragnostic gadgets in cancer","volume":"44","author":"Aminolroayaei","year":"2023","journal-title":"Rev Inorg Chem"},{"key":"2024073015475660600_bib28","doi-asserted-by":"publisher","first-page":"6291","DOI":"10.1039\/c3ta01663c","article-title":"Polyoxometalates: formation, structures, principal properties, main deposition methods and application in sensing","volume":"1","author":"Ammam","year":"2013","journal-title":"J Mater Chem A"},{"key":"2024073015475660600_bib29","doi-asserted-by":"publisher","first-page":"7590","DOI":"10.1039\/c2cs35153f","article-title":"Diphosphates and diphosphonates in polyoxometalate chemistry","volume":"41","author":"Banerjee","year":"2012","journal-title":"Chem Soc Rev"},{"key":"2024073015475660600_bib30","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.ccr.2015.06.016","article-title":"Hybrid polyoxometalate materials for photo(electro-) chemical applications","volume":"306","author":"Walsh","year":"2016","journal-title":"Coord Chem Rev"},{"key":"2024073015475660600_bib31","doi-asserted-by":"publisher","first-page":"2980","DOI":"10.1002\/anie.201803868","article-title":"Polyoxometalates as potential next-generation metallodrugs in the combat against cancer","volume":"58","author":"Bijelic","year":"2019","journal-title":"Angew Chem Int Ed"},{"key":"2024073015475660600_bib32","first-page":"884","article-title":"Recent advances on polyoxometalates as metallodrug agents for Alzheimer's disease","volume":"41","author":"Ma","year":"2020","journal-title":"Chem J Chin Univ"},{"key":"2024073015475660600_bib33","doi-asserted-by":"publisher","first-page":"6109","DOI":"10.1021\/acs.inorgchem.1c00125","article-title":"Interweaving disciplines to advance chemistry: applying polyoxometalates in biology","volume":"60","author":"Gumerova","year":"2021","journal-title":"Inorg Chem"},{"key":"2024073015475660600_bib34","doi-asserted-by":"publisher","first-page":"20779","DOI":"10.1002\/anie.202008054","article-title":"Polyoxometalate-based compounds for photo- and electrocatalytic applications","volume":"59","author":"Li","year":"2020","journal-title":"Angew Chem Int Ed"},{"key":"2024073015475660600_bib35","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.ccr.2019.07.005","article-title":"Recent advances in POM-organic frameworks and POM-organic polyhedra","volume":"397","author":"Li","year":"2019","journal-title":"Coord Chem Rev"},{"key":"2024073015475660600_bib36","doi-asserted-by":"publisher","first-page":"e202319700","DOI":"10.1002\/anie.202319700","article-title":"A giant heterometallic polyoxometalate nanocluster for enhanced brain-targeted glioma therapy","volume":"63","author":"Song","year":"2024","journal-title":"Angew Chem Int Ed"},{"key":"2024073015475660600_bib37","doi-asserted-by":"publisher","first-page":"e202303989","DOI":"10.1002\/anie.202303989","article-title":"A polyoxometalate-based pathologically activated assay for efficient bioorthogonal catalytic selective therapy","volume":"62","author":"Zhao","year":"2023","journal-title":"Angew Chem Int Ed"},{"key":"2024073015475660600_bib38","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1007\/s00775-022-01942-7","article-title":"Promising application of polyoxometalates in the treatment of cancer, infectious diseases and Alzheimer's disease","volume":"27","author":"Wang","year":"2022","journal-title":"J Biol Inorg Chem"},{"key":"2024073015475660600_bib39","doi-asserted-by":"publisher","first-page":"362","DOI":"10.2174\/0929867326666190827153532","article-title":"Polyoxometalates in biomedicine: update and overview","volume":"27","author":"\u010colovi\u0107","year":"2020","journal-title":"Curr Med Chem"},{"key":"2024073015475660600_bib40","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.copbio.2018.11.013","article-title":"Interactions between polyoxometalates and biological systems: from drug design to artificial enzymes","volume":"58","author":"Van Rompuy","year":"2019","journal-title":"Curr Opin Biotechnol"},{"key":"2024073015475660600_bib41","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1021\/jacsau.3c00011","article-title":"Exploring the reactivity of polyoxometalates toward proteins: from interactions to mechanistic insights","volume":"3","author":"Salazar Marcano","year":"2023","journal-title":"JACS Au"},{"key":"2024073015475660600_bib42","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.ccr.2015.03.018","article-title":"The use of polyoxometalates in protein crystallography\u2014an attempt to widen a well-known bottleneck","volume":"299","author":"Bijelic","year":"2015","journal-title":"Coord Chem Rev"},{"key":"2024073015475660600_bib43","doi-asserted-by":"publisher","first-page":"e202303817","DOI":"10.1002\/anie.202303817","article-title":"Exploiting interactions between polyoxometalates and proteins for applications in (bio)chemistry and medicine","volume":"62","author":"Lentink","year":"2023","journal-title":"Angew Chem Int Ed"},{"key":"2024073015475660600_bib44","doi-asserted-by":"publisher","first-page":"4184","DOI":"10.1002\/anie.201007067","article-title":"Polyoxometalates as inhibitors of the aggregation of amyloid \u03b2 peptides associated with Alzheimer's disease","volume":"50","author":"Geng","year":"2011","journal-title":"Angew Chem Int Ed"},{"key":"2024073015475660600_bib45","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.colsurfa.2010.11.068","article-title":"Inhibition of amyloid-\u03b2 protein fibrillization upon interaction with polyoxometalates nanoclusters","volume":"375","author":"Zhou","year":"2011","journal-title":"Colloids and Surfaces A: Physicochem Eng Aspects"},{"key":"2024073015475660600_bib46","doi-asserted-by":"publisher","first-page":"6886","DOI":"10.1039\/C3NR05906E","article-title":"Mo polyoxometalate nanoclusters capable of inhibiting the aggregation of abeta-peptide associated with Alzheimer's disease","volume":"6","author":"Chen","year":"2014","journal-title":"Nanoscale"},{"key":"2024073015475660600_bib47","doi-asserted-by":"publisher","first-page":"3422","DOI":"10.1038\/ncomms4422","article-title":"Transition-metal-substituted polyoxometalate derivatives as functional anti-amyloid agents for Alzheimer's disease","volume":"5","author":"Gao","year":"2014","journal-title":"Nat Commun"},{"key":"2024073015475660600_bib48","doi-asserted-by":"publisher","first-page":"2367","DOI":"10.1039\/D1CC05792H","article-title":"Keggin-type polyoxometalates as Cu(II) chelators in the context of Alzheimer's disease","volume":"58","author":"Atrian-Blasco","year":"2022","journal-title":"Chem Commun"},{"key":"2024073015475660600_bib49","doi-asserted-by":"publisher","first-page":"2510","DOI":"10.1039\/D1SC05879G","article-title":"Polyoxometalates as chemically and structurally versatile components in self-assembled materials","volume":"13","author":"Gao","year":"2022","journal-title":"Chem Sci"},{"key":"2024073015475660600_bib50","doi-asserted-by":"publisher","first-page":"4945","DOI":"10.1039\/D1DT04376E","article-title":"Insights into organic-inorganic hybrid molecular materials: organoimido functionalized polyoxomolybdates","volume":"51","author":"Pardiwala","year":"2022","journal-title":"Dalton Trans"},{"key":"2024073015475660600_bib51","doi-asserted-by":"publisher","first-page":"20210089","DOI":"10.1002\/EXP.20210089","article-title":"Advanced bioactive nanomaterials for biomedical applications","volume":"1","author":"Zhao","year":"2021","journal-title":"Exploration"},{"key":"2024073015475660600_bib52","doi-asserted-by":"publisher","first-page":"13533","DOI":"10.1021\/acs.inorgchem.8b02115","article-title":"Modulating conformation of A\u03b2-peptide: an effective way to prevent protein-misfolding disease","volume":"57","author":"Ma","year":"2018","journal-title":"Inorg Chem"},{"key":"2024073015475660600_bib53","doi-asserted-by":"publisher","first-page":"18032","DOI":"10.1002\/anie.201910521","article-title":"Organoplatinum-substituted polyoxometalate inhibits beta-amyloid aggregation for Alzheimer's therapy","volume":"58","author":"Zhao","year":"2019","journal-title":"Angew Chem Int Ed"},{"key":"2024073015475660600_bib54","doi-asserted-by":"publisher","first-page":"6915","DOI":"10.1021\/jacs.8b12537","article-title":"Chirality-selected chemical modulation of amyloid aggregation","volume":"141","author":"Gao","year":"2019","journal-title":"J Am Chem Soc"},{"key":"2024073015475660600_bib55","doi-asserted-by":"publisher","first-page":"4790","DOI":"10.1038\/s41467-020-18525-2","article-title":"Chiral gold nanoparticles enantioselectively rescue memory deficits in a mouse model of Alzheimer's disease","volume":"11","author":"Hou","year":"2020","journal-title":"Nat Commun"},{"key":"2024073015475660600_bib56","doi-asserted-by":"publisher","first-page":"6721","DOI":"10.1007\/s12274-022-4303-9","article-title":"Chiral effect on A\u03b2 fibrillation from molecular-scale to nanoscale","volume":"15","author":"Gao","year":"2022","journal-title":"Nano Res"},{"key":"2024073015475660600_bib57","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/s41573-020-0090-8","article-title":"Engineering precision nanoparticles for drug delivery","volume":"20","author":"Mitchell","year":"2021","journal-title":"Nat Rev Drug Discov"},{"key":"2024073015475660600_bib58","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1080\/10601325.2016.1110459","article-title":"Polymer nanocomposites in medicine","volume":"53","author":"Feldman","year":"2016","journal-title":"J Macromol Sci A"},{"key":"2024073015475660600_bib59","doi-asserted-by":"publisher","first-page":"3372","DOI":"10.1002\/anie.201906908","article-title":"Peptide-based molecular strategies to interfere with protein misfolding, aggregation, and cell degeneration","volume":"59","author":"Armiento","year":"2020","journal-title":"Angew Chem Int Ed"},{"key":"2024073015475660600_bib60","doi-asserted-by":"publisher","first-page":"3455","DOI":"10.1002\/smll.201202612","article-title":"Self-assembled peptide-polyoxometalate hybrid nanospheres: two in one enhances targeted inhibition of amyloid beta-peptide aggregation associated with Alzheimer's disease","volume":"9","author":"Li","year":"2013","journal-title":"Small"},{"key":"2024073015475660600_bib61","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1002\/cnma.201900057","article-title":"Peptide-modified Mo polyoxometalate nanoparticles suppress Zn2+-induced A\u03b2 aggregation","volume":"5","author":"Liu","year":"2019","journal-title":"ChemNanoMat"},{"key":"2024073015475660600_bib62","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1002\/chem.201404562","article-title":"Gold-nanoparticle-based multifunctional amyloid-\u03b2 inhibitor against Alzheimer's disease","volume":"21","author":"Gao","year":"2015","journal-title":"Chem Eur J"},{"key":"2024073015475660600_bib63","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1126\/science.283.5408.1727","article-title":"How strong is a covalent bond?","volume":"283","author":"Grandbois","year":"1999","journal-title":"Science"},{"key":"2024073015475660600_bib64","doi-asserted-by":"publisher","first-page":"e202115336","DOI":"10.1002\/anie.202115336","article-title":"Site-directed chemical modification of amyloid by polyoxometalates for inhibition of protein misfolding and aggregation","volume":"61","author":"Gao","year":"2022","journal-title":"Angew Chem Int Ed"},{"key":"2024073015475660600_bib65","doi-asserted-by":"publisher","first-page":"8065","DOI":"10.1039\/D0CS00215A","article-title":"Emerging combination strategies with phototherapy in cancer nanomedicine","volume":"49","author":"Xie","year":"2020","journal-title":"Chem Soc Rev"},{"key":"2024073015475660600_bib66","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1038\/s41571-020-0410-2","article-title":"Clinical development and potential of photothermal and photodynamic therapies for cancer","volume":"17","author":"Li","year":"2020","journal-title":"Nat Rev Clin Oncol"},{"key":"2024073015475660600_bib67","doi-asserted-by":"publisher","first-page":"9894","DOI":"10.1021\/acsnano.0c02733","article-title":"A biocompatible second near-infrared nanozyme for spatiotemporal and non-invasive attenuation of amyloid deposition through scalp and skull","volume":"14","author":"Ma","year":"2020","journal-title":"ACS Nano"},{"key":"2024073015475660600_bib68","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.actbio.2022.10.049","article-title":"Transcranial deep-tissue phototherapy for Alzheimer's disease using low-dose X-ray-activated long-afterglow scintillators","volume":"155","author":"Ma","year":"2023","journal-title":"Acta Biomater"},{"key":"2024073015475660600_bib69","doi-asserted-by":"publisher","first-page":"8156","DOI":"10.1021\/jacs.6b03375","article-title":"A polyoxometalate cluster paradigm with self-adaptive electronic structure for acidity\/reducibility-specific photothermal conversion","volume":"138","author":"Zhang","year":"2016","journal-title":"J Am Chem Soc"},{"key":"2024073015475660600_bib70","doi-asserted-by":"publisher","first-page":"8189","DOI":"10.1039\/D0TB01375G","article-title":"Recent advances of polyoxometalates in multi-functional imaging and photothermal therapy","volume":"8","author":"Kong","year":"2020","journal-title":"J Mater Chem B"},{"key":"2024073015475660600_bib71","doi-asserted-by":"publisher","first-page":"11394","DOI":"10.1039\/c3cc46772d","article-title":"Photodegradation of \u03b2-sheet amyloid fibrils associated with Alzheimer's disease by using polyoxometalates as photocatalysts","volume":"49","author":"Li","year":"2013","journal-title":"Chem Commun"},{"key":"2024073015475660600_bib72","doi-asserted-by":"publisher","first-page":"e1800320","DOI":"10.1002\/adhm.201800320","article-title":"Redox-activated near-infrared-responsive polyoxometalates used for photothermal treatment of Alzheimer's disease","volume":"7","author":"Ma","year":"2018","journal-title":"Adv Healthc Mater"},{"key":"2024073015475660600_bib73","doi-asserted-by":"publisher","first-page":"e147","DOI":"10.1038\/emm.2014.117","article-title":"Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies","volume":"47","author":"Ciechanover","year":"2015","journal-title":"Exp Mol Med"},{"key":"2024073015475660600_bib74","doi-asserted-by":"publisher","first-page":"24540","DOI":"10.1074\/jbc.M007579200","article-title":"Degradation of the Alzheimer's amyloid \u03b2 peptide by endothelin-converting enzyme","volume":"276","author":"Eckman","year":"2001","journal-title":"J Biol Chem"},{"key":"2024073015475660600_bib75","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1039\/c2mt20105d","article-title":"Metallostasis and amyloid \u03b2-degrading enzymes","volume":"4","author":"Grasso","year":"2012","journal-title":"Metallomics"},{"key":"2024073015475660600_bib76","doi-asserted-by":"publisher","first-page":"2234","DOI":"10.1021\/jacs.6b09681","article-title":"Mechanistic insights into tunable metal-mediated hydrolysis of amyloid-\u03b2 peptides","volume":"139","author":"Derrick","year":"2017","journal-title":"J Am Chem Soc"},{"key":"2024073015475660600_bib77","doi-asserted-by":"publisher","first-page":"11852","DOI":"10.1002\/chem.201902828","article-title":"A near-infrared-controllable artificial metalloprotease used for degrading amyloid-\u03b2 monomers and aggregates","volume":"25","author":"Ma","year":"2019","journal-title":"Chem Eur J"},{"key":"2024073015475660600_bib78","doi-asserted-by":"publisher","first-page":"7064","DOI":"10.1002\/anie.200702399","article-title":"Cleavage agents for soluble oligomers of amyloid beta peptides","volume":"46","author":"Suh","year":"2007","journal-title":"Angew Chem Int Ed"},{"key":"2024073015475660600_bib79","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1007\/s12274-016-1000-6","article-title":"Polyoxometalate-based nanozyme: design of a multifunctional enzyme for multi-faceted treatment of Alzheimer's disease","volume":"9","author":"Gao","year":"2016","journal-title":"Nano Res"},{"key":"2024073015475660600_bib80","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.biomaterials.2016.05.005","article-title":"Ceria\/POMs hybrid nanoparticles as a mimicking metallopeptidase for treatment of neurotoxicity of amyloid-\u03b2 peptide","volume":"98","author":"Guan","year":"2016","journal-title":"Biomaterials"},{"key":"2024073015475660600_bib81","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s40360-017-0133-x","article-title":"Genotoxicity and acute and subchronic toxicity studies of a bioactive polyoxometalate in Wistar rats","volume":"18","author":"Qu","year":"2017","journal-title":"BMC Pharmacol Toxicol"}],"container-title":["National Science Review"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/nsr\/advance-article-pdf\/doi\/10.1093\/nsr\/nwae226\/58362289\/nwae226.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nsr\/article-pdf\/11\/7\/nwae226\/58691662\/nwae226.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nsr\/article-pdf\/11\/7\/nwae226\/58691662\/nwae226.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T21:05:01Z","timestamp":1722373501000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nsr\/article\/doi\/10.1093\/nsr\/nwae226\/7701423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,13]]},"references-count":81,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,6,13]]}},"URL":"https:\/\/doi.org\/10.1093\/nsr\/nwae226","relation":{},"ISSN":["2095-5138","2053-714X"],"issn-type":[{"value":"2095-5138","type":"print"},{"value":"2053-714X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,7]]},"published":{"date-parts":[[2024,6,13]]},"article-number":"nwae226"}}