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Their adsorptive separation by porous materials is hampered by their similar dimensions. Metal-organic frameworks (MOFs) with versatile pore environments are capable of molecular discrimination, but the separation of trace substrates in liquid-phase remains extremely challenging. Herein, we report a robust MOF (NKU-300) with triangular channels decorated with crown ether that can discriminate trace benzene from cyclohexane, exhibiting an unprecedented selectivity of 8615(10) for the mixture of benzene\/cyclohexane (v\/v\u00a0=\u00a01\/1000). Remarkably, NKU-300 demonstrates exceptional selectivities for the extraction of benzene from cyclohexane over a wide range of concentrations of 0.1%\u201350% with ultrafast sorption kinetics and excellent stability. Single-crystal X-ray diffraction and computational modelling reveal that multiple supramolecular interactions cooperatively immobilise benzene molecules in the triangular channel, enabling superior separation performance. This study will promote the application of advanced sorbents with tailored binding sites for challenging industrial separations.<\/jats:p>","DOI":"10.1093\/nsr\/nwae342","type":"journal-article","created":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T03:49:18Z","timestamp":1728013758000},"source":"Crossref","is-referenced-by-count":32,"title":["Rapid extraction of trace benzene by a crown-ether-based metal-organic framework"],"prefix":"10.1093","volume":"11","author":[{"given":"Zhonghang","family":"Chen","sequence":"first","affiliation":[{"name":"Frontiers Science Center for New Organic Matter, Key Laboratory of Advanced Energy Materials Chemistry (MOE), and State Key Laboratory of Advanced Chemical Power Sources, College of Chemistry, Nankai University , Tianjin 300071 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyu","family":"Fang","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University , Beijing 100871 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangnan","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University , Beijing 100871 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Han","sequence":"additional","affiliation":[{"name":"College of Chemistry, Beijing Normal University , Beijing 100875 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhao","family":"Huang","sequence":"additional","affiliation":[{"name":"Frontiers Science Center for New Organic Matter, Key Laboratory of Advanced Energy Materials Chemistry (MOE), and State Key Laboratory of Advanced Chemical Power Sources, College of Chemistry, Nankai University , Tianjin 300071 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyue","family":"Cui","sequence":"additional","affiliation":[{"name":"Frontiers Science Center for New Organic Matter, Key Laboratory of Advanced Energy Materials Chemistry (MOE), and State Key Laboratory of Advanced Chemical Power Sources, College of Chemistry, Nankai University , Tianjin 300071 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University , Beijing 100871 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R","family":"Warren","sequence":"additional","affiliation":[{"name":"Diamond Light Source, Harwell Science and Innovation Campus , Oxfordshire OX11 0DE,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Allan","sequence":"additional","affiliation":[{"name":"Diamond Light Source, Harwell Science and Innovation Campus , Oxfordshire OX11 0DE,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Cheng","sequence":"additional","affiliation":[{"name":"Frontiers Science Center for New Organic Matter, Key Laboratory of Advanced Energy Materials Chemistry (MOE), and State Key Laboratory of Advanced Chemical Power Sources, College of Chemistry, Nankai University , Tianjin 300071 ,","place":["China"]},{"name":"Haihe Laboratory of Sustainable Chemical Transformations , Tianjin 300192 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sihai","family":"Yang","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University , Beijing 100871 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Shi","sequence":"additional","affiliation":[{"name":"Frontiers Science Center for New Organic Matter, Key Laboratory of Advanced Energy Materials Chemistry (MOE), and State Key Laboratory of Advanced Chemical Power Sources, College of Chemistry, Nankai University , Tianjin 300071 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,10,3]]},"reference":[{"key":"2025011114332924800_bib1","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/532435a","article-title":"Seven chemical separations to change the world","volume":"532","author":"Sholl","year":"2016","journal-title":"Nature"},{"key":"2025011114332924800_bib2","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1038\/s41467-024-45005-8","article-title":"Three-dimensional covalent organic frameworks with nia nets for 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