{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T20:29:51Z","timestamp":1783369791679,"version":"3.54.6"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T00:00:00Z","timestamp":1730332800000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFA0709202"],"award-info":[{"award-number":["2019YFA0709202"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFF1200700"],"award-info":[{"award-number":["2021YFF1200700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2304100"],"award-info":[{"award-number":["2022YFC2304100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFA1201003"],"award-info":[{"award-number":["2021YFA1201003"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22437006"],"award-info":[{"award-number":["22437006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22237006"],"award-info":[{"award-number":["22237006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22122704"],"award-info":[{"award-number":["22122704"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22107098"],"award-info":[{"award-number":["22107098"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82241066"],"award-info":[{"award-number":["82241066"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jilin Innovation Project","award":["2023DJ02"],"award-info":[{"award-number":["2023DJ02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,30]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>The Mpox virus (MPXV) has emerged as a formidable orthopoxvirus, posing an immense challenge to global public health. An understanding of the regulatory mechanisms of MPXV infection, replication and immune evasion will benefit the development of novel antiviral strategies. Despite the involvement of G-quadruplexes (G4s) in modulating the infection and replication processes of multiple viruses, their roles in the MPXV life cycle remain largely unknown. Here, we found a highly conservative and stable G4 in MPXV that acts as a positive regulatory element for viral immunodominant protein expression. Furthermore, by screening 42 optically pure chiral metal complexes, we identified the \u039b enantiomer of a pair of chiral helical compounds that can selectively target mRNA G4 and enhance expression of the 39-kDa core protein encoded by the MPXV A5L gene. Mechanistically, RNA G4-specific helicase DHX36 inhibits A5L protein expression by unwinding G4s. In contrast, MH3 \u039b enhanced mRNA stability by specifically targeting G4 structures and subsequently increased protein expression. Furthermore, given the pivotal role of the 39-kDa core protein in activating immune responses and facilitating virion maturation, modulation of MPXV G4 folding by MH3 \u039b exhibited inhibitory effects on MPXV replication through enhancing the immune response. Our findings underscore the critical involvement of G4 in the MPXV life cycle and offer potential avenues for developing antiviral drugs that target G4.<\/jats:p>","DOI":"10.1093\/nsr\/nwae388","type":"journal-article","created":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T09:53:56Z","timestamp":1730368436000},"source":"Crossref","is-referenced-by-count":11,"title":["Metallo-supramolecular complexes enantioselectively target monkeypox virus RNA G-quadruplex and bolster immune responses against MPXV"],"prefix":"10.1093","volume":"12","author":[{"given":"Jie","family":"Yang","sequence":"first","affiliation":[{"name":"Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022 ,","place":["China"]},{"name":"School of Applied Chemistry and Engineering, University of Science and Technology of China , Hefei 230026 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geng","family":"Qin","sequence":"additional","affiliation":[{"name":"Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022 ,","place":["China"]},{"name":"School of Applied Chemistry and Engineering, University of Science and Technology of China , Hefei 230026 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoying","family":"Huang","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID) , Beijing 102206 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hualong","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Warwick , Coventry CV4 7AL ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiewei","family":"Sun","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID) , Beijing 102206 ,","place":["China"]},{"name":"School of Pharmacy, Xinxiang Medical University , Xinxiang 453003 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miles","family":"Postings","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Warwick , Coventry CV4 7AL ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Warwick , Coventry CV4 7AL ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanqi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022 ,","place":["China"]},{"name":"School of Applied Chemistry and Engineering, University of Science and Technology of China , Hefei 230026 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyu","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Supramolecular Structure and Materials, Jilin University , Changchun 130012 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5963-1136","authenticated-orcid":false,"given":"Wenjie","family":"Tan","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID) , Beijing 102206 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinsong","family":"Ren","sequence":"additional","affiliation":[{"name":"Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022 ,","place":["China"]},{"name":"School of Applied Chemistry and Engineering, University of Science and Technology of China , Hefei 230026 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2868-3205","authenticated-orcid":false,"given":"Xiaogang","family":"Qu","sequence":"additional","affiliation":[{"name":"Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022 ,","place":["China"]},{"name":"School of Applied Chemistry and Engineering, University of Science and Technology of China , Hefei 230026 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,10,30]]},"reference":[{"key":"2025012011001753500_bib1","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/S0140-6736(22)02075-X","article-title":"Monkeypox","volume":"401","author":"Mitja","year":"2023","journal-title":"Lancet"},{"key":"2025012011001753500_bib2","doi-asserted-by":"publisher","first-page":"e0009222","DOI":"10.1128\/cmr.00092-22","article-title":"Monkeypox virus infections in humans","volume":"35","author":"Elsayed","year":"2022","journal-title":"Clin Microbiol Rev"},{"key":"2025012011001753500_bib3","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/S0140-6736(22)01422-2","article-title":"Monkeypox: a global wake-up call","volume":"400","author":"The","year":"2022","journal-title":"Lancet"},{"key":"2025012011001753500_bib4","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1038\/s41392-023-01675-2","article-title":"Mpox (formerly monkeypox): pathogenesis, prevention, and treatment","volume":"8","author":"Lu","year":"2023","journal-title":"Sig Transduct Target Ther"},{"key":"2025012011001753500_bib5","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1007\/s40265-022-01742-y","article-title":"Prevention and treatment of monkeypox","volume":"82","author":"Rizk","year":"2022","journal-title":"Drugs"},{"key":"2025012011001753500_bib6","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1038\/s41587-022-01463-3","article-title":"Monkeypox response relies on three vaccine suppliers","volume":"40","author":"Harrison","year":"2022","journal-title":"Nat Biotechnol"},{"key":"2025012011001753500_bib7","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1056\/NEJMp2210125","article-title":"Tecovirimat and the treatment of monkeypox\u2014past, present, and future considerations","volume":"387","author":"Sherwat","year":"2022","journal-title":"N Engl J Med"},{"key":"2025012011001753500_bib8","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1001\/jama.2022.14857","article-title":"Update on the monkeypox outbreak","volume":"328","author":"Del Rio","year":"2022","journal-title":"JAMA"},{"key":"2025012011001753500_bib9","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1038\/s41580-020-0236-x","article-title":"The regulation and functions of DNA and RNA G-quadruplexes","volume":"21","author":"Varshney","year":"2020","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2025012011001753500_bib10","doi-asserted-by":"publisher","first-page":"5426","DOI":"10.1093\/nar\/gkab187","article-title":"RNA G-quadruplexes (rG4s): genomics and biological functions","volume":"49","author":"Lyu","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"2025012011001753500_bib11","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/nrm.2017.3","article-title":"DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential","volume":"18","author":"Hansel-Hertsch","year":"2017","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2025012011001753500_bib12","doi-asserted-by":"publisher","first-page":"7429","DOI":"10.1093\/nar\/gkm711","article-title":"Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics","volume":"35","author":"Patel","year":"2007","journal-title":"Nucleic Acids Res"},{"key":"2025012011001753500_bib13","doi-asserted-by":"publisher","first-page":"4816","DOI":"10.1093\/nar\/gkab164","article-title":"G-quadruplexes as pathogenic drivers in neurodegenerative disorders","volume":"49","author":"Wang","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"2025012011001753500_bib14","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1124\/pharmrev.120.000230","article-title":"Unlocking G-quadruplexes as antiviral targets","volume":"73","author":"Abiri","year":"2021","journal-title":"Pharmacol Rev"},{"key":"2025012011001753500_bib15","article-title":"A peculiar evolutionary feature of monkeypox virus","author":"Dai","year":"2022","journal-title":"Biorxiv"},{"key":"2025012011001753500_bib16","doi-asserted-by":"publisher","first-page":"10343","DOI":"10.1093\/nar\/gkw968","article-title":"Visualization of DNA G-quadruplexes in herpes simplex virus 1-infected cells","volume":"44","author":"Artusi","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"2025012011001753500_bib17","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1038\/nchembio.1479","article-title":"G-quadruplexes regulate Epstein-Barr virus-encoded nuclear antigen 1 mRNA translation","volume":"10","author":"Murat","year":"2014","journal-title":"Nat Chem Biol"},{"key":"2025012011001753500_bib18","doi-asserted-by":"publisher","first-page":"105151","DOI":"10.1016\/j.jbc.2023.105151","article-title":"G-quadruplex in hepatitis B virus pregenomic RNA promotes its translation","volume":"299","author":"Wang","year":"2023","journal-title":"J Biol Chem"},{"key":"2025012011001753500_bib19","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1002\/cjoc.202200486","article-title":"Unlocking G-quadruplexes as targets and tools against COVID-19","volume":"41","author":"Qin","year":"2023","journal-title":"Chin J Chem"},{"key":"2025012011001753500_bib20","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1038\/s41421-022-00450-x","article-title":"RNA G-quadruplex formed in SARS-CoV-2 used for COVID-19 treatment in animal models","volume":"8","author":"Qin","year":"2022","journal-title":"Cell Discov"},{"key":"2025012011001753500_bib21","doi-asserted-by":"publisher","first-page":"D1115","DOI":"10.1093\/nar\/gks1101","article-title":"G4LDB: a database for discovering and studying G-quadruplex ligands","volume":"41","author":"Li","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"2025012011001753500_bib22","doi-asserted-by":"publisher","first-page":"5293","DOI":"10.1039\/c1cs15117g","article-title":"Methods for investigating G-quadruplex DNA\/ligand interactions","volume":"40","author":"Murat","year":"2011","journal-title":"Chem Soc Rev"},{"key":"2025012011001753500_bib23","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.trechm.2019.07.002","article-title":"The structure and function of DNA G-quadruplexes","volume":"2","author":"Spiegel","year":"2020","journal-title":"Trends Chem"},{"key":"2025012011001753500_bib24","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1081\/NCN-120015067","article-title":"Interaction of distamycin A and netropsin with quadruplex and duplex structures: a comparative 1H-NMR study","volume":"21","author":"Randazzo","year":"2002","journal-title":"Nucleosides Nucleotides Nucleic Acids"},{"key":"2025012011001753500_bib25","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/s41586-018-0209-9","article-title":"Structural basis of G-quadruplex unfolding by the DEAH\/RHA helicase DHX36","volume":"558","author":"Chen","year":"2018","journal-title":"Nature"},{"key":"2025012011001753500_bib26","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1038\/nchem.2024","article-title":"Asymmetric triplex metallohelices with high and selective activity against cancer cells","volume":"6","author":"Faulkner","year":"2014","journal-title":"Nat Chem"},{"key":"2025012011001753500_bib27","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/nchem.1206","article-title":"Optically pure, water-stable metallo-helical \u2018flexicate\u2019 assemblies with antibiotic activity","volume":"4","author":"Howson","year":"2012","journal-title":"Nature Chem"},{"key":"2025012011001753500_bib28","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1039\/C5SC03677A","article-title":"Anticancer metallohelices: nanomolar potency and high selectivity","volume":"7","author":"Kaner","year":"2016","journal-title":"Chem Sci"},{"key":"2025012011001753500_bib29","doi-asserted-by":"publisher","first-page":"9708","DOI":"10.1039\/C9SC03532J","article-title":"Metallohelices that kill Gram-negative pathogens using intracellular antimicrobial peptide pathways","volume":"10","author":"Simpson","year":"2019","journal-title":"Chem Sci"},{"key":"2025012011001753500_bib30","doi-asserted-by":"publisher","first-page":"5026","DOI":"10.1093\/nar\/gkx244","article-title":"Chiral metallohelices enantioselectively target hybrid human telomeric G-quadruplex DNA","volume":"45","author":"Zhao","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"2025012011001753500_bib31","doi-asserted-by":"publisher","first-page":"8547","DOI":"10.1039\/C9SC02651G","article-title":"Discovery of selective, antimetastatic and anti-cancer stem cell metallohelices via post-assembly modification","volume":"10","author":"Song","year":"2019","journal-title":"Chem Sci"},{"key":"2025012011001753500_bib32","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.1039\/D0SC06412B","article-title":"Metallohelices emulate the properties of short cationic alpha-helical peptides","volume":"12","author":"Song","year":"2021","journal-title":"Chem Sci"},{"key":"2025012011001753500_bib33","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/S1359-6446(03)02904-0","article-title":"Trends in the development of chiral drugs","volume":"9","author":"Caner","year":"2004","journal-title":"Drug Discovery Today"},{"key":"2025012011001753500_bib34","doi-asserted-by":"publisher","first-page":"4466","DOI":"10.1039\/c000408c","article-title":"Pharmacologically active compounds in the environment and their chirality","volume":"39","author":"Kasprzyk-Hordern","year":"2010","journal-title":"Chem Soc Rev"},{"key":"2025012011001753500_bib35","doi-asserted-by":"publisher","first-page":"15723","DOI":"10.1002\/anie.201809207","article-title":"Mirror-image dependence: targeting enantiomeric G-quadruplex DNA using triplex metallohelices","volume":"57","author":"Zhao","year":"2018","journal-title":"Angew Chem Int Ed"},{"key":"2025012011001753500_bib36","doi-asserted-by":"publisher","first-page":"18786","DOI":"10.1021\/ja410723r","article-title":"Targeting human telomeric higher-order DNA: dimeric G-quadruplex units serve as preferred binding site","volume":"135","author":"Zhao","year":"2013","journal-title":"J Am Chem Soc"},{"key":"2025012011001753500_bib37","doi-asserted-by":"publisher","first-page":"16201","DOI":"10.1021\/jacs.7b07490","article-title":"Metallo-supramolecular complexes enantioselectively eradicate cancer stem cells in vivo","volume":"139","author":"Qin","year":"2017","journal-title":"J Am Chem Soc"},{"key":"2025012011001753500_bib38","doi-asserted-by":"publisher","first-page":"5695","DOI":"10.1093\/nar\/gkn569","article-title":"Chiral metallo-supramolecular complexes selectively recognize human telomeric G-quadruplex DNA","volume":"36","author":"Yu","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"2025012011001753500_bib39","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.meegid.2009.10.001","article-title":"The evolutionary biology of poxviruses","volume":"10","author":"Hughes","year":"2010","journal-title":"Infect Genet Evol"},{"key":"2025012011001753500_bib40","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1006\/viro.2002.1446","article-title":"Analysis of the monkeypox virus genome","volume":"297","author":"Shchelkunov","year":"2002","journal-title":"Virology"},{"key":"2025012011001753500_bib41","doi-asserted-by":"publisher","first-page":"W676","DOI":"10.1093\/nar\/gkl253","article-title":"QGRS Mapper: a web-based server for predicting G-quadruplexes in nucleotide sequences","volume":"34","author":"Kikin","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"2025012011001753500_bib42","doi-asserted-by":"publisher","first-page":"1746","DOI":"10.1093\/nar\/gkw006","article-title":"Re-evaluation of G-quadruplex propensity with G4Hunter","volume":"44","author":"Bedrat","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"2025012011001753500_bib43","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.ymeth.2012.03.020","article-title":"A FRET-based screening assay for nucleic acid ligands","volume":"57","author":"Renciuk","year":"2012","journal-title":"Methods"},{"key":"2025012011001753500_bib44","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1128\/jvi.66.1.386-398.1992","article-title":"Identification and characterization of vaccinia virus genes encoding proteins that are highly antigenic in animals and are immunodominant in vaccinated humans","volume":"66","author":"Demkowicz","year":"1992","journal-title":"J Virol"},{"key":"2025012011001753500_bib45","doi-asserted-by":"publisher","first-page":"4590","DOI":"10.1128\/JVI.73.6.4590-4599.1999","article-title":"Vaccinia virus WR gene A5L is required for morphogenesis of mature virions","volume":"73","author":"Williams","year":"1999","journal-title":"J Virol"},{"key":"2025012011001753500_bib46","doi-asserted-by":"publisher","first-page":"12352","DOI":"10.1093\/nar\/gku999","article-title":"G-quadruplexes in viruses: function and potential therapeutic applications","volume":"42","author":"Metifiot","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"2025012011001753500_bib47","doi-asserted-by":"publisher","first-page":"10984","DOI":"10.3390\/ijms222010984","article-title":"G-quadruplex targeting in the fight against viruses: an update","volume":"22","author":"Ruggiero","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2025012011001753500_bib48","doi-asserted-by":"publisher","first-page":"4702","DOI":"10.1002\/anie.201801999","article-title":"Tracking the dynamic folding and unfolding of RNA G-quadruplexes in live cells","volume":"57","author":"Chen","year":"2018","journal-title":"Angew Chem Int Ed"},{"key":"2025012011001753500_bib49","doi-asserted-by":"publisher","first-page":"7482","DOI":"10.1039\/b901889a","article-title":"Selectivity in small molecule binding to human telomeric RNA and DNA quadruplexes","volume":"48","author":"Collie","year":"2009","journal-title":"Chem Commun"},{"key":"2025012011001753500_bib50","doi-asserted-by":"publisher","first-page":"11073","DOI":"10.1002\/anie.201206281","article-title":"Selective RNA versus DNA G-quadruplex targeting by in situ click chemistry","volume":"51","author":"Di Antonio","year":"2012","journal-title":"Angew Chem Int Ed"}],"container-title":["National Science Review"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/nsr\/advance-article-pdf\/doi\/10.1093\/nsr\/nwae388\/60257314\/nwae388.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nsr\/article-pdf\/12\/1\/nwae388\/60257314\/nwae388.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nsr\/article-pdf\/12\/1\/nwae388\/60257314\/nwae388.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T11:00:37Z","timestamp":1737370837000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nsr\/article\/doi\/10.1093\/nsr\/nwae388\/7854301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,30]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,12,30]]}},"URL":"https:\/\/doi.org\/10.1093\/nsr\/nwae388","relation":{},"ISSN":["2095-5138","2053-714X"],"issn-type":[{"value":"2095-5138","type":"print"},{"value":"2053-714X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,1]]},"published":{"date-parts":[[2024,10,30]]},"article-number":"nwae388"}}