{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:38:19Z","timestamp":1790959099433,"version":"4.1.0"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T00:00:00Z","timestamp":1736553600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82325023"],"award-info":[{"award-number":["82325023"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFA0804200"],"award-info":[{"award-number":["2020YFA0804200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"\u2018Pioneer\u2019 and \u2018Leading Goose\u2019 R&D Program of Zhejiang","award":["2024SDXHDX0001"],"award-info":[{"award-number":["2024SDXHDX0001"]}]},{"name":"HRHI program of Westlake Laboratory of Life Sciences and Biomedicine","award":["202309001"],"award-info":[{"award-number":["202309001"]}]},{"DOI":"10.13039\/100018928","name":"Westlake University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018928","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Crohn's disease (CD) is a prevalent type of inflammatory bowel disease (IBD) with dysregulated antibody responses. However, there is a lack of comprehensive analysis of B cell responses in CD. Here, we collected B cells from the small intestine, colon and blood of CD patients and control subjects. Through the coupled analysis of transcriptome and immunoglobulin (Ig) gene in individual cells, we characterized the cellular composition, transcriptome and Ig clonotype in different B cell subtypes. We observed shared disruptions in plasma cell (PC) responses between different IBD subtypes. We revealed heterogeneity in memory B cells (MBCs) and showed a positive correlation between gut resident-like MBCs and disease severity. Furthermore, our clonotype analysis demonstrated an increased direct differentiation of MBCs into PCs in CD patients. Overall, this study demonstrates significantly altered B cell responses associated with chronic inflammation during CD and highlights the potential role of mucosal MBCs in CD pathogenesis.<\/jats:p>","DOI":"10.1093\/nsr\/nwaf009","type":"journal-article","created":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T12:10:11Z","timestamp":1736597411000},"source":"Crossref","is-referenced-by-count":9,"title":["The multi-organ landscape of B cells highlights dysregulated memory B cell responses in Crohn's disease"],"prefix":"10.1093","volume":"12","author":[{"given":"Dianyu","family":"Chen","sequence":"first","affiliation":[{"name":"Westlake Laboratory of Life Sciences and Biomedicine , Hangzhou 310024 ,","place":["China"]},{"name":"Laboratory of Systems Immunology, School of Medicine, Westlake University , Hangzhou 310024 ,","place":["China"]},{"name":"Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University , Hangzhou 310024 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Second Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou 310000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nursing, The Second Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou 310009 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuying","family":"Wang","sequence":"additional","affiliation":[{"name":"Westlake Laboratory of Life Sciences and Biomedicine , Hangzhou 310024 ,","place":["China"]},{"name":"Laboratory of Systems Immunology, School of Medicine, Westlake University , Hangzhou 310024 ,","place":["China"]},{"name":"Key Laboratory of Growth Regulation and Translational 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