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Here, we report a continuous-flow microfluidic strategy for mass production of Pt SACs on hierarchical nitrogen-doped carbon nanocages (Pt1\/hNCNC), which fundamentally overcomes this limitation. Combined experiments and theoretical simulations indicate that the microfluidic microreactor efficiently avoids local supersaturation via rapid and uniform mixing. In synergy with micropore trapping and nitrogen anchoring of hNCNC, continuous local adsorption equilibrium is maintained, promoting stable immobilization of isolated atoms while suppressing aggregation. This method achieves scalable synthesis of Pt1\/hNCNC SACs with high Pt loading (10 wt%), excellent uniformity, and a nearly 300-fold increase in productivity compared to the batch method. When applied in a proton exchange membrane water electrolyzer, the cathode with an ultralow loading of 20 \u03bcgPt cm\u22122 delivers industrial current densities of 1.0\/3.0 A cm\u22122 at low voltages of 1.66\/2.00\u00a0V, respectively, and operates stably for over 500\u00a0h at 1.0 A cm\u22122. This microfluidic synthesis is also successfully extended to various noble metals (Pd, Au, Ir, Rh, Ru, and multi-elements) and nitrogen-doped carbons, demonstrating broad generality. This work establishes a practical and scalable paradigm for manufacturing high-performance noble metal SACs with deep insights into the dual-scale cooperation between macroscopic fluid dynamics and microscopic support chemistry, bridging laboratory discovery with industrial application of single-atom catalysis.<\/jats:p>","DOI":"10.1093\/nsr\/nwag276","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T11:43:23Z","timestamp":1778845403000},"source":"Crossref","is-referenced-by-count":0,"title":["Scalable microfluidic synthesis of noble metal single-atom catalysts"],"prefix":"10.1093","volume":"13","author":[{"given":"Jingyi","family":"Tian","sequence":"first","affiliation":[{"name":"State Key Laboratory of Coordination Chemistry and Key Laboratory of Mesoscopic Chemistry of MOE, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing 210023 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210023 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyu","family":"Deng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Coordination Chemistry and Key Laboratory of Mesoscopic Chemistry of MOE, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing 210023 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yang","sequence":"additional","affiliation":[{"name":"Shanghai Advanced Research Institute, Chinese Academy of Sciences , Shanghai 201210 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwen","family":"Huang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Coordination Chemistry and Key Laboratory of Mesoscopic Chemistry of MOE, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing 210023 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xizhang","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Coordination Chemistry and Key Laboratory of Mesoscopic Chemistry of MOE, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing 210023 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6858-1719","authenticated-orcid":false,"given":"Qiang","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Coordination Chemistry and Key Laboratory of Mesoscopic Chemistry of MOE, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing 210023 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Coordination Chemistry and Key Laboratory of Mesoscopic Chemistry of MOE, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing 210023 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Coordination Chemistry and Key Laboratory of Mesoscopic Chemistry of MOE, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing 210023 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"key":"2026081011140356700_bib1","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1093\/nsr\/nwy077","article-title":"Single-atom catalyst: a rising star for green synthesis of fine chemicals","volume":"5","author":"Zhang","year":"2018","journal-title":"Natl Sci Rev"},{"key":"2026081011140356700_bib2","doi-asserted-by":"publisher","first-page":"11900","DOI":"10.1021\/acs.chemrev.9b00818","article-title":"Chemical 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