{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T15:51:52Z","timestamp":1789487512296,"version":"build-2803163510"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"17","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["T2222013"],"award-info":[{"award-number":["T2222013"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52573174"],"award-info":[{"award-number":["52573174"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Vitreoretinal diseases often require vitrectomy followed by intraocular tamponade to stabilize the retina. Although commonly used expansile gases and silicone oil (SO) can promote retinal reattachment, long-term vitreous replacement remains limited by postural requirements and postoperative complications, including inflammation and SO emulsification. Here, we report an injectable poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) zwitterionic hydrogel stabilized by topological chain entanglements as a vitreous substitute with clinical translational potential. The PMPC hydrogel is delivered via minimally invasive shear-thinning injection and demonstrates favorable long-term intraocular tolerability and biocompatibility in a rabbit vitrectomy model. We further assess its tamponade-relevant performance in a rabbit rhegmatogenous retinal detachment model by examining its ability to maintain break coverage and support sustained retinal reattachment. Importantly, this PMPC hydrogel is built from a clinically validated zwitterionic polymer with established industrial supply and regulatory precedent, which may reduce manufacturing and regulatory complexity and facilitate earlier clinical evaluation as a practical alternative to SO.<\/jats:p>","DOI":"10.1093\/nsr\/nwag413","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T11:24:30Z","timestamp":1783337070000},"source":"Crossref","is-referenced-by-count":0,"title":["Chain entanglement-stabilized injectable zwitterionic hydrogel for vitreous replacement and retinal tamponade"],"prefix":"10.1093","volume":"13","author":[{"given":"Haolun","family":"Wang","sequence":"first","affiliation":[{"name":"School of Materials Science and Engineering, State Key Laboratory of Precious Metal Functional Materials, Tianjin University , Tianjin 300350 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongying","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, State Key Laboratory of Precious Metal Functional Materials, Tianjin University , Tianjin 300350 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Lang","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, State Key Laboratory of Precious Metal Functional Materials, Tianjin University , Tianjin 300350 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijie","family":"Hao","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, State Key Laboratory of Precious Metal Functional Materials, Tianjin University , Tianjin 300350 ,","place":["China"]},{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital , Tianjin 300384 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqin","family":"Cheng","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, State Key Laboratory of Precious Metal Functional Materials, Tianjin University , Tianjin 300350 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danyang","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, State Key Laboratory of Precious Metal Functional Materials, Tianjin University , Tianjin 300350 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Tian","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, State Key Laboratory of Precious Metal Functional Materials, Tianjin University , Tianjin 300350 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boshi","family":"Liu","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital , Tianjin 300384 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Xing","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital , Tianjin 300384 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaorong","family":"Li","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital , Tianjin 300384 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenguang","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, State Key Laboratory of Precious Metal Functional Materials, Tianjin University , Tianjin 300350 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0598-6804","authenticated-orcid":false,"given":"Jianhai","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, State Key Laboratory of Precious Metal Functional Materials, Tianjin University , Tianjin 300350 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