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Decades of work from rodents provide a foundational understanding of the anatomy and functional organization of the claustrum, which is more recently aided by human functional neuroimaging studies. However, important questions remain with broad functional implications. These center on claustrum anatomical boundaries, functional organization, and the putative expansion of human claustrum connectivity over that predicted by rodent studies alone. Providing new insights by spanning the large rodent-to-human void, a landmark study by Lei and colleagues recently provided thorough molecular and connectivity profiling of the macaque claustrum. Surprising findings of lateralized and expanded claustrum connectivity with cortical and subcortical partners help to explain human functional connectivity data and the discovery of a well-developed organization of the monkey claustrum into overlapping functional sub-domains provides deep insight into claustrum function when considering rodent synaptic connectivity data. Contextualizing these findings, we provide an elaborated model of the function of the claustrum in cognition.<\/jats:p>","DOI":"10.1093\/nsr\/nwag414","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T23:29:38Z","timestamp":1783380578000},"source":"Crossref","is-referenced-by-count":0,"title":["New functional insights from the monkey claustrum"],"prefix":"10.1093","volume":"13","author":[{"given":"Andreas B","family":"Wulff","sequence":"first","affiliation":[{"name":"School of Medicine, University of Maryland Department of Pharmacology and Physiology, , Baltimore, MD 21201 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2912-8625","authenticated-orcid":false,"given":"Brian N","family":"Mathur","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Maryland Department of Pharmacology and Physiology, , Baltimore, MD 21201 ,","place":["USA"]},{"name":"School of Medicine, University of Maryland Department of Psychiatry, , Baltimore, MD 21201 ,","place":["USA"]},{"name":"University of Maryland Medicine Institute for Neuroscience Discovery, University of Maryland , Baltimore, MD 21201 ,","place":["USA"]},{"name":"Kahlert Institute for Addiction Medicine, University of Maryland , Baltimore, MD 21201 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"2026081210362013000_bib1","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1002\/cne.20444","article-title":"Vglut2 afferents to the medial prefrontal and primary somatosensory cortices: a combined retrograde tracing in situ hybridization","volume":"483","author":"Hur","year":"2005","journal-title":"J Comp Neurol"},{"key":"2026081210362013000_bib2","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.1002\/cne.24021","article-title":"In situ hybridization analyses of 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