{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:55:09Z","timestamp":1791219309978,"version":"4.1.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"18","license":[{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32030047"],"award-info":[{"award-number":["32030047"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32300805"],"award-info":[{"award-number":["32300805"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32488101"],"award-info":[{"award-number":["32488101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2019YFA0110102"],"award-info":[{"award-number":["2019YFA0110102"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2022YFA1106000"],"award-info":[{"award-number":["2022YFA1106000"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["20002150110"],"award-info":[{"award-number":["20002150110"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["22120230292"],"award-info":[{"award-number":["22120230292"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,21]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>In the mammalian brain, adult neural stem cells (NSCs) located in the ventricular\u2013subventricular zone (V\u2013SVZ) of lateral ventricles and dentate gyrus continuously generate new neurons and glia throughout life. The adult NSCs in V\u2013SVZ are derived from ventricular radial glial cells (RGCs) which become quiescent during embryonic development. However, the origin and establishment of this adult NSC pool remain elusive, primarily due to the challenge of tracing the lineage from embryonic RGCs to their quiescent adult successors. Here, by leveraging Vcam1\u2014a marker continuously expressed from embryonic RGCs to adult NSCs, we unravel the dynamic process and regulatory mechanism underlying the fate bifurcation that gives rise to quiescent seed cells. We demonstrate that Vcam1+ embryonic RGCs directly contribute to the adult NSC pool. A subpopulation of quiescent Vcam1+ RGCs emerges early and is maintained throughout development, while a parallel population of proliferative Vcam1+ progenitors actively replenishes this quiescent reservoir. Through the combinatory analysis of single-cell multiomics and clonal lineage tracing of Vcam1+ cells, we identify the TGF-\u03b2\/Smad3 pathway as a critical regulator of quiescence. Our work thus provides a mechanistic dissection of how the foundational adult NSC pool is established through precisely regulated fate decisions during embryogenesis, offering new insights into the principles of lifelong neurogenesis.<\/jats:p>","DOI":"10.1093\/nsr\/nwag516","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T15:06:22Z","timestamp":1788015982000},"source":"Crossref","is-referenced-by-count":0,"title":["Integrative analysis of the embryonic origin of adult neural stem cells in forebrain subventricular zones"],"prefix":"10.1093","volume":"13","author":[{"given":"Huan","family":"Wu","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory of Maternal and Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University; Frontier Science Center for Stem Cell Research, Tongji University , Shanghai 200092 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Tang","sequence":"additional","affiliation":[{"name":"Tongji University; Frontier Science Center for Stem Cell Research, Tongji University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Orthopedic Department of Tongji Hospital, School of Life Sciences and Technology, , Shanghai 200092 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruimin","family":"Xu","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Maternal and Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University; Frontier Science Center for Stem Cell Research, Tongji University , Shanghai 200092 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Li","sequence":"additional","affiliation":[{"name":"Tongji University Department of Neurology, Shanghai Tongji Hospital, School of Medicine, , Shanghai 200092 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keke","family":"Liang","sequence":"additional","affiliation":[{"name":"Tongji University Department of Neurology, Shanghai Tongji Hospital, School of Medicine, , Shanghai 200092 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanxuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Maternal and Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University; Frontier Science Center for Stem Cell Research, Tongji University , Shanghai 200092 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deyuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Maternal and Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University; Frontier Science Center for Stem Cell Research, Tongji University , Shanghai 200092 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijia","family":"Yang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Maternal and Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University; Frontier Science Center for Stem Cell Research, Tongji University , Shanghai 200092 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxuan","family":"Yin","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Maternal and Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University; Frontier Science Center for Stem Cell Research, Tongji University , Shanghai 200092 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayang","family":"Xie","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Maternal and Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University; Frontier Science Center for Stem Cell Research, Tongji University , Shanghai 200092 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Li","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Maternal and Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University; Frontier Science Center for Stem Cell Research, Tongji University , Shanghai 200092 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6622-9316","authenticated-orcid":false,"given":"Xiaoyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Maternal and Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University; Frontier Science Center for Stem Cell Research, Tongji University , Shanghai 200092 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Ran","family":"Bai","sequence":"additional","affiliation":[{"name":"Tongji University; Frontier Science Center for Stem Cell Research, Tongji University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Orthopedic Department of Tongji Hospital, School of Life Sciences and Technology, , Shanghai 200092 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7573-3768","authenticated-orcid":false,"given":"Chenfei","family":"Wang","sequence":"additional","affiliation":[{"name":"Tongji University; Frontier Science Center for Stem Cell Research, Tongji University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Orthopedic Department of Tongji Hospital, School of Life Sciences and Technology, , Shanghai 200092 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9000-494X","authenticated-orcid":false,"given":"Qin","family":"Shen","sequence":"additional","affiliation":[{"name":"Tongji University; Frontier Science Center for Stem Cell Research, Tongji University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Orthopedic Department of Tongji Hospital, School of Life Sciences and Technology, , Shanghai 200092 ,","place":["China"]},{"name":"Tongji University Brain and Spinal Cord Clinical Research Center , Shanghai 200092 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1041-3928","authenticated-orcid":false,"given":"Shaorong","family":"Gao","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Maternal and Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University; Frontier Science Center for Stem Cell Research, Tongji University , Shanghai 200092 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,29]]},"reference":[{"key":"2026100511521493300_bib1","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1146\/annurev.neuro.051508.135600","article-title":"The glial nature of embryonic and adult neural stem cells","volume":"32","author":"Kriegstein","year":"2009","journal-title":"Annu Rev Neurosci"},{"key":"2026100511521493300_bib2","doi-asserted-by":"publisher","first-page":"dev156059","DOI":"10.1242\/dev.156059","article-title":"Neural stem cells: origin, heterogeneity and regulation in the adult mammalian brain","volume":"146","author":"Obernier","year":"2019","journal-title":"Development"},{"key":"2026100511521493300_bib3","doi-asserted-by":"publisher","first-page":"a018820","DOI":"10.1101\/cshperspect.a018820","article-title":"The adult ventricular-subventricular zone (V-SVZ) and olfactory bulb (OB) neurogenesis","volume":"8","author":"Lim","year":"2016","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"2026100511521493300_bib4","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.stem.2015.09.003","article-title":"Adult mammalian neural stem cells and neurogenesis: five decades later","volume":"17","author":"Bond","year":"2015","journal-title":"Cell Stem Cell"},{"key":"2026100511521493300_bib5","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1016\/S0896-6273(04)00140-0","article-title":"Radial glia serve as neuronal progenitors in all regions of the central nervous system","volume":"41","author":"Anthony","year":"2004","journal-title":"Neuron"},{"key":"2026100511521493300_bib6","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1038\/nn1144","article-title":"The glial identity of neural stem cells","volume":"6","author":"Doetsch","year":"2003","journal-title":"Nat Neurosci"},{"key":"2026100511521493300_bib7","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/S0896-6273(00)81172-1","article-title":"Radial glial identity is promoted by Notch1 signaling in the murine forebrain","volume":"26","author":"Gaiano","year":"2000","journal-title":"Neuron"},{"key":"2026100511521493300_bib8","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1016\/j.cell.2015.05.041","article-title":"Embryonic origin of postnatal neural stem cells","volume":"161","author":"Fuentealba","year":"2015","journal-title":"Cell"},{"key":"2026100511521493300_bib9","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1038\/nn.3989","article-title":"Slowly dividing neural progenitors are an embryonic origin of adult neural stem cells","volume":"18","author":"Furutachi","year":"2015","journal-title":"Nat Neurosci"},{"key":"2026100511521493300_bib10","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1111\/ped.14368","article-title":"Regeneration using endogenous neural stem cells following neonatal brain injury","volume":"63","author":"Jinnou","year":"2021","journal-title":"Pediatr Int"},{"key":"2026100511521493300_bib11","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.expneurol.2015.04.017","article-title":"Endogenous neurogenic cell response in the mature mammalian brain following traumatic injury","volume":"275","author":"Sun","year":"2016","journal-title":"Exp Neurol"},{"key":"2026100511521493300_bib12","doi-asserted-by":"publisher","first-page":"332","DOI":"10.3389\/fnins.2016.00332","article-title":"Traumatic brain injury activation of the adult subventricular zone neurogenic niche","volume":"10","author":"Chang","year":"2016","journal-title":"Front Neurosci"},{"key":"2026100511521493300_bib13","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.brainres.2016.01.055","article-title":"Strategies targeting endogenous neurogenic cell response to improve recovery following traumatic brain injury","volume":"1640","author":"Patel","year":"2016","journal-title":"Brain Res"},{"key":"2026100511521493300_bib14","doi-asserted-by":"publisher","first-page":"236","DOI":"10.2174\/157488912803251998","article-title":"Postnatal neurogenesis and dopamine alterations in early psychosis","volume":"7","author":"Inta","year":"2012","journal-title":"Recent Pat CNS Drug Discov"},{"key":"2026100511521493300_bib15","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.neuron.2010.02.014","article-title":"A possible role for the striatum in the pathogenesis of the cognitive symptoms of schizophrenia","volume":"65","author":"Simpson","year":"2010","journal-title":"Neuron"},{"key":"2026100511521493300_bib16","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1016\/j.cell.2019.02.010","article-title":"A common embryonic origin of stem cells drives developmental and adult neurogenesis","volume":"177","author":"Berg","year":"2019","journal-title":"Cell"},{"key":"2026100511521493300_bib17","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.neuron.2017.06.047","article-title":"Persistent expression of VCAM1 in radial glial cells is required for the embryonic origin of postnatal neural stem cells","volume":"95","author":"Hu","year":"2017","journal-title":"Neuron"},{"key":"2026100511521493300_bib18","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.stem.2012.06.016","article-title":"VCAM1 is essential to maintain the structure of the SVZ niche and acts as an environmental sensor to regulate SVZ lineage progression","volume":"11","author":"Kokovay","year":"2012","journal-title":"Cell Stem Cell"},{"key":"2026100511521493300_bib19","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.stem.2015.07.002","article-title":"Single-cell transcriptomics reveals a population of dormant neural stem cells that become activated upon brain injury","volume":"17","author":"Llorens-Bobadilla","year":"2015","journal-title":"Cell Stem Cell"},{"key":"2026100511521493300_bib20","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.neuron.2014.02.039","article-title":"Prospective identification and purification of quiescent adult neural stem cells from their in vivo niche","volume":"82","author":"Codega","year":"2014","journal-title":"Neuron"},{"key":"2026100511521493300_bib21","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.cell.2014.10.027","article-title":"Deterministic progenitor behavior and unitary production of neurons in the neocortex","volume":"159","author":"Gao","year":"2014","journal-title":"Cell"},{"key":"2026100511521493300_bib22","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1126\/science.1208884","article-title":"Clonal production and organization of inhibitory interneurons in the neocortex","volume":"334","author":"Brown","year":"2011","journal-title":"Science"},{"key":"2026100511521493300_bib23","doi-asserted-by":"publisher","first-page":"3717","DOI":"10.1093\/cercor\/bhz337","article-title":"Radial glial cell-derived VCAM1 regulates cortical angiogenesis through distinct enrichments in the proximal and distal radial processes","volume":"30","author":"Zhang","year":"2020","journal-title":"Cereb Cortex"},{"key":"2026100511521493300_bib24","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1146\/annurev-cellbio-120320-040213","article-title":"The organism as the niche: physiological states crack the code of adult neural stem cell heterogeneity","volume":"40","author":"Chaker","year":"2024","journal-title":"Annu Rev Cell Dev Biol"},{"key":"2026100511521493300_bib25","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/S0896-6273(04)00111-4","article-title":"For the long run: maintaining germinal niches in the adult brain","volume":"41","author":"Alvarez-Buylla","year":"2004","journal-title":"Neuron"},{"key":"2026100511521493300_bib26","doi-asserted-by":"publisher","first-page":"e67436","DOI":"10.7554\/eLife.67436","article-title":"Single-cell analysis of the ventricular-subventricular zone reveals signatures of dorsal and ventral adult neurogenesis","volume":"10","author":"Cebrian-Silla","year":"2021","journal-title":"eLife"},{"key":"2026100511521493300_bib27","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1002\/1097-0029(20010101)52:1%3c112::AID-JEMT13%3e3.0.CO;2-5","article-title":"Involvement of the choroid plexus in central nervous system inflammation","volume":"52","author":"Engelhardt","year":"2001","journal-title":"Microsc Res Tech"},{"key":"2026100511521493300_bib28","doi-asserted-by":"publisher","first-page":"e202402659","DOI":"10.26508\/lsa.202402659","article-title":"Autocrine VEGF drives neural stem cell proximity to the adult hippocampus vascular niche","volume":"7","author":"Dause","year":"2024","journal-title":"Life Sci Alliance"},{"key":"2026100511521493300_bib29","doi-asserted-by":"publisher","first-page":"108442","DOI":"10.1016\/j.isci.2023.108442","article-title":"Tsc2 coordinates neuroprogenitor differentiation","volume":"26","author":"Riley","year":"2023","journal-title":"iScience"},{"key":"2026100511521493300_bib30","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1016\/j.stem.2021.01.003","article-title":"Coordinated changes in cellular behavior ensure the lifelong maintenance of the hippocampal stem cell population","volume":"28","author":"Harris","year":"2021","journal-title":"Cell Stem Cell"},{"key":"2026100511521493300_bib31","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.stem.2015.07.013","article-title":"Single-cell RNA-seq with waterfall reveals molecular cascades underlying adult neurogenesis","volume":"17","author":"Shin","year":"2015","journal-title":"Cell Stem Cell"},{"key":"2026100511521493300_bib32","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1038\/s41467-019-09670-4","article-title":"Single-cell trajectories reconstruction, exploration and mapping of omics data with STREAM","volume":"10","author":"Chen","year":"2019","journal-title":"Nat Commun"},{"key":"2026100511521493300_bib33","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1038\/s41592-021-01282-5","article-title":"Single-cell chromatin state analysis with Signac","volume":"18","author":"Stuart","year":"2021","journal-title":"Nat Methods"},{"key":"2026100511521493300_bib34","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s13059-020-1934-6","article-title":"Lisa: inferring transcriptional regulators through integrative modeling of public chromatin accessibility and ChIP-seq data","volume":"21","author":"Qin","year":"2020","journal-title":"Genome Biol"},{"key":"2026100511521493300_bib35","doi-asserted-by":"publisher","first-page":"D61","DOI":"10.1093\/nar\/gkad1069","article-title":"Cistrome Data Browser: integrated search, analysis and visualization of chromatin data","volume":"52","author":"Taing","year":"2024","journal-title":"Nucleic Acids Res"},{"key":"2026100511521493300_bib36","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.bbrc.2016.02.060","article-title":"TET1 contributes to neurogenesis onset time during fetal brain development in mice","volume":"471","author":"Kim","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"key":"2026100511521493300_bib37","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1159\/000338108","article-title":"Activation of MAPK\/PI3K\/SMAD pathways by TGF-\u03b2(1) controls differentiation of radial glia into astrocytes in vitro","volume":"34","author":"Stipursky","year":"2012","journal-title":"Dev Neurosci"},{"key":"2026100511521493300_bib38","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/S1567-133X(01)00022-9","article-title":"Expression of the bHLH transcription factor Tcf12 (ME1) gene is linked to the expansion of precursor cell populations during neurogenesis","volume":"1","author":"Uittenbogaard","year":"2002","journal-title":"Gene Expr Patterns"},{"key":"2026100511521493300_bib39","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.neures.2020.11.007","article-title":"Notch1 and Notch2 collaboratively maintain radial glial cells in mouse neurogenesis","volume":"170","author":"Mase","year":"2021","journal-title":"Neurosci Res"},{"key":"2026100511521493300_bib40","doi-asserted-by":"publisher","first-page":"4490","DOI":"10.1016\/j.celrep.2020.03.027","article-title":"Cortical neural stem cell lineage progression is regulated by extrinsic signaling molecule sonic hedgehog","volume":"30","author":"Zhang","year":"2020","journal-title":"Cell Rep"},{"key":"2026100511521493300_bib41","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1016\/j.celrep.2014.07.006","article-title":"Gli3 repressor controls cell fates and cell adhesion for proper establishment of neurogenic niche","volume":"8","author":"Wang","year":"2014","journal-title":"Cell Rep"},{"key":"2026100511521493300_bib42","doi-asserted-by":"publisher","first-page":"676","DOI":"10.4161\/epi.20590","article-title":"Modulating epigenetic mechanisms: the diverse functions of Ski during cortical development","volume":"7","author":"Baranek","year":"2012","journal-title":"Epigenetics"},{"key":"2026100511521493300_bib43","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3390\/cells13010021","article-title":"Hedgehog signaling in cortical development","volume":"13","author":"Cai","year":"2023","journal-title":"Cells"},{"key":"2026100511521493300_bib44","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1523\/JNEUROSCI.2386-20.2021","article-title":"The Wnt effector TCF7l2 promotes oligodendroglial differentiation by repressing autocrine BMP4-mediated signaling","volume":"41","author":"Zhang","year":"2021","journal-title":"J Neurosci"},{"key":"2026100511521493300_bib45","doi-asserted-by":"publisher","first-page":"27678","DOI":"10.1074\/jbc.272.44.27678","article-title":"TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling","volume":"272","author":"Abdollah","year":"1997","journal-title":"J Biol Chem"},{"key":"2026100511521493300_bib46","doi-asserted-by":"publisher","first-page":"28107","DOI":"10.1074\/jbc.272.44.28107","article-title":"Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling","volume":"272","author":"Souchelnytskyi","year":"1997","journal-title":"J Biol Chem"},{"key":"2026100511521493300_bib47","doi-asserted-by":"publisher","first-page":"10669","DOI":"10.1073\/pnas.94.20.10669","article-title":"Transforming growth factor beta-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells","volume":"94","author":"Liu","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026100511521493300_bib48","doi-asserted-by":"publisher","first-page":"3157","DOI":"10.1101\/gad.11.23.3157","article-title":"Dual role of the Smad4\/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes","volume":"11","author":"Liu","year":"1997","journal-title":"Genes Dev"},{"key":"2026100511521493300_bib49","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/S0092-8674(00)81701-8","article-title":"SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor","volume":"95","author":"Tsukazaki","year":"1998","journal-title":"Cell"}],"container-title":["National Science Review"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/nsr\/advance-article-pdf\/doi\/10.1093\/nsr\/nwag516\/70852625\/nwag516.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nsr\/article-pdf\/13\/18\/nwag516\/70852625\/nwag516.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nsr\/article-pdf\/13\/18\/nwag516\/70852625\/nwag516.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:52:35Z","timestamp":1791215555000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nsr\/article\/doi\/10.1093\/nsr\/nwag516\/8774603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,29]]},"references-count":49,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2026,9,21]]}},"URL":"https:\/\/doi.org\/10.1093\/nsr\/nwag516","relation":{},"ISSN":["2095-5138","2053-714X"],"issn-type":[{"value":"2095-5138","type":"print"},{"value":"2053-714X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,9]]},"published":{"date-parts":[[2026,8,29]]},"article-number":"nwag516"}}