{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T02:22:55Z","timestamp":1783995775456,"version":"3.55.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T00:00:00Z","timestamp":1650931200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Quit Genius"},{"name":"Digital Therapeutics, Inc"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>This study evaluated the secondary effectiveness outcomes for Quit Genius, a digital clinician-assisted cognitive behavioral therapy (CBT) intervention for smoking cessation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adult smokers (N = 556) were randomly assigned to Quit Genius (n = 277), a digital, clinician-assisted CBT intervention or very brief advice (VBA) to stop smoking, an evidence-based, 30-s intervention designed to facilitate quit attempts, coupled with referral to a cessation service (n = 279). Participants were offered combination nicotine replacement therapy (patches and gum) tailored to individual nicotine dependence. Analyses (n = 530), by intention-to-treat, compared Quit Genius and VBA at 4, 26, and 52 weeks post-quit date (QD). The primary outcome was self-reported 7-day point prevalence abstinence (PPA) at 4 weeks post-QD. Consecutive 7-day point-prevalence abstinence, defined as abstinent at two or more consecutive timepoints, was examined at weeks 26 and 52 to indicate long-term effectiveness. Abstinence was verified using a random sample of participants with carbon monoxide breath testing of &amp;lt;5 parts per million (n = 280).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Self-reported consecutive 7-day PPA at weeks 26 and 52 for Quit Genius was 27.2% and 22.6%, respectively, compared with VBA which was 16.6% and 13.2% (RR = 1.70, 95% CI, 1.22-2.37; p = .003, 26 weeks; RR = 1.71, 95% CI, 1.17\u20132.50; P = .005, 52 weeks). Biochemically verified abstinence was significantly different at 26- (p = .03) but not 52 weeks (p = .16). Quit Genius participants were more likely to remain abstinent than those who received VBA (RR = 1.71, 95% CI 1.17\u20132.50; p = .005).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study provides secondary evidence for the long-term effectiveness of Quit Genius in comparison with VBA. Future trials of digital interventions without clinician support and comparisons with active treatment are needed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Implications<\/jats:title>\n                    <jats:p>The long-term effectiveness of clinician-assisted digital smoking cessation interventions has not been well studied. This study established the long-term effectiveness of an extended CBT-based intervention; results may inform implementation of scalable approaches to smoking cessation in the health system.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ntr\/ntac113","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T07:16:01Z","timestamp":1650870961000},"page":"1763-1772","source":"Crossref","is-referenced-by-count":33,"title":["Long-Term Effectiveness of a Clinician-Assisted Digital Cognitive Behavioral Therapy Intervention for Smoking Cessation: Secondary Outcomes From a Randomized Controlled Trial"],"prefix":"10.1093","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1020-0773","authenticated-orcid":false,"given":"Jamie","family":"Webb","sequence":"first","affiliation":[{"name":"Department of Clinical Affairs, Digital Therapeutics, Inc. , San Francisco, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarrah","family":"Peerbux","sequence":"additional","affiliation":[{"name":"School of Medicine, Imperial College London , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Ang","sequence":"additional","affiliation":[{"name":"Department of Clinical Affairs, Digital Therapeutics, Inc. , San Francisco, CA , USA"},{"name":"Integrated Substance Abuse Programs, David Geffen School of Medicine, UCLA , Los Angeles CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarim","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Department of Clinical Affairs, Digital Therapeutics, Inc. , San Francisco, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf","family":"Sherwani","sequence":"additional","affiliation":[{"name":"Department of Clinical Affairs, Digital Therapeutics, Inc. , San Francisco, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maroof","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Clinical Affairs, Digital Therapeutics, Inc. , San Francisco, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"MacRae","sequence":"additional","affiliation":[{"name":"Department of Clinical Affairs, Digital Therapeutics, Inc. , San Francisco, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Puri","sequence":"additional","affiliation":[{"name":"Department of Clinical Affairs, Digital Therapeutics, Inc. , San Francisco, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azeem","family":"Majeed","sequence":"additional","affiliation":[{"name":"School of Medicine, Imperial College London , London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzette","family":"Glasner","sequence":"additional","affiliation":[{"name":"Department of Clinical Affairs, Digital Therapeutics, Inc. , San Francisco, CA , USA"},{"name":"Integrated Substance Abuse Programs, David Geffen School of Medicine, UCLA , Los Angeles CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,4,26]]},"reference":[{"key":"2022102605494173800_CIT0001"},{"issue":"1","key":"2022102605494173800_CIT0002","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1136\/tobaccocontrol-2016-053305","article-title":"Global economic cost of smoking-attributable diseases.","volume":"27","author":"Goodchild","year":"2018","journal-title":"Tob Control."},{"issue":"24","key":"2022102605494173800_CIT0003","doi-asserted-by":"crossref","first-page":"3244","DOI":"10.1001\/jama.283.24.3244","article-title":"A clinical practice guideline for treating tobacco use and dependence: A US Public Health Service report. 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