{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T14:30:10Z","timestamp":1774362610340,"version":"3.50.1"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,22]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Recent research has found widespread misperceptions about nicotine. This study tests perceptions among U.S. adults with respect to nicotine addictiveness and cancer harm, while distinguishing between nicotine misperceptions (ie an incorrect response) and \u201cdon\u2019t know\u201d (DK) responses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims and Methods<\/jats:title><jats:p>Data from three cycles of the Health Information National Trends Survey, fielded in 2015, 2017, and 2019 were merged for analysis. Weighted multinominal logistic regression models were conducted where nicotine addictiveness and cancer harm beliefs (DK, incorrect, and correct responses) were regressed on survey year and demographic variables. We also tested for interactions between survey year and demographic variables to assess if previously identified disparities had evolved during these years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Analyses showed lower odds of misperceptions about nicotine addictiveness, but higher odds of misperceptions about nicotine cancer harm in 2019 compared to 2015. There was no change in DK responses during these years. Disparities by sociodemographics and tobacco use status were observed, mostly for cancer harm. Survey year significantly interacted with age in the model for cancer harm, which was driven primarily by increased incorrect responses and decreased DK responses over time among the youngest age group (18\u201334 years). There were no significant interactions between survey year and race and ethnicity or level of educational attainment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Disparities in nicotine addictiveness and cancer harm perceptions reflect the uneven distribution of knowledge in the U.S. adult population. Nicotine cancer harm misperceptions are increasing and educational efforts to address this misperception are warranted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Implications<\/jats:title><jats:p>Future educational efforts targeting nicotine addictiveness beliefs may benefit by focusing on DK responders. The growing trend of misperceptions of nicotine\u2019s role in cancer harm may negatively impact perceptions about nicotine replacement therapy and low nicotine content cigarettes. Future efforts should focus on correcting nicotine cancer harm misperception, particularly among young adults.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ntr\/ntac245","type":"journal-article","created":{"date-parts":[[2022,10,22]],"date-time":"2022-10-22T13:57:25Z","timestamp":1666447045000},"page":"639-647","source":"Crossref","is-referenced-by-count":8,"title":["Disparities in Nicotine Addictiveness and Cancer Harm Perceptions Among U.S. Adults: A Trend Analysis Using the Health Information National Trends Survey"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5234-038X","authenticated-orcid":false,"given":"Emily B","family":"Peterson","sequence":"first","affiliation":[{"name":"Office of Health Communication and Education, Center for Tobacco Products, U.S. Food and Drug Administration , Silver Spring, MD , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsay","family":"Pitzer","sequence":"additional","affiliation":[{"name":"Office of Health Communication and Education, Center for Tobacco Products, U.S. Food and Drug Administration , Silver Spring, MD , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0264-6262","authenticated-orcid":false,"given":"Xiaoquan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Communication, George Mason University , Fairfax, VA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,10,22]]},"reference":[{"issue":"6","key":"2023041113511664600_","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1161\/01.HYP.0000018825.76673.EA","article-title":"Cardiovascular effects of nasal and transdermal nicotine and cigarette 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