{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T12:47:33Z","timestamp":1784551653174,"version":"3.55.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T00:00:00Z","timestamp":1690416000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Our previous study showed major changes in biomarkers on quitting compared to the smoking state. They reflected a decrease in inflammation, endothelial activation, and oxidative stress, as well as an improved lipid profile. Nicotine replacement therapy (NRT) is effective to increase the rate of successful quitting, but healthcare professionals may have concerns to prescribe this first-line smoking cessation treatment because its effect on inflammation and related processes is controversial.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aims and Methods<\/jats:title>\n                  <jats:p>The present study assessed the influence of NRT on biomarkers of inflammation, endothelial function, oxidative stress, and lipids, in people who quit smoking. Sixty-five subjects who daily smoke cigarettes were recruited and followed on quitting. Thirty-five quit using NRT and thirty quit without NRT. Biomarkers of inflammation, endothelial function, oxidative stress, and lipids were quantified at baseline when actively smoking and after cessation in the presence of NRT or not.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Changes in biomarkers on quitting did not differ according to the treatment used. No difference was found when comparing participants who were exposed to NRT and those who were not.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>These results may indicate that NRT has no effect on inflammation, endothelial function, oxidative stress, and lipids, when used as a medication aid for quitting smoking.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Implications<\/jats:title>\n                  <jats:p>This study provides new evidence to support the safety profile of NRT products regarding the biomarkers of endothelial function, oxidative stress, inflammation, and lipids.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ntr\/ntad130","type":"journal-article","created":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T14:18:35Z","timestamp":1690467515000},"page":"1875-1881","source":"Crossref","is-referenced-by-count":5,"title":["Effect of the Nicotine Replacement Therapy on Biomarkers of Inflammation, Endothelial Dysfunction, Oxidative Stress, and Lipids in Smokers Who Quit Smoking"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3559-5529","authenticated-orcid":false,"given":"Marie-Lise","family":"Colsoul","sequence":"first","affiliation":[{"name":"Medical Laboratory, CHU UCL Namur , Yvoir , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Goderniaux","sequence":"additional","affiliation":[{"name":"Medical Laboratory, CHU UCL Namur , Yvoir , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Onorati","sequence":"additional","affiliation":[{"name":"Medical Laboratory, CHU UCL Namur , Yvoir , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Dupuis","sequence":"additional","affiliation":[{"name":"Medical Laboratory, CHU UCL Namur , Yvoir , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Jamart","sequence":"additional","affiliation":[{"name":"Scientific Support Unit, CHU UCL Namur , Yvoir , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Vanpee","sequence":"additional","affiliation":[{"name":"IRSS , UCLouvain, Woluwe-Saint-Lambert , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5928-5616","authenticated-orcid":false,"given":"Ivan","family":"Berlin","sequence":"additional","affiliation":[{"name":"Department of Medical Pharmacology, Piti\u00e9-Salp\u00eatri\u00e8re Hospital , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Galanti","sequence":"additional","affiliation":[{"name":"Medical Laboratory, CHU UCL Namur , Yvoir , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,7,27]]},"reference":[{"key":"2023112211091140700_CIT0001","author":"World Health Organization (WHO)","year":"2022"},{"key":"2023112211091140700_CIT0002","author":"World Health Organization Regional Office for Europe. European tobacco use: Trends report 2019","year":"2019"},{"issue":"17","key":"2023112211091140700_CIT0003","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.2174\/092986707781058832","article-title":"Relevance of endothelial-haemostatic dysfunction in cigarette smoking","volume":"14","author":"Cacciola","year":"2007","journal-title":"Curr Med Chem."},{"issue":"2","key":"2023112211091140700_CIT0004","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.gheart.2012.05.003","article-title":"Pathophysiological mechanisms of tobacco-related CVD","volume":"7","author":"Salahuddin","year":"2012","journal-title":"Global Heart"},{"issue":"6","key":"2023112211091140700_CIT0005","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1007\/s00424-010-0822-4","article-title":"Human endothelial dysfunction: EDRFs","volume":"459","author":"Flammer","year":"2010","journal-title":"Pflugers Arch."},{"issue":"4","key":"2023112211091140700_CIT0006","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1161\/CIRCRESAHA.115.306301","article-title":"Endothelial cell dysfunction and the pathobiology of atherosclerosis","volume":"118","author":"Gimbrone","year":"2016","journal-title":"Circ Res."},{"issue":"3","key":"2023112211091140700_CIT0007","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1093\/ntr\/ntaa135","article-title":"Changes in biomarkers of exposure on switching from a conventional cigarette to the glo tobacco heating product: a randomized, controlled ambulatory study","volume":"23","author":"Gale","year":"2020","journal-title":"Nicotine Tob Res."},{"key":"2023112211091140700_CIT0008","author":"World Health Organization","year":"2011"},{"issue":"8","key":"2023112211091140700_CIT0009","doi-asserted-by":"crossref","first-page":"e13996","DOI":"10.1111\/eci.13996","article-title":"Changes in biomarkers of endothelial function, oxidative stress, inflammation and lipids after smoking cessation: acohort study","volume":"53","author":"Colsoul","year":"2023","journal-title":"Eur J Clin Invest."},{"issue":"2","key":"2023112211091140700_CIT0010","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1360-0443.2011.03657.x","article-title":"DSM criteria for tobacco use disorder and tobacco withdrawal: a critique and proposed revisions for DSM-5","volume":"107","author":"Baker","year":"2012","journal-title":"Addiction."},{"issue":"8","key":"2023112211091140700_CIT0011","doi-asserted-by":"crossref","first-page":"461","DOI":"10.31128\/AJGP-08-20-1234e","article-title":"Editorial: smoking cessation","volume":"49","author":"Margolis","year":"2020","journal-title":"Aust J Gen Pract"},{"issue":"10","key":"2023112211091140700_CIT0012","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.3390\/ijerph14101147","article-title":"Clinical effects of cigarette smoking: epidemiologic impact and review of pharmacotherapy options","volume":"14","author":"Onor","year":"2017","journal-title":"Int J Environ Res Public Health."},{"issue":"2","key":"2023112211091140700_CIT0013","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0025-7125(16)30362-5","article-title":"Methods of smoking cessation","volume":"76","author":"Schwartz","year":"1992","journal-title":"Med Clin N Am."},{"issue":"6","key":"2023112211091140700_CIT0014","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.4103\/jfmpc.jfmpc_313_20","article-title":"Nicotine replacement therapy: a friend or foe","volume":"9","author":"Devi","year":"2020","journal-title":"J Family Med Prim Care"},{"key":"2023112211091140700_CIT0015","author":"National Center for Chronic Disease Prevention and Health Promotion (US) Office on Smoking and Health","year":"2014"},{"issue":"4","key":"2023112211091140700_CIT0016","doi-asserted-by":"crossref","first-page":"e13631","DOI":"10.1111\/apha.13631","article-title":"Nicotine and vascular dysfunction","volume":"231","author":"Whitehead","year":"2021","journal-title":"Acta Physiol (Oxf)."},{"issue":"10","key":"2023112211091140700_CIT0017","first-page":"e1","article-title":"Does nicotine prevent cytokine storms in COVID-19","volume":"12","author":"Dratcu","year":"1220","journal-title":"Cureus"},{"key":"2023112211091140700_CIT0018","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.imlet.2020.06.002","article-title":"How nicotine can inhibit cytokine storm in the lungs and prevent or lessen the severity of COVID-19 infection","volume":"224","author":"Kloc","year":"2020","journal-title":"Immunol Lett."},{"issue":"3","key":"2023112211091140700_CIT0019","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1007\/s12291-020-00903-8","article-title":"Oral nicotine induces oxidative stress and inflammation but does not subvert tumor suppressor and DNA repair responses in mice","volume":"36","author":"Devi","year":"2021","journal-title":"Indian J Clin Biochem."},{"issue":"10","key":"2023112211091140700_CIT0020","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.7150\/ijbs.7502","article-title":"The vascular endothelium and human diseases","volume":"9","author":"Rajendran","year":"2013","journal-title":"Int J Biol Sci."},{"issue":"10","key":"2023112211091140700_CIT0021","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1161\/CIRCULATIONAHA.106.652859","article-title":"Endothelial function and dysfunction: testing and clinical relevance","volume":"115","author":"Deanfield","year":"2007","journal-title":"Circulation."},{"issue":"e155","key":"2023112211091140700_CIT0022","first-page":"1","article-title":"Nicotine, an anti-inflammation molecule","volume":"1","author":"Han","year":"2014","journal-title":"Inflamm Cell Signal"},{"key":"2023112211091140700_CIT0023","first-page":"826889","article-title":"Nicotine in inflammatory diseases: anti-inflammatory and pro-inflammatory effects","volume-title":"Front Immunol.","author":"Zhang","year":"2022"},{"key":"2023112211091140700_CIT0024","doi-asserted-by":"crossref","first-page":"108929","DOI":"10.1016\/j.cbi.2019.108929","article-title":"Sodium acetate protects against nicotine-induced excess hepatic lipid in male rats by suppressing xanthine oxidase activity","volume":"316","author":"Dangana","year":"2020","journal-title":"Chem Biol Interact."},{"key":"2023112211091140700_CIT0025","author":"European Medicines Agency (EMA)","year":"2018"},{"issue":"12","key":"2023112211091140700_CIT0026","first-page":"1668","article-title":"Anabasine and anatabine as biomarkers for tobacco use during nicotine replacement therapy","volume":"11","author":"Jacob","year":"2002","journal-title":"Cancer Epidemiol Biomarkers Prev."},{"issue":"7","key":"2023112211091140700_CIT0027","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1093\/ntr\/ntz132","article-title":"Biochemical verification of tobacco use and abstinence: 2019 update","volume":"22","author":"Benowitz","year":"2020","journal-title":"Nicotine Tob Res."},{"key":"2023112211091140700_CIT0028","doi-asserted-by":"crossref","first-page":"123476","DOI":"10.1016\/j.jchromb.2022.123476","article-title":"Development of an Ultra-High Performance Liquid Chromatography method for the simultaneous mass detection of tobacco biomarkers in urine","volume":"1210","author":"Colsoul","year":"2022","journal-title":"J Chromatogr B."},{"issue":"9","key":"2023112211091140700_CIT0029","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1093\/clinchem\/48.9.1460","article-title":"Simultaneous analysis of nicotine, nicotine metabolites, and tobacco alkaloids in serum or urine by tandem mass spectrometry, with clinically relevant metabolic profiles","volume":"48","author":"Moyer","year":"2002","journal-title":"Clin Chem."},{"key":"2023112211091140700_CIT0030","author":"Mayo Clinic Laboratories"},{"key":"2023112211091140700_CIT0031","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.clinbiochem.2023.04.010","article-title":"Novel proposed cutoff values for anatabine and anabasine in differentiating smokers from non-smokers","volume":"116","author":"Colsoul","year":"2023","journal-title":"Clin Biochem."},{"issue":"3","key":"2023112211091140700_CIT0032","doi-asserted-by":"crossref","first-page":"L425","DOI":"10.1152\/ajplung.00343.2016","article-title":"Biomarkers of exposure to new and emerging tobacco delivery products","volume":"313","author":"Schick","year":"2017","journal-title":"Am J Physiol Lung Cell Mol Physiol."}],"container-title":["Nicotine and Tobacco Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ntr\/advance-article-pdf\/doi\/10.1093\/ntr\/ntad130\/51048757\/ntad130.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ntr\/article-pdf\/25\/12\/1875\/53481427\/ntad130.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ntr\/article-pdf\/25\/12\/1875\/53481427\/ntad130.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T17:22:35Z","timestamp":1700673755000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ntr\/article\/25\/12\/1875\/7232211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,27]]},"references-count":32,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,7,27]]},"published-print":{"date-parts":[[2023,11,22]]}},"URL":"https:\/\/doi.org\/10.1093\/ntr\/ntad130","relation":{},"ISSN":["1469-994X"],"issn-type":[{"value":"1469-994X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,12,1]]},"published":{"date-parts":[[2023,7,27]]}}}