{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T07:01:48Z","timestamp":1784876508744,"version":"3.55.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T00:00:00Z","timestamp":1749168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21CA261233"],"award-info":[{"award-number":["R21CA261233"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Providence\/Boston Center for AIDS Research","award":["P30AI042853"],"award-info":[{"award-number":["P30AI042853"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Smoking cessation rates in people with HIV (PWH) are lower than in the general population, even when evidence-based treatments are used. This 16-week study examined the feasibility, acceptability, and preliminary efficacy of preloading with nicotine replacement therapy (NRT) in PWH to improve cessation outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty-nine participants were randomized to nicotine patch preloading (NRT-P) for 3\u00a0weeks prior to the target quit date (TQD) or standard treatment with no preloading (ST). All participants received combination NRT for 8\u00a0weeks at TQD, with five sessions of behavioral counseling. At week 16, biochemically verified 7-day point-prevalence abstinence was assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mean preloading patch days was 19.7 (out of 21\u00a0days; SD 2.7), indicating excellent acceptability. Mean patch days post-TQD (out of 56\u00a0days) was 47.4 (SD\u2009=\u200913.2) in NRT-P and 32.7 (SD\u2009=\u200921.8) in ST (t\u2009=\u2009\u22122.48, p\u2009=\u2009.01). At week 16 there was no group difference in week 16 point-prevalence abstinence, but NRT-P participants smoked significantly fewer cigarettes per week (10.1 [SD 14.7] vs. 47.2 [SD 67.6]) and had lower carbon monoxide levels (5.22 [SD 3.6] vs. 10.89 [SD 11.3], p\u2009=\u2009.04) compared to ST participants. Cessation self-efficacy increased significantly over time in the NRT-P condition only.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>NRT preloading is feasible and acceptable among PWH, with excellent adherence to preloading, and benefits observed relative to ST following TQD in patch adherence, self-efficacy, cigarettes smoked per day, and carbon monoxide levels. The lack of effect of preloading on smoking abstinence suggests further study is needed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Implications<\/jats:title>\n                    <jats:p>Preloading with nicotine patch among PWH who smoke prior to the TQD may be an effective means of improving adherence to smoking cessation medications both pre- and post-quit. By increasing self-efficacy for quitting and lowering cigarette dependence, preloading may improve cessation rates and help reduce the burden of tobacco-related disease among PWH. Further research is needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ntr\/ntaf123","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T07:34:03Z","timestamp":1748936043000},"page":"2322-2327","source":"Crossref","is-referenced-by-count":0,"title":["Preloading With Nicotine Replacement Therapy in People With HIV Who Smoke: A Pilot Randomized Controlled Trial"],"prefix":"10.1093","volume":"27","author":[{"given":"Patricia A","family":"Cioe","sequence":"first","affiliation":[{"name":"Center for Alcohol and Addiction Studies, Department of Behavioral and Social Sciences, Brown University School of Public Health , Providence, RI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garrett S","family":"Stang","sequence":"additional","affiliation":[{"name":"Center for Alcohol and Addiction Studies, Department of Behavioral and Social Sciences, Brown University School of Public Health , Providence, RI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danish","family":"Azam","sequence":"additional","affiliation":[{"name":"Center for Alcohol and Addiction Studies, Department of Behavioral and Social Sciences, Brown University School of Public Health , Providence, RI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan E","family":"Piper","sequence":"additional","affiliation":[{"name":"Center for Tobacco Research and Intervention, Department of Medicine, School of Medicine and Public Health, University of Wisconsin , Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher W","family":"Kahler","sequence":"additional","affiliation":[{"name":"Center for Alcohol and Addiction Studies, Department of Behavioral and Social Sciences, Brown University School of Public Health , Providence, RI"},{"name":"Center for Tobacco Research and Intervention, Department of Medicine, School of Medicine and Public Health, University of 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