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Yet not much is known about factors associated with same-day polysubstance use among adolescents. This study examined correlates of same-day tobacco and cannabis use\/co-use among adolescents who use tobacco\/cannabis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cross-sectional data were from 10th and 11th grade students (n\u2009=\u2009536) who reported tobacco\/cannabis use. Regression models were used to examine intrapersonal, psychological (anxiety, depression), societal (societal concern, discrimination), and environmental (public and home secondhand smoke\/vape exposure) correlates of past 30-day usage frequency (no, infrequent, and frequent use) of same-day: poly-product use (poly-tobacco\/nicotine [use of different types of nicotine\/tobacco]; poly-cannabis [use of different types of or marijuana\/tetrahydrocannabinol (THC)]); poly-drug use [tobacco\/nicotine and marijuana\/THC], and nicotine and THC vape mixing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Participants were predominantly Hispanic (66.23%) and male (62.50%). Among participants, 8.58%, reported frequent same-day poly-tobacco use, 13.81% frequent same-day poly-cannabis use, 13.25% frequent same-day poly-drug use, and 3.36% vape mixing. Past 30-day alcohol use was associated with higher odds (1.88\u20138.31, p&amp;lt;.05) of infrequent and frequent same day use of all study outcomes except vape mixing. Secondhand smoke\/vapor exposure was consistently associated with higher odds (1.13\u20131.26, p\u2009&amp;lt;\u2009.05) of infrequent\/frequent same day use. Discrimination increased the odds of some same-day polysubstance use while societal concerns had inconsistent effects across study outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A significant proportion of adolescents who use tobacco\/cannabis products might engage in high-risk use patterns. Alcohol use, societal, and environmental factors significantly increase the likelihood of same-day poly-use of tobacco and cannabis products.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Implications<\/jats:title>\n                    <jats:p>Frequent same-day poly-product\/drug use is common among adolescents who use tobacco and\/or cannabis. Alcohol use, societal concerns, and environmental exposure to secondhand smoke\/vape are significant contributors to same-day poly-product\/drug use and nicotine and marijuana\/THC vape mixing among these adolescents. Findings suggest that while infrequent same-day poly-product\/drug use may be more opportunistic and situation-dependent, often occurring in contexts where alcohol is present, frequent use may be more influenced by social contexts and environmental cues. Understanding these complex relationships between substances and high-risk use patterns is crucial for developing effective prevention strategies and treatment approaches for poly-drug use disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ntr\/ntaf150","type":"journal-article","created":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T11:53:47Z","timestamp":1752926027000},"page":"26-35","source":"Crossref","is-referenced-by-count":2,"title":["Multilevel Correlates of Same Day Poly-Product Use\/Co-Use among Adolescents Who Use Tobacco and Cannabis"],"prefix":"10.1093","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4293-5635","authenticated-orcid":false,"given":"Wura","family":"Jacobs","sequence":"first","affiliation":[{"name":"Department of Applied Health Science, School of Public Health, Indiana University Bloomington , 1025 E. 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