{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:21:33Z","timestamp":1759530093064},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1093\/ntr\/ntn034","type":"journal-article","created":{"date-parts":[[2009,3,24]],"date-time":"2009-03-24T01:40:55Z","timestamp":1237858855000},"page":"286-292","source":"Crossref","is-referenced-by-count":17,"title":["Examination of the Nicotine Dependence (NICSNP) Consortium findings in the Iowa adoption studies population"],"prefix":"10.1093","volume":"11","author":[{"given":"Robert A.","family":"Philibert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Todorov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Hollenbeck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracy","family":"Gunter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Heath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela","family":"Madden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2009,3,23]]},"reference":[{"key":"key\n\t\t\t\t20170523191304_bib1","volume-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"1994","edition":"4th ed."},{"key":"key\n\t\t\t\t20170523191304_bib2","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1093\/hmg\/ddl441","article-title":"Novel genes identified in a high-density genome wide association study for nicotine dependence","volume":"16","author":"Bierut","year":"2007","journal-title":"Human Molecular Genetics"},{"key":"key\n\t\t\t\t20170523191304_bib3","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/ajmg.b.30185","article-title":"Relationship of serotonin transporter gene polymorphisms and haplotypes to mRNA transcription","volume":"136","author":"Bradley","year":"2005","journal-title":"American Journal of Medical Genetics"},{"key":"key\n\t\t\t\t20170523191304_bib4","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1001\/archpsyc.58.9.810","article-title":"Nicotine dependence in the United States: Prevalence, trends, and smoking persistence","volume":"58","author":"Breslau","year":"2001","journal-title":"Archives of General Psychiatry"},{"key":"key\n\t\t\t\t20170523191304_bib5","doi-asserted-by":"crossref","first-page":"149","DOI":"10.15288\/jsa.1994.55.149","article-title":"A new, semi-structured psychiatric interview for use in genetic linkage studies: A report on the reliability of the SSAGA","volume":"55","author":"Bucholz","year":"1994","journal-title":"Journal of Studies of Alcohol"},{"key":"key\n\t\t\t\t20170523191304_bib6","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1001\/archpsyc.1986.01800120017004","article-title":"An adoption study of genetic and environmental factors in drug abuse","volume":"43","author":"Cadoret","year":"1986","journal-title":"Archives of General Psychiatry"},{"key":"key\n\t\t\t\t20170523191304_bib7","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1001\/archpsyc.1995.03950130042005","article-title":"Adoption study demonstrating two genetic pathways to drug abuse","volume":"52","author":"Cadoret","year":"1995","journal-title":"Archives of General Psychiatry"},{"key":"key\n\t\t\t\t20170523191304_bib8","first-page":"300","article-title":"Annual smoking-attributable mortality, years of potential life lost, and economic costs\u2014United States, 1995\u20131999","volume":"51","author":"Centers for Disease Control and Prevention","year":"2002","journal-title":"MMWR Morbidity and Mortality Weekly Report"},{"key":"key\n\t\t\t\t20170523191304_bib9","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1159\/000077543","article-title":"A novel permutation testing method implicates sixteen nicotinic acetylcholine receptor genes as risk factors for smoking in schizophrenia families","volume":"57","author":"Faraone","year":"2004","journal-title":"Human Heredity"},{"key":"key\n\t\t\t\t20170523191304_bib10","author":"Gauderman","year":"2006","journal-title":"QUANTO 1.1: A computer program for power and sample size calculations for genetic-epidemiology studies"},{"key":"key\n\t\t\t\t20170523191304_bib11","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/sj.mp.4001774","article-title":"Why do young women smoke? I. Direct and interactive effects of environment, psychological characteristics and nicotinic cholinergic receptor genes","volume":"11","author":"Greenbaum","year":"2006","journal-title":"Molecular Psychiatry"},{"key":"key\n\t\t\t\t20170523191304_bib12","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1111\/j.1360-0443.1991.tb01879.x","article-title":"The Fagerstr\u00f6m Test for Nicotine Dependence: A revision of the Fagerstr\u00f6m Tolerance Questionnaire","volume":"86","author":"Heatherton","year":"1991","journal-title":"British Journal of Addiction"},{"key":"key\n\t\t\t\t20170523191304_bib13","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1001\/archpsyc.64.9.1078","article-title":"CHRNA4 and tobacco dependence: From gene regulation to treatment outcome","volume":"64","author":"Hutchison","year":"2007","journal-title":"Archives of General Psychiatry"},{"key":"key\n\t\t\t\t20170523191304_bib14","doi-asserted-by":"crossref","first-page":"5444","DOI":"10.1093\/nar\/19.19.5444","article-title":"A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies","volume":"19","author":"Lahiri","year":"1991","journal-title":"Nucleic Acids Research"},{"key":"key\n\t\t\t\t20170523191304_bib15","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/s11920-006-0016-0","article-title":"The genetics of nicotine dependence","volume":"8","author":"Li","year":"2006","journal-title":"Current Psychiatry Reports"},{"key":"key\n\t\t\t\t20170523191304_bib16","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1093\/hmg\/ddi132","article-title":"Ethnic- and gender-specific association of the nicotinic acetylcholine receptor {alpha}4 subunit gene (CHRNA4) with nicotine dependence","volume":"14","author":"Li","year":"2005","journal-title":"Human Molecular Genetics"},{"key":"key\n\t\t\t\t20170523191304_bib17","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s00439-006-0229-7","article-title":"Gene-based analysis suggests association of the nicotinic acetylcholine receptor beta1 subunit (CHRNB1) and M1 muscarinic acetylcholine receptor (CHRM1) with vulnerability for nicotine dependence","volume":"120","author":"Lou","year":"2006","journal-title":"Human Genetics"},{"key":"key\n\t\t\t\t20170523191304_bib18","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1086\/383251","article-title":"A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other","volume":"74","author":"Nyholt","year":"2004","journal-title":"American Journal of Human Genetics"},{"key":"key\n\t\t\t\t20170523191304_bib19","article-title":"(in press). The role of GABRA2 on risk for alcohol, nicotine and cannabis dependence in the Iowa adoption studies","author":"Philibert","journal-title":"Psychiatric Genetics"},{"key":"key\n\t\t\t\t20170523191304_bib20","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1002\/ajmg.b.30512","article-title":"Transcriptional profiling of subjects from the Iowa adoption studies","volume":"144","author":"Philibert","year":"2007","journal-title":"American Journal of Medical Genetics"},{"key":"key\n\t\t\t\t20170523191304_bib21","first-page":"543","article-title":"The relationship of 5HTT methylation and genotype on mRNA expression and liability to major depression and alcohol dependence in subjects from the Iowa adoption studies","volume":"147","author":"Philibert","year":"2007","journal-title":"American Journal of Medical Genetics"},{"key":"key\n\t\t\t\t20170523191304_bib22","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1172\/JCI10266","article-title":"Searching for genes in complex diseases: Lessons from systemic lupus erythematosus","volume":"105","author":"Risch","year":"2000","journal-title":"Journal of Clinical Investigation"},{"key":"key\n\t\t\t\t20170523191304_bib23","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1093\/hmg\/ddl438","article-title":"Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs","volume":"16","author":"Saccone","year":"2007","journal-title":"Human Molecular Genetics"},{"key":"key\n\t\t\t\t20170523191304_bib24","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1086\/319501","article-title":"A new statistical method for haplotype reconstruction from population data","volume":"68","author":"Stephens","year":"2001","journal-title":"American Journal of Human Genetics"},{"key":"key\n\t\t\t\t20170523191304_bib25","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/ajmg.b.20138","article-title":"Candidate genes for nicotine dependence via linkage, epistasis, and bioinformatics","volume":"126","author":"Sullivan","year":"2004","journal-title":"American Journal of Medical Genetics"},{"key":"key\n\t\t\t\t20170523191304_bib26","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1001\/archpsyc.56.7.655","article-title":"Common genetic vulnerability for nicotine and alcohol dependence in men","volume":"56","author":"True","year":"1999","journal-title":"Archives of General Psychiatry"},{"key":"key\n\t\t\t\t20170523191304_bib27","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1080\/10673220127912","article-title":"The harvard twin study of substance abuse: What we have learned","volume":"9","author":"Tsuang","year":"2001","journal-title":"Harvard Reviews of Psychiatry"},{"key":"key\n\t\t\t\t20170523191304_bib28","first-page":"95","article-title":"The Iowa adoption studies methods and results","volume-title":"On the way to individuality: Methodological issues in behavioral genetics","author":"Yates","year":"1998"},{"key":"key\n\t\t\t\t20170523191304_bib29","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1093\/hmg\/ddm344","article-title":"The neuronal nicotinic receptor subunit genes (CHRNA6 and CHRNB3) are associated with subjective responses to tobacco","volume":"17","author":"Zeiger","year":"2008","journal-title":"Human Molecular Genetics"}],"container-title":["Nicotine & Tobacco Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ntr\/article-pdf\/11\/3\/286\/17488858\/ntn034.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T21:49:20Z","timestamp":1503524960000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ntr\/article-lookup\/doi\/10.1093\/ntr\/ntn034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":29,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2009,3,23]]},"published-print":{"date-parts":[[2009,3]]}},"URL":"https:\/\/doi.org\/10.1093\/ntr\/ntn034","relation":{},"ISSN":["1469-994X","1462-2203"],"issn-type":[{"value":"1469-994X","type":"electronic"},{"value":"1462-2203","type":"print"}],"subject":[],"published":{"date-parts":[[2009,3]]}}}