{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:24:55Z","timestamp":1791228295315,"version":"4.1.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1093\/ntr\/ntr325","type":"journal-article","created":{"date-parts":[[2012,2,22]],"date-time":"2012-02-22T00:50:31Z","timestamp":1329871831000},"page":"1073-1082","source":"Crossref","is-referenced-by-count":28,"title":["Deregulation of Gene Expression Induced by Environmental Tobacco Smoke Exposure in Pregnancy"],"prefix":"10.1093","volume":"14","author":[{"given":"Hana","family":"Votavova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Dostalova Merkerova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zdenek","family":"Krejcik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamila","family":"Fejglova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alzbeta","family":"Vasikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Pastorkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana","family":"Tabashidze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Topinka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Balascak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radim J.","family":"Sram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radim","family":"Brdicka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,2,21]]},"reference":[{"key":"key\n\t\t\t\t20170523170701_bib1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.mehy.2004.06.019","article-title":"Direct placental effects of cigarette smoke protect women from pre-eclampsia: The specific roles of carbon monoxide and antioxidant systems in the placenta","volume":"64","author":"Bainbridge","year":"2005","journal-title":"Medical Hypotheses"},{"key":"key\n\t\t\t\t20170523170701_bib2","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/j.1365-2141.2006.06216.x","article-title":"Localisation of proteins of iron metabolism in the human placenta and liver","volume":"134","author":"Bastin","year":"2006","journal-title":"British Journal of Haematology"},{"key":"key\n\t\t\t\t20170523170701_bib3","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.placenta.2007.09.001","article-title":"Hypoxia enhances the expression of follistatin-like 3 in term human trophoblasts","volume":"29","author":"Biron-Shental","year":"2008","journal-title":"Placenta"},{"key":"key\n\t\t\t\t20170523170701_bib4","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1136\/bmj.313.7051.195","article-title":"Smoking and the sudden infant death syndrome: Results from 1993-5 case-control study for confidential inquiry into stillbirths and deaths in infancy. Confidential Enquiry into Stillbirths and Deaths Regional Coordinators and Researchers","volume":"313","author":"Blair","year":"1996","journal-title":"British Medical Journal"},{"key":"key\n\t\t\t\t20170523170701_bib5","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1289\/ehp.0010873","article-title":"Risk of childhood cancer and adult lung cancer after childhood exposure to passive smoke: A meta-analysis","volume":"108","author":"Boffetta","year":"2000","journal-title":"Environmental Health Perspectives"},{"key":"key\n\t\t\t\t20170523170701_bib6","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.placenta.2009.12.016","article-title":"Effect of maternal tobacco smoke exposure on the placental transcriptome","volume":"31","author":"Bruchova","year":"2010","journal-title":"Placenta"},{"key":"key\n\t\t\t\t20170523170701_bib7","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ejogrb.2010.12.006","article-title":"The effect of tobacco smoking during pregnancy on plasma oxidant and antioxidant status in mother and newborn","volume":"155","author":"Chelchowska","year":"2011","journal-title":"European Journal of Obstetrics, Gynecology, and Reproductive Biology"},{"key":"key\n\t\t\t\t20170523170701_bib8","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1002\/dvg.20320","article-title":"The TGF-beta pseudoreceptor gene Bambi is dispensable for mouse embryonic development and postnatal survival","volume":"45","author":"Chen","year":"2007","journal-title":"Genesis"},{"key":"key\n\t\t\t\t20170523170701_bib9","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s00431-009-0967-3","article-title":"Environmental tobacco smoke (ETS) and respiratory health in children","volume":"168","author":"Cheraghi","year":"2009","journal-title":"European Journal of Pediatrics"},{"key":"key\n\t\t\t\t20170523170701_bib10","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1289\/ehp.02110601","article-title":"The exposure of nonsmoking and smoking mothers to environmental tobacco smoke during different gestational phases and fetal growth","volume":"110","author":"Dejmek","year":"2002","journal-title":"Environmental Health Perspectives"},{"key":"key\n\t\t\t\t20170523170701_bib11","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1001\/jama.293.10.1212","article-title":"Chromosomal instability in amniocytes from fetuses of mothers who smoke","volume":"293","author":"de la Chica","year":"2005","journal-title":"Journal of the American Medical Association"},{"key":"key\n\t\t\t\t20170523170701_bib12","first-page":"747","article-title":"Fetal growth and development: Roles of fatty acid transport proteins and nuclear transcription factors in human placenta","volume":"42","author":"Duttaroy","year":"2004","journal-title":"Indian Journal of Experimental Biology"},{"key":"key\n\t\t\t\t20170523170701_bib13","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1136\/adc.88.12.1086","article-title":"Adverse health effects of prenatal and postnatal tobacco smoke exposure on children","volume":"88","author":"Hofhuis","year":"2003","journal-title":"Archives of Disease in Childhood"},{"key":"key\n\t\t\t\t20170523170701_bib14","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1203\/PDR.0b013e31817c5507","article-title":"Effects of prenatal tobacco exposure on gene expression profiling in umbilical cord tissue","volume":"64","author":"Hussain","year":"2008","journal-title":"Pediatric Research"},{"key":"key\n\t\t\t\t20170523170701_bib15","volume-title":"IARC monographs on the evaluation of carcinogenic risks to humans: Tobacco smoke and involuntary smoking","author":"International Agency for Research on Cancer","year":"2004"},{"key":"key\n\t\t\t\t20170523170701_bib16","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.earlhumdev.2007.07.016","article-title":"Morphological and biological effects of maternal exposure to tobacco smoke on the feto-placental unit","volume":"83","author":"Jauniaux","year":"2007","journal-title":"Early Human Development"},{"key":"key\n\t\t\t\t20170523170701_bib17","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1095\/biolreprod.103.020651","article-title":"Osteopontin: Roles in implantation and placentation","volume":"69","author":"Johnson","year":"2003","journal-title":"Biology of Reproduction"},{"key":"key\n\t\t\t\t20170523170701_bib18","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/0076-6879(82)84050-0","article-title":"Radioimmunoassay of nicotine, cotinine, and gamma-(3-pyridyl)-gamma-oxo-N-methylbutyramide","volume":"84","author":"Langone","year":"1982","journal-title":"Methods in Enzymology"},{"key":"key\n\t\t\t\t20170523170701_bib19","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1194\/jlr.M600098-JLR200","article-title":"Gestational and hormonal regulation of human placental lipoprotein lipase","volume":"47","author":"Magnusson-Olsson","year":"2006","journal-title":"Journal of Lipid Research"},{"key":"key\n\t\t\t\t20170523170701_bib20","doi-asserted-by":"crossref","first-page":"e358","DOI":"10.1542\/peds.2007-1332","article-title":"Etiologic classification of attention-deficit\/hyperactivity disorder","volume":"121","author":"Millichap","year":"2008","journal-title":"Pediatrics"},{"key":"key\n\t\t\t\t20170523170701_bib21","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1080\/105504901750160420","article-title":"Maternal transmission of nicotine dependence: Psychiatric, neurocognitive and prenatal factors","volume":"10","author":"Niaura","year":"2001","journal-title":"American Journal on Addictions"},{"key":"key\n\t\t\t\t20170523170701_bib22","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.placenta.2004.12.007","article-title":"IGFBP1 and Follistatin-like 3 genes are significantly up-regulated in expression profiles of the IUGR placenta","volume":"27","author":"Okamoto","year":"2006","journal-title":"Placenta"},{"key":"key\n\t\t\t\t20170523170701_bib23","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1183\/09059180.00003609","article-title":"Epidemiology of chronic COPD","volume":"18","author":"Raherison","year":"2009","journal-title":"European Respiratory Review"},{"key":"key\n\t\t\t\t20170523170701_bib24","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1089\/jwh.2008.1024","article-title":"Consequences of smoking during pregnancy on maternal health","volume":"18","author":"Roelands","year":"2009","journal-title":"Journal of Women\u2019s Health"},{"key":"key\n\t\t\t\t20170523170701_bib25","first-page":"79, 289","article-title":"DNA adducts in human placenta exposed to ambient environment and passive cigarette smoke during pregnancy","author":"Sanyal","year":"2007","journal-title":"Birth Defects Research. Part A, Clinical and Molecular Teratology"},{"key":"key\n\t\t\t\t20170523170701_bib26","doi-asserted-by":"crossref","first-page":"R754","DOI":"10.1152\/ajpregu.00505.2006","article-title":"Effect of cigarette smoke on placental antioxidant enzyme expression","volume":"293","author":"Sidle","year":"2007","journal-title":"American Journal of Physiology. Regulatory, Integrative and Comparative Physiology"},{"key":"key\n\t\t\t\t20170523170701_bib27","doi-asserted-by":"crossref","first-page":"5478","DOI":"10.1073\/pnas.0508035103","article-title":"Gene expression patterns in human placenta","volume":"103","author":"Sood","year":"2006","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"key\n\t\t\t\t20170523170701_bib28","doi-asserted-by":"crossref","first-page":"47079","DOI":"10.1074\/jbc.M308124200","article-title":"EndoPDI, a novel protein-disulfide isomerase-like protein that is preferentially expressed in endothelial cells acts as a stress survival factor","volume":"278","author":"Sullivan","year":"2003","journal-title":"Journal of Chemical Biology"},{"key":"key\n\t\t\t\t20170523170701_bib29","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1016\/j.metabol.2010.01.013","article-title":"In utero tobacco exposure epigenetically modifies placental CYP1A1 expression","volume":"59","author":"Suter","year":"2010","journal-title":"Metabolism"},{"key":"key\n\t\t\t\t20170523170701_bib30","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.mrfmmm.2009.04.011","article-title":"Biomarkers of exposure to tobacco smoke and environmental pollutants in mothers and their transplacental transfer to the foetus. Part I: Bulky DNA adducts","volume":"669","author":"Topinka","year":"2009","journal-title":"Mutation Research"},{"key":"key\n\t\t\t\t20170523170701_bib31","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.placenta.2009.03.015","article-title":"Endocannabinoid system in first trimester placenta: Low FAAH and high CB1 expression characterize spontaneous miscarriage","volume":"30","author":"Trabucco","year":"2009","journal-title":"Placenta"},{"key":"key\n\t\t\t\t20170523170701_bib32","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1093\/toxsci\/kfi168","article-title":"Differential gene expression in human peripheral blood mononuclear cells induced by cigarette smoke and its constituents","volume":"86","author":"Van Leeuwen","year":"2005","journal-title":"Toxicological Sciences"},{"key":"key\n\t\t\t\t20170523170701_bib33","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s10024-004-0105-1","article-title":"Maternal smoking, intrauterine growth restriction, and placental apoptosis","volume":"7","author":"Vogt","year":"2004","journal-title":"Pediatric and Developmental Pathology"},{"key":"key\n\t\t\t\t20170523170701_bib34","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.placenta.2011.06.022","article-title":"Transcriptome alterations in maternal and fetal cells induced by tobacco smoke","volume":"32","author":"Votavova","year":"2011","journal-title":"Placenta"},{"key":"key\n\t\t\t\t20170523170701_bib35","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1080\/10937400801921320","article-title":"Epidemiologic evidence of relationships between reproductive and child health outcomes and environmental chemical contaminants","volume":"11","author":"Wigle","year":"2008","journal-title":"Journal of Toxicology and Environmental Health. Part B, Critical reviews"},{"key":"key\n\t\t\t\t20170523170701_bib36","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1002\/jps.20973","article-title":"Effect of placental fatty acid metabolism and regulation by peroxisome proliferator activated receptor on pregnancy and fetal outcomes","volume":"96","author":"Xu","year":"2007","journal-title":"Journal of Pharmaceutical Sciences"},{"key":"key\n\t\t\t\t20170523170701_bib37","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.coph.2009.06.009","article-title":"Current concepts on the role of inflammation in COPD and lung cancer","volume":"9","author":"Yao","year":"2009","journal-title":"Current Opinion in Pharmacology"},{"key":"key\n\t\t\t\t20170523170701_bib38","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1203\/01.pdr.0000228327.63820.41","article-title":"Effects of benzopyrene-7,8-diol-9,10-epoxide (BPDE) in vitro and of maternal smoking in vivo on micronuclei frequencies in fetal cord blood","volume":"60","author":"Zalacain","year":"2006","journal-title":"Pediatric Research"}],"container-title":["Nicotine & Tobacco Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ntr\/article-pdf\/14\/9\/1073\/17490345\/ntr325.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T16:57:27Z","timestamp":1503507447000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ntr\/article-lookup\/doi\/10.1093\/ntr\/ntr325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,21]]},"references-count":38,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2012,2,21]]},"published-print":{"date-parts":[[2012,9]]}},"URL":"https:\/\/doi.org\/10.1093\/ntr\/ntr325","relation":{},"ISSN":["1469-994X","1462-2203"],"issn-type":[{"value":"1469-994X","type":"electronic"},{"value":"1462-2203","type":"print"}],"subject":[],"published":{"date-parts":[[2012,2,21]]}}}