{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:31:44Z","timestamp":1792794704109,"version":"4.5.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T00:00:00Z","timestamp":1515369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21606060"],"award-info":[{"award-number":["21606060"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science Innovation Foundation of China National Tobacco Quality and Supervision and Test Center","award":["512016CA0060"],"award-info":[{"award-number":["512016CA0060"]}]},{"name":"State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences","award":["KF 2015-04"],"award-info":[{"award-number":["KF 2015-04"]}],"id":[{"id":"https:\/\/ror.org\/03rpsvy57","id-type":"ROR","asserted-by":"crossref"}]},{"name":"State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences","award":["KF 2014-03"],"award-info":[{"award-number":["KF 2014-03"]}],"id":[{"id":"https:\/\/ror.org\/03rpsvy57","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,1,1]]},"DOI":"10.1093\/ntr\/nty005","type":"journal-article","created":{"date-parts":[[2018,1,6]],"date-time":"2018-01-06T07:09:25Z","timestamp":1515222565000},"page":"111-118","source":"Crossref","is-referenced-by-count":133,"title":["Chemical Analysis and Simulated Pyrolysis of Tobacco Heating System 2.2 Compared to Conventional Cigarettes"],"prefix":"10.1093","volume":"21","author":[{"given":"Xiangyu","family":"Li","sequence":"first","affiliation":[{"name":"Department of Environmental Science and Technology, School of Environment, Tsinghua University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanbo","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyi","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, School of International Education, Henan University of Technology, Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongfei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Tobacco Chemistry, School Of Food Science and Engineering, Zhengzhou University of Light Industry, Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengpeng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Tobacco Chemistry, School Of Food Science and Engineering, Zhengzhou University of Light Industry, Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaodong","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of polymer science and engineer, Sichuan University, Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Inorganic Chemistry, Chemistry, University of Science and Technology of China, Hefei, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyuan","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Optics, Anhui Institute of Optics and Fine Mechanics, The Chinese Academy of Sciences, Hefei, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqiang","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Chemistry, University of Science and Technology of China, Hefei, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,1,8]]},"reference":[{"issue":"29","key":"key\n\t\t\t\t2018122106180894000_CIT0001","first-page":"642","article-title":"Cigarette smoking among adults-United States, 2000","volume":"51","author":"CDC (Centers for Disease Control and Preventiation)","year":"2002","journal-title":"Morbid Mortal W"},{"key":"key\n\t\t\t\t2018122106180894000_CIT0002","volume-title":"Reducing tobacco use: a report of the Surgeon General","author":"HHS (U. S. Department of Health and Human Services)","year":"2000"},{"issue":"2","key":"key\n\t\t\t\t2018122106180894000_CIT0003","doi-asserted-by":"crossref","first-page":"e33","DOI":"10.1016\/j.amepre.2016.10.036","article-title":"Overview of Electronic Nicotine Delivery Systems: A Systematic Review","volume":"52","author":"Glasser","year":"2017","journal-title":"Am J Prev Med"},{"key":"key\n\t\t\t\t2018122106180894000_CIT0004","article-title":"E-cigarettes rapidly lose steam","volume-title":"The Wall Street Journal","author":"Mickle","year":"2015"},{"key":"key\n\t\t\t\t2018122106180894000_CIT0005","article-title":"Heat-not-burn tobacco products are about to reach their boiling point","author":"Caputi","year":"2016","journal-title":"Tob Control"},{"key":"key\n\t\t\t\t2018122106180894000_CIT0006","unstructured":"PMI. Investigator at the Consumer Analyst Group of New York (CAGNY) Conference. CAGNY Conference; February 22, 2017; Boca Raton, Florida."},{"issue":"1","key":"key\n\t\t\t\t2018122106180894000_CIT0007","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0165-2370(03)00090-1","article-title":"The pyrolysis of tobacco ingredients","volume":"71","author":"Baker","year":"2004","journal-title":"J Anal Appl pyrol"},{"key":"key\n\t\t\t\t2018122106180894000_CIT0008","volume-title":"Public Law 111\u201331,\u201dThe Family Smoking Prevention and Tobacco Control Act (FSPTCA).\u201d","year":"2009"},{"key":"key\n\t\t\t\t2018122106180894000_CIT0009","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1016\/j.yrtph.2016.07.006","article-title":"Evaluation of the Tobacco Heating System 2.2. Part 1: Description of the system and the scientific assessment program","volume":"81","author":"Smith","year":"2016","journal-title":"Regul Toxicol Pharm: RTP"},{"key":"key\n\t\t\t\t2018122106180894000_CIT0010","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1016\/j.yrtph.2016.10.001","article-title":"Evaluation of the Tobacco Heating System 2.2. Part 2: Chemical composition, genotoxicity, cytotoxicity, and physical properties of the aerosol","volume":"81","author":"Schaller","year":"2016","journal-title":"Regul Toxicol Pharm: RTP"},{"key":"key\n\t\t\t\t2018122106180894000_CIT0011","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.1016\/j.yrtph.2016.10.016","article-title":"Evaluation of the Tobacco Heating System 2.2. Part 3: Influence of the tobacco blend on the formation of harmful and potentially harmful constituents of the Tobacco Heating System 2.2 aerosol","volume":"81","author":"Schaller","year":"2016","journal-title":"Regul Toxicol Pharm: RTP"},{"key":"key\n\t\t\t\t2018122106180894000_CIT0012","doi-asserted-by":"crossref","first-page":"S59","DOI":"10.1016\/j.yrtph.2016.10.015","article-title":"Evaluation of the Tobacco Heating System 2.2. Part 4: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects compared with cigarette smoke","volume":"81","author":"Wong","year":"2016","journal-title":"Regul Toxicol Pharm: RTP"},{"key":"key\n\t\t\t\t2018122106180894000_CIT0013","doi-asserted-by":"crossref","first-page":"S82","DOI":"10.1016\/j.yrtph.2016.11.018","article-title":"Evaluation of the Tobacco Heating System 2.2 (THS2.2). Part 5: microRNA expression from a 90-day rat inhalation study indicates that exposure to THS2.2 aerosol causes reduced effects on lung tissue compared with cigarette smoke","volume":"81","author":"Sewer","year":"2016","journal-title":"Regul Toxicol Pharm: RTP"},{"key":"key\n\t\t\t\t2018122106180894000_CIT0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.yrtph.2016.11.004","article-title":"Evaluation of the Tobacco Heating System 2.2. Part 6: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of a mentholated version compared with mentholated and non-mentholated cigarette smoke","author":"Oviedo","year":"2016","journal-title":"Regul Toxicol Pharm: RTP"},{"key":"key\n\t\t\t\t2018122106180894000_CIT0015","doi-asserted-by":"crossref","first-page":"S123","DOI":"10.1016\/j.yrtph.2016.11.001","article-title":"Evaluation of the Tobacco Heating System 2.2. Part 7: Systems toxicological assessment of a mentholated version revealed reduced cellular and molecular exposure effects compared with mentholated and non-mentholated cigarette smoke","volume":"81","author":"Kogel","year":"2016","journal-title":"Regul Toxicol Pharm: RTP"},{"key":"key\n\t\t\t\t2018122106180894000_CIT0016","doi-asserted-by":"crossref","first-page":"S139","DOI":"10.1016\/j.yrtph.2016.11.003","article-title":"Evaluation of the Tobacco Heating System 2.2. Part 8: 5-Day randomized reduced exposure clinical study in Poland","volume":"81","author":"Haziza","year":"2016","journal-title":"Regul Toxicol Pharm: RTP"},{"key":"key\n\t\t\t\t2018122106180894000_CIT0017","doi-asserted-by":"crossref","first-page":"S151","DOI":"10.1016\/j.yrtph.2016.11.011","article-title":"Evaluation of the tobacco heating system 2.2. Part 9: Application of systems pharmacology to identify exposure response markers in peripheral blood of smokers switching to THS2.2","volume":"81","author":"Martin","year":"2016","journal-title":"Regul Toxicol Pharm: RTP"},{"issue":"1","key":"key\n\t\t\t\t2018122106180894000_CIT0018","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1021\/acs.chemrestox.5b00321","article-title":"In Vitro systems toxicology assessment of a candidate modified risk tobacco product shows reduced toxicity compared to that of a conventional cigarette","volume":"29","author":"Gonzalez-Suarez","year":"2016","journal-title":"Chem Res Toxicol"},{"issue":"2","key":"key\n\t\t\t\t2018122106180894000_CIT0019","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1093\/ntr\/ntw287","article-title":"Effects of switching to the Tobacco Heating System 2.2 Menthol, smoking abstinence, or continued cigarette smoking on biomarkers of exposure: a randomized, controlled, open-label, multicenter study in sequential confinement and ambulatory settings (Part 1)","volume":"20","author":"Ludicke","year":"2018","journal-title":"Nicotine & tobacco research: official journal of the Society for Research on Nicotine and Tobacco"},{"issue":"2","key":"key\n\t\t\t\t2018122106180894000_CIT0020","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1093\/ntr\/ntx028","article-title":"Effects of switching to the Menthol Tobacco Heating System 2.2, smoking abstinence, or continued cigarette smoking on clinically relevant risk markers: a randomized, controlled, open-label, multicenter study in sequential confinement and ambulatory settings (Part 2)","volume":"20","author":"Ludicke","year":"2018","journal-title":"Nicotine & tobacco research: official journal of the Society for Research on Nicotine and Tobacco"},{"issue":"7","key":"key\n\t\t\t\t2018122106180894000_CIT0021","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1001\/jamainternmed.2017.1419","article-title":"Heat-Not-Burn Tobacco Cigarettes","volume":"177","author":"Auer","year":"2017","journal-title":"JAMA Intern Med"},{"issue":"1","key":"key\n\t\t\t\t2018122106180894000_CIT0022","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/MLR.0b013e31817e18d1","article-title":"Long-term results of a smoking reduction program","volume":"47","author":"Glasgow","year":"2009","journal-title":"Med care"},{"issue":"5","key":"key\n\t\t\t\t2018122106180894000_CIT0023","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1093\/aje\/kwt038","article-title":"Does smoking reduction in midlife reduce mortality risk? Results of 2 long-term prospective cohort studies of men and women in Scotland","volume":"178","author":"Hart","year":"2013","journal-title":"Am J Epidemiol"},{"key":"key\n\t\t\t\t2018122106180894000_CIT0024","volume-title":"ISO 4387:2000 Cigarettes \u2013 Determination of total and nicotine-free dry particulate matter using a routing analytical smoking machine","year":"2000"},{"issue":"1","key":"key\n\t\t\t\t2018122106180894000_CIT0025","doi-asserted-by":"crossref","first-page":"316","DOI":"10.2478\/cttr-2013-0912","article-title":"Mainstream Smoke Chemistry and in Vitro and In Vivo Toxicity of the Reference Cigarettes 3R4F and 2R4F","volume":"25","author":"Roemer","year":"2014","journal-title":"Beitr\u00e4ge Zur Tabakforschung"},{"issue":"2","key":"key\n\t\t\t\t2018122106180894000_CIT0026","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.jaap.2009.01.008","article-title":"Phenolic compound formation from the low temperature pyrolysis of tobacco","volume":"84","author":"McGrath","year":"2009","journal-title":"J Anal Appl Pyrol"},{"issue":"1","key":"key\n\t\t\t\t2018122106180894000_CIT0027","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jaap.2008.10.001","article-title":"Formation of selected toxicants from tobacco under different pyrolysis conditions","volume":"85","author":"Cz\u00e9g\u00e9ny","year":"2009","journal-title":"J Anal Appl Pyrol"},{"key":"key\n\t\t\t\t2018122106180894000_CIT0028","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jaap.2012.10.029","article-title":"Analytical pyrolysis of tobacco residue: Effect of temperature and inorganic additives","volume":"99","author":"Cardoso","year":"2013","journal-title":"J Anal Appl Pyrol"},{"key":"key\n\t\t\t\t2018122106180894000_CIT0029","volume-title":"ISO 3402:1999 Tobacco and tobacco products\u2013atmosphere for conditioning and testing","year":"2015"},{"key":"key\n\t\t\t\t2018122106180894000_CIT0030","volume-title":"ISO 4387:2000 Cigarettes -- Determination of total and nicotine-free dry particulate matter using a routine analytical smoking machine","year":"2016"},{"key":"key\n\t\t\t\t2018122106180894000_CIT0031","volume-title":"ISO 10315:2013 Cigarettes -- Determination of nicotine in smoke condensates -- Gas-chromatographic method","year":"2013"},{"key":"key\n\t\t\t\t2018122106180894000_CIT0032","volume-title":"ISO 8454:2007 Cigarettes -- Determination of carbon monoxide in the vapour phase of cigarette smoke -- NDIR method","year":"2016"},{"key":"key\n\t\t\t\t2018122106180894000_CIT0033","volume-title":"Additives, Cigarette Design and Tobacco Product Regulation","author":"Wigand","year":"2006"},{"issue":"4","key":"key\n\t\t\t\t2018122106180894000_CIT0034","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.chroma.2011.07.046","article-title":"Features for non-targeted cross-sample analysis with comprehensive two-dimensional chromatography","volume":"1226","author":"Reichenbach","year":"2012","journal-title":"J Chromatogr A"},{"issue":"4","key":"key\n\t\t\t\t2018122106180894000_CIT0035","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/j.talanta.2010.09.057","article-title":"Informatics for cross-sample analysis with comprehensive two-dimensional gas chromatography and high-resolution mass spectrometry (GCxGC-HRMS)","volume":"83","author":"Reichenbach","year":"2011","journal-title":"Talanta"},{"issue":"4","key":"key\n\t\t\t\t2018122106180894000_CIT0036","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0165-2370(83)80004-7","article-title":"Formation of carbon oxides during tobacco combustion","volume":"4","author":"Baker","year":"1983","journal-title":"J Anal Appl Pyrol"},{"key":"key\n\t\t\t\t2018122106180894000_CIT0037","volume-title":"Agents classified by the IARC Monographs","author":"IARC","year":"2012"},{"issue":"46","key":"key\n\t\t\t\t2018122106180894000_CIT0038","doi-asserted-by":"crossref","first-page":"20097","DOI":"10.1021\/jp906702p","article-title":"Kinetics and Mechanism of Cellulose Pyrolysis","volume":"113","author":"Lin","year":"2009","journal-title":"J Phys Chem C"},{"issue":"1","key":"key\n\t\t\t\t2018122106180894000_CIT0039","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1021\/jo00800a038","article-title":"Mechanisms of hydrogen cyanide formation from the pyrolysis of amino acids and related compounds","volume":"36","author":"Johnson","year":"1971","journal-title":"J Org Chem"},{"issue":"7","key":"key\n\t\t\t\t2018122106180894000_CIT0040","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2478\/cttr-2013-0724","article-title":"Studies of Polycyclic Aromatic Hydrocarbons in Cigarette Mainstream Smoke: Identification, Tobacco Precursors, Control of Levels: A Review","volume":"19","author":"Rodgman","year":"2014","journal-title":"Beitr\u00e4ge Zur Tabakforschung"},{"issue":"1\u20132","key":"key\n\t\t\t\t2018122106180894000_CIT0041","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jaap.2008.10.001","article-title":"Formation of selected toxicants from tobacco under different pyrolysis conditions","volume":"85","author":"Cz\u00e9g\u00e9ny","year":"2009","journal-title":"J Anal Appl Pyrol"},{"key":"key\n\t\t\t\t2018122106180894000_CIT0042","first-page":"331","article-title":"TSNA Levels in the Mainstream Smoke of Simplified Blend Prototypes","volume-title":"Beitr\u00e4ge zur Tabakforschung International\/Contributions to Tobacco Research","author":"Zuber","year":"2003"},{"issue":"1","key":"key\n\t\t\t\t2018122106180894000_CIT0043","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.jaap.2004.09.005","article-title":"Pyrolysis of saccharide tobacco ingredients: a TGA\u2013FTIR investigation","volume":"74","author":"Baker","year":"2005","journal-title":"J Anal Appl Pyrol"},{"key":"key\n\t\t\t\t2018122106180894000_CIT0044","first-page":"S64","article-title":"Study on formation mechanisms of ammonia and hydrogen cyanide during pyrolysis of proline","volume-title":"Tob Sci Tech","author":"Wang","year":"2015"},{"issue":"3","key":"key\n\t\t\t\t2018122106180894000_CIT0045","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.yrtph.2014.10.010","article-title":"Comparison of select analytes in aerosol from e-cigarettes with smoke from conventional cigarettes and with ambient air","volume":"70","author":"Tayyarah","year":"2014","journal-title":"Regul. Toxicol. Pharm"},{"issue":"2","key":"key\n\t\t\t\t2018122106180894000_CIT0046","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1136\/tobaccocontrol-2012-050859","article-title":"Levels of selected carcinogens and toxicants in vapour from electronic cigarettes","volume":"23","author":"Goniewicz","year":"2014","journal-title":"Tob Control"},{"issue":"8","key":"key\n\t\t\t\t2018122106180894000_CIT0047","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1111\/add.12942","article-title":"E-cigarettes generate high levels of aldehydes only in \u2018dry puff\u2019 conditions","volume":"110","author":"Farsalinos","year":"2015","journal-title":"Addiction"},{"key":"key\n\t\t\t\t2018122106180894000_CIT0048","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.jhazmat.2017.10.057","article-title":"Assessment of reactive oxygen species generated by electronic cigarettes using acellular and cellular approaches","volume":"344","author":"Zhao","year":"2017","journal-title":"J Hazard Mater"},{"issue":"8","key":"key\n\t\t\t\t2018122106180894000_CIT0049","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1093\/ntr\/ntx138","article-title":"Nicotine delivery to the aerosol of a heat-not-burn tobacco product: comparison with a tobacco cigarette and e-cigarettes","volume":"20","author":"Farsalinos","year":"2018","journal-title":"Nicotine & tobacco research: official journal of the Society for Research on Nicotine and Tobacco"},{"issue":"12","key":"key\n\t\t\t\t2018122106180894000_CIT0050","doi-asserted-by":"crossref","first-page":"L1398","DOI":"10.1152\/ajplung.00272.2015","article-title":"Will chronic e-cigarette use cause lung disease","volume":"309","author":"Rowell","year":"2015","journal-title":"American journal of physiology. Lung cellular and molecular physiology"},{"issue":"4","key":"key\n\t\t\t\t2018122106180894000_CIT0051","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1515\/cttr-2016-0015","article-title":"Cigarette Mainstream Smoke: The Evolution of Methods and Devices for Generation, Exposure and Collection","volume":"27","author":"Klus","year":"2016","journal-title":"Beitr\u00e4ge Zur Tabakforschung International\/contributions to Tobacco Research"}],"container-title":["Nicotine &amp; Tobacco Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ntr\/article-pdf\/21\/1\/111\/27228192\/nty005.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,8]],"date-time":"2019-10-08T22:51:27Z","timestamp":1570575087000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ntr\/article\/21\/1\/111\/4793230"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,8]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,1,8]]},"published-print":{"date-parts":[[2019,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ntr\/nty005","relation":{},"ISSN":["1462-2203","1469-994X"],"issn-type":[{"value":"1462-2203","type":"print"},{"value":"1469-994X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,1]]},"published":{"date-parts":[[2018,1,8]]}}}