{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:18:59Z","timestamp":1790057939213,"version":"4.0.1"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T00:00:00Z","timestamp":1534982400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA-192940"],"award-info":[{"award-number":["R01 CA-192940"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>When animals undergo nicotine deprivation, rewards become less rewarding (ie, anhedonia occurs). We searched for tests of whether anhedonia occurs in abstinent smokers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The major inclusion criterion was a within-participants comparison of behavioral measures of reward sensitivity or self-reported anhedonia during smoking versus during abstinence among daily smokers. A computerized search of PubMed, PsychInfo, and Cochrane databases and other methods located 13 studies. All but one were laboratory studies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The number of studies and participants were small and the results mixed. In terms of anticipatory anhedonia (ie, wanting a reward), abstinence appeared to decrease willingness to work for immediately available rewards, but did not appear to influence how much adding rewards to a task increased responding. Abstinence also appeared to produce small increases in self-reported anticipatory anhedonia. In terms of consummatory anhedonia (ie, liking a reward), self-report measures found anhedonia decreased pleasure from rewards in some but not all tests. In terms of learning (ie, learning to choose a more frequent reward), abstinence did not reliably decrease allocating responding to high versus low frequency reward options.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Although results were mixed, abstinence appears to increase anticipatory anhedonia. It is unclear if abstinence increases consummatory or reward learning-based anhedonia. Further studies of anhedonia in clinical settings are needed (1) to estimate the reliability and clinical significance of anhedonia as a symptom of tobacco withdrawal, (2) to assess if effects represent withdrawal versus offset processes, and (3) to assess if anhedonia interferes with the ability to stop smoking.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Implications<\/jats:title>\n                  <jats:p>Anticipatory anhedonia appears to be a symptom of tobacco withdrawal and should be added to tobacco withdrawal checklists and diagnostic criteria. Further study of consummatory and learning-based anhedonia is warranted.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ntr\/nty171","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T19:18:12Z","timestamp":1534965492000},"page":"11-17","source":"Crossref","is-referenced-by-count":18,"title":["Possible New Symptoms of Tobacco Withdrawal II: Anhedonia\u2014A Systematic Review"],"prefix":"10.1093","volume":"22","author":[{"given":"John R","family":"Hughes","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Center for Behavior and Health, University of Vermont, Burlington, VT"},{"name":"Department of Psychological Science, University of Vermont, Burlington, VT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias M","family":"Klemperer","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Center for Behavior and Health, University of Vermont, Burlington, VT"},{"name":"Department of Psychological Science, University of Vermont, Burlington, VT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Peasley-Miklus","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Center for Behavior and Health, University of Vermont, Burlington, VT"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,8,23]]},"reference":[{"issue":"3","key":"2020061608132244700_CIT0001","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14622200701188919","article-title":"Effects of abstinence from tobacco: valid symptoms and time course","volume":"9","author":"Hughes","year":"2007","journal-title":"Nicotine Tob Res"},{"issue":"4","key":"2020061608132244700_CIT0002","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1080\/14622200410001734067","article-title":"Recommendation for the assessment of tobacco craving and withdrawal in smoking cessation trials","volume":"6","author":"Shiffman","year":"2004","journal-title":"Nicotine Tob Res"},{"key":"2020061608132244700_CIT0003","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"1980","edition":"3rd ed"},{"key":"2020061608132244700_CIT0004","doi-asserted-by":"crossref","DOI":"10.1176\/appi.books.9780890425596","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"2013","edition":"5th ed"},{"issue":"5","key":"2020061608132244700_CIT0005","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1093\/ntr\/ntu220","article-title":"Is impulsivity a symptom of initial tobacco withdrawal? 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