{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T14:46:51Z","timestamp":1775314011842,"version":"3.50.1"},"reference-count":39,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2018,12,17]],"date-time":"2018-12-17T00:00:00Z","timestamp":1545004800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"RFT: Foundation","award":["FDN-154294"],"award-info":[{"award-number":["FDN-154294"]}]},{"name":"Centre for Addiction and Mental Health and the CAMH Foundation"},{"DOI":"10.13039\/501100000196","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","award":["20289"],"award-info":[{"award-number":["20289"]}],"id":[{"id":"10.13039\/501100000196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000196","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","award":["16014"],"award-info":[{"award-number":["16014"]}],"id":[{"id":"10.13039\/501100000196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.1093\/ntr\/nty265","type":"journal-article","created":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T08:46:05Z","timestamp":1544777165000},"source":"Crossref","is-referenced-by-count":2,"title":["Changes in Nicotine Metabolite Ratio Among Daily Smokers Receiving Treatment for Alcohol Use Disorder"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4998-6803","authenticated-orcid":false,"given":"Sarah S","family":"Dermody","sequence":"first","affiliation":[{"name":"School of Psychological Science, Oregon State University, Corvallis, OR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian S","family":"Hendershot","sequence":"additional","affiliation":[{"name":"Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada"},{"name":"Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada"},{"name":"Department of Psychology, University of Toronto, Toronto, Ontario, Canada"},{"name":"Institute for Mental Health Policy Research, Centre for Addiction and Mental Health, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allyson K","family":"Andrade","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Guelph, Guelph, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Novalen","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel F","family":"Tyndale","sequence":"additional","affiliation":[{"name":"Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada"},{"name":"Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada"},{"name":"Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,12,17]]},"reference":[{"issue":"3","key":"key\n\t\t\t\t2019012511192140400_CIT0001","first-page":"162","article-title":"An epidemiologic analysis of co-occurring alcohol and tobacco use and disorders: findings from the National Epidemiologic Survey on Alcohol and Related Conditions","volume":"29","author":"Falk","year":"2006","journal-title":"Alcohol Res Health"},{"issue":"3","key":"key\n\t\t\t\t2019012511192140400_CIT0002","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0376-8716(99)00130-1","article-title":"Drinking as a risk factor for sustained smoking","volume":"59","author":"Dawson","year":"2000","journal-title":"Drug Alcohol Depend"},{"key":"key\n\t\t\t\t2019012511192140400_CIT0003","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.drugalcdep.2017.07.009","article-title":"Cigarette smoking quit rates among adults with and without alcohol use disorders and heavy alcohol use, 2002\u20132015: a representative sample of the United States population","volume":"180","author":"Weinberger","year":"2017","journal-title":"Drug Alcohol Depend"},{"issue":"10","key":"key\n\t\t\t\t2019012511192140400_CIT0004","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1093\/jnci\/djk179","article-title":"Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium","volume":"99","author":"Hashibe","year":"2007","journal-title":"J Natl Cancer Inst"},{"key":"key\n\t\t\t\t2019012511192140400_CIT0005","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1146\/annurev-clinpsy-050212-185549","article-title":"How can we use our knowledge of alcohol\u2013tobacco interactions to reduce alcohol use","volume":"9","author":"McKee","year":"2013","journal-title":"Annu Rev Clin Psychol"},{"issue":"9","key":"key\n\t\t\t\t2019012511192140400_CIT0006","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1111\/j.1530-0277.2012.01767.x","article-title":"Tobacco quitlines need to assess and intervene with callers\u2019 hazardous drinking","volume":"36","author":"Toll","year":"2012","journal-title":"Alcohol Clin Exp Res"},{"issue":"3","key":"key\n\t\t\t\t2019012511192140400_CIT0007","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/acer.13321","article-title":"A critical review of the effects of nicotine and alcohol coadministration in human laboratory studies","volume":"41","author":"Dermody","year":"2017","journal-title":"Alcohol Clin Exp Res"},{"issue":"2","key":"key\n\t\t\t\t2019012511192140400_CIT0008","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1097\/00008877-199603000-00005","article-title":"Alcohol and the reward value of cigarette smoking","volume":"7","author":"Glautier","year":"1996","journal-title":"Behav Pharmacol"},{"issue":"24","key":"key\n\t\t\t\t2019012511192140400_CIT0009","doi-asserted-by":"crossref","first-page":"4649","DOI":"10.1007\/s00213-014-3613-3","article-title":"Acute effects of low and high dose alcohol on smoking lapse behavior in a laboratory analogue task","volume":"231","author":"Kahler","year":"2014","journal-title":"Psychopharmacology (Berl)"},{"issue":"3","key":"key\n\t\t\t\t2019012511192140400_CIT0010","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0306-4603(85)90001-2","article-title":"Alcohol increases cigarette smoking: a laboratory demonstration","volume":"10","author":"Mintz","year":"1985","journal-title":"Addict Behav"},{"issue":"3","key":"key\n\t\t\t\t2019012511192140400_CIT0011","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s00213-010-1831-x","article-title":"Alcohol expectancy increases positive responses to cigarettes in young, escalating smokers","volume":"210","author":"McKee","year":"2010","journal-title":"Psychopharmacology (Berl)"},{"issue":"2","key":"key\n\t\t\t\t2019012511192140400_CIT0012","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s00213-006-0551-8","article-title":"Modeling the effect of alcohol on smoking lapse behavior","volume":"189","author":"McKee","year":"2006","journal-title":"Psychopharmacology (Berl)"},{"issue":"4","key":"key\n\t\t\t\t2019012511192140400_CIT0013","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1097\/00008877-199506000-00006","article-title":"Effects of varying ethanol dose on cigarette consumption in healthy normal volunteers","volume":"6","author":"Mitchell","year":"1995","journal-title":"Behav Pharmacol"},{"issue":"3","key":"key\n\t\t\t\t2019012511192140400_CIT0014","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1037\/a0023033","article-title":"The subjective effects of alcohol\u2013tobacco co-use: an ecological momentary assessment investigation","volume":"120","author":"Piasecki","year":"2011","journal-title":"J Abnorm Psychol"},{"issue":"3","key":"key\n\t\t\t\t2019012511192140400_CIT0015","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s00213-012-2721-1","article-title":"Responses to alcohol and cigarette use during ecologically assessed drinking episodes","volume":"223","author":"Piasecki","year":"2012","journal-title":"Psychopharmacology (Berl)"},{"issue":"8","key":"key\n\t\t\t\t2019012511192140400_CIT0016","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1093\/ntr\/ntu037","article-title":"The predicted impact of reducing the nicotine content in cigarettes on alcohol use","volume":"16","author":"Dermody","year":"2014","journal-title":"Nicotine Tob Res"},{"issue":"3","key":"key\n\t\t\t\t2019012511192140400_CIT0017","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1016\/S0022-3565(24)36947-2","article-title":"A major role for CYP2A6 in nicotine C-oxidation by human liver microsomes","volume":"282","author":"Messina","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"issue":"1","key":"key\n\t\t\t\t2019012511192140400_CIT0018","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.clpt.2004.02.011","article-title":"Nicotine metabolite ratio as an index of cytochrome P450 2A6 metabolic activity","volume":"76","author":"Dempsey","year":"2004","journal-title":"Clin Pharmacol Ther"},{"issue":"1","key":"key\n\t\t\t\t2019012511192140400_CIT0019","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.pbb.2008.10.016","article-title":"Nicotine metabolic rate predicts successful smoking cessation with transdermal nicotine: a validation study","volume":"92","author":"Schnoll","year":"2009","journal-title":"Pharmacol Biochem Behav"},{"issue":"3","key":"key\n\t\t\t\t2019012511192140400_CIT0020","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/clpt.2008.57","article-title":"Toward personalized therapy for smoking cessation: a randomized placebo-controlled trial of bupropion","volume":"84","author":"Patterson","year":"2008","journal-title":"Clin Pharmacol Ther"},{"issue":"6","key":"key\n\t\t\t\t2019012511192140400_CIT0021","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.clpt.2006.02.006","article-title":"Nicotine metabolite ratio predicts efficacy of transdermal nicotine for smoking cessation","volume":"79","author":"Lerman","year":"2006","journal-title":"Clin Pharmacol Ther"},{"issue":"9","key":"key\n\t\t\t\t2019012511192140400_CIT0022","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1158\/1055-9965.EPI-14-0427","article-title":"Known and novel sources of variability in the nicotine metabolite ratio in a large sample of treatment-seeking smokers","volume":"23","author":"Chenoweth","year":"2014","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"key\n\t\t\t\t2019012511192140400_CIT0023","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.drugalcdep.2016.04.006","article-title":"Cessation of alcohol consumption decreases rate of nicotine metabolism in male alcohol-dependent smokers","volume":"163","author":"Gubner","year":"2016","journal-title":"Drug Alcohol Depend"},{"issue":"5","key":"key\n\t\t\t\t2019012511192140400_CIT0024","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.clpt.2006.01.008","article-title":"Female sex and oral contraceptive use accelerate nicotine metabolism","volume":"79","author":"Benowitz","year":"2006","journal-title":"Clin Pharmacol Ther"},{"issue":"1","key":"key\n\t\t\t\t2019012511192140400_CIT0025","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.drugalcdep.2006.11.012","article-title":"Nicotine metabolism and CYP2A6 activity in a population of black African descent: impact of gender and light smoking","volume":"89","author":"Mwenifumbo","year":"2007","journal-title":"Drug Alcohol Depend"},{"issue":"7","key":"key\n\t\t\t\t2019012511192140400_CIT0026","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1158\/1055-9965.EPI-12-0236","article-title":"Reproducibility of the nicotine metabolite ratio in cigarette smokers","volume":"21","author":"St Helen","year":"2012","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"8","key":"key\n\t\t\t\t2019012511192140400_CIT0027","doi-asserted-by":"crossref","first-page":"e70938","DOI":"10.1371\/journal.pone.0070938","article-title":"Variation in trans-3\u2032-hydroxycotinine glucuronidation does not alter the nicotine metabolite ratio or nicotine intake","volume":"8","author":"Zhu","year":"2013","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2019012511192140400_CIT0028","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/978-1-4612-0357-5_3","article-title":"Timeline follow-back: a technique for assessing self-reported alcohol consumption","volume-title":"Measuring Alcohol Consumption: Psychosocial and Biological Methods","author":"Sobell","year":"1992"},{"issue":"6","key":"key\n\t\t\t\t2019012511192140400_CIT0029","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1111\/j.1360-0443.1993.tb02093.x","article-title":"Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO collaborative project on early detection of persons with harmful alcohol consumption\u2013II","volume":"88","author":"Saunders","year":"1993","journal-title":"Addiction"},{"issue":"9","key":"key\n\t\t\t\t2019012511192140400_CIT0030","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1111\/j.1360-0443.1991.tb01879.x","article-title":"The Fagerstr\u00f6m Test for Nicotine dependence: a revision of the Fagerstr\u00f6m Tolerance Questionnaire","volume":"86","author":"Heatherton","year":"1991","journal-title":"Br J Addict"},{"issue":"8","key":"key\n\t\t\t\t2019012511192140400_CIT0031","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1158\/1055-9965.EPI-14-1381","article-title":"Nicotine metabolite ratio (3-hydroxycotinine\/cotinine) in plasma and urine by different analytical methods and laboratories: implications for clinical implementation","volume":"24","author":"Tanner","year":"2015","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"2","key":"key\n\t\t\t\t2019012511192140400_CIT0032","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1124\/jpet.117.245126","article-title":"Longitudinal influence of pregnancy on nicotine metabolic pathways","volume":"364","author":"Taghavi","year":"2018","journal-title":"J Pharmacol Exp Ther"},{"issue":"8","key":"key\n\t\t\t\t2019012511192140400_CIT0033","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1158\/1055-9965.EPI-18-0018","article-title":"A comparison of direct and indirect analytical approaches to measuring total nicotine equivalents in urine","volume":"27","author":"Taghavi","year":"2018","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"key\n\t\t\t\t2019012511192140400_CIT0034","volume-title":"Hierarchical Linear Models: Applications and Data Analysis Methods","author":"Raudenbush","year":"2002"},{"issue":"6","key":"key\n\t\t\t\t2019012511192140400_CIT0035","doi-asserted-by":"crossref","first-page":"545","DOI":"10.2105\/AJPH.67.6.545","article-title":"Expired air carbon monoxide and serum thiocyanate as objective measures of cigarette exposure","volume":"67","author":"Vogt","year":"1977","journal-title":"Am J Public Health"},{"issue":"6","key":"key\n\t\t\t\t2019012511192140400_CIT0036","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1158\/1055-9965.EPI-08-0242","article-title":"Stability of the nicotine metabolite ratio in ad libitum and reducing smokers","volume":"17","author":"Mooney","year":"2008","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"5","key":"key\n\t\t\t\t2019012511192140400_CIT0037","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1158\/1055-9965.EPI-09-1303","article-title":"Estimation of nicotine dose after low-level exposure using plasma and urine nicotine metabolites","volume":"19","author":"Benowitz","year":"2010","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"3","key":"key\n\t\t\t\t2019012511192140400_CIT0038","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1124\/jpet.112.198564","article-title":"Differential effects of nicotine treatment and ethanol self-administration on CYP2A6, CYP2B6 and nicotine pharmacokinetics in African green monkeys","volume":"343","author":"Ferguson","year":"2012","journal-title":"J Pharmacol Exp Ther"},{"issue":"2-3","key":"key\n\t\t\t\t2019012511192140400_CIT0039","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.drugalcdep.2006.06.008","article-title":"Alcohol treatment utilization: findings from the National Epidemiologic Survey on Alcohol and Related Conditions","volume":"86","author":"Cohen","year":"2007","journal-title":"Drug Alcohol Depend"}],"container-title":["Nicotine & Tobacco Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ntr\/advance-article-pdf\/doi\/10.1093\/ntr\/nty265\/27442339\/nty265.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T13:47:10Z","timestamp":1775310430000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ntr\/advance-article\/doi\/10.1093\/ntr\/nty265\/5250675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,17]]},"references-count":39,"URL":"https:\/\/doi.org\/10.1093\/ntr\/nty265","relation":{"has-preprint":[{"id-type":"doi","id":"10.32920\/21618744.v1","asserted-by":"object"},{"id-type":"doi","id":"10.32920\/21618744","asserted-by":"object"}]},"ISSN":["1462-2203","1469-994X"],"issn-type":[{"value":"1462-2203","type":"print"},{"value":"1469-994X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,17]]}}}