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The current literature indicates that maternal exposure to a high-fat diet exerts an irreversible influence on the general health of the offspring. This review of preclinical research examines the relationship between a maternal high-fat diet during pregnancy or lactation and metabolic changes, molecular alterations in the brain, and behavioral disorders in offspring. Animal models indicate that offspring exposed to a maternal high-fat diet during pregnancy and lactation manifest increased depressive-like and aggressive behaviors, reduced cognitive development, and symptoms of metabolic syndrome. Recently, epigenetic and molecular studies have shown that maternal nutrition during pregnancy and the suckling period modifies the development of neurotransmitter circuits and many other factors important to central nervous system development. This finding confirms the importance of a balanced maternal diet for the health of offspring.<\/jats:p>","DOI":"10.1093\/nutrit\/nuaa020","type":"journal-article","created":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T08:33:03Z","timestamp":1583915583000},"page":"709-725","source":"Crossref","is-referenced-by-count":82,"title":["Relationship of maternal high-fat diet during pregnancy and lactation to offspring health"],"prefix":"10.1093","volume":"79","author":[{"given":"Kinga","family":"Gawli\u0144ska","sequence":"first","affiliation":[{"name":"Department of Drug Addiction Pharmacology, Maj Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawid","family":"Gawli\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Drug Addiction Pharmacology, Maj Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4321-7942","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"Filip","sequence":"additional","affiliation":[{"name":"Department of Drug Addiction Pharmacology, Maj Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmund","family":"Przegali\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Drug Addiction Pharmacology, Maj Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,5,23]]},"reference":[{"key":"2021051213071608600_nuaa020-B1","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/0140-6736(93)91224-A","article-title":"Fetal nutrition and cardiovascular disease in adult 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