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In addition, gluten withdrawal is popular and occasionally is suggested as a treatment for other autoimmune diseases (ADs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The current systematic review summarizes those entities and discusses the logic behind using a GFD in classical non\u2013gluten-dependentADs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources<\/jats:title><jats:p>A search for medical articles in PubMed\/MEDLINE, Web of Sciences, LILACS, and Scielo published between 1960 and 2020 was conducted, using the key words for various ADs and GFDs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Exxtraction<\/jats:title><jats:p>Eight-three articles were included in the systematic review (using PRISMA guidelines).<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Analysis<\/jats:title><jats:p>Reduction in symptoms of ADs after observance of a GFD was observed in 911 out of 1408 patients (64.7%) and in 66 out of the 83 selected studies (79.5%). The age of the patients ranged from 9\u2009months to 69\u2009years. The duration of the GFD varied from 1\u2009month to 9\u2009years. A GFD can suppress several harmful intraluminal intestinal events. Potential mechanisms and pathways for the action of GFD in the gut \u2013 remote organs\u2019 axis have been suggested.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A GFD might represent a novel nutritional therapeutic strategy for classical non\u2013gluten-dependent autoimmune conditions.<\/jats:p><\/jats:sec>","DOI":"10.1093\/nutrit\/nuab039","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T11:28:42Z","timestamp":1620818922000},"page":"525-543","source":"Crossref","is-referenced-by-count":35,"title":["Gluten-free diet can ameliorate the symptoms of non-celiac autoimmune diseases"],"prefix":"10.1093","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6779-4090","authenticated-orcid":false,"given":"Aaron","family":"Lerner","sequence":"first","affiliation":[{"name":"The Zabludowicz Research Center for Autoimmune Diseases, Chaim Sheba Medical Center, Tel Hashomer, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joz\u00e9lio","family":"Freire de Carvalho","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Institute for Health Sciences of the Federal University of Bahia, Salvador, Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Kotrova","sequence":"additional","affiliation":[{"name":"Department of Autoimmune research, Saint Petersburg State University, St. Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehuda","family":"Shoenfeld","sequence":"additional","affiliation":[{"name":"The Zabludowicz Research Center for Autoimmune Diseases, Chaim Sheba Medical Center, Tel Hashomer, Israel"},{"name":"Department of Autoimmune research, Saint Petersburg State University, St. Petersburg, Russia"},{"name":"Department of Administration, Ariel University, Israel"},{"name":"Department of Autoimmune research, I.M Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,8,2]]},"reference":[{"key":"2022021009334430300_nuab039-B1","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s12916-019-1380-z","article-title":"Celiac disease: a comprehensive current review","volume":"17","author":"Caio","year":"2019","journal-title":"BMC Med."},{"key":"2022021009334430300_nuab039-B2","doi-asserted-by":"crossref","first-page":"151","DOI":"10.12691\/ijcd-3-4-8","article-title":"The world incidence and prevalence of autoimmune diseases is increasing","volume":"3","author":"Lerner","year":"2016","journal-title":"Int J Celiac Dis."},{"key":"2022021009334430300_nuab039-B3","first-page":"5491","article-title":"The world incidence of celiac disease is increasing: a review","volume":"7","author":"Lerner","year":"2015","journal-title":"Int J Recent Sci Res"},{"key":"2022021009334430300_nuab039-B4","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nri.2017.111","article-title":"The hygiene hypothesis in autoimmunity: the role of pathogens and commensals","volume":"18","author":"Bach","year":"2018","journal-title":"Nat Rev Immunol."},{"key":"2022021009334430300_nuab039-B5","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.3389\/fmicb.2017.01392","article-title":"Microbes and viruses are bugging the gut in celiac disease. 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