{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:30:34Z","timestamp":1787009434238,"version":"build-2736575974"},"reference-count":102,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T00:00:00Z","timestamp":1630281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"publisher","award":["2016\/25207-5"],"award-info":[{"award-number":["2016\/25207-5"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CAPES (Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior \u2013 Brasil \u2013 Finance","award":["001"],"award-info":[{"award-number":["001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Excessive consumption of high-fat diets has increased in the population over time and is harmful to female fertility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate and discuss the effects of a high-fat diet on ovarian follicles in rodents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data source<\/jats:title>\n                    <jats:p>A systematic literature search of PubMed, EMBASE, Web of Science, and SCOPUS was carried out.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Extraction<\/jats:title>\n                    <jats:p>Study characteristics, including study design, population, intervention, outcome, and risk of bias were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Analysis<\/jats:title>\n                    <jats:p>Twenty-two articles were included in a systematic review. Given the availability of studies, a quantitative meta-analysis included 12 studies that were performed for outcomes. There was a decrease in primordial follicles in female rodents that received a high-fat diet compared with the standard diet group. The offspring of mothers exposed to a high-fat diet showed an increased number of cystic follicles and a decreased number of secondary follicles and antral follicles, compared with the control diet group. Therefore, these high-fat diet\u2013induced follicular alterations might impair the fertility of dams and their female newborns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The consumption of a high-fat diet causes damage to ovarian follicular development, and this commitment will persist in the next generation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic Review Registration<\/jats:title>\n                    <jats:p>PROSPERO registration no. CRD42019133865.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/nutrit\/nuab049","type":"journal-article","created":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T15:13:12Z","timestamp":1624374792000},"page":"889-903","source":"Crossref","is-referenced-by-count":10,"title":["Intergenerational high-fat diet impairs ovarian follicular development in rodents: a systematic review and meta-analysis"],"prefix":"10.1093","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1590-9781","authenticated-orcid":false,"given":"Ver\u00f4nyca G","family":"Paula","sequence":"first","affiliation":[{"name":"V.G. Paula, G. Vesentini, Y.K. Sinzato, R.Q. Moraes-Souza, and D.C. Damasceno are with the Laboratory of Experimental Research on Gynecology and Obstetrics, Gynecology, Postgraduate Course on Tocogynecology, Botucatu Medical School, S\u00e3o Paulo State University (Unesp) , Botucatu, S\u00e3o Paulo,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7116-1667","authenticated-orcid":false,"given":"Giovana","family":"Vesentini","sequence":"additional","affiliation":[{"name":"V.G. Paula, G. Vesentini, Y.K. Sinzato, R.Q. Moraes-Souza, and D.C. Damasceno are with the Laboratory of Experimental Research on Gynecology and Obstetrics, Gynecology, Postgraduate Course on Tocogynecology, Botucatu Medical School, S\u00e3o Paulo State University (Unesp) , Botucatu, S\u00e3o Paulo,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri K","family":"Sinzato","sequence":"additional","affiliation":[{"name":"V.G. Paula, G. Vesentini, Y.K. Sinzato, R.Q. Moraes-Souza, and D.C. Damasceno are with the Laboratory of Experimental Research on Gynecology and Obstetrics, Gynecology, Postgraduate Course on Tocogynecology, Botucatu Medical School, S\u00e3o Paulo State University (Unesp) , Botucatu, S\u00e3o Paulo,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafaianne Q","family":"Moraes-Souza","sequence":"additional","affiliation":[{"name":"V.G. Paula, G. Vesentini, Y.K. Sinzato, R.Q. Moraes-Souza, and D.C. Damasceno are with the Laboratory of Experimental Research on Gynecology and Obstetrics, Gynecology, Postgraduate Course on Tocogynecology, Botucatu Medical School, S\u00e3o Paulo State University (Unesp) , Botucatu, S\u00e3o Paulo,","place":["Brazil"]},{"name":"G.T. Volpato and R.Q. Moraes-Souza are with the Laboratory of System Physiology and Reproductive Toxicology, Institute of Biological and Health Sciences, Federal University of Mato Grosso (UFMT) , Barra do Gar\u00e7as, Mato Grosso,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo T","family":"Volpato","sequence":"additional","affiliation":[{"name":"G.T. Volpato and R.Q. Moraes-Souza are with the Laboratory of System Physiology and Reproductive Toxicology, Institute of Biological and Health Sciences, Federal University of Mato Grosso (UFMT) , Barra do Gar\u00e7as, Mato Grosso,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9bora C","family":"Damasceno","sequence":"additional","affiliation":[{"name":"V.G. Paula, G. Vesentini, Y.K. Sinzato, R.Q. Moraes-Souza, and D.C. 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