{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:43:04Z","timestamp":1789580584628,"version":"build-2803163510"},"reference-count":77,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T00:00:00Z","timestamp":1631059200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Institute of Nutrition, Mahidol University, Mahidol University"},{"DOI":"10.13039\/501100004508","name":"Prince of Songkla University","doi-asserted-by":"publisher","award":["AGR6402088N"],"award-info":[{"award-number":["AGR6402088N"]}],"id":[{"id":"10.13039\/501100004508","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Global Innovation Center and Thai Union Group PCL"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Dietary habits and lifestyle-related diseases indicate that food has a direct impact on individual health. Hence, a diet containing essential nutrients is important for healthy living. Fish and fish products are important in diets worldwide because of their nutritional value, especially their easily digestible proteins with essential amino acids. Similarly, fish protein hydrolysate (FPH) obtained from fish muscle and by-products has been reported to exhibit various biological activities and to have functional properties, which make FPH a suitable nutraceutical candidate. This review focuses on the health-promoting ability of FPH in terms of skin health, bone and cartilage health, blood lipid profile, and body-weight management studied in rats and human model systems. The absorption and bioavailability of FPH in humans is discussed, and challenges and obstacles of FPH as a functional food ingredient are outlined.<\/jats:p>","DOI":"10.1093\/nutrit\/nuab065","type":"journal-article","created":{"date-parts":[[2021,7,25]],"date-time":"2021-07-25T11:06:38Z","timestamp":1627211198000},"page":"1013-1026","source":"Crossref","is-referenced-by-count":40,"title":["Fish protein hydrolysates as a health-promoting ingredient\u2014recent update"],"prefix":"10.1093","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2732-4534","authenticated-orcid":false,"given":"Nilesh P","family":"Nirmal","sequence":"first","affiliation":[{"name":"Institute of Nutrition, Mahidol University, Nakhon Pathom, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chalat","family":"Santivarangkna","sequence":"additional","affiliation":[{"name":"Institute of Nutrition, Mahidol University, Nakhon Pathom, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soottawat","family":"Benjakul","sequence":"additional","affiliation":[{"name":"The International Center of Excellence in Seafood Science and Innovation, Prince of Songkla University, Songkhla, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sajid","family":"Maqsood","sequence":"additional","affiliation":[{"name":"Department of Food Science, College of Agriculture and Veterinary Medicine, United Arab Emirates University, Al Ain, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,9,8]]},"reference":[{"key":"2022040807521024100_nuab065-B1","doi-asserted-by":"crossref","first-page":"613","DOI":"10.3390\/md17110613","article-title":"Antihypertensive and angiotensin-I-converting enzyme (ACE)-inhibitory peptides from fish as potential cardioprotective compounds","volume":"17","author":"Abachi","year":"2019","journal-title":"Mar Drugs"},{"key":"2022040807521024100_nuab065-B2","first-page":"127","volume-title":"Advances in Food and Nutrition Research","author":"L\u00f3pez-Pedrouso","year":"2020"},{"key":"2022040807521024100_nuab065-B3","doi-asserted-by":"crossref","first-page":"3507","DOI":"10.29219\/fnr.v63.3507","article-title":"Acute effect of a cod protein hydrolysate on postprandial acylated ghrelin concentration and sensations associated with appetite in healthy subjects: a double-blind crossover trial","volume":"63","author":"Dale","year":"2019","journal-title":"Food Nutr Res"},{"key":"2022040807521024100_nuab065-B4","doi-asserted-by":"crossref","first-page":"72","DOI":"10.5539\/gjhs.v4n3p72","article-title":"Seafood consumption and components for health","volume":"4","author":"Hosomi","year":"2012","journal-title":"Glob J Health Sci."},{"key":"2022040807521024100_nuab065-B5","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.foodchem.2017.10.087","article-title":"Immunomodulatory and anticancer protein hydrolysates (peptides) from food proteins: a review","volume":"245","author":"Chalamaiah","year":"2018","journal-title":"Food Chem."},{"key":"2022040807521024100_nuab065-B6","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/978-1-4614-9590-1_11","volume-title":"Seafood Processing By-Products: Trends and Applications","author":"Himaya","year":"2014"},{"key":"2022040807521024100_nuab065-B7","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.biotechadv.2014.12.003","article-title":"Recent advances in food biopeptides: production, biological functionalities and therapeutic applications","volume":"33","author":"Saadi","year":"2015","journal-title":"Biotechnol Adv."},{"key":"2022040807521024100_nuab065-B8","doi-asserted-by":"crossref","first-page":"e33","DOI":"10.1017\/jns.2018.23","article-title":"Effect of a cod protein hydrolysate on postprandial glucose metabolism in healthy subjects: a double-blind cross-over trial","volume":"7","author":"Dale","year":"2018","journal-title":"J Nutr Sci."},{"key":"2022040807521024100_nuab065-B9","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1111\/jfpp.12304","article-title":"Characteristics and antioxidative activity of gelatin hydrolysates from unicorn leatherjacket skin as affected by autolysis-assisted process","volume":"39","author":"Karnjanapratum","year":"2015","journal-title":"J Food Process Preserv"},{"key":"2022040807521024100_nuab065-B10","doi-asserted-by":"crossref","first-page":"e40","DOI":"10.1017\/jns.2019.37","article-title":"Supplementation with cod protein hydrolysate in older adults: a dose range cross-over study","volume":"8","author":"Jensen","year":"2019","journal-title":"J Nutr Sci."},{"key":"2022040807521024100_nuab065-B11","doi-asserted-by":"crossref","first-page":"e12734","DOI":"10.1111\/jfbc.12734","article-title":"Protein hydrolysate from salmon frames: production, characteristics and antioxidative activity","volume":"43","author":"Idowu","year":"2019","journal-title":"J Food Biochem."},{"key":"2022040807521024100_nuab065-B12","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1039\/C5FO00492F","article-title":"Cholesterol regulatory effects and antioxidant activities of protein hydrolysates from zebra blenny (Salaria basilisca) in cholesterol-fed rats","volume":"6","author":"Ktari","year":"2015","journal-title":"Food Funct."},{"key":"2022040807521024100_nuab065-B13","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1080\/10498850.2019.1695033","article-title":"Effect of heat treatment on the antioxidant and antihypertensive activity as well as in vitro digestion stability of mackerel (Scomber scombrus) protein hydrolysates","volume":"29","author":"Korczek","year":"2020","journal-title":"J Aqua Food Prod Technol"},{"key":"2022040807521024100_nuab065-B14","doi-asserted-by":"crossref","first-page":"784","DOI":"10.3892\/ijmm.2017.3063","article-title":"Anti-obesity effects of yellow catfish protein hydrolysate on mice fed a 45% kcal high-fat diet","volume":"40","author":"Kim","year":"2017","journal-title":"Int J Mol Med."},{"key":"2022040807521024100_nuab065-B15","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.semcancer.2017.03.011","article-title":"Anticancer and cancer preventive compounds from edible marine organisms","volume":"46","author":"Correia-da-Silva","year":"2017","journal-title":"Semin Cancer Biol."},{"key":"2022040807521024100_nuab065-B16","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s41240-019-0125-4","article-title":"Biological activity of peptides purified from fish skin hydrolysates","volume":"22","author":"Abuine","year":"2019","journal-title":"Fish Aquat Sci"},{"key":"2022040807521024100_nuab065-B17","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1080\/10408398.2018.1452182","article-title":"Antihypertensive activity of fish protein hydrolysates and its peptides","volume":"59","author":"Yathisha","year":"2019","journal-title":"Crit Rev Food Sci Nutr"},{"key":"2022040807521024100_nuab065-B18","first-page":"1922","article-title":"Biological effect of hydrolyzed collagen on bone metabolism","volume":"57","author":"Daneault","year":"2017","journal-title":"Crit Rev Food Sci Nutr"},{"key":"2022040807521024100_nuab065-B19","first-page":"205","article-title":"Effects of ultrasound treatment on structural, chemical and functional properties of protein hydrolysate of rainbow trout (Oncorhynchus mykiss) by-products","volume":"31","author":"Misir","year":"2019","journal-title":"Italian J Food Sci"},{"key":"2022040807521024100_nuab065-B20","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.foodchem.2014.07.086","article-title":"Recovery, viscoelastic and functional properties of Barbel skin gelatine: investigation of anti-DPP-IV and anti-prolyl endopeptidase activities of generated gelatine polypeptides","volume":"168","author":"Sila","year":"2015","journal-title":"Food Chem."},{"key":"2022040807521024100_nuab065-B21","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1016\/j.foodchem.2010.07.089","article-title":"Functionalities and antioxidant properties of protein hydrolysates from the muscle of ornate threadfin bream treated with pepsin from skipjack tuna","volume":"124","author":"Nalinanon","year":"2011","journal-title":"Food Chem"},{"key":"2022040807521024100_nuab065-B22","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.tifs.2016.02.007","article-title":"Functional and bioactive properties of fish protein hydolysates and peptides: a comprehensive review","volume":"51","author":"Halim","year":"2016","journal-title":"Trends Food Sci Technol"},{"key":"2022040807521024100_nuab065-B23","doi-asserted-by":"crossref","first-page":"5647","DOI":"10.1007\/s12649-019-00812-9","article-title":"Proteins and co-products from seafood processing discards: their recovery, functional properties and applications","volume":"11","author":"Sasidharan","year":"2020","journal-title":"Waste Biomass Valor."},{"key":"2022040807521024100_nuab065-B24","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1021\/acs.jafc.8b06896","article-title":"Amount of collagen in the meat contained in Japanese daily dishes and the collagen peptide content in human blood after ingestion of cooked fish meat","volume":"67","author":"Asai","year":"2019","journal-title":"J Agric Food Chem."},{"key":"2022040807521024100_nuab065-B25","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1248\/bpb.b15-00624","article-title":"Absorption and urinary excretion of peptides after collagen tripeptide ingestion in humans","volume":"39","author":"Yamamoto","year":"2016","journal-title":"Biol Pharm Bull."},{"key":"2022040807521024100_nuab065-B26","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1080\/09168451.2015.1062711","article-title":"Absorption and plasma kinetics of collagen tripeptide after peroral or intraperitoneal administration in rats","volume":"79","author":"Yamamoto","year":"2015","journal-title":"Biosci Biotechnol Biochem."},{"key":"2022040807521024100_nuab065-B27","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.2741\/3820","article-title":"Amino acid metabolism in intestinal bacteria: links between gut ecology and host health","volume":"16","author":"Dai","year":"2011","journal-title":"Front Biosci (Landmark Ed)."},{"key":"2022040807521024100_nuab065-B28","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/1750-3841.14970","article-title":"Effects of fish protein hydrolysate ingestion on postexercise aminoacidemia compared with whey protein hydrolysate in young individuals","volume":"85","author":"Cordeiro","year":"2020","journal-title":"J Food Sci."},{"key":"2022040807521024100_nuab065-B29","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3109\/09637480903257711","article-title":"Hydroxyproline-containing dipeptides and tripeptides quantified at high concentration in human blood after oral administration of gelatin hydrolysate","volume":"61","author":"Ichikawa","year":"2010","journal-title":"Int J Food Sci Nutr."},{"key":"2022040807521024100_nuab065-B30","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.foodchem.2011.05.066","article-title":"Identification of a novel food-derived collagen peptide, hydroxyprolyl-glycine, in human peripheral blood by pre-column derivatisation with phenyl isothiocyanate","volume":"129","author":"Shigemura","year":"2011","journal-title":"Food Chem."},{"key":"2022040807521024100_nuab065-B31","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1080\/09168451.2019.1580559","article-title":"Orally administered collagen peptide protects against UVB-induced skin aging through the absorption of dipeptide forms, Gly-Pro and Pro-Hyp","volume":"83","author":"Lee","year":"2019","journal-title":"Biosci Biotechnol Biochem."},{"key":"2022040807521024100_nuab065-B32","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3390\/ijms21010229","article-title":"Food-derived collagen peptides, prolyl-hydroxyproline (Pro-Hyp), and hydroxyprolyl-glycine (Hyp-Gly) enhance growth of primary cultured mouse skin fibroblast using fetal bovine serum free from hydroxyprolyl peptide","volume":"21","author":"Asai","year":"2019","journal-title":"Int J Mol Sci."},{"key":"2022040807521024100_nuab065-B33","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.nut.2014.08.006","article-title":"Chemical composition and immunomodulatory effects of enzymatic protein hydrolysates from common carp (Cyprinus carpio) egg","volume":"31","author":"Chalamaiah","year":"2015","journal-title":"Nutrition."},{"key":"2022040807521024100_nuab065-B34","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.3945\/jn.114.208215","article-title":"Low-molecular-weight peptides from salmon protein prevent obesity-linked glucose intolerance, inflammation, and dyslipidemia in LDLR\u2212\/\u2212\/ApoB100\/100 mice","volume":"145","author":"Chevrier","year":"2015","journal-title":"J Nutr"},{"key":"2022040807521024100_nuab065-B35","first-page":"1203","article-title":"The protective effect of Liza klunzingeri protein hydrolysate on carbon tetrachloride-induced oxidative stress and toxicity in male rats","volume":"22","author":"Rabiei","year":"2019","journal-title":"Iran J Basic Med Sci"},{"key":"2022040807521024100_nuab065-B36","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.jff.2011.09.001","article-title":"Bioactive peptides from marine processing waste and shellfish: a review","volume":"4","author":"Harnedy","year":"2012","journal-title":"J Funct Foods"},{"key":"2022040807521024100_nuab065-B37","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1093\/nutrit\/nuz016","article-title":"Fish-derived proteins and their potential to improve human health","volume":"77","author":"Dale","year":"2019","journal-title":"Nutr Rev"},{"key":"2022040807521024100_nuab065-B38","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.ifset.2016.03.015","article-title":"Sustainable valorisation of seafood by-products: recovery of collagen and development of collagen-based novel functional food ingredients","volume":"37","author":"Pal","year":"2016","journal-title":"Innov Food Sci Emerg Technol"},{"key":"2022040807521024100_nuab065-B39","doi-asserted-by":"crossref","first-page":"826","DOI":"10.3390\/nu10070826","article-title":"Oral intake of low-molecular-weight collagen peptide improves hydration, elasticity, and wrinkling in human skin: a randomized, double-blind, placebo-controlled study","volume":"10","author":"Kim","year":"2018","journal-title":"Nutrients"},{"key":"2022040807521024100_nuab065-B40","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/jocd.12174","article-title":"The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from ex vivo model and randomized, placebo-controlled clinical trials","volume":"14","author":"Asserin","year":"2015","journal-title":"J Cosmet Dermatol."},{"key":"2022040807521024100_nuab065-B41","doi-asserted-by":"crossref","first-page":"3551","DOI":"10.3390\/ijms19113551","article-title":"Oral intake of collagen peptide attenuates ultraviolet B irradiation-induced skin dehydration in vivo by regulating hyaluronic acid synthesis","volume":"19","author":"Kang","year":"2018","journal-title":"Int J Mol Sci."},{"key":"2022040807521024100_nuab065-B42","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1111\/ijfs.13772","article-title":"Hydrolysed collagen from Lates calcarifer skin: its acute toxicity and impact on cell proliferation and collagen production of fibroblasts","volume":"53","author":"Benjakul","year":"2018","journal-title":"Int J Food Sci Technol."},{"key":"2022040807521024100_nuab065-B43","doi-asserted-by":"crossref","first-page":"e12825","DOI":"10.1111\/jfbc.12825","article-title":"Hydrolyzed collagen from porcine lipase-defatted seabass skin: antioxidant, fibroblast cell proliferation, and collagen production activities","volume":"43","author":"Chotphruethipong","year":"2019","journal-title":"J Food Biochem."},{"key":"2022040807521024100_nuab065-B44","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1152\/physiolgenomics.00009.2015","article-title":"Effect of orally administered collagen hydrolysate on gene expression profiles in mouse skin: a DNA microarray analysis","volume":"47","author":"Oba","year":"2015","journal-title":"Physiol Genomics."},{"key":"2022040807521024100_nuab065-B45","doi-asserted-by":"crossref","first-page":"482","DOI":"10.3390\/md16120482","article-title":"Effects of composite supplement containing collagen peptide and ornithine on skin conditions and plasma IGF-1 levels-a randomized, double-blind, placebo-controlled trial","volume":"16","author":"Ito","year":"2018","journal-title":"Mar Drugs"},{"key":"2022040807521024100_nuab065-B46","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s10989-017-9626-0","article-title":"Effects of dietary supplementation with fish scales-derived collagen peptides on skin parameters and condition: a randomized, placebo-controlled, double-blind study","volume":"24","author":"Koizumi","year":"2018","journal-title":"Int J Pept Res Ther."},{"key":"2022040807521024100_nuab065-B47","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.jphotobiol.2016.07.038","article-title":"Protective effect of gelatin polypeptides from Pacific cod (Gadus macrocephalus) against UV irradiation-induced damages by inhibiting inflammation and improving transforming growth factor-\u03b2\/Smad signaling pathway","volume":"162","author":"Chen","year":"2016","journal-title":"J Photochem Photobiol B."},{"key":"2022040807521024100_nuab065-B48","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1039\/C6FO01397J","article-title":"The effect of collagen hydrolysates from silver carp (Hypophthalmichthys molitrix) skin on UV-induced photoaging in mice: molecular weight affects skin repair","volume":"8","author":"Song","year":"2017","journal-title":"Food Funct."},{"key":"2022040807521024100_nuab065-B49","doi-asserted-by":"crossref","first-page":"420","DOI":"10.3390\/nu10040420","article-title":"Protective effects of LSGYGP from fish skin gelatin hydrolysates on UVB-induced MEFs by regulation of oxidative stress and matrix metalloproteinase activity","volume":"10","author":"Ma","year":"2018","journal-title":"Nutrients"},{"key":"2022040807521024100_nuab065-B50","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.3390\/nu10101434","article-title":"Effect of collagen hydrolysates from silver carp skin (Hypophthalmichthys molitrix) on osteoporosis in chronologically aged mice: increasing bone remodeling","volume":"10","author":"Zhang","year":"2018","journal-title":"Nutrients"},{"key":"2022040807521024100_nuab065-B51","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s12013-017-0817-2","article-title":"Fish collagen hydrolysates modulate cartilage metabolism","volume":"76","author":"Boonmaleerat","year":"2018","journal-title":"Cell Biochem Biophys."},{"key":"2022040807521024100_nuab065-B52","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1186\/s12891-017-1745-4","article-title":"Effects of dietary gelatin hydrolysates on bone mineral density in magnesium-deficient rats","volume":"18","author":"Noma","year":"2017","journal-title":"BMC Musculoskel Dis"},{"key":"2022040807521024100_nuab065-B53","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.jff.2013.12.001","article-title":"Isolation of a calcium-binding peptide from tilapia scale protein hydrolysate and its calcium bioavailability in rats","volume":"6","author":"Chen","year":"2014","journal-title":"J Funct Foods"},{"key":"2022040807521024100_nuab065-B54","doi-asserted-by":"crossref","first-page":"N1595","DOI":"10.1111\/1750-3841.12912","article-title":"Core-shell collagen peptide chelated calcium\/calcium alginate nanoparticles from fish scales for calcium supplementation","volume":"80","author":"Guo","year":"2015","journal-title":"J Food Sci."},{"key":"2022040807521024100_nuab065-B55","doi-asserted-by":"crossref","first-page":"9383","DOI":"10.1039\/C7RA13102J","article-title":"Preventive effect of goby fish protein hydrolysates on hyperlipidemia and cardiovascular disease in Wistar rats fed a high-fat\/fructose diet","volume":"8","author":"Nasri","year":"2018","journal-title":"RSC Adv."},{"key":"2022040807521024100_nuab065-B56","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.ijbiomac.2017.05.151","article-title":"Fish collagen peptide inhibits the adipogenic differentiation of preadipocytes and ameliorates obesity in high fat diet-fed mice","volume":"104","author":"Lee","year":"2017","journal-title":"Int J Biol Macromol."},{"key":"2022040807521024100_nuab065-B57","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.lfs.2016.07.012","article-title":"Hypolipidemic, antiobesity and cardioprotective effects of sardinelle meat flour and its hydrolysates in high-fat and fructose diet fed Wistar rats","volume":"176","author":"Jemil","year":"2017","journal-title":"Life Sci."},{"key":"2022040807521024100_nuab065-B58","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1017\/S0007114516003548","article-title":"Dietary fish protein hydrolysates containing bioactive motifs affect serum and adipose tissue fatty acid compositions, serum lipids, postprandial glucose regulation and growth in obese Zucker fa\/fa rats","volume":"116","author":"Drotningsvik","year":"2016","journal-title":"Br J Nutr."},{"key":"2022040807521024100_nuab065-B59","doi-asserted-by":"crossref","first-page":"29857","DOI":"10.3402\/fnr.v60.29857","article-title":"Supplementation with a fish protein hydrolysate (Micromesistius poutassou): effects on body weight, body composition, and CCK\/GLP-1 secretion","volume":"60","author":"Nobile","year":"2016","journal-title":"Food Nutr Res"},{"key":"2022040807521024100_nuab065-B60","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1108\/NFS-06-2013-0075","article-title":"Evaluation of the satiating properties of a fish protein hydrolysate among overweight women: a pilot study","volume":"44","author":"Za\u00efr","year":"2014","journal-title":"Nutr Food Sci"},{"key":"2022040807521024100_nuab065-B61","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.cbi.2015.08.003","article-title":"Ameliorating effects of goby fish protein hydrolysates on high-fat-high-fructose diet-induced hyperglycemia, oxidative stress and deterioration of kidney function in rats","volume":"242","author":"Nasri","year":"2015","journal-title":"Chem Biol Interact."},{"key":"2022040807521024100_nuab065-B62","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.jff.2018.04.066","article-title":"Acute effect of fish protein hydrolysate supplementation on vascular function in healthy individuals","volume":"46","author":"Alvares","year":"2018","journal-title":"J Funct Foods"},{"key":"2022040807521024100_nuab065-B63","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1016\/j.foodchem.2012.06.076","article-title":"Antioxidative and functional properties of protein hydrolysate from defatted skipjack (Katsuwonous pelamis) roe","volume":"135","author":"Intarasirisawat","year":"2012","journal-title":"Food Chem"},{"key":"2022040807521024100_nuab065-B64","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.btre.2016.08.003","article-title":"Bioactivities of fish protein hydrolysates from defatted salmon backbones","volume":"11","author":"Slizyte","year":"2016","journal-title":"Biotechnol Rep."},{"key":"2022040807521024100_nuab065-B65","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1111\/1750-3841.14687","article-title":"Effect of pulsed electric field-assisted process in combination with porcine lipase on defatting of seabass skin","volume":"84","author":"Chotphruethipong","year":"2019","journal-title":"J Food Sci"},{"key":"2022040807521024100_nuab065-B66","doi-asserted-by":"crossref","first-page":"e12978","DOI":"10.1111\/jfbc.12978","article-title":"Bitterness of fish protein hydrolysate and its debittering prospects","volume":"43","author":"Idowu","year":"2019","journal-title":"J Food Biochem."},{"key":"2022040807521024100_nuab065-B67","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s13197-019-04075-z","article-title":"Effect of proteases and alcohols used for debittering on characteristics and antioxidative activity of protein hydrolysate from salmon frames","volume":"57","author":"Sinthusamran","year":"2020","journal-title":"J Food Sci Technol."},{"key":"2022040807521024100_nuab065-B68","doi-asserted-by":"crossref","first-page":"126686","DOI":"10.1016\/j.foodchem.2020.126686","article-title":"Debittering of salmon (Salmo salar) frame protein hydrolysate using 2-butanol in combination with \u03b2-cyclodextrin: impact on some physicochemical characteristics and antioxidant activities","volume":"321","author":"Singh","year":"2020","journal-title":"Food Chem"},{"key":"2022040807521024100_nuab065-B69","doi-asserted-by":"crossref","first-page":"E108","DOI":"10.1111\/1750-3841.12684","article-title":"Fish protein hydrolysates: application in deep-fried food and food safety analysis","volume":"80","author":"He","year":"2015","journal-title":"J Food Sci."},{"key":"2022040807521024100_nuab065-B70","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1080\/10498850.2020.1868644","article-title":"Sensory and chemical properties of protein hydrolysates based on mackerel (Scomber scombrus) and salmon (Salmo salar) side stream materials","volume":"30","author":"Aspevik","year":"2021","journal-title":"J Aqua Food Prod Technol"},{"key":"2022040807521024100_nuab065-B71","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1080\/10408398.2012.758085","article-title":"Storage stability of food protein hydrolysates\u2014a review","volume":"56","author":"Rao","year":"2016","journal-title":"Crit Rev Food Sci Nutr"},{"key":"2022040807521024100_nuab065-B72","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/raq.12481","article-title":"Enzymatic fish protein hydrolysates in finfish aquaculture: a review","volume":"13","author":"Siddik","year":"2021","journal-title":"Rev Aquacult."},{"key":"2022040807521024100_nuab065-B73","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/bs.afnr.2016.10.003","article-title":"Protein hydrolysates and biopeptides: production, biological activities, and applications in foods and health benefits. A review","volume":"81","author":"Nasri","year":"2017","journal-title":". Adv Food Nutr Res"},{"key":"2022040807521024100_nuab065-B74","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yrtph.2014.02.009","article-title":"Safety evaluation of fish protein hydrolysate supplementation in malnourished children","volume":"69","author":"Nesse","year":"2014","journal-title":"Regul Toxicol Pharmacol."},{"key":"2022040807521024100_nuab065-B75","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1185\/030079908X291967","article-title":"24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain","volume":"24","author":"Clark","year":"2008","journal-title":"Curr Med Res Opin."},{"key":"2022040807521024100_nuab065-B76","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jff.2019.04.050","article-title":"Regulatory requirements of bioactive peptides (protein hydrolysates) from food proteins","volume":"58","author":"Chalamaiah","year":"2019","journal-title":"J Funct Foods"},{"key":"2022040807521024100_nuab065-B77","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.2174\/0929866523666161102122637","article-title":"Fish hydrolysates: a regulatory perspective of bioactive peptides","volume":"23","author":"Bert","year":"2016","journal-title":"Protein Pept Lett"}],"container-title":["Nutrition Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/nutritionreviews\/article-pdf\/80\/5\/1013\/43295222\/nuab065.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nutritionreviews\/article-pdf\/80\/5\/1013\/43295222\/nuab065.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T08:03:57Z","timestamp":1649405037000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nutritionreviews\/article\/80\/5\/1013\/6366489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,8]]},"references-count":77,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,9,8]]},"published-print":{"date-parts":[[2022,4,8]]}},"URL":"https:\/\/doi.org\/10.1093\/nutrit\/nuab065","relation":{},"ISSN":["0029-6643","1753-4887"],"issn-type":[{"value":"0029-6643","type":"print"},{"value":"1753-4887","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,5,1]]},"published":{"date-parts":[[2021,9,8]]}}}