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This review provides an overview of physiological mechanisms involved in satiety and of methodologies to assess food intake and satiety in both animal models and humans. The following topics are highlighted: differences between satiety and satiation; how the central nervous system regulates food intake and satiety; the impact of different macronutrients on satiety; and how the manipulation of food composition might influence overall satiety. Bringing together knowledge on this myriad of satiety mechanisms and how we can study them is useful to better understand and control obesity and other eating disorders.<\/jats:p>","DOI":"10.1093\/nutrit\/nuac010","type":"journal-article","created":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T15:16:57Z","timestamp":1643815017000},"page":"1942-1957","source":"Crossref","is-referenced-by-count":15,"title":["A look on food intake and satiety: from humans to rodent models"],"prefix":"10.1093","volume":"80","author":[{"given":"Daniela G","family":"Costa","sequence":"first","affiliation":[{"name":"Center for Neuroscience and Cell Biology, and the Center for Innovative Biomedicine and Biotechnology, University of Coimbra , Coimbra, Portugal"},{"name":"Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal. S. Carmo-Silva is with the Multidisciplinary Institute of Ageing\u2013 Portugal, University of Coimbra , Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udia","family":"Almeida","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal. S. Carmo-Silva is with the Multidisciplinary Institute of Ageing\u2013 Portugal, University of Coimbra , Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udia","family":"Cavadas","sequence":"additional","affiliation":[{"name":"Center for Neuroscience and Cell Biology, and the Center for Innovative Biomedicine and Biotechnology, University of Coimbra , Coimbra, Portugal"},{"name":"Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal. S. Carmo-Silva is with the Multidisciplinary Institute of Ageing\u2013 Portugal, University of Coimbra , Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Carmo-Silva","sequence":"additional","affiliation":[{"name":"Center for Neuroscience and Cell Biology, and the Center for Innovative Biomedicine and Biotechnology, University of Coimbra , Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,2,22]]},"reference":[{"key":"2022070807570441100_nuac010-B1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.foostr.2016.08.002","article-title":"Designing foods for satiety: the roles of food structure and oral processing in satiation and satiety","volume":"13","author":"Campbell","year":"2017","journal-title":"Food Struct"},{"key":"2022070807570441100_nuac010-B2","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/nrendo.2013.136","article-title":"The endocrinology of food intake","volume":"9","author":"Begg","year":"2013","journal-title":"Nat Rev Endocrinol."},{"key":"2022070807570441100_nuac010-B3","doi-asserted-by":"crossref","first-page":"e0133761","DOI":"10.1371\/journal.pone.0133761","article-title":"Association of rotating night shift work with BMI and abdominal obesity among nurses and midwives","volume":"10","author":"Peplonska","year":"2015","journal-title":"PLoS One."},{"key":"2022070807570441100_nuac010-B4","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s13679-019-00340-6","article-title":"Issues in measuring and interpreting human appetite (satiety\/satiation) and its contribution to obesity","volume":"8","author":"Gibbons","year":"2019","journal-title":"Curr Obes Rep."},{"key":"2022070807570441100_nuac010-B5","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.coph.2017.09.002","article-title":"An appetite for life: brain regulation of hunger and satiety","volume":"37","author":"Heisler","year":"2017","journal-title":"Curr Opin Pharmacol."},{"key":"2022070807570441100_nuac010-B6","first-page":"651","article-title":"Alteration of peptidergic gut-brain signaling under conditions of obesity","volume":"70","author":"Kuhne","year":"2019","journal-title":"J Physiol Pharmacol"},{"key":"2022070807570441100_nuac010-B7","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.physbeh.2015.07.017","article-title":"Effects of chewing on appetite, food intake and gut hormones: a systematic review and meta-analysis","volume":"151","author":"Miquel-Kergoat","year":"2015","journal-title":"Physiol Behav"},{"key":"2022070807570441100_nuac010-B8","first-page":"205","author":"Blundell","year":"1987"},{"key":"2022070807570441100_nuac010-B9","doi-asserted-by":"crossref","first-page":"332","DOI":"10.12968\/bjcn.2009.14.8.43512","article-title":"Satiety and the anorexia of ageing","volume":"14","author":"Benelam","year":"2009","journal-title":"Br J Community Nurs."},{"key":"2022070807570441100_nuac010-B10","doi-asserted-by":"crossref","first-page":"615","DOI":"10.3390\/nu8100615","article-title":"Soluble fiber with high water-binding capacity, swelling capacity, and fermentability reduces food intake by promoting satiety rather than satiation in rats","volume":"8","author":"Tan","year":"2016","journal-title":"Nutrients"},{"key":"2022070807570441100_nuac010-B11","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/S1542-3565(05)00285-5","article-title":"Effect of gastric volume or emptying on meal-related symptoms after liquid nutrients in obesity: a pharmacologic study","volume":"3","author":"Delgado-Aros","year":"2005","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2022070807570441100_nuac010-B12","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1006\/appe.1998.0177","article-title":"Relative contributions of intestinal, gastric, oro-sensory influences and information to changes in appetite induced by the same liquid meal","volume":"31","author":"Cecil","year":"1998","journal-title":"Appetite."},{"key":"2022070807570441100_nuac010-B13","first-page":"9","article-title":"Satiation, satiety and the action of fibre on food intake","volume":"11(suppl 1","author":"Blundell","year":"1987","journal-title":"Int J Obes."},{"key":"2022070807570441100_nuac010-B14","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0031-9384(81)90014-7","article-title":"Variety in a meal enhances food intake in man","volume":"26","author":"Rolls","year":"1981","journal-title":". 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