{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T15:13:32Z","timestamp":1784042012028,"version":"3.55.0"},"reference-count":100,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T00:00:00Z","timestamp":1663718400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072422"],"award-info":[{"award-number":["82072422"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022M712113"],"award-info":[{"award-number":["2022M712113"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cellular activities such as DNA synthesis, adenosine triphosphate production, and mitochondrial respiration are affected by iron metabolism. Disturbance of iron homeostasis usually leads to damage in cells and organs in the context of iron overload or deficiency. Thus, iron, a key regulator in nutritional immunity, was shown to be critical in innate and adaptive immunity. Unlike apoptosis, ferroptosis, a feature of iron-dependent lipid peroxidation, is thought to be associated with immune regulation because of its immunogenic nature. In this review, we summarize the role of iron and ferroptosis in immune regulation and discuss their therapeutic potential in the treatment of arthropathies like osteoarthritis and rheumatoid arthritis.<\/jats:p>","DOI":"10.1093\/nutrit\/nuac071","type":"journal-article","created":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T22:06:33Z","timestamp":1663797993000},"page":"587-596","source":"Crossref","is-referenced-by-count":23,"title":["A double-edged sword with a therapeutic target: iron and ferroptosis in immune regulation"],"prefix":"10.1093","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9126-8464","authenticated-orcid":false,"given":"Shuo","family":"Ni","sequence":"first","affiliation":[{"name":"Shanghai Jiaotong University Affiliated Sixth People\u2019s Hospital Department of Orthopedic Surgery and Shanghai Institute of Microsurgery on Extremities, , Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Yuan","sequence":"additional","affiliation":[{"name":"Zhejiang University State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, School of Medicine, , Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangdao","family":"Song","sequence":"additional","affiliation":[{"name":"Zhejiang University School of Medicine Department of Rehabilitation Medicine, Affiliated Jinhua Hospital, , Jinhua, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Li","sequence":"additional","affiliation":[{"name":"Shanghai Jiaotong University Affiliated Sixth People\u2019s Hospital Department of Orthopedic Surgery and Shanghai Institute of Microsurgery on Extremities, , Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,9,21]]},"reference":[{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/S1357-2725(01)00063-2","article-title":"Chemistry and biology of eukaryotic iron metabolism","volume":"33","author":"Aisen","year":"2001","journal-title":"Int J Biochem Cell Biol"},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.immuni.2016.02.016","article-title":"Macrophages and iron metabolism","volume":"44","author":"Soares","year":"2016","journal-title":"Immunity"},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1146\/annurev-pathol-012513-104651","article-title":"Nox enzymes and new thinking on reactive oxygen: a double-edged sword revisited","volume":"9","author":"Lambeth","year":"2014","journal-title":"Annu Rev Pathol."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1016\/j.bbagen.2019.06.010","article-title":"Iron homeostasis and iron-regulated ROS in cell death, senescence and human diseases","volume":"1863","author":"Nakamura","year":"2019","journal-title":"Biochim Biophys Acta Gen Subj."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1186\/s12935-020-01494-3","article-title":"Mitochondrion-mediated iron accumulation promotes carcinogenesis and Warburg effect through reactive oxygen species in osteosarcoma","volume":"20","author":"Ni","year":"2020","journal-title":"Cancer Cell Int."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"614778","DOI":"10.3389\/fonc.2021.614778","article-title":"Iron regulates the Warburg effect and ferroptosis in colorectal cancer","volume":"11","author":"Yuan","year":"2021","journal-title":"Front Oncol."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/s41586-018-0701-2","article-title":"The metabolite BH4 controls T cell proliferation in autoimmunity and cancer","volume":"563","author":"Cronin","year":"2018","journal-title":"Nature"},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.immuni.2018.05.008","article-title":"Iron drives T helper cell pathogenicity by promoting RNA-binding protein PCBP1-mediated proinflammatory cytokine production","volume":"49","author":"Wang","year":"2018","journal-title":"Immunity"},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41418-018-0173-9","article-title":"Ferroptosis and necroinflammation, a yet poorly explored link","volume":"26","author":"Proneth","year":"2019","journal-title":"Cell Death Differ."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/emmm.200900014","article-title":"Innate instruction of adaptive immunity revisited: the inflammasome","volume":"1","author":"Eisenbarth","year":"2009","journal-title":"EMBO Mol Med."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.micinf.2011.10.001","article-title":"Iron metabolism and the innate immune response to infection","volume":"14","author":"Johnson","year":"2012","journal-title":"Microbes Infect."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.3389\/fimmu.2017.01153","article-title":"Nutritional immunity triggers the modulation of iron metabolism genes in the sub-antarctic notothenioid Eleginops maclovinus in response to Piscirickettsia salmonis","volume":"8","author":"Mart\u00ednez","year":"2017","journal-title":"Front Immunol."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1126\/science.184.4140.952","article-title":"Iron and susceptibility to infectious disease","volume":"184","author":"Weinberg","year":"1974","journal-title":"Science."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: molecular mechanisms and health implications","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/ni.3325","article-title":"The role of the local environment and epigenetics in shaping macrophage identity and their effect on tissue homeostasis","volume":"17","author":"Amit","year":"2016","journal-title":"Nat Immunol."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.it.2011.03.007","article-title":"Iron trafficking and metabolism in macrophages: contribution to the polarized phenotype","volume":"32","author":"Cairo","year":"2011","journal-title":"Trends Immunol."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/imr.12603","article-title":"Metabolic regulation of macrophage phenotype and function","volume":"280","author":"Saha","year":"2017","journal-title":"Immunol Rev."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1172\/JCI44490","article-title":"An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice","volume":"121","author":"Sindrilaru","year":"2011","journal-title":"J Clin Invest."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1182\/blood-2011-01-330324","article-title":"Ferroportin1 deficiency in mouse macrophages impairs iron homeostasis and inflammatory responses","volume":"118","author":"Zhang","year":"2011","journal-title":"Blood"},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"e2003543","DOI":"10.1002\/smll.202003543","article-title":"A biomimetic polymer magnetic nanocarrier polarizing tumor-associated macrophages for potentiating immunotherapy","volume":"16","author":"Liu","year":"2020","journal-title":"Small."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"101611","DOI":"10.1016\/j.redox.2020.101611","article-title":"Iron regulates myeloma cell\/macrophage interaction and drives resistance to bortezomib","volume":"36","author":"Camiolo","year":"2020","journal-title":"Redox Biol."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.4049\/jimmunol.1701135","article-title":"M1 means kill; M2 means heal","volume":"199","author":"Ley","year":"2017","journal-title":"J Immunol."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/hep.31790","article-title":"Macrophage heterogeneity in NASH: more than just nomenclature","volume":"74","author":"Parthasarathy","year":"2021","journal-title":"Hepatology."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"121038","DOI":"10.1016\/j.biomaterials.2021.121038","article-title":"Sequential activation of heterogeneous macrophage phenotypes is essential for biomaterials-induced bone regeneration","volume":"276","author":"Qiao","year":"2021","journal-title":"Biomaterials"},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/s41420-019-0146-x","article-title":"Three cell deaths and a funeral: macrophage clearance of cells undergoing distinct modes of cell death","volume":"5","author":"Kl\u00f6ditz","year":"2019","journal-title":"Cell Death Discov."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1038\/s41418-020-00719-2","article-title":"Oxygenated phosphatidylethanolamine navigates phagocytosis of ferroptotic cells by interacting with TLR2","volume":"28","author":"Luo","year":"2021","journal-title":"Cell Death Differ."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1182\/blood-2017-12-822619","article-title":"Increased erythrophagocytosis induces ferroptosis in red pulp macrophages in a mouse model of transfusion","volume":"131","author":"Youssef","year":"2018","journal-title":"Blood"},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.chom.2018.05.009","article-title":"Lipid peroxidation drives gasdermin D-mediated pyroptosis in lethal polymicrobial sepsis","volume":"24","author":"Kang","year":"2018","journal-title":"Cell Host Microbe."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/hep.29117","article-title":"Characterization of ferroptosis in murine models of hemochromatosis","volume":"66","author":"Wang","year":"2017","journal-title":"Hepatology."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1080\/15548627.2020.1714209","article-title":"Autophagy-dependent ferroptosis drives tumor-associated macrophage polarization via release and uptake of oncogenic KRAS protein","volume":"16","author":"Dai","year":"2020","journal-title":"Autophagy"},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1039\/C4MT00346B","article-title":"Trace element landscape of resting and activated human neutrophils on the sub-micrometer level","volume":"7","author":"Niemiec","year":"2015","journal-title":"Metallomics."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3389\/fmolb.2019.00116","article-title":"The role of iron regulation in immunometabolism and immune-related disease","volume":"6","author":"Cronin","year":"2019","journal-title":"Front Mol Biosci."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nature03104","article-title":"Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron","volume":"432","author":"Flo","year":"2004","journal-title":"Nature"},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/nchembio.1891","article-title":"Human calprotectin is an iron-sequestering host-defense protein","volume":"11","author":"Nakashige","year":"2015","journal-title":"Nat Chem Biol."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1179\/135100003225002664","article-title":"Redox properties of myeloperoxidase","volume":"8","author":"Arnhold","year":"2003","journal-title":"Redox Rep."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1172\/JCI126645","article-title":"Epidermal hepcidin is required for neutrophil response to bacterial infection","volume":"130","author":"Malerba","year":"2020","journal-title":"J Clin Invest."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"e02152","DOI":"10.1128\/AAC.02152-18","article-title":"Iron chelator deferasirox reduces Candida albicans invasion of oral epithelial cells and infection levels in murine oropharyngeal candidiasis","volume":"63","author":"Puri","year":"2019","journal-title":"Antimicrob Agents Chemother."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"e2110166119","DOI":"10.1073\/pnas.2110166119","article-title":"Hemochromatosis drives acute lethal intestinal responses to hyperyersiniabactin-producing Yersinia pseudotuberculosis","volume":"119","author":"Das","year":"2022","journal-title":"Proc Natl Acad Sci USA."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/j.kint.2021.12.024","article-title":"Divergent roles of haptoglobin and hemopexin deficiency for disease progression of Shiga-toxin-induced hemolytic-uremic syndrome in mice","volume":"101","author":"Pirschel","year":"2022","journal-title":"Kidney Int"},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1038\/s41467-017-00770-7","article-title":"Neutrophil polarization by IL-27 as a therapeutic target for intracerebral hemorrhage","volume":"8","author":"Zhao","year":"2017","journal-title":"Nat Commun."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1189\/jlb.5BT0615-234R","article-title":"At the bedside: neutrophil extracellular traps (NETs) as targets for biomarkers and therapies in autoimmune diseases","volume":"99","author":"Barnado","year":"2016","journal-title":"J Leukoc Biol."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nrmicro1710","article-title":"Beneficial suicide: why neutrophils die to make NETs","volume":"5","author":"Brinkmann","year":"2007","journal-title":"Nat Rev Microbiol."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1083\/jcb.201006052","article-title":"Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps","volume":"191","author":"Papayannopoulos","year":"2010","journal-title":"J Cell Biol."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s12035-021-02635-z","article-title":"Neutrophil extracellular traps exacerbate ischemic brain damage","volume":"59","author":"Li","year":"2022","journal-title":"Mol Neurobiol."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.4049\/jimmunol.1004201","article-title":"Innate immune collectin surfactant protein D simultaneously binds both neutrophil extracellular traps and carbohydrate ligands and promotes bacterial trapping","volume":"187","author":"Douda","year":"2011","journal-title":"J Immunol."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"6748","DOI":"10.1073\/pnas.0900226106","article-title":"Leishmania amazonensis promastigotes induce and are killed by neutrophil extracellular traps","volume":"106","author":"Guimar\u00e3es-Costa","year":"2009","journal-title":"Proc Natl Acad Sci USA."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"e48111","DOI":"10.1371\/journal.pone.0048111","article-title":"Cytokines induced neutrophil extracellular traps formation: implication for the inflammatory disease condition","volume":"7","author":"Keshari","year":"2012","journal-title":"PLoS One."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.1016\/j.febslet.2010.06.006","article-title":"Activated endothelial cells induce neutrophil extracellular traps and are susceptible to NETosis-mediated cell death","volume":"584","author":"Gupta","year":"2010","journal-title":"FEBS Lett."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1126\/scitranslmed.3005580","article-title":"NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis","volume":"5","author":"Khandpur","year":"2013","journal-title":"Sci Transl Med"},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"44123","DOI":"10.1074\/jbc.M405883200","article-title":"Induction of genes mediating interferon-dependent extracellular trap formation during neutrophil differentiation","volume":"279","author":"Martinelli","year":"2004","journal-title":"J Biol Chem."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nm1565","article-title":"Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood","volume":"13","author":"Clark","year":"2007","journal-title":"Nat Med."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.bbrc.2011.08.052","article-title":"Singlet oxygen is essential for neutrophil extracellular trap formation","volume":"413","author":"Nishinaka","year":"2011","journal-title":"Biochem Biophys Res Commun."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"7668","DOI":"10.3390\/ijms21207668","article-title":"Adenosine triphosphate accumulated following cerebral ischemia induces neutrophil extracellular trap formation","volume":"21","author":"Kim","year":"2020","journal-title":"IJMS."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/s00109-009-0481-0","article-title":"Innate immunity turned inside-out: antimicrobial defense by phagocyte extracellular traps","volume":"87","author":"von K\u00f6ckritz-Blickwede","year":"2009","journal-title":"J Mol Med (Berl)."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.1182\/blood-2012-01-405993","article-title":"Mammalian target of rapamycin regulates neutrophil extracellular trap formation via induction of hypoxia-inducible factor 1 \u03b1","volume":"120","author":"McInturff","year":"2012","journal-title":"Blood"},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"518","DOI":"10.3389\/fimmu.2016.00518","article-title":"Formation of neutrophil extracellular traps under low oxygen level","volume":"7","author":"Branitzki-Heinemann","year":"2016","journal-title":"Front Immunol."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"e00333","DOI":"10.1042\/BSR20160031","article-title":"Iron-chelating agent desferrioxamine stimulates formation of neutrophil extracellular traps (NETs) in human blood-derived neutrophils","volume":"36","author":"V\u00f6llger","year":"2016","journal-title":"Biosci Rep"},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1038\/s41598-022-06036-7","article-title":"Impaired neutrophil extracellular trap formation in \u03b2-thalassaemia\/HbE","volume":"12","author":"Thubthed","year":"2022","journal-title":"Sci Rep."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/imcb.12509","article-title":"Iron excess affects release of neutrophil extracellular traps and reactive oxygen species but does not influence other functions of neutrophils","volume":"100","author":"Ku\u017amicka","year":"2022","journal-title":"Immunol Cell Biol."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"3818","DOI":"10.1182\/blood-2013-10-529982","article-title":"Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease","volume":"123","author":"Chen","year":"2014","journal-title":"Blood"},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1182\/blood.V128.22.161.161","article-title":"Free iron in sera of patients with sickle cell disease contributes to the release of neutrophil extracellular traps","volume":"128","author":"Van Avondt","year":"2016","journal-title":"Blood"},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"11060","DOI":"10.1073\/pnas.1811717115","article-title":"Metastatic growth instructed by neutrophil-derived transferrin","volume":"115","author":"Liang","year":"2018","journal-title":"Proc Natl Acad Sci USA."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"16026","DOI":"10.1038\/s41598-017-15668-z","article-title":"Hyperoxidation of ether-linked phospholipids accelerates neutrophil extracellular trap formation","volume":"7","author":"Yotsumoto","year":"2017","journal-title":"Sci Rep."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1038\/s41590-021-00993-3","article-title":"Glutathione peroxidase 4\u2013regulated neutrophil ferroptosis induces systemic autoimmunity","volume":"22","author":"Li","year":"2021","journal-title":"Nat Immunol."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"5424","DOI":"10.1038\/s41467-020-19193-y","article-title":"Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression","volume":"11","author":"Yee","year":"2020","journal-title":"Nat Commun."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1172\/JCI126428","article-title":"Ferroptotic cell death and TLR4\/Trif signaling initiate neutrophil recruitment after heart transplantation","volume":"129","author":"Li","year":"2019","journal-title":"J Clin Invest."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"4477","DOI":"10.4049\/jimmunol.1401558","article-title":"mTORC1-dependent metabolic reprogramming is a prerequisite for NK cell effector function","volume":"193","author":"Donnelly","year":"2014","journal-title":"J Immunol."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1038\/s41467-018-04719-2","article-title":"Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice","volume":"9","author":"Loftus","year":"2018","journal-title":"Nat Commun."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"5376","DOI":"10.1038\/s41467-021-25715-z","article-title":"Metabolic requirements of NK cells during the acute response against retroviral infection","volume":"12","author":"Littwitz-Salomon","year":"2021","journal-title":"Nat Commun."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"224","DOI":"10.3389\/fimmu.2019.00224","article-title":"Iron and ferritin modulate MHC class I expression and NK cell recognition","volume":"10","author":"Sottile","year":"2019","journal-title":"Front Immunol."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"21026","DOI":"10.1038\/s41598-020-78037-3","article-title":"Acute invariant NKT cell activation triggers an immune response that drives prominent changes in iron homeostasis","volume":"10","author":"Huang","year":"2020","journal-title":"Sci Rep."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1097\/JCMA.0000000000000587","article-title":"The role of micronutrient and immunomodulation effect in the vaccine era of COVID-19","volume":"84","author":"Lai","year":"2021","journal-title":"J Chin Med Assoc"},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.healun.2017.03.004","article-title":"Disturbances in iron homeostasis result in accelerated rejection after experimental heart transplantation","volume":"36","author":"Resch","year":"2017","journal-title":"J Heart Lung Transplant"},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"557","DOI":"10.4161\/onci.19367","article-title":"The wolf in sheep's clothing: platelet-derived \u201cpseudo self\u201d impairs cancer cell \u201cmissing self\u201d recognition by NK cells","volume":"1","author":"Placke","year":"2012","journal-title":"Oncoimmunology"},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"e28539","DOI":"10.4161\/onci.28539","article-title":"Iron-induced parafibrin formation in tumors fosters immune evasion","volume":"3","author":"Lipinski","year":"2014","journal-title":"Oncoimmunology"},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/nri3863","article-title":"Iron homeostasis in host defence and inflammation","volume":"15","author":"Ganz","year":"2015","journal-title":"Nat Rev Immunol."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.15252\/embr.201540558","article-title":"The Iron Age of host\u2013microbe interactions","volume":"16","author":"Soares","year":"2015","journal-title":"EMBO Rep."},{"key":"2023041108152658600_","first-page":"164","article-title":"Hepcidin-mediated hypoferremia disrupts immune responses to vaccination and infection","volume":"2","author":"Frost","year":"2021","journal-title":"Med (N Y)."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/ng.3465","article-title":"A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency","volume":"48","author":"Jabara","year":"2016","journal-title":"Nat Genet."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1038\/s41467-019-11002-5","article-title":"Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses","volume":"10","author":"Jiang","year":"2019","journal-title":"Nat Commun."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"e0136106","DOI":"10.1371\/journal.pone.0136106","article-title":"Iron deficiency impairs intra-hepatic lymphocyte mediated immune response","volume":"10","author":"Bonaccorsi-Riani","year":"2015","journal-title":"PLoS One."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/imr.13045","article-title":"Micro but mighty\u2014micronutrients in the epigenetic regulation of adaptive immune responses","volume":"305","author":"Chen","year":"2022","journal-title":"Immunol Rev."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.cell.2010.04.040","article-title":"A mammalian siderophore synthesized by an enzyme with a bacterial homolog involved in enterobactin production","volume":"141","author":"Devireddy","year":"2010","journal-title":"Cell"},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1084\/jem.20140857","article-title":"T cell lipid peroxidation induces ferroptosis and prevents immunity to infection","volume":"212","author":"Matsushita","year":"2015","journal-title":"J Exp Med."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1158\/2326-6066.CIR-20-0384","article-title":"Pharmacologic screening identifies metabolic vulnerabilities of CD8(+) T Cells","volume":"9","author":"Drijvers","year":"2021","journal-title":"Cancer Immunol Res."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s12943-020-01234-1","article-title":"Regulatory T cells in tumor microenvironment: new mechanisms, potential therapeutic strategies and future prospects","volume":"19","author":"Li","year":"2020","journal-title":"Mol Cancer."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-019-1170-y","article-title":"CD8(+) T cells regulate tumour ferroptosis during cancer immunotherapy","volume":"569","author":"Wang","year":"2019","journal-title":"Nature"},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"e69621","DOI":"10.7554\/eLife.69621","article-title":"The mitochondrial iron transporter ABCB7 is required for B cell development, proliferation, and class switch recombination in mice","volume":"10","author":"Lehrke","year":"2021","journal-title":"eLife"},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"5438","DOI":"10.1182\/blood-2010-07-296483","article-title":"Heme regulates B-cell differentiation, antibody class switch, and heme oxygenase-1 expression in B cells as a ligand of Bach2","volume":"117","author":"Watanabe-Matsui","year":"2011","journal-title":"Blood"},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.4049\/jimmunol.1700787","article-title":"Efficacy and mechanism of antitumor activity of an antibody targeting transferrin receptor 1 in mouse models of human multiple myeloma","volume":"200","author":"Leoh","year":"2018","journal-title":"J Immunol."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1111\/bjh.17284","article-title":"Deferasirox induces cyclin D1 degradation and apoptosis in mantle cell lymphoma in a reactive oxygen species- and GSK3\u03b2-dependent mechanism","volume":"192","author":"Samara","year":"2021","journal-title":"Br J Haematol."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1182\/blood.2021011079","article-title":"CYB561A3 is the key lysosomal iron reductase required for Burkitt B-cell growth and survival","volume":"138","author":"Wang","year":"2021","journal-title":"Blood"},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1016\/j.celrep.2019.10.070","article-title":"B1 and marginal zone B cells but not follicular B2 cells require gpx4 to prevent lipid peroxidation and ferroptosis","volume":"29","author":"Muri","year":"2019","journal-title":"Cell Rep."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"e20210518","DOI":"10.1084\/jem.20210518","article-title":"Ferroptosis in infection, inflammation, and immunity","volume":"218","author":"Chen","year":"2021","journal-title":"J Exp Med"},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.gendis.2014.07.005","article-title":"Bone morphogenetic protein (BMP) signaling in development and human diseases","volume":"1","author":"Wang","year":"2014","journal-title":"Genes Dis."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1182\/blood-2015-03-635524","article-title":"IL-1\u03b2, in contrast to TNF\u03b1, is pivotal in blood-induced cartilage damage and is a potential target for therapy","volume":"126","author":"van Vulpen","year":"2015","journal-title":"Blood"},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1056\/NEJMra1004965","article-title":"The pathogenesis of rheumatoid arthritis","volume":"365","author":"McInnes","year":"2011","journal-title":"N Engl J Med."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/s41467-021-27948-4","article-title":"TNF antagonist sensitizes synovial fibroblasts to ferroptotic cell death in collagen-induced arthritis mouse models","volume":"13","author":"Wu","year":"2022","journal-title":"Nat Commun."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","first-page":"101481","DOI":"10.1016\/j.arr.2021.101481","article-title":"Iron homeostasis in arthropathies: from pathogenesis to therapeutic potential","volume":"72","author":"Sun","year":"2021","journal-title":"Ageing Res Rev."},{"key":"2023041108152658600_","doi-asserted-by":"crossref","DOI":"10.1093\/rheumatology\/keac069","article-title":"Glycine increased ferroptosis via SAM-mediated GPX4 promoter methylation in rheumatoid arthritis","author":"Ling","year":"2022","journal-title":"Rheumatology."}],"container-title":["Nutrition Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/nutritionreviews\/article-pdf\/81\/5\/587\/49788773\/nuac071.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nutritionreviews\/article-pdf\/81\/5\/587\/49788773\/nuac071.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,26]],"date-time":"2023-11-26T04:32:36Z","timestamp":1700973156000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nutritionreviews\/article\/81\/5\/587\/6710339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,21]]},"references-count":100,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,9,21]]},"published-print":{"date-parts":[[2023,4,11]]}},"URL":"https:\/\/doi.org\/10.1093\/nutrit\/nuac071","relation":{},"ISSN":["0029-6643","1753-4887"],"issn-type":[{"value":"0029-6643","type":"print"},{"value":"1753-4887","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,5,1]]},"published":{"date-parts":[[2022,9,21]]}}}