{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T09:56:04Z","timestamp":1791453364180,"version":"4.3.3"},"reference-count":81,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T00:00:00Z","timestamp":1687478400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100020884","name":"ANID","doi-asserted-by":"publisher","award":["1210188"],"award-info":[{"award-number":["1210188"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Anticariogenic properties have been ascribed to polyphenolic compounds present in high concentrations in numerous fruits. Berries, in particular, have been reported as potentially having an inhibitory effect on the dental biofilm and subsequently on caries, but the evidence is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of this review was to explore the literature and summarize the evidence for berries having an inhibitory effect on the dental biofilm and an anticariogenic effect.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources<\/jats:title>\n                    <jats:p>Following Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines, the PubMed, Web of Science, and SCOPUS databases were scanned using predefined and accessible terms, with a search strategy based on a structured PICO question.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Extraction<\/jats:title>\n                    <jats:p>After article selection, 23 studies met the inclusion criteria, most of them being in vitro studies. A risk assessment was performed, and data were extracted and presented in a table for qualitative analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Analysis<\/jats:title>\n                    <jats:p>Meta-analyses were conducted using standardized mean differences (SMDs) with a 95% confidence interval (CI) by Review manager 5.4.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Only 3 types of berries were found to have a reported anticaries effect: grape seed extract (GSE), cranberry, and sour cherry. Nine studies that fulfilled the eligibility criteria were subjected to quantitative analysis. Meta-analyses showed GSE was associated with enhanced remineralization of dental enamel (SMD\u2009=\u2009.96 95% CI [.45, 1.46], P\u2009&amp;lt;\u2009.0002) and of dentin (SMD\u2009=\u2009.65 95% CI [.13, 1.17], P\u2009=\u2009.01). Cranberry extracts positively influenced the cariogenic dental biofilm by decreasing the biofilm biomass (SMD\u2009=\u2009\u20132.23 95% CI [\u20134.40, \u2013.05], P\u2009=\u2009.04), and biovolume (SMD\u2009=\u2009\u20132.86 95% CI [\u20134.34, \u20131.37], P\u2009=\u2009.0002), and increasing the biofilm pH (SMD\u2009=\u20097.9 95% CI [3.49, 12.31], P\u2009&amp;lt;\u2009.0004).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Within the limitations of this systematic review and metaanalysis, GSE and cranberries or their active compounds could represent an alternative for caries management. Further clinical trials are needed to verify this effect in a clinical setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic Review Registration<\/jats:title>\n                    <jats:p>PROSPERO registration no. CRD42020223579.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/nutrit\/nuad063","type":"journal-article","created":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T16:33:15Z","timestamp":1684945995000},"page":"302-317","source":"Crossref","is-referenced-by-count":12,"title":["Anticaries properties of natural berries: systematic literature review"],"prefix":"10.1093","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5734-6059","authenticated-orcid":false,"given":"Natalia","family":"Garc\u00eda-Manr\u00edquez","sequence":"first","affiliation":[{"name":"Cariology Unit, Department of Oral Rehabilitation, Faculty of Dentistry, University of Talca , Talca, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Lozano","sequence":"additional","affiliation":[{"name":"Biochemistry and Oral Biology Laboratory, Research Institute for Dental Sciences, Faculty of Dentistry, University of Chile , Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Cariology Unit, Department of Oral Rehabilitation, Faculty of Dentistry, University of Talca , Talca, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Fernanda","family":"Morales","sequence":"additional","affiliation":[{"name":"Cariology Unit, Department of Oral Rehabilitation, Faculty of Dentistry, University of Talca , Talca, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3362-5173","authenticated-orcid":false,"given":"Rodrigo A","family":"Giacaman","sequence":"additional","affiliation":[{"name":"Cariology Unit, Department of Oral Rehabilitation, Faculty of Dentistry, University of Talca , Talca, Chile"},{"name":"Biochemistry and Oral Biology Laboratory, Research Institute for Dental Sciences, Faculty of Dentistry, University of Chile , Santiago, Chile"},{"name":"In , Chile"},{"name":"teruniversity Center for Healthy Aging, Chilean State Universities , Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,6,23]]},"reference":[{"key":"2024021208100309600_nuad063-B1","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1177\/0022034515573272","article-title":"Global burden of untreated caries: a systematic review and metaregression","volume":"94","author":"Kassebaum","year":"2015","journal-title":"J Dent Res"},{"key":"2024021208100309600_nuad063-B2","author":"World Health Organization (WHO).","year":"2017"},{"key":"2024021208100309600_nuad063-B3","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.tim.2014.10.010","article-title":"Solving the etiology of dental caries","volume":"23","author":"Sim\u00f3n-Soro","year":"2015","journal-title":"Trends Microbiol"},{"key":"2024021208100309600_nuad063-B4","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1177\/0022034510379602","article-title":"The role of bacteria in the caries process: ecological perspectives","volume":"90","author":"Takahashi","year":"2011","journal-title":"J Dent Res"},{"key":"2024021208100309600_nuad063-B5","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1111\/odi.12778","article-title":"Sugars and beyond. The role of sugars and the other nutrients and their potential impact on caries","volume":"24","author":"Giacaman","year":"2018","journal-title":"Oral Dis"},{"key":"2024021208100309600_nuad063-B6","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.jdent.2009.02.003","article-title":"Polyphenols, oral health and disease: a review","volume":"37","author":"Petti","year":"2009","journal-title":"J Dent"},{"key":"2024021208100309600_nuad063-B7","doi-asserted-by":"publisher","first-page":"1486","DOI":"10.3390\/molecules16021486","article-title":"Plant polyphenols and their anti-cariogenic properties: a review","volume":"16","author":"Ferrazzano","year":"2011","journal-title":"Molecules."},{"key":"2024021208100309600_nuad063-B8","doi-asserted-by":"publisher","first-page":"e03013","DOI":"10.1016\/j.heliyon.2019.e03013","article-title":"Effect of flavonoids on antimicrobial activity of microorganisms present in dental plaque","volume":"5","author":"Guti\u00e9rrez-Venegas","year":"2019","journal-title":"Heliyon"},{"key":"2024021208100309600_nuad063-B9","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1128\/AAC.01016-10","article-title":"The tea catechin epigallocatechin gallate suppresses cariogenic virulence factors of Streptococcus mutans","volume":"55","author":"Xu","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"2024021208100309600_nuad063-B10","doi-asserted-by":"publisher","first-page":"4892","DOI":"10.3390\/ijms22094892","article-title":"Preventive applications of polyphenols in dentistry\u2014a review","volume":"22","author":"Flemming","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2024021208100309600_nuad063-B11","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1111\/j.1364-3703.2010.00625.x","article-title":"The roles of plant phenolics in defence and communication during Agrobacterium and Rhizobium infection","volume":"11","author":"Bhattacharya","year":"2010","journal-title":"Mol Plant Pathol"},{"key":"2024021208100309600_nuad063-B12","doi-asserted-by":"publisher","first-page":"515","DOI":"10.3390\/nu8080515","article-title":"Natural polyphenols for prevention and treatment of cancer","volume":"8","author":"Zhou","year":"2016","journal-title":"Nutrients"},{"key":"2024021208100309600_nuad063-B13","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.fitote.2018.11.012","article-title":"Polyphenols in the prevention and treatment of periodontal disease: a systematic review of in vivo, ex vivo and in vitro studies","volume":"132","author":"Bunte","year":"2019","journal-title":"Fitoterapia"},{"key":"2024021208100309600_nuad063-B14","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.3390\/nu10111618","article-title":"The immunomodulatory and anti-inflammatory role of polyphenols","volume":"10","author":"Yahfoufi","year":"2018","journal-title":"Nutrients"},{"key":"2024021208100309600_nuad063-B15","doi-asserted-by":"publisher","first-page":"3447","DOI":"10.3390\/molecules26113447","article-title":"Applications of fruit polyphenols and their functionalized nanoparticles against foodborne bacteria: a mini review","volume":"26","author":"Kumar","year":"2021","journal-title":"Molecules"},{"key":"2024021208100309600_nuad063-B16","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1021\/np960040+","article-title":"Natural polyphenols (vegetable tannins) as drugs: possible modes of action","volume":"59","author":"Haslam","year":"1996","journal-title":"J Nat Prod"},{"key":"2024021208100309600_nuad063-B17","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1128\/CMR.12.4.564","article-title":"Plant products as antimicrobial agents","volume":"12","author":"Cowan","year":"1999","journal-title":"Clin Microbiol Rev"},{"key":"2024021208100309600_nuad063-B18","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.fitote.2009.04.006","article-title":"Anti-cariogenic effects of polyphenols from plant stimulant beverages (cocoa, coffee, tea)","volume":"80","author":"Ferrazzano","year":"2009","journal-title":"Fitoterapia"},{"key":"2024021208100309600_nuad063-B19","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1207\/s15327914nc5401_4","article-title":"Berry phenolics: antimicrobial properties and mechanisms of action against severe human pathogens","volume":"54","author":"Nohynek","year":"2006","journal-title":"Nutr Cancer"},{"key":"2024021208100309600_nuad063-B20","doi-asserted-by":"publisher","first-page":"43","DOI":"10.3390\/beverages7030043","article-title":"Beverages containing plant-derived polyphenols inhibit growth and biofilm formation of Streptococcus mutans and children\u2019s supragingival plaque bacteria","volume":"7","author":"Wu","year":"2021","journal-title":"Beverages"},{"key":"2024021208100309600_nuad063-B21","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1248\/cpb.38.717","article-title":"Effect of tea polyphenols on glucan synthesis by glucosyltransferase from Streptococcus mutans","volume":"38","author":"Hattori","year":"1990","journal-title":"Chem Pharm Bull (Tokyo)"},{"key":"2024021208100309600_nuad063-B22","doi-asserted-by":"publisher","first-page":"229","DOI":"10.4248\/IJOS.09086","article-title":"Extracellular polysaccharides matrix\u2014an often forgotten virulence factor in oral biofilm research","volume":"1","author":"Koo","year":"2009","journal-title":"Int J Oral Sci"},{"key":"2024021208100309600_nuad063-B23","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1016\/j.archoralbio.2011.10.021","article-title":"Tea catechin epigallocatechin gallate inhibits Streptococcus mutans biofilm formation by suppressing gtf genes","volume":"57","author":"Xu","year":"2012","journal-title":"Arch Oral Biol"},{"key":"2024021208100309600_nuad063-B24","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1021\/jf071988k","article-title":"Berry fruits: compositional elements, biochemical activities, and the impact of their intake on human health, performance, and disease","volume":"56","author":"Seeram","year":"2008","journal-title":"J Agric Food Chem"},{"key":"2024021208100309600_nuad063-B25","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1111\/j.1753-4887.1998.tb01670.x","article-title":"Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance","volume":"56","author":"Bravo","year":"1998","journal-title":"Nutr Rev"},{"key":"2024021208100309600_nuad063-B26","doi-asserted-by":"publisher","first-page":"602","DOI":"10.3390\/antiox11030602","article-title":"Antioxidants of fruit extracts as antimicrobial agents against pathogenic bacteria","volume":"11","author":"Suriyaprom","year":"2022","journal-title":"Antioxidants (Basel)"},{"key":"2024021208100309600_nuad063-B27","doi-asserted-by":"publisher","first-page":"108","DOI":"10.3390\/molecules27010108","article-title":"Recent studies on berry bioactives and their health-promoting roles","volume":"27","author":"Vahapoglu","year":"2021","journal-title":"Molecules"},{"key":"2024021208100309600_nuad063-B28","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1007\/s00253-004-1817-x","article-title":"Bioactive berry compounds\u2014novel tools against human pathogens","volume":"67","author":"Puupponen-Pimi\u00e4","year":"2005","journal-title":"Appl Microbiol Biotechnol"},{"key":"2024021208100309600_nuad063-B29","doi-asserted-by":"publisher","first-page":"1960","DOI":"10.1111\/j.1365-2672.2007.03441.x","article-title":"Influence of cranberry phenolics on glucan synthesis by glucosyltransferases and Streptococcus mutans acidogenicity","volume":"103","author":"Gregoire","year":"2007","journal-title":"J Appl Microbiol"},{"key":"2024021208100309600_nuad063-B30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.archoralbio.2019.03.026","article-title":"Effect of polyphenol-rich cranberry extracts on cariogenic biofilm properties and microbial composition of polymicrobial biofilms","volume":"102","author":"Philip","year":"2019","journal-title":"Arch Oral Biol"},{"key":"2024021208100309600_nuad063-B31","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1016\/j.archoralbio.2013.09.007","article-title":"The role of grape seed extract in the remineralization of demineralized dentine: micromorphological and physical analyses","volume":"58","author":"Tang","year":"2013","journal-title":"Arch Oral Biol"},{"key":"2024021208100309600_nuad063-B32","doi-asserted-by":"publisher","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"2024021208100309600_nuad063-B33","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1016\/j.rec.2021.07.010","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"74","author":"Page","year":"2021","journal-title":"Rev Esp Cardiol (Engl Ed)."},{"key":"2024021208100309600_nuad063-B34","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.toxlet.2009.05.013","article-title":"\u201cToxRTool\u201d, a new tool to assess the reliability of toxicological data","volume":"189","author":"Schneider","year":"2009","journal-title":"Toxicol Lett"},{"key":"2024021208100309600_nuad063-B35","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1111\/eos.12602","article-title":"Inhibitory effects of fruit berry extracts on Streptococcus mutans biofilms","volume":"127","author":"Philip","year":"2019","journal-title":"Eur J Oral Sci"},{"key":"2024021208100309600_nuad063-B36","first-page":"56","article-title":"Polyphenol-rich cranberry extracts modulate virulence of Streptococcus mutans\u2013Candida albicans biofilms implicated in the pathogenesis of early childhood caries","volume":"41","author":"Philip","year":"2019","journal-title":"Pediatr Dent."},{"key":"2024021208100309600_nuad063-B37","doi-asserted-by":"publisher","first-page":"6761","DOI":"10.1039\/c6py01362g","article-title":"Effective in situ repair and bacteriostatic material of tooth enamel based on salivary acquired pellicle inspired oligomeric procyanidins","volume":"7","author":"Zhang","year":"2016","journal-title":"Polym Chem"},{"key":"2024021208100309600_nuad063-B38","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1016\/j.jdent.2009.03.017","article-title":"Polyphenolic beverages reduce initial bacterial adherence to enamel in situ","volume":"37","author":"Hannig","year":"2009","journal-title":"J Dent"},{"key":"2024021208100309600_nuad063-B39","doi-asserted-by":"publisher","first-page":"128","DOI":"10.4103\/0970-4388.155125","article-title":"Effect of high-molecular-weight component of Cranberry on plaque and salivary Streptococcus mutans counts in children: an in vivo study","volume":"33","author":"Gupta","year":"2015","journal-title":"J Indian Soc Pedod Prev Dent"},{"key":"2024021208100309600_nuad063-B40","doi-asserted-by":"publisher","first-page":"4008","DOI":"10.1039\/c8fo00064f","article-title":"Sour cherry extract inhibits human salivary \u03b1-amylase and growth of Streptococcus mutans (a pilot clinical study)","volume":"9","author":"Homoki","year":"2018","journal-title":"Food Funct"},{"key":"2024021208100309600_nuad063-B41","doi-asserted-by":"publisher","first-page":"920","DOI":"10.5005\/jp-journals-10024-2617","article-title":"Comparison of Punica granatum, Terminalia chebula, and Vitis vinifera seed extracts used as mouthrinse on salivary Streptococcus mutans levels in children","volume":"20","author":"Mishra","year":"2019","journal-title":"J Contemp Dent Pract"},{"key":"2024021208100309600_nuad063-B42","doi-asserted-by":"publisher","first-page":"425","DOI":"10.5005\/jp-journals-10024-1162","article-title":"Grape seed extract as a potential remineralizing agent: a comparative in vitro study","volume":"13","author":"Benjamin","year":"2012","journal-title":"J Contemp Dent Pract"},{"key":"2024021208100309600_nuad063-B43","doi-asserted-by":"publisher","first-page":"415","DOI":"10.4103\/JCD.JCD_287_16","article-title":"Grape seed extract: an innovation in remineralization","volume":"20","author":"Jawale","year":"2017","journal-title":"J Conserv Dent"},{"key":"2024021208100309600_nuad063-B44","doi-asserted-by":"publisher","first-page":"425","DOI":"10.3389\/fphys.2014.00425","article-title":"Grape seed extracts inhibit dentin matrix degradation by MMP-3","volume":"5","author":"Khaddam","year":"2014","journal-title":"Front Physiol"},{"key":"2024021208100309600_nuad063-B45","doi-asserted-by":"publisher","first-page":"206","DOI":"10.5681\/joddd.2013.033","article-title":"Remineralization of artificial caries in primary teeth by grape seed extract: an in vitro study","volume":"7","author":"Mirkarimi","year":"2013","journal-title":"J Dent Res Dent Clin Dent Prospects"},{"key":"2024021208100309600_nuad063-B46","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1159\/000330599","article-title":"Biomimetic approach for root caries prevention using a proanthocyanidin-rich agent","volume":"45","author":"Pavan","year":"2011","journal-title":"Caries Res"},{"key":"2024021208100309600_nuad063-B47","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1590\/1678-775720140304","article-title":"Effectiveness of plant-derived proanthocyanidins on demineralization on enamel and dentin under artificial cariogenic challenge","volume":"23","author":"Pereira da Silva","year":"2015","journal-title":"J Appl Oral Sci."},{"key":"2024021208100309600_nuad063-B48","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/j.archoralbio.2012.01.001","article-title":"Inhibitory effects of the phenolic fraction from the pomace of Vitis coignetiae on biofilm formation by Streptococcus mutans","volume":"57","author":"Yano","year":"2012","journal-title":"Arch Oral Biol"},{"key":"2024021208100309600_nuad063-B49","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1016\/j.jdent.2008.07.011","article-title":"In vitro remineralization effects of grape seed extract on artificial root caries","volume":"36","author":"Xie","year":"2008","journal-title":"J Dent"},{"key":"2024021208100309600_nuad063-B50","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1016\/j.jdent.2014.05.006","article-title":"The preventive effect of grape seed extract on artificial enamel caries progression in a microbial biofilm\u2013induced caries model","volume":"42","author":"Zhao","year":"2014","journal-title":"J Dent"},{"key":"2024021208100309600_nuad063-B51","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1111\/j.1574-6968.2006.00147.x","article-title":"Inhibitory effects of cranberry polyphenols on formation and acidogenicity of Streptococcus mutans biofilms","volume":"257","author":"Duarte","year":"2006","journal-title":"Fems Microbiol Lett"},{"key":"2024021208100309600_nuad063-B52","doi-asserted-by":"publisher","first-page":"e0145844","DOI":"10.1371\/journal.pone.0145844","article-title":"Cranberry flavonoids modulate cariogenic properties of mixed-species biofilm through exopolysaccharides-matrix disruption","volume":"10","author":"Kim","year":"2015","journal-title":"Plos One"},{"key":"2024021208100309600_nuad063-B53","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1159\/000088901","article-title":"Influence of cranberry juice on glucan-mediated processes involved in Streptococcus mutans biofilm development","volume":"40","author":"Koo","year":"2006","journal-title":"Caries Res"},{"key":"2024021208100309600_nuad063-B54","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1159\/000296306","article-title":"Influence of cranberry proanthocyanidins on formation of biofilms by Streptococcus mutans on saliva-coated apatitic surface and on dental caries development in vivo","volume":"44","author":"Koo","year":"2010","journal-title":"Caries Res"},{"key":"2024021208100309600_nuad063-B55","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1590\/s0100-204x2016000700068","article-title":"Formation pathways, stability and chemical characteristics of soil aggregates in agroecological management systems","volume":"51","author":"Rossi","year":"2016","journal-title":"Pesq Agropec Bras"},{"key":"2024021208100309600_nuad063-B56","doi-asserted-by":"publisher","first-page":"454","DOI":"10.3389\/fgene.2019.00454","article-title":"Multi-omic analysis of the microbiome and metabolome in healthy subjects reveals microbiome-dependent relationships between diet and metabolites","volume":"10","author":"Tang","year":"2019","journal-title":"Front Genet"},{"key":"2024021208100309600_nuad063-B57","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1016\/j.ijbiomac.2018.06.189","article-title":"Study on interaction between human salivary \u03b1-amylase and sorghum procyanidin tetramer: binding characteristics and structural analysis","volume":"118","author":"Zhao","year":"2018","journal-title":"Int J Biol Macromol"},{"key":"2024021208100309600_nuad063-B58","doi-asserted-by":"publisher","first-page":"308","DOI":"10.3389\/fphys.2013.00308","article-title":"Dentin matrix degradation by host matrix metalloproteinases: inhibition and clinical perspectives toward regeneration","volume":"4","author":"Chaussain","year":"2013","journal-title":"Front Physiol"},{"key":"2024021208100309600_nuad063-B59","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1177\/10454411930040030701","article-title":"Salivary alpha-amylase: role in dental plaque and caries formation","volume":"4","author":"Scannapieco","year":"1993","journal-title":"Crit Rev Oral Biol Med"},{"key":"2024021208100309600_nuad063-B60","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/0003-9969(95)00129-8","article-title":"Interactions of streptococcal glucosyltransferases with alpha-amylase and starch on the surface of saliva-coated hydroxyapatite","volume":"41","author":"Vacca-Smith","year":"1996","journal-title":"Arch Oral Biol"},{"key":"2024021208100309600_nuad063-B61","doi-asserted-by":"publisher","first-page":"108999","DOI":"10.1016\/j.biopha.2019.108999","article-title":"Proanthocyanidins: a comprehensive review","volume":"116","author":"Rauf","year":"2019","journal-title":"Biomed Pharmacother"},{"key":"2024021208100309600_nuad063-B62","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1080\/10408390802145377","article-title":"Phytochemicals of cranberries and cranberry products: characterization, potential health effects, and processing stability","volume":"49","author":"Pappas","year":"2009","journal-title":"Crit Rev Food Sci Nutr"},{"key":"2024021208100309600_nuad063-B63","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1021\/jf034970s","article-title":"Characterization of flavonols in cranberry (Vaccinium macrocarpon) powder","volume":"52","author":"Vvedenskaya","year":"2004","journal-title":"J Agric Food Chem"},{"key":"2024021208100309600_nuad063-B64","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1021\/jf8024979","article-title":"Antilisterial activities of polyphenol-rich extracts of grapes and vinification byproducts","volume":"57","author":"Anastasiadi","year":"2009","journal-title":"J Agric Food Chem"},{"key":"2024021208100309600_nuad063-B65","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1111\/j.1399-302X.2008.00441.x","article-title":"Effect of antiplaque compounds and mouthrinses on the activity of glucosyltransferases from Streptococcus sobrinus and insoluble glucan production","volume":"23","author":"Furiga","year":"2008","journal-title":"Oral Microbiol Immunol"},{"key":"2024021208100309600_nuad063-B66","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1159\/000104791","article-title":"The antibacterial activity of plant extracts containing polyphenols against Streptococcus mutans","volume":"41","author":"Smullen","year":"2007","journal-title":"Caries Res"},{"key":"2024021208100309600_nuad063-B67","doi-asserted-by":"publisher","first-page":"2403","DOI":"10.1007\/s10856-011-4430-4","article-title":"The effect of transient proanthocyanidins preconditioning on the cross-linking and mechanical properties of demineralized dentin","volume":"22","author":"Liu","year":"2011","journal-title":"J Mater Sci Mater Med"},{"key":"2024021208100309600_nuad063-B68","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1002\/jbm.a.10460","article-title":"Proanthocyanidin: a natural crosslinking reagent for stabilizing collagen matrices","volume":"65","author":"Han","year":"2003","journal-title":"J Biomed Mater Res A"},{"key":"2024021208100309600_nuad063-B69","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1016\/j.dental.2010.06.001","article-title":"Mechanical characterization of proanthocyanidin\u2013dentin matrix interaction","volume":"26","author":"Castellan","year":"2010","journal-title":"Dent Mater"},{"key":"2024021208100309600_nuad063-B70","doi-asserted-by":"publisher","first-page":"1875","DOI":"10.1902\/jop.2009.090251","article-title":"Grape seed extract suppresses lipopolysaccharide-induced matrix metalloproteinase (MMP) secretion by macrophages and inhibits human MMP-1 and -9 activities","volume":"80","author":"La","year":"2009","journal-title":"J Periodontol"},{"key":"2024021208100309600_nuad063-B71","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.arr.2012.01.006","article-title":"Natural polyphenols against neurodegenerative disorders: potentials and pitfalls","volume":"11","author":"Ebrahimi","year":"2012","journal-title":"Ageing Res Rev"},{"key":"2024021208100309600_nuad063-B72","doi-asserted-by":"publisher","first-page":"2101","DOI":"10.1021\/jf990489j","article-title":"Effect of pH on the stability of plant phenolic compounds","volume":"48","author":"Friedman","year":"2000","journal-title":"J Agric Food Chem"},{"key":"2024021208100309600_nuad063-B73","doi-asserted-by":"publisher","first-page":"10815","DOI":"10.1021\/jf302939p","article-title":"Oxidative stability of (\u2013)-epigallocatechin gallate in the presence of thiols","volume":"60","author":"Unnadkat","year":"2012","journal-title":"J Agric Food Chem"},{"key":"2024021208100309600_nuad063-B74","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1128\/iai.53.2.331-338.1986","article-title":"Acid tolerance, proton permeabilities, and membrane ATPases of oral streptococci","volume":"53","author":"Bender","year":"1986","journal-title":"Infect Immun"},{"key":"2024021208100309600_nuad063-B75","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1177\/154411130201300203","article-title":"Do we need to be concerned about dental caries in the coming millennium?","volume":"13","author":"Bowen","year":"2002","journal-title":"Crit Rev Oral Biol Med"},{"key":"2024021208100309600_nuad063-B76","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/s0065-2911(00)42004-7","article-title":"Adaptation of oral streptococci to low pH","volume":"42","author":"Quivey","year":"2000","journal-title":"Adv Microb Physiol"},{"key":"2024021208100309600_nuad063-B77","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1111\/j.0902-0055.2004.00130.x","article-title":"Inhibitory effects of cranberry juice on attachment of oral streptococci and biofilm formation","volume":"19","author":"Yamanaka","year":"2004","journal-title":"Oral Microbiol Immunol"},{"key":"2024021208100309600_nuad063-B78","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1093\/jac\/dkh254","article-title":"Effect of a high-molecular-weight component of cranberry on constituents of dental biofilm","volume":"54","author":"Steinberg","year":"2004","journal-title":"J Antimicrob Chemother"},{"key":"2024021208100309600_nuad063-B79","doi-asserted-by":"publisher","first-page":"7069","DOI":"10.1021\/jf061058l","article-title":"Cranberry phytochemicals: isolation, structure elucidation, and their antiproliferative and antioxidant activities","volume":"54","author":"He","year":"2006","journal-title":"J Agric Food Chem"},{"key":"2024021208100309600_nuad063-B80","doi-asserted-by":"publisher","first-page":"2287","DOI":"10.1128\/aem.58.7.2287-2291.1992","article-title":"Comparative acid tolerances and inhibitor sensitivities of isolated F-ATPases of oral lactic acid bacteria","volume":"58","author":"Sturr","year":"1992","journal-title":"Appl Environ Microbiol"},{"key":"2024021208100309600_nuad063-B81","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1139\/m95-108","article-title":"Weak acid effects and fluoride inhibition of glycolysis by Streptococcus mutans GS-5","volume":"41","author":"Belli","year":"1995","journal-title":"Can J Microbiol"}],"container-title":["Nutrition Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/nutritionreviews\/article-pdf\/82\/3\/302\/56644104\/nuad063.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nutritionreviews\/article-pdf\/82\/3\/302\/56644104\/nuad063.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T03:10:20Z","timestamp":1707707420000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nutritionreviews\/article\/82\/3\/302\/7205925"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,23]]},"references-count":81,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,6,23]]},"published-print":{"date-parts":[[2024,2,12]]}},"URL":"https:\/\/doi.org\/10.1093\/nutrit\/nuad063","relation":{},"ISSN":["0029-6643","1753-4887"],"issn-type":[{"value":"0029-6643","type":"print"},{"value":"1753-4887","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,3,1]]},"published":{"date-parts":[[2023,6,23]]}}}