{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:11:20Z","timestamp":1790964680801,"version":"4.1.0"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T00:00:00Z","timestamp":1690329600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Although some research suggests that vitamin B12 (hereafter, B12) supplements can lower homocysteine (Hcy) levels and treat hyperhomocysteinemia, these results are still ambiguous when B12 is taken as an isolated supplement.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This study sought to determine how existing randomized controlled trials (RCTs) could be used to examine the effects of B12 supplementation on Hcy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Data Sources<\/jats:title>\n                  <jats:p>To find pertinent RCTs up to June 2022, databases, including PubMed\/Medline, Web of Science, Scopus, Cochrane Library, and Embase, were searched.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Data Extraction<\/jats:title>\n                  <jats:p>All selected RCTs investigated the impact of B12 supplements on Hcy. A meta-analysis of the eligible studies was performed using the random-effects model.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Data Analysis<\/jats:title>\n                  <jats:p>This review included a total of 21 RCTs (N = 1625 participants). Hcy levels were significantly lower after B12 supplementation compared with the control group (pooled weighted mean difference, \u20134.15\u2009\u03bcmol\/L; 95% confidence interval, \u20134.86, \u20133.45; P\u2009&amp;lt;\u20090.001), and this reduction was even greater with intervention durations \u226512\u2009weeks and doses &amp;gt;500\u2009\u00b5g\/d. Furthermore, the effect of B12 supplementation in the form of hydroxocobalamin on the reduction of Hcy level was greater compared with other forms.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In conclusion, this meta-analysis shows that B12 supplementation has a positive impact on lowering blood Hcy levels, particularly when administered for a longer period and at a larger dose.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Systematic Review Registration<\/jats:title>\n                  <jats:p>PROSPERO registration no. CRD42022364066<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/nutrit\/nuad091","type":"journal-article","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T23:20:29Z","timestamp":1690413629000},"page":"726-737","source":"Crossref","is-referenced-by-count":15,"title":["A comprehensive review and meta-regression analysis of randomized controlled trials examining the impact of vitamin B12 supplementation on homocysteine levels"],"prefix":"10.1093","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6723-7112","authenticated-orcid":false,"given":"Mohammad Hassan","family":"Sohouli","sequence":"first","affiliation":[{"name":"Student Research Committee, Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences , Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal","family":"Almuqayyid","sequence":"additional","affiliation":[{"name":"College of Medicine, Alfaisal University , Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Alfardous Alazm","sequence":"additional","affiliation":[{"name":"College of Medicine, Alfaisal University , Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fateme","family":"Ziamanesh","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Hepatology Research Center, Pediatrics Centre of Excellence, Children\u2019s Medical Center, Tehran University of Medical Sciences , Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elma","family":"Izze da Silva Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Food, Nutrition and Health, Department of Clinical Nutrition and Dietetics, Federal University of Rio Grande do Sul ,S\u00e3o Lu\u00eds, MA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyedeh Elaheh","family":"Bagheri","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Tehran University of Medical Sciences , Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Rodrigues de Oliveira","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Food, Nutrition and Health, Department of Clinical Nutrition and Dietetics, Federal University of Rio Grande do Sul ,S\u00e3o Lu\u00eds, MA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Alfardous Alazm","sequence":"additional","affiliation":[{"name":"University of Medical Sciences and Technology , Khartoum, Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul Rahman","family":"Adi","sequence":"additional","affiliation":[{"name":"College of Medicine, Alfaisal University , Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Alomar","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, King Saud University Medical City , Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Abu-Zaid","sequence":"additional","affiliation":[{"name":"College of Medicine, Alfaisal University , Riyadh, Saudi Arabia"},{"name":"College of Graduate Health Sciences, University of Tennessee Health Science Center , Memphis, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,7,26]]},"reference":[{"key":"2024051007514727700_nuad091-B1","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/3-540-27661-0_11","volume-title":"Atherosclerosis: Diet and Drugs. 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