{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:30:34Z","timestamp":1787009434343,"version":"build-2736575974"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T00:00:00Z","timestamp":1694131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Scientific Foundation of China","doi-asserted-by":"crossref","award":["82003400"],"award-info":[{"award-number":["82003400"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Science and Technology Program of Henan Province","award":["232102311079"],"award-info":[{"award-number":["232102311079"]}]},{"name":"Science and Technology Program of Henan Province","award":["212102310622"],"award-info":[{"award-number":["212102310622"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Coronavirus disease 2019 (COVID-19) could induce the\u00a0\u201ccytokine storm\u201d due to overactivation of immune system and accompanied by acute respiratory distress syndrome as a serious complication. Vitamin\u2009C has been effective in improving lung function of patients by reducing inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim was to explore the therapeutic effects of high-dose vitamin\u2009C supplementation for patients with COVID-19 using meta-analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources<\/jats:title>\n                    <jats:p>Published studies were searched from PubMed, Cochrane Library, Web of Science, EMBASE, and China National Knowledge Infrastructure databases up to August 2022 using the terms \u201cvitamin\u2009C\u201d and \u201cCOVID-19\u201d. Data analyses were performed independently by 2 researchers using the PRISMA guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Extraction<\/jats:title>\n                    <jats:p>Heterogeneity between the included studies was assessed using I2 statistics. When I2 \u226550%, the random-effects model was used; otherwise, a fixed-effects model was applied. Stata 14.0 software was used to pool data by standardized mean differences (SMDs) with 95% CIs or odds ratios (ORs) with 95% CIs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Analysis<\/jats:title>\n                    <jats:p>The 14 studies had a total of 751 patients and 1583 control participants in 7 randomized controlled trials and 7 retrospective studies. The vitamin\u2009C supplement significantly increased ferritin (SMD\u2009=\u20090.272; 95% CI: 0.059 to 0.485; P\u2009=\u20090.012) and lymphocyte count levels (SMD\u2009=\u20090.376; 95% CI: 0.153 to 0.599; P\u2009=\u20090.001) in patients with COVID-19. Patients administered vitamin\u2009C in the length of intensive care unit staying (SMD\u2009=\u20090.226; 95% CI: 0.073 to 0.379; P\u2009=\u20090.004). Intake of vitamin\u2009C prominently alleviate disease aggravation (OR\u2009=\u20090.344, 95%CI: 0.135 to 0.873, P\u2009=\u20090.025).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>High-dose vitamin\u2009C supplementation can alleviate inflammatory response and hinder the aggravation of COVID-19.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/nutrit\/nuad105","type":"journal-article","created":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T17:03:30Z","timestamp":1692291810000},"page":"1056-1068","source":"Crossref","is-referenced-by-count":10,"title":["Therapeutic effects of high-dose vitamin C supplementation in patients with COVID-19: a meta-analysis"],"prefix":"10.1093","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6134-1592","authenticated-orcid":false,"given":"Lei","family":"Sun","sequence":"first","affiliation":[{"name":"Department 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