{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:30:41Z","timestamp":1787009441598,"version":"build-2736575974"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T00:00:00Z","timestamp":1695859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Frederick Banting and Charles Best Canada Graduate Scholarship Doctoral"},{"DOI":"10.13039\/501100000024","name":"Canadian Institute of Health Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000245","name":"Michael Smith Foundation for Health Research Scholar","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000245","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Canada Research Chair in Micronutrients and Human Health"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Polycystic ovary syndrome (PCOS) is a common and complex endocrine disorder in women of reproductive age. Vitamin\u2009D supplementation is a promising complementary therapy for PCOS, yet there is no consensus on an optimal dose, leading to a lack of evidence-based supplementation guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of this study was to conduct a vitamin\u2009D dose\u2013response meta-analysis among women with PCOS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data sources<\/jats:title>\n                    <jats:p>MEDLINE, CINAHL, and EMBASE databases from inception to November 2022 were searched for relevant articles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data extraction<\/jats:title>\n                    <jats:p>Study screening and bias assessment were conducted by 2 independent reviewers. Eight relevant studies were identified; data for serum 25(OH)D (nmol\/L) at baseline and at 12\u2009weeks in each intervention group (mean \u00b1 SD) and vitamin\u2009D dose were extracted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data analysis<\/jats:title>\n                    <jats:p>Estimates across studies were used to create a pooled curve, using restricted cubic splines with knots at the 10th, 50th, and 90th percentiles of the distribution of doses, to estimate the mean difference in effect for serum 25(OH)D at each dose compared with 0\u2009IU\/day. Sensitivity analyses were conducted fixing knots at 4000\u2009IU\/day and 7000\u2009IU\/day, which were a priori identified as potentially important thresholds, and to assess model fit and estimate heterogeneity. The pooled analysis demonstrated strong evidence of a dose\u2013response relationship (P\u2009&amp;lt;\u2009.001), suggesting an increasing effect with increasing dose. An initial increase in serum 25(OH)D was evident until doses of approximately 3000\u2009IU\/day; this was followed by a plateau in effect between approximately 3000\u2009IU\/day and 5000\u2009IU\/day. The effect of supplementation with &amp;gt;5000\u2009IU\/day was unclear, given the minimal data at higher doses. The curve produced robust results for moderate doses (3000\u2009IU\/day to 4000\u2009IU\/day), which were not sensitive to model specification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Women with PCOS are responsive to vitamin\u2009D supplementation, but the benefit of providing doses of &amp;gt;3000\u2009IU\/day appears minimal. Further data is required to determine dose\u2013response at doses of &amp;gt;5000\u2009IU\/day, and whether higher intakes provide a clinically meaningful advantage in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic Review Registration<\/jats:title>\n                    <jats:p>PROSPERO registration no. CRD42021259396.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/nutrit\/nuad117","type":"journal-article","created":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T13:37:14Z","timestamp":1693748234000},"page":"1176-1186","source":"Crossref","is-referenced-by-count":7,"title":["Optimizing vitamin D status in polycystic ovary syndrome: a systematic review and dose\u2013response meta-analysis"],"prefix":"10.1093","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5628-2850","authenticated-orcid":false,"given":"Kelsey M","family":"Cochrane","sequence":"first","affiliation":[{"name":"Food, Nutrition and Health, Faculty of Land and Food Systems, The University of British Columbia , Vancouver, BC, Canada"},{"name":"BC Children\u2019s Hospital Research Institute, The University of British Columbia , Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7704-1677","authenticated-orcid":false,"given":"Jeffrey N","family":"Bone","sequence":"additional","affiliation":[{"name":"BC Children\u2019s Hospital Research Institute, The University of British Columbia , Vancouver, BC, Canada"},{"name":"Department of Obstetrics and Gynaecology, Faculty of Medicine, The University of British Columbia , Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brock A","family":"Williams","sequence":"additional","affiliation":[{"name":"Food, Nutrition and Health, Faculty of Land and Food Systems, The University of British Columbia , Vancouver, BC, Canada"},{"name":"BC Children\u2019s Hospital Research Institute, The University of British Columbia , Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1025-2194","authenticated-orcid":false,"given":"Crystal 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