{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T20:58:59Z","timestamp":1782766739305,"version":"3.54.5"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["202040090"],"award-info":[{"award-number":["202040090"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Previous research evaluating the effects in B-vitamins on the prevention and treatment of cardiovascular disease (CVD) has substantial limitations and lacks recently published large prospective studies; hence, conducting an updated meta-analysis is needed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We investigated the association between vitamin\u2009B status and human CVD development in order to provide more specific advice about vitamin\u2009B intake for those at risk of CVD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Data Sources<\/jats:title>\n                  <jats:p>Relevant articles were identified by JSTOR, PubMed, and ProQuest databases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Data Extraction<\/jats:title>\n                  <jats:p>Key words used to identify the studies included the different combinations of B-vitamins, folate, folic acid, vitamin B6, vitamin B12, homocysteine, cardiovascular disease, stroke, coronary disease, myocardial infarction, and cerebrovascular and transient ischemic attack. The database search was supplemented by hand-searching of reference lists of selected articles.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Data Analysis<\/jats:title>\n                  <jats:p>Pooled estimates were calculated from the mean differences using a random-effects model.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Supplementation with folic acid was reported to have a clinical benefit of significantly reducing carotid intima-media thickness. Higher intakes of folic acid, vitamin B6, and vitamin B12 were generally associated with a lower risk of CVD in the general population, except in those without normal renal function and those with unstable angina or past non\u2013ST-elevation myocardial infarction.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Vitamin\u2009B supplementation resulted in the greatest cardiovascular benefit in those with normal renal function and without unstable angina or non\u2013ST-elevation myocardial infarction recently. Factors such as age, gender, and genetic polymorphisms contribute to varying effects.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/nutrit\/nuad127","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T08:17:36Z","timestamp":1697617056000},"page":"1386-1401","source":"Crossref","is-referenced-by-count":24,"title":["The effect of B-vitamins on the prevention and treatment of cardiovascular diseases: a systematic review and meta-analysis"],"prefix":"10.1093","volume":"82","author":[{"given":"Ya","family":"Miao","sequence":"first","affiliation":[{"name":"Department of Geriatrics, Shanghai Sixth People's Hospital Affiliated with Shanghai Jiao Tong University School of Medicine , Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihan","family":"Guo","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, The University of Queensland , Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8852-2572","authenticated-orcid":false,"given":"Yixin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Shanghai Sixth People's Hospital Affiliated with Shanghai Jiao Tong University School of Medicine , Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijia","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Shanghai Sixth People's Hospital Affiliated with Shanghai Jiao Tong University School of Medicine , Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Shanghai Sixth People's Hospital Affiliated with Shanghai Jiao Tong University School of Medicine , Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihao","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Shanghai Sixth People's Hospital Affiliated with Shanghai Jiao Tong University School of Medicine , Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,10,17]]},"reference":[{"key":"2024091007533556500_nuad127-B1","doi-asserted-by":"publisher","first-page":"68","DOI":"10.3390\/nu8020068","article-title":"B vitamins and the brain: mechanisms, dose and efficacy\u2014a review","volume":"8","author":"Kennedy","year":"2016","journal-title":"Nutrients"},{"key":"2024091007533556500_nuad127-B2","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1007\/s12603-015-0650-5","article-title":"Hyperhomocysteinemia is associated with vitamin B-12 deficiency: a cross-sectional study in a rural, elderly population of Shanxi China","volume":"20","author":"Zhang","year":"2016","journal-title":"J Nutr Health Aging"},{"key":"2024091007533556500_nuad127-B3","first-page":"7","article-title":"Vitamin B6 status, deficiency and its consequences\u2014an overview","volume":"22","author":"Spinneker","year":"2007","journal-title":"Nutr Hosp"},{"key":"2024091007533556500_nuad127-B4","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1001\/jama.279.5.359","article-title":"Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women","volume":"279","author":"Rimm","year":"1998","journal-title":"JAMA"},{"key":"2024091007533556500_nuad127-B5","doi-asserted-by":"publisher","first-page":"2442","DOI":"10.1161\/hc4501.098925","article-title":"Low plasma levels of vitamin B(6) are independently associated with a heightened risk of deep-vein thrombosis","volume":"104","author":"Cattaneo","year":"2001","journal-title":"Circulation"},{"key":"2024091007533556500_nuad127-B6","doi-asserted-by":"publisher","first-page":"2674","DOI":"10.1161\/01.cir.103.22.2674","article-title":"Low dietary folate intake is associated with an excess incidence of acute coronary events: the Kuopio Ischemic Heart Disease Risk Factor Study","volume":"103","author":"Voutilainen","year":"2001","journal-title":"Circulation"},{"key":"2024091007533556500_nuad127-B7","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1161\/01.STR.0000106762.55994.86","article-title":"Folate, vitamin B6, and B12 intakes in relation to risk of stroke among men","volume":"35","author":"He","year":"2004","journal-title":"Stroke"},{"key":"2024091007533556500_nuad127-B8","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.numecd.2005.01.001","article-title":"Dietary and serum vitamins and minerals as predictors of myocardial infarction and stroke in elderly subjects","volume":"15","author":"Marniemi","year":"2005","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"2024091007533556500_nuad127-B9","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1093\/jn\/137.2.407","article-title":"High prevalence of hyperhomocysteinemia in Chinese adults is associated with low folate, vitamin B-12, and vitamin B-6 status","volume":"137","author":"Hao","year":"2007","journal-title":"J Nutr"},{"key":"2024091007533556500_nuad127-B10","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1080\/07315724.2008.10719684","article-title":"Intake of folate, vitamin B6 and vitamin B12 and the risk of CHD: the Japan Public Health Center-Based Prospective Study Cohort I","volume":"27","author":"Ishihara","year":"2008","journal-title":"J Am Coll Nutr"},{"key":"2024091007533556500_nuad127-B11","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1161\/STROKEAHA.110.578906","article-title":"Dietary folate and vitamin B6 and B12 intake in relation to mortality from cardiovascular diseases: Japan Collaborative Cohort Study","volume":"41","author":"Cui","year":"2010","journal-title":"Stroke"},{"key":"2024091007533556500_nuad127-B12","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.dsx.2016.06.013","article-title":"Nutritional factors and metabolic variables in relation to the risk of coronary heart disease: a case control study in Armenian adults","volume":"11","author":"Fazeli Moghadam","year":"2017","journal-title":"Diabetes Metab Syndr"},{"key":"2024091007533556500_nuad127-B13","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1016\/j.clnu.2018.04.016","article-title":"Prospective cohort studies of dietary vitamin B6 intake and risk of cause-specific mortality","volume":"38","author":"Zhao","year":"2019","journal-title":"Clin Nutr"},{"key":"2024091007533556500_nuad127-B14","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.3390\/nu11071484","article-title":"Dietary vitamin B(6) intake associated with a decreased risk of cardiovascular disease: a prospective cohort study","volume":"11","author":"Jeon","year":"2019","journal-title":"Nutrients"},{"key":"2024091007533556500_nuad127-B15","doi-asserted-by":"publisher","first-page":"4149","DOI":"10.1007\/s12325-020-01474-z","article-title":"Folic acid supplementation in patients with elevated homocysteine levels","volume":"37","author":"Kaye","year":"2020","journal-title":"Adv Ther"},{"key":"2024091007533556500_nuad127-B16","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1681\/ASN.V1161106","article-title":"Effect of high dose folic acid therapy on hyperhomocysteinemia in hemodialysis patients: results of the Vienna Multicenter Study","volume":"11","author":"Sunder-Plassmann","year":"2000","journal-title":"J Am Soc Nephrol"},{"key":"2024091007533556500_nuad127-B17","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1161\/01.str.0000014607.90464.88","article-title":"Dietary intake of folate and risk of stroke in US men and women: NHANES I Epidemiologic Follow-up Study. National Health and Nutrition Examination Survey","volume":"33","author":"Bazzano","year":"2002","journal-title":"Stroke"},{"key":"2024091007533556500_nuad127-B18","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1097\/00001648-200211000-00015","article-title":"Dietary folate and the risk of nonfatal myocardial infarction","volume":"13","author":"Hern\u00e1ndez-D\u00edaz","year":"2002","journal-title":"Epidemiology"},{"key":"2024091007533556500_nuad127-B19","first-page":"PI19","article-title":"Effects of folic acid treatment on homocysteine levels and vascular disease in hemodialysis patients","volume":"9","author":"Righetti","year":"2003","journal-title":"Med Sci Monit Int Med J Exp Clin Res"},{"key":"2024091007533556500_nuad127-B20","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1079\/phn2005863","article-title":"Dietary intake of folate equivalents and risk of myocardial infarction in the European Prospective Investigation into Cancer and Nutrition (EPIC)\u2013Potsdam study","volume":"9","author":"Drogan","year":"2006","journal-title":"Public Health Nutr"},{"key":"2024091007533556500_nuad127-B21","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1016\/j.jacc.2005.10.064","article-title":"Cardiovascular morbidity and mortality in the Atherosclerosis and Folic Acid Supplementation Trial (ASFAST) in chronic renal failure: a multicenter, randomized, controlled trial","volume":"47","author":"Zoungas","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"2024091007533556500_nuad127-B22","doi-asserted-by":"publisher","first-page":"941","DOI":"10.3945\/ajcn.110.006429","article-title":"Effect of 3 y of folic acid supplementation on the progression of carotid intima-media thickness and carotid arterial stiffness in older adults","volume":"93","author":"Durga","year":"2011","journal-title":"Am J Clin Nutr"},{"key":"2024091007533556500_nuad127-B23","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.ijcard.2006.07.031","article-title":"Effect of folic acid treatment on carotid intima-media thickness of patients with coronary disease","volume":"118","author":"Fern\u00e1ndez-Miranda","year":"2007","journal-title":"Int J Cardiol"},{"key":"2024091007533556500_nuad127-B24","doi-asserted-by":"publisher","first-page":"2262","DOI":"10.1161\/CIRCULATIONAHA.106.679084","article-title":"Global improvement of vascular function and redox state with low-dose folic acid: implications for folate therapy in patients with coronary artery disease","volume":"115","author":"Shirodaria","year":"2007","journal-title":"Circulation"},{"key":"2024091007533556500_nuad127-B25","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1111\/j.1542-4758.2007.00171.x","article-title":"Uremic hyperhomocysteinemia: a randomized trial of folate treatment for the prevention of cardiovascular events","volume":"11","author":"Vianna","year":"2007","journal-title":"Hemodial Int"},{"key":"2024091007533556500_nuad127-B26","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1038\/sj.ejcn.1602725","article-title":"Prospective study on dietary intakes of folate, betaine, and choline and cardiovascular disease risk in women","volume":"62","author":"Dalmeijer","year":"2008","journal-title":"Eur J Clin Nutr"},{"key":"2024091007533556500_nuad127-B27","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1111\/j.1365-2796.2009.02077.x","article-title":"Plasma folate and total homocysteine levels are associated with the risk of myocardial infarction, independently of each other and of renal function","volume":"266","author":"Van Guelpen","year":"2009","journal-title":"J Intern Med"},{"key":"2024091007533556500_nuad127-B28","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.ijcard.2009.01.023","article-title":"The effect of folic acid supplementation on carotid intima-media thickness in patients with cardiovascular risk: a randomized, placebo-controlled trial","volume":"143","author":"Ntaios","year":"2010","journal-title":"Int J Cardiol"},{"key":"2024091007533556500_nuad127-B29","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1016\/j.annepidem.2011.08.007","article-title":"Interaction of folate intake and the paraoxonase Q192R polymorphism with risk of incident coronary heart disease and ischemic stroke: the Atherosclerosis Risk in Communities Study","volume":"21","author":"Luu","year":"2011","journal-title":"Ann Epidemiol"},{"key":"2024091007533556500_nuad127-B30","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1001\/jama.2015.2274","article-title":"Efficacy of folic acid therapy in primary prevention of stroke among adults with hypertension in China: the CSPPT randomized clinical trial","volume":"313","author":"Huo","year":"2015","journal-title":"JAMA"},{"key":"2024091007533556500_nuad127-B31","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.01.044","article-title":"B-vitamin serum concentrations predicting long-term overall and stroke-free survival after carotid endarterectomy","volume":"25","author":"Duschek","year":"2016","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"2024091007533556500_nuad127-B32","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1159\/000448295","article-title":"The effects of folate supplementation on carotid intima-media thickness and metabolic status in patients with metabolic syndrome","volume":"69","author":"Talari","year":"2016","journal-title":"Ann Nutr Metab"},{"key":"2024091007533556500_nuad127-B33","doi-asserted-by":"publisher","first-page":"470","DOI":"10.4103\/1673-5374.291381","article-title":"Role of vitamin B12 deficiency in ischemic stroke risk and outcome","volume":"16","author":"Yahn","year":"2021","journal-title":"Neural Regen Res"},{"key":"2024091007533556500_nuad127-B34","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1001\/jama.288.8.973","article-title":"Effect of homocysteine-lowering therapy with folic acid, vitamin B12, and vitamin B6 on clinical outcome after percutaneous coronary intervention: the Swiss Heart Study: a randomized controlled trial","volume":"288","author":"Schnyder","year":"2002","journal-title":"JAMA"},{"key":"2024091007533556500_nuad127-B35","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1097\/01.TP.0000058810.59825.58","article-title":"Vitamin supplementation reduces the progression of atherosclerosis in hyperhomocysteinemic renal-transplant recipients","volume":"75","author":"Marcucci","year":"2003","journal-title":"Transplantation"},{"key":"2024091007533556500_nuad127-B36","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.atherosclerosis.2004.12.043","article-title":"Decrease of carotid intima-media thickness in patients at risk to cerebral ischemia after supplementation with folic acid, vitamins B6 and B12","volume":"181","author":"Till","year":"2005","journal-title":"Atherosclerosis"},{"key":"2024091007533556500_nuad127-B37","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1056\/NEJMoa055227","article-title":"Homocysteine lowering and cardiovascular events after acute myocardial infarction","volume":"354","author":"B\u00f8naa","year":"2006","journal-title":"N Engl J Med"},{"key":"2024091007533556500_nuad127-B38","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/s0828-282x(06)70238-0","article-title":"Rationale, design and baseline characteristics of a large, simple, randomized trial of combined folic acid and vitamins B6 and B12 in high-risk patients: the Heart Outcomes Prevention Evaluation (HOPE)-2 trial","volume":"22","author":"Lonn","year":"2006","journal-title":"Can J Cardiol"},{"key":"2024091007533556500_nuad127-B39","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1001\/jama.298.10.1163","article-title":"Effect of homocysteine lowering on mortality and vascular disease in advanced chronic kidney disease and end-stage renal disease: a randomized controlled trial","volume":"298","author":"Jamison","year":"2007","journal-title":"JAMA"},{"key":"2024091007533556500_nuad127-B40","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1038\/sj.ejcn.1602606","article-title":"B-group vitamins, MTHFR C677T polymorphism and carotid intima-media thickness in clinically healthy subjects","volume":"61","author":"Liu","year":"2007","journal-title":"Eur J Clin Nutr"},{"key":"2024091007533556500_nuad127-B41","doi-asserted-by":"publisher","first-page":"2027","DOI":"10.1001\/jama.299.17.2027","article-title":"Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease: a randomized trial","volume":"299","author":"Albert","year":"2008","journal-title":"JAMA"},{"key":"2024091007533556500_nuad127-B42","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/1471-2261-8-24","article-title":"The effect of long-term homocysteine-lowering on carotid intima-media thickness and flow-mediated vasodilation in stroke patients: a randomized controlled trial and meta-analysis","volume":"8","author":"Potter","year":"2008","journal-title":"BMC Cardiovasc Disord"},{"key":"2024091007533556500_nuad127-B43","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1177\/0218492309102494","article-title":"Folic acid-based intervention in non-ST elevation acute coronary syndromes","volume":"17","author":"Imasa","year":"2009","journal-title":"Asian Cardiovasc Thorac Ann"},{"key":"2024091007533556500_nuad127-B44","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1161\/STROKEAHA.108.526798","article-title":"High-dose B vitamin supplementation and progression of subclinical atherosclerosis: a randomized controlled trial","volume":"40","author":"Hodis","year":"2009","journal-title":"Stroke"},{"key":"2024091007533556500_nuad127-B45","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1161\/STROKEAHA.108.529503","article-title":"Homocysteine-lowering therapy and stroke risk, severity, and disability: additional findings from the HOPE 2 trial","volume":"40","author":"Saposnik","year":"2009","journal-title":"Stroke"},{"key":"2024091007533556500_nuad127-B46","doi-asserted-by":"publisher","first-page":"2486","DOI":"10.1001\/jama.2010.840","article-title":"Effects of homocysteine-lowering with folic acid plus vitamin B12 vs placebo on mortality and major morbidity in myocardial infarction survivors: a randomized trial","volume":"303","author":"Armitage","year":"2010","journal-title":"JAMA"},{"key":"2024091007533556500_nuad127-B47","doi-asserted-by":"publisher","first-page":"c6273","DOI":"10.1136\/bmj.c6273","article-title":"Effects of B vitamins and omega 3 fatty acids on cardiovascular diseases: a randomised placebo controlled trial","volume":"341","author":"Galan","year":"2010","journal-title":"BMJ."},{"key":"2024091007533556500_nuad127-B48","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1161\/CIRCULATIONAHA.109.904672","article-title":"B vitamins and the risk of total mortality and cardiovascular disease in end-stage renal disease: results of a randomized controlled trial","volume":"121","author":"Heinz","year":"2010","journal-title":"Circulation"},{"key":"2024091007533556500_nuad127-B49","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/S1474-4422(10)70187-3","article-title":"B vitamins in patients with recent transient ischaemic attack or stroke in the VITAmins TO Prevent Stroke (VITATOPS) trial: a randomised, double-blind, parallel, placebo-controlled trial","volume":"9","author":"VITATOPS Trial Study Group","year":"2010","journal-title":"Lancet Neurol"},{"key":"2024091007533556500_nuad127-B50","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1016\/S1474-4422(12)70091-1","article-title":"Antiplatelet therapy and the effects of B vitamins in patients with previous stroke or transient ischaemic attack: a post-hoc subanalysis of VITATOPS, a randomised, placebo-controlled trial","volume":"11","author":"Hankey","year":"2012","journal-title":"Lancet Neurol"},{"key":"2024091007533556500_nuad127-B51","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1159\/000360153","article-title":"Homocysteine-lowering therapy and risk of recurrent stroke, myocardial infarction and death: the impact of age in the VISP trial","volume":"37","author":"Towfighi","year":"2014","journal-title":"Cerebrovasc Dis"},{"key":"2024091007533556500_nuad127-B52","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1161\/STROKEAHA.114.006927","article-title":"Differential effect of B-vitamin therapy by antiplatelet use on risk of recurrent vascular events after stroke","volume":"46","author":"Arshi","year":"2015","journal-title":"Stroke"},{"key":"2024091007533556500_nuad127-B53","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.1097\/HJH.0000000000000647","article-title":"Effects of 2-year vitamin B12 and folic acid supplementation in hyperhomocysteinemic elderly on arterial stiffness and cardiovascular outcomes within the B-PROOF trial","volume":"33","author":"van Dijk","year":"2015","journal-title":"J Hypertens"},{"key":"2024091007533556500_nuad127-B54","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/j.numecd.2015.12.009","article-title":"B vitamin treatments modify the risk of myocardial infarction associated with a MTHFD1 polymorphism in patients with stable angina pectoris","volume":"26","author":"Ding","year":"2016","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"2024091007533556500_nuad127-B55","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.nutres.2023.04.007","article-title":"Daily folate consumption is associated with reduced all-cause and cardiovascular disease mortality among US adults with diabetes, prediabetes, or insulin resistance","volume":"114","author":"Liu","year":"2023","journal-title":"Nutr Res"}],"container-title":["Nutrition Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/nutritionreviews\/article-pdf\/82\/10\/1386\/59066810\/nuad127.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nutritionreviews\/article-pdf\/82\/10\/1386\/59066810\/nuad127.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T12:14:02Z","timestamp":1725970442000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nutritionreviews\/article\/82\/10\/1386\/7320271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,17]]},"references-count":55,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,10,17]]},"published-print":{"date-parts":[[2024,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/nutrit\/nuad127","relation":{},"ISSN":["0029-6643","1753-4887"],"issn-type":[{"value":"0029-6643","type":"print"},{"value":"1753-4887","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,10]]},"published":{"date-parts":[[2023,10,17]]}}}