{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T23:48:01Z","timestamp":1783381681657,"version":"3.54.6"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T00:00:00Z","timestamp":1712102400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Student Research Committee, Isfahan University of Medical Sciences","award":["1401364"],"award-info":[{"award-number":["1401364"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Several studies have investigated the relationship between serum vitamin\u2009D and dyslipidemia in children and adolescents, but the findings have been contradictory.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The current systematic review and dose\u2013response meta-analysis investigated the serum vitamin\u2009D \u2013 dyslipidemia relationship in children and adolescents.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Data Sources<\/jats:title>\n                  <jats:p>ISI Web of Science, Scopus, MEDLINE (PubMed), EMBASE databases, and Google Scholar, were searched up to December 2022.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Data Extraction<\/jats:title>\n                  <jats:p>Observational studies that investigated the odds of dyslipidemia in categories of serum vitamin\u2009D levels in children were included, and their data were extracted.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Data Analysis<\/jats:title>\n                  <jats:p>Pooling of 17 effect sizes from 15 studies (39\u2009342 participants) showed that subjects with higher serum vitamin\u2009D had 27% lower odds of hypertriglyceridemia (odds ratio [OR]\u2009=\u20090.73; 95% confidence interval [CI]: 0.60, 0.88). A meta-analysis of 18 effect sizes from 16 studies (39\u2009718 participants) illustrated that highest vs lowest serum vitamin\u2009D was related to 22% lower odds of low high-density lipoprotein cholesterol (HDL-c) (OR\u2009=\u20090.78; 95% CI: 0.66, 0.91). Also, a nonlinear association between serum vitamin\u2009D and odds of abnormal lipid profile was found: elevating values of 25-hydroxyvitamin D from 35\u2009nmol\/L to 55\u2009nmol\/L was associated with a decreasing trend in odds of hypertriglyceridemia, hyper low-density lipoprotein cholesterolemia, hypercholesterolemia, and hypo HDL-cholesterolemia. However, no significant linear association was observed. Based on the Grading of Recommendations, Assessment, Development and Evaluations (GRADE), the certainty of all evidence was rated as high.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This meta-analysis revealed that the level of 25-hydroxyvitamin D was inversely related to odds of abnormal serum triglycerides and HDL-c in children and adolescents. Increasing serum vitamin\u2009D from 35\u2009nmol\/L to 55\u2009nmol\/L was associated with a decreasing trend in the odds of abnormal serum triglycerides, HDL-c, low-density lipoprotein cholesterol, and total cholesterol in children.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Systematic Review Registration<\/jats:title>\n                  <jats:p>PROSPERO registration no. 42023400787.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/nutrit\/nuae020","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T18:34:43Z","timestamp":1712169283000},"page":"e88-e105","source":"Crossref","is-referenced-by-count":3,"title":["The association between serum vitamin D levels and abnormal lipid profile in pediatrics: A GRADE-assessed systematic review and dose\u2013response meta-analysis of epidemiologic 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Isfahan,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1194-9687","authenticated-orcid":false,"given":"Gholamreza","family":"Askari","sequence":"additional","affiliation":[{"name":"Department of Community Nutrition, School of Nutrition and Food Science, Nutrition and Food Security Research Center, Isfahan University of Medical Sciences , Isfahan,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4605-7833","authenticated-orcid":false,"given":"Parvane","family":"Saneei","sequence":"additional","affiliation":[{"name":"Department of Community Nutrition, School of Nutrition and Food Science, Nutrition and Food Security Research Center, Isfahan University of Medical Sciences , 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