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The fetus undergoes a crucial period of plasticity in the uterus; metabolic changes in the fetus during pregnancy caused by maternal nutrition not only influence fetal growth and development but also have a long-term or even life-long impact for the offspring. Epigenetic modifications, such as DNA methylation, histone modification, and non-coding RNAs, play important roles in intergenerational and transgenerational effects. In this context, this narrative review comprehensively summarizes and analyzes the molecular mechanisms underlying how maternal nutrition, including a high-fat diet, polyunsaturated fatty acid diet, methyl donor nutrient supplementation, feed restriction, and protein restriction during pregnancy, impacts the genes involved in glucolipid metabolism in the liver, adipose tissue, hypothalamus, muscle, and oocytes of the offspring in terms of the epigenetic modifications. This will provide a foundation for the further exploration of nutrigenetic and epigenetic mechanisms for integrative mother\u2013child nutrition and promotion of the offspring\u2019s health through the regulation of maternal nutrition during pregnancy. Note: This paper is part of the Nutrition Reviews Special Collection on Precision Nutrition.<\/jats:p>","DOI":"10.1093\/nutrit\/nuae048","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T14:32:02Z","timestamp":1713277922000},"page":"728-748","source":"Crossref","is-referenced-by-count":31,"title":["Nutrigenetic and Epigenetic Mechanisms of Maternal Nutrition\u2013Induced Glucolipid Metabolism Changes in the Offspring"],"prefix":"10.1093","volume":"83","author":[{"given":"Peng","family":"Jiao","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, Anhui Agricultural University , Hefei,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huizhen","family":"Lu","sequence":"additional","affiliation":[{"name":"Biotechnology Center, Anhui Agricultural University , Hefei,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhuang","family":"Hao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Plateau Grazing Animal Nutrition and Feed Science of Qinghai Province, Qinghai Plateau Yak Research Center, Qinghai Academy of Science and Veterinary Medicine of Qinghai University , Xining,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A Allan","family":"Degen","sequence":"additional","affiliation":[{"name":"Desert Animal Adaptations and Husbandry, Wyler Department of Dryland Agriculture, Blaustein Institutes for Desert Research, Ben-Gurion University of the Negev , Beer Sheva,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbo","family":"Cheng","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Anhui Agricultural University , Hefei,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongjun","family":"Yin","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Anhui Agricultural University , Hefei,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengyong","family":"Mao","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University , Nanjing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0257-3825","authenticated-orcid":false,"given":"Yanfeng","family":"Xue","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Anhui Agricultural University , 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