{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:31:56Z","timestamp":1772159516015,"version":"3.50.1"},"reference-count":66,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Students\u2019 Research Committee","award":["140223"],"award-info":[{"award-number":["140223"]}]},{"DOI":"10.13039\/501100003970","name":"Isfahan University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003970","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Although several investigations have been conducted on the association between serum vitamin\u2009D levels and prediabetes and type 2 diabetes mellitus (T2DM) in children and adolescents, their findings are inconsistent.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We conducted a systematic review and dose-response meta-analysis to summarize this subject.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Data Sources<\/jats:title>\n                  <jats:p>The electronic databases of ISI Web of Science, Scopus, PubMed, and motor engineering of Google Scholar were comprehensively searched up to May 2023.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Data Extraction<\/jats:title>\n                  <jats:p>Epidemiologic studies that investigated the risk of hyperglycemia and insulin resistance in relation to serum 25-hydroxy vitamin\u2009D levels in children and adolescents were included.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Data Analysis<\/jats:title>\n                  <jats:p>Twenty-two investigations, with a total of 38\u200a622 participants, were systematically reviewed. Meta-analysis of 15 studies (n\u2009=\u200932\u200a720 participants) showed that participants with the highest serum vitamin\u2009D levels had 42% lower risk of hyperglycemia, compared with those in the lowest category of serum vitamin\u2009D levels (relative risk [RR]\u2009=\u20090.58; 95%CI, 0.48, 0.71). Moreover, pooling 8 studies (n\u2009=\u200910\u200a465 participants) illustrated that highest serum vitamin\u2009D level was associated with a 44% lower risk of insulin resistance compared with the lowest serum vitamin\u2009D level (RR\u2009=\u20090.56; 95%CI, 0.37, 0.83). Based on linear dose-response analysis, each 10\u2009nmol\/L increment in serum 25-hydroxy vitamin\u2009D was associated with a 6% decreased risk of hyperglycemia and insulin resistance in children. Furthermore, nonlinear dose-response analysis revealed that increasing serum vitamin\u2009D concentration from 40\u2009nmol\/L to sufficient values (&amp;gt;50\u2009nmol\/L) was associated with a decreasing trend in risk of hyperglycemia and insulin resistance.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This meta-analysis revealed inverse associations between serum vitamin\u2009D levels and hyperglycemia and insulin resistance in children and adolescents, in a dose-response manner. Increasing serum vitamin\u2009D concentration from 40\u2009nmol\/L to sufficient values (&amp;gt;50\u2009nmol\/L) was associated with a decreasing trend in hyperglycemia and insulin resistance risk. Systematic Review Registration: PROSPERO registration no. CRD42023458155.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/nutrit\/nuae060","type":"journal-article","created":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T06:54:49Z","timestamp":1718780089000},"page":"344-359","source":"Crossref","is-referenced-by-count":2,"title":["Serum 25-Hydroxyvitamin D Is Associated With Prediabetes, Type 2 Diabetes Mellitus, and Insulin Resistance in Children: A Systematic Review and Dose-Response Meta-analysis of Epidemiologic Studies"],"prefix":"10.1093","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4312-0294","authenticated-orcid":false,"given":"Zahra","family":"Hajhashemy","sequence":"first","affiliation":[{"name":"Students\u2019 Research Committee, Isfahan University of Medical Sciences , Isfahan 81746-73461,","place":["Iran"]},{"name":"Department of Community Nutrition, School of Nutrition and Food Science, Nutrition and Food Security Research Center, Isfahan University of Medical Sciences , Isfahan 81746-73461,","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahele","family":"Ziaei","sequence":"additional","affiliation":[{"name":"Department of Community Nutrition, School of Nutrition and Food Science, Nutrition and Food Security Research Center, Isfahan University of Medical Sciences , Isfahan 81746-73461,","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1194-9687","authenticated-orcid":false,"given":"Gholamreza","family":"Askari","sequence":"additional","affiliation":[{"name":"Department of Community Nutrition, School of Nutrition and Food Science, Nutrition and Food Security Research Center, Isfahan University of Medical Sciences , Isfahan 81746-73461,","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4605-7833","authenticated-orcid":false,"given":"Parvane","family":"Saneei","sequence":"additional","affiliation":[{"name":"Department of Community Nutrition, School of Nutrition and Food Science, Nutrition and Food Security Research Center, Isfahan University of Medical Sciences , Isfahan 81746-73461,","place":["Iran"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,6,18]]},"reference":[{"issue":"5","key":"2025011020364916500_nuae060-B1","first-page":"1","article-title":"Classification, pathophysiology, diagnosis and management of diabetes mellitus","volume":"6","author":"Baynes","year":"2015","journal-title":"J Diabetes Metab"},{"issue":"6","key":"2025011020364916500_nuae060-B2","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.2337\/dc05-2470","article-title":"Prevalence of diabetes 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