{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T02:40:17Z","timestamp":1788230417767,"version":"build-2803163510"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T00:00:00Z","timestamp":1722211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373558"],"award-info":[{"award-number":["82373558"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Undergraduate Innovation Experiment"},{"DOI":"10.13039\/501100012505","name":"Hebei Medical University","doi-asserted-by":"crossref","award":["USIP2023005"],"award-info":[{"award-number":["USIP2023005"]}],"id":[{"id":"10.13039\/501100012505","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>As living standards have improved and lifestyles have undergone changes, metabolic diseases associated with obesity have become increasingly prevalent. It is well established that sesamin (Ses) (PubChem CID: 72307), the primary lignans in sesame seeds and sesame oil, possess antioxidant and anti-inflammatory effects.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>In this study, a systematic review and meta-analysis of the effects of Ses on animal models of obesity-related diseases was performed to assess their impact on relevant disease parameters. Importantly, this study sought to provide insights for the design of future human clinical studies utilizing Ses as a nutritional supplement or drug.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Data Sources<\/jats:title>\n                  <jats:p>This study conducted a comprehensive search in PubMed, Web of Science, Embase, Scopus, and the Cochrane Library, identifying English language articles published from inception to April 2023.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Data Extraction<\/jats:title>\n                  <jats:p>The search incorporated keywords such as \u201csesamin,\u201d \u201cobesity,\u201d \u201cnon-alcoholic fatty liver disease,\u201d \u201ctype 2 diabetes mellitus,\u201d and \u201cmetabolic syndrome.\u201d The meta-analysis included 17 articles on non-alcoholic fatty liver disease, type 2 diabetes, and metabolic syndrome.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Data Analysis<\/jats:title>\n                  <jats:p>Overall, the pooled results demonstrated that Ses significantly reduced levels of total serum cholesterol (P\u2009=\u2009.010), total serum triglycerides (P\u2009=\u2009.003), alanine transaminase (P\u2009=\u2009.003), and blood glucose (P\u2009&amp;lt;\u2009.001), and increased high-density lipoprotein cholesterol levels (P\u2009=\u2009.012) in animal models of nonalcoholic fatty liver disease. In the type 2 diabetes model, Ses mitigated drug-induced weight loss (P\u2009&amp;lt;\u2009.001), high-fat-diet\u2013induced weight gain (P\u2009&amp;lt;\u2009.001), and blood glucose levels (P\u2009=\u2009.001). In the metabolic syndrome model, Ses was associated with a significant reduction in body weight (P\u2009&amp;lt;\u2009.001), total serum cholesterol (P\u2009&amp;lt;\u2009.001), total serum triglycerides (P\u2009&amp;lt;\u2009.001), blood glucose (P\u2009&amp;lt;\u2009.001), and alanine transaminase levels (P\u2009=\u2009.039).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The meta-analysis results of this study suggest that Ses supplementation yields favorable effects in animal models of obesity-related diseases, including hypolipidemic, insulin-lowering, and hypoglycemic abilities, as well as organ protection from oxidative stress and reduced inflammation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Systematic Review Registration<\/jats:title>\n                  <jats:p>PROSPERO registration No. CRD42023438502.<\/jats:p>\n         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