{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T03:16:34Z","timestamp":1787886994103,"version":"build-2784847793"},"reference-count":68,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T00:00:00Z","timestamp":1750982400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Hubei"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Probiotics supplementation has many beneficial impacts on periodontitis outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This umbrella meta-analysis evaluated the effectiveness of probiotics in treating periodontitis, focusing on primary outcome measures, including reductions in probing pocket depth (PPD), clinical attachment level (CAL), bleeding on probing (BOP), plaque index (PI), gingival index (GI), and PDD reduction in medium and deep pockets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Source<\/jats:title>\n                    <jats:p>The Scopus, PubMed, Web of Science, Embase, and Google Scholar online databases were searched up to January 2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Extraction<\/jats:title>\n                    <jats:p>All meta-analyses evaluating the impact of probiotics supplementation on periodontitis outcomes were considered eligible.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Analysis<\/jats:title>\n                    <jats:p>A random-effects model was employed to estimate the pooled results. Subgroup and sensitivity analyses were conducted. The quality of the studies was evaluated using the AMSTAR2 tool. Overall, 19 meta-analyses with 67 data sets were included in this umbrella review. Our findings indicated that probiotics supplementation significantly decreased BOP (effect size [ES]: \u22128.20; 95% CI: \u221215.10 to \u22121.31; P\u2009=\u2009.02) and CAL after sensitivity analysis (ES: \u22120.52; 95% CI: \u22120.75 to \u22120.28; P\u2009&amp;lt;\u2009.05). No other significant effect was observed on PPD, PI, GI, or PDD reduction in medium and deep pockets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This umbrella meta-analysis found that, during their treatment process, probiotics supplementation may positively affect BOP and CAL in people with periodontitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/nutrit\/nuae190","type":"journal-article","created":{"date-parts":[[2024,11,17]],"date-time":"2024-11-17T07:13:19Z","timestamp":1731827599000},"page":"379-394","source":"Crossref","is-referenced-by-count":5,"title":["The Impacts of Probiotics Supplementation on the Treatment of Periodontitis: An Umbrella Meta-Analysis"],"prefix":"10.1093","volume":"84","author":[{"given":"Junfeng","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Orthopedics, The Fifth Hospital of Wuhan , Wuhan, Hubei 430050,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of the Operating Room, The Fifth Hospital of Wuhan , Wuhan, Hubei 430050,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of the Operating Room, The Fifth Hospital of Wuhan , Wuhan, Hubei 430050,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, The Fifth Hospital of Wuhan , Wuhan, Hubei 430050,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6518-5362","authenticated-orcid":false,"given":"Mehrdad","family":"Jamali","sequence":"additional","affiliation":[{"name":"Student Research Committee, Tabriz University of Medical Sciences , Tabriz 5166614711,","place":["Iran"]},{"name":"Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences , Tabriz 5166614711,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Jamloo","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Tabriz University of Medical Sciences , Tabriz 5166614711,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosana","family":"Farjaminejad","sequence":"additional","affiliation":[{"name":"School of Health and Psychological Sciences, Department of Health Services Research and Management, University of London , London WC1E 7HU,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changjiang","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Oncology, The Fifth Hospital of Wuhan , Wuhan, Hubei 430050,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Saedisomeolia","sequence":"additional","affiliation":[{"name":"College of Health Sciences, Education Centre of Australia , Parramatta, NSW 2150,","place":["Australia"]},{"name":"School of Human Nutrition, McGill University, Sainte Anne de Bellevue , Quebec H9X 3V9,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8389-2584","authenticated-orcid":false,"given":"Abdolreza","family":"Jamilian","sequence":"additional","affiliation":[{"name":"City of London Dental School, University of Bolton , London BL11NE,","place":["United Kingdom"]},{"name":"Orthodontic Department, Dental School, Tehran Medical Sciences, Islamic Azad University , Tehran 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