{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T15:24:18Z","timestamp":1765380258831,"version":"3.41.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T00:00:00Z","timestamp":1736553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"Abstract<\/jats:title>\n \n Context<\/jats:title>\n Chronic pain is a debilitating condition that affects a significant proportion of the population. Palmitoylethanolamide (PEA), a naturally occurring fatty acid amide derived from omega-7 fatty acids, has emerged as a safe and effective alternative for pain management and exerts its effects by interacting with the endocannabinoid system, modulating inflammation, and regulating immune responses.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n A comprehensive meta-analysis was conducted to evaluate the efficacy of PEA in alleviating pain across various pathologies, considering the nociceptive, neuropathic, or nociplastic nature of pain.<\/jats:p>\n <\/jats:sec>\n \n Data Sources<\/jats:title>\n A systematic search was conducted of 4 databases: PubMed, Embase, Scopus, and Cochrane Collaboration Library.<\/jats:p>\n <\/jats:sec>\n \n Data Extraction<\/jats:title>\n Randomized clinical trials were selected for analysis. This meta-analysis included 18 studies involving 1196 patients.<\/jats:p>\n <\/jats:sec>\n \n Data Analysis<\/jats:title>\n Continuous variables were assessed using a standard mean difference (SMD). Heterogeneity was evaluated using the \u03c72 test and I2 statistics. Pain was significantly reduced in the PEA group at 6 weeks (SMD, \u20130.9; 95% CI, \u20131.60 to \u20130.31), 8 weeks (SMD, \u20130.98; 95% CI, \u20131.61 to \u20130.36), and 24-26\u2009weeks (SMD, \u20131.16; 95% CI, \u20132.15 to \u20130.17). Quality of life, including pain-related items, was significantly higher in the PEA group (SMD, \u20130.61; 95% CI, \u20130.93 to \u20130.30). Significant differences in favor of PEA were observed at 4 (SMD, \u20130.36; 95% CI, \u20130.65 to \u20130.07) and 8\u2009weeks (SMD, \u20130.66; 95% CI, \u20131.15 to \u20130.17). Palmitoylethanolamide was effective for all pain types: nociceptive (SMD, \u20130.74; 95% CI, \u20131.42 to \u20130.06), neuropathic (SMD, \u20130.97; 95% CI, \u20131.54 to \u20130.39), and nociplastic (SMD, \u20130.59; 95% CI, \u20131.15 to \u20130.03).<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n This meta-analysis confirmed that PEA effectively reduces pain and enhances quality of life, with significant benefits observed within 4-6\u2009weeks of treatment. Palmitoylethanolamide is a promising alternative to chronic opioid analgesics, potentially reducing the risk of opioid abuse and dependency.<\/jats:p>\n <\/jats:sec>\n \n Systematic Review Registration<\/jats:title>\n PROSPERO registration no. CRD42024550546.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/nutrit\/nuae203","type":"journal-article","created":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T20:04:58Z","timestamp":1736625898000},"page":"e1604-e1618","source":"Crossref","is-referenced-by-count":2,"title":["Meta-Analysis of Palmitoylethanolamide in Pain Management: Addressing Literature Gaps and Enhancing Understanding"],"prefix":"10.1093","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6571-152X","authenticated-orcid":false,"given":"Isabel","family":"Vi\u00f1a","sequence":"first","affiliation":[{"name":"IVBwellness Lab , Valencia,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0553-6210","authenticated-orcid":false,"given":"Miguel","family":"L\u00f3pez-Moreno","sequence":"additional","affiliation":[{"name":"Diet, Planetary Health and Performance, Faculty of Health Sciences, Universidad Francisco de Vitoria , 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