{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:02:58Z","timestamp":1791410578795,"version":"4.3.3"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T00:00:00Z","timestamp":1738022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Previous studies have explored the relationship between vitamin\u2009D and lipid profile in individuals with obesity or overweight women, but the results have been inconsistent.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This meta-analysis and systematic review of randomized controlled trials (RCTs) was conducted to assess the effect of vitamin\u2009D on lipid profile in women who are overweight or obese.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Data Sources<\/jats:title>\n                  <jats:p>A meticulous search strategy was used across the Scopus, PubMed\/Medline, Web of Science, and Embase databases up to June 2024.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Data Extraction<\/jats:title>\n                  <jats:p>RCT studies administering vitamin\u2009D to overweight or obese women were extracted. A random-effects model was applied to compute the weighted mean difference (WMD) and 95% CIs of the intervention on each variable.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Data Analyses<\/jats:title>\n                  <jats:p>Thirteen eligible publications with 16 arms focused on low-density-lipoprotein cholesterol (LDL-C), 16 arms on high-density-lipoprotein cholesterol (HDL-C), 18 arms on total cholesterol (TC), and 18 arms on triglycerides (TG) were included in the final quantitative analysis. Vitamin\u2009D supplementation resulted in significant reductions in TG (WMD: \u22126.13\u2009mg\/dL; 95% CI: \u22128.99 to \u22123.28; P\u2009=\u2009.000) and TC (WMD: \u22124.45\u2009mg\/dL; 95% CI: \u22127.06 to \u22121.83; P\u2009=\u2009.001), as well as a significant increase in HDL-C concentrations (WMD: 1.54\u2009mg\/dL; 95% CI: 0.57 to 2.52; P\u2009=\u2009.002). Stratified analysis indicated a greater reduction in TG levels in studies with a mean baseline TG concentration \u2265150\u2009mg\/dL (WMD: \u221223.58\u2009mg\/dL) and when vitamin\u2009D was administered for \u226426\u2009weeks (WMD: \u221211.44\u2009mg\/dL).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>According to our findings, vitamin\u2009D has a significant effect on hypertriglyceridemia in individuals who are overweight or obese. However, vitamin\u2009D has no significant effect on LDL-C concentrations in this population.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/nutrit\/nuae226","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T07:24:51Z","timestamp":1735197891000},"page":"1657-1668","source":"Crossref","is-referenced-by-count":10,"title":["Effect of Vitamin D Supplementation on Lipid Profile in Overweight or Obese Women: A Meta-analysis and Systematic Review of Randomized Controlled Trials"],"prefix":"10.1093","volume":"83","author":[{"given":"Li","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, The Affiliated Hospital, Southwest Medical University , Luzhou, Sichuan 64600,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Periyannan","family":"Velu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology, Annamalai University , Chidambaram, Tamil Nadu 608002,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kousalya","family":"Prabahar","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Faculty of Pharmacy, University of Tabuk , Tabuk 71491,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Hern\u00e1ndez-Wolters","sequence":"additional","affiliation":[{"name":"University Center for Health Science, Universidad de Guadalajara , Guadalajara, Jalisco 44340,","place":["Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7675-4405","authenticated-orcid":false,"given":"Hamed","family":"Kord-Varkaneh","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, School of Medicine, Nutrition Health Research Center, Hamadan University of Medical Sciences , Hamadan 65156,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7242-5314","authenticated-orcid":false,"given":"Yan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, The Affiliated Hospital, Southwest Medical University , Luzhou, Sichuan 64600,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,1,28]]},"reference":[{"key":"2025081220071163800_nuae226-B1","first-page":"118","article-title":"Vitamin D: the \u201csunshine\u201d vitamin","volume":"3","author":"Nair","year":"2012","journal-title":"J Pharmacol Pharmacother"},{"key":"2025081220071163800_nuae226-B2","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.chembiol.2013.12.016","article-title":"Vitamin D metabolism, mechanism of action, and clinical applications","volume":"21","author":"Bikle","year":"2014","journal-title":"Chem 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