{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:55:42Z","timestamp":1791942942410,"version":"4.3.4"},"reference-count":169,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Polish National Science Centre","doi-asserted-by":"crossref","award":["2018\/30\/M\/NZ3\/00682"],"award-info":[{"award-number":["2018\/30\/M\/NZ3\/00682"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"crossref"}]},{"name":"University Jean Monnet"},{"name":"Saint-Etienne and INSERM"},{"name":"AAP 2017 of UJM Saint-Etienne"},{"name":"French Rheumatology Society","award":["SFR 2020"],"award-info":[{"award-number":["SFR 2020"]}]},{"name":"2021 EFSD-Boehringer Ingelheim"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The ketogenic diet (KD) has recently gained increasing popularity. This high-fat, adequate-protein, and carbohydrate-poor eating pattern leads to nutritional ketosis. The KD has long been known for its antidiabetic and antiepileptic effects and has been used therapeutically in these contexts. Recently, the KD, due to its effectiveness in inducing weight loss, has also been proposed as a possible approach to treat obesity. Likewise, a KD is currently explored as a supporting element in the treatment of obesity-associated metabolic disorders and certain forms of cancer. Here, we discuss the metabolic and biochemical mechanisms at play during the shift of metabolism to fatty acids and fatty acid\u2013derived ketone bodies as main fuel molecules, in the substitution of carbohydrates, in ketogenic nutrition. Different sources of ketone bodies and KDs as alternatives to glucose and carbohydrates as main energy substrates are discussed, together with an attempt to weigh the benefits and risks posed by the chronic use of a KD in the context of weight loss, and also considering the molecular effects that ketone bodies exert on metabolism and on the endocrine system.<\/jats:p>","DOI":"10.1093\/nutrit\/nuaf010","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T15:22:29Z","timestamp":1739978549000},"page":"1957-1972","source":"Crossref","is-referenced-by-count":18,"title":["The Impact of Ketogenic Nutrition on Obesity and Metabolic Health: Mechanisms and Clinical Implications"],"prefix":"10.1093","volume":"83","author":[{"given":"Marta","family":"Biesiekierska","sequence":"first","affiliation":[{"name":"Department of Oncobiology and Epigenetics, Faculty of Biology and Environmental Protection, University of Lodz , 90-236 Lodz,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maura","family":"Strigini","sequence":"additional","affiliation":[{"name":"University Jean Monnet Saint-Etienne, INSERM, Mines Saint Etienne, SAINBIOSE U1059 , F-42023 Saint-Etienne,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"\u015aliwi\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Nucleic Acid Biochemistry, Medical University of Lodz , 92-213 Lodz,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6539-5435","authenticated-orcid":false,"given":"Luciano","family":"Pirola","sequence":"additional","affiliation":[{"name":"INSERM Unit 1060, CarMeN Laboratory, Lyon 1 University , F-69495 Pierre B\u00e9nite,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aneta","family":"Balcerczyk","sequence":"additional","affiliation":[{"name":"Department of Oncobiology and Epigenetics, Faculty of Biology and Environmental Protection, University of Lodz , 90-236 Lodz,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,2,26]]},"reference":[{"key":"2025091010314847000_nuaf010-B1","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.cmet.2019.05.008","article-title":"Ultra-processed diets cause excess calorie intake and weight gain: an inpatient randomized controlled trial of ad libitum food intake","volume":"30","author":"Hall","year":"2019","journal-title":"Cell Metab"},{"key":"2025091010314847000_nuaf010-B2","doi-asserted-by":"publisher","first-page":"e13615","DOI":"10.1111\/obr.13615","article-title":"Correlates of physical activity and sedentary behavior in 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