{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:38:28Z","timestamp":1782880708101,"version":"3.54.5"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T00:00:00Z","timestamp":1749859200000},"content-version":"vor","delay-in-days":80,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Research suggests that alcohol consumption is associated with neuroinflammation, impacting brain regions associated with addiction and cognitive function. Long-chain omega-3 (n-3) polyunsaturated fatty acids (PUFAs), in particular docosahexaenoic acid (DHA), have been proposed to have neuroprotective effects against alcohol, reversing synaptic deficits caused by alcohol and alleviating anxiety in animal models.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The aim of this study was to evaluate the impact of an n-3 intervention in ameliorating behavioral changes, biochemical alterations, and the inflammatory responses induced by alcohol consumption.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Data Sources<\/jats:title>\n                  <jats:p>A systematic review was performed using PubMed (Medline), Scopus, Web of Science, and OpenGrey databases. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Data Extraction<\/jats:title>\n                  <jats:p>A total of 3829 records were identified. The records were subject to screening against the eligibility criteria, and the data extraction and risk-of-bias assessment were carried out by 2 investigators independently.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Data Analysis<\/jats:title>\n                  <jats:p>Twelve articles addressed n-3 PUFA interventions, and its effects on alcohol-related outcomes were finally included. Preclinical studies demonstrated that n-3 PUFAs improved behavioral, inflammation, lipid metabolism, and hepatic parameters altered by alcohol. However, clinical trials yielded inconclusive evidence.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Despite the paucity of clinical and preclinical studies, available evidence suggests that n-3 PUFAs may exert a protective influence on alcohol-related outcomes at both the behavioral and molecular levels.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Systematic Review Registration<\/jats:title>\n                  <jats:p>PROSPERO registration no. CRD42023443095.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/nutrit\/nuaf036","type":"journal-article","created":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T12:17:59Z","timestamp":1741177079000},"page":"1214-1226","source":"Crossref","is-referenced-by-count":4,"title":["Impact of Omega-3 Polyunsaturated Fatty Acids on Alcohol Use and Negative Consequences: A Systematic Review"],"prefix":"10.1093","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6761-3598","authenticated-orcid":false,"given":"Diana","family":"Cardona","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences, Department of Nursing Science, Physiotherapy and Medicine, University of Almer\u00eda , 04120 Almer\u00eda, Andalus\u00eda,","place":["Spain"]},{"name":"Health Research Center CEINSA, University of Almer\u00eda , 04120 Almer\u00eda, Andalus\u00eda,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4507-2863","authenticated-orcid":false,"given":"Francisca","family":"Carvajal","sequence":"additional","affiliation":[{"name":"Health Research Center CEINSA, University of Almer\u00eda , 04120 Almer\u00eda, Andalus\u00eda,","place":["Spain"]},{"name":"Department of Psychology, University of Almer\u00eda , 04120 Almer\u00eda, Andalusia,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6986-5510","authenticated-orcid":false,"given":"Jose Manuel","family":"Lerma-Cabrera","sequence":"additional","affiliation":[{"name":"Health Research Center CEINSA, University of Almer\u00eda , 04120 Almer\u00eda, Andalus\u00eda,","place":["Spain"]},{"name":"Department of Psychology, University of Almer\u00eda , 04120 Almer\u00eda, Andalusia,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6709-9964","authenticated-orcid":false,"given":"Ainhoa","family":"S\u00e1nchez-Gil","sequence":"additional","affiliation":[{"name":"Health Research Center CEINSA, University of Almer\u00eda , 04120 Almer\u00eda, Andalus\u00eda,","place":["Spain"]},{"name":"Department of Psychology, University of Almer\u00eda , 04120 Almer\u00eda, Andalusia,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0151-8018","authenticated-orcid":false,"given":"Lola","family":"Rueda-Ruzafa","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Department of Nursing Science, Physiotherapy and Medicine, University of Almer\u00eda , 04120 Almer\u00eda, Andalus\u00eda,","place":["Spain"]},{"name":"Health Research Center CEINSA, University of Almer\u00eda , 04120 Almer\u00eda, 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