{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T19:31:52Z","timestamp":1778009512179,"version":"3.51.4"},"reference-count":90,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T00:00:00Z","timestamp":1751068800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100002924","name":"FEDER","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007480","name":"University of Castilla-La Mancha","doi-asserted-by":"publisher","award":["2022-PROD-20657"],"award-info":[{"award-number":["2022-PROD-20657"]}],"id":[{"id":"10.13039\/501100007480","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Moderate alcohol use has been shown in prior research to significantly lower the risk of cardiovascular disease and metabolic syndrome. Metabolic syndrome is a major public health problem.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The objective of this study was to analyze the effects of wine consumption on glucose, insulin, systolic blood pressure (SBP), diastolic blood pressure (DBP), and body mass index (BMI), some of the most important cardiovascular parameters associated with metabolic syndrome.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Data Sources<\/jats:title>\n                  <jats:p>To perform this systematic review and meta-analysis, we searched the MEDLINE, Scopus, Cochrane Library, and Web of Science databases from their inception until March 14, 2025.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Data Extraction<\/jats:title>\n                  <jats:p>A total of 2145 articles were identified by the search, from which 18 studies were selected for the systematic review and meta-analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Data Analysis<\/jats:title>\n                  <jats:p>The DerSimonian and Laird methods were used to determine the mean differences (MDs) of the different parameters included. The risk of bias assessment was assessed via the Rob2 and ROBINS-I tools, and the Grading of Recommendations, Assessment, Development, and Evaluation tool (GRADE) certainty assessment was also performed. The pooled MD value of pre\u2013post studies assessing the effects of wine consumption on the studied factors was \u22121.49 (95% CI: \u22123.40, 0.41) mg\/dL for glucose, \u22121.45 (95% CI: \u22124.53, 1.64) \u03bcU\/mL for insulin, \u22121.22 (95% CI: \u22122.08, \u22120.37) mmHg for SBP, \u22120.18 (95% CI: \u22122.62, 2.25) mmHg for DBP, and \u22120.40 (95% CI: \u22121.27, 0.46) kg\/m2 for BMI. The pooled MD value of randomized controlled trial and crossover studies for the effect of wine on the studied factors was 1.98 (95% CI: \u22120.17, 4.13) mg\/dL for glucose, \u22121.34 (95% CI: \u22122.27, 0.40) \u03bcU\/mL for insulin, 0.10 (95% CI: \u22120.07, 0.26) mmHg for SBP, 0.34 (95% CI: \u22121.70, 2.37) mmHg for DBP, and 0.62 (95% CI: \u22120.31, 1.56) kg\/m2 for BMI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This systematic review and meta-analysis did not reveal any effect of wine intake on glucose, insulin, DBP, or BMI; a significant effect of wine consumption on SBP was only found in pre\u2013post studies and insulin in clinical trials. Future studies of possible effects of wine consumption on cardiovascular parameters associated with metabolic syndrome should take into account types of wine and quantities consumed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Systematic Review Registration<\/jats:title>\n                  <jats:p>PROSPERO registration No. CRD42023396666.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/nutrit\/nuaf078","type":"journal-article","created":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T08:06:04Z","timestamp":1746259564000},"page":"2055-2072","source":"Crossref","is-referenced-by-count":1,"title":["The Effects of Wine Consumption on Metabolic Syndrome: A Systematic Review and Meta-Analysis of Clinical Trials"],"prefix":"10.1093","volume":"83","author":[{"given":"Maribel","family":"Lucer\u00f3n-Lucas-Torres","sequence":"first","affiliation":[{"name":"Health and Social Research Center, University of Castilla-La Mancha , 16002 Cuenca,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5032-8210","authenticated-orcid":false,"given":"Mar\u00eda Jos\u00e9","family":"Guzm\u00e1n-Pav\u00f3n","sequence":"additional","affiliation":[{"name":"Facultad de Fisioterapia y Enfermer\u00eda, Universidad de Castilla-La Mancha , 45004 Toledo,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta C","family":"Ruiz-Grao","sequence":"additional","affiliation":[{"name":"Department of Nursing, University of Castilla-La Mancha , 02071 Albacete,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"di Lorenzo","sequence":"additional","affiliation":[{"name":"Department of Pharmacological and Biomolecular Sciences, Universit\u00e0 degli Studi di Milano , 20133 Milan,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Lorenzo-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Health and Social Research Center, University of Castilla-La Mancha , 16002 Cuenca,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2617-0430","authenticated-orcid":false,"given":"Iv\u00e1n","family":"Cavero-Redondo","sequence":"additional","affiliation":[{"name":"Health and Social Research Center, University of Castilla-La Mancha , 16002 Cuenca,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celia","family":"\u00c1lvarez-Bueno","sequence":"additional","affiliation":[{"name":"Health and Social Research Center, University of Castilla-La Mancha , 16002 Cuenca,","place":["Spain"]},{"name":"Facultad de Ciencias de la Salud, Universidad Aut\u00f3noma de Chile , Talca,","place":["Chile"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,6,28]]},"reference":[{"key":"2025101009015397800_nuaf078-B1","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1007\/s40200-021-00965-2","article-title":"Metabolic syndrome; definition, pathogenesis, elements, and the effects of medicinal plants on it is elements","volume":"21","author":"Ahmed","year":"2022","journal-title":"J Diabetes Metab Disord"},{"key":"2025101009015397800_nuaf078-B2","doi-asserted-by":"publisher","first-page":"2486","DOI":"10.1001\/jama.285.19.2486","article-title":"Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III)","volume":"285","author":"Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults","year":"2001","journal-title":"JAMA"},{"key":"2025101009015397800_nuaf078-B3","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1093\/oxfordjournals.aje.a009572","article-title":"Syndrome X and mortality: a population-based study. Risk factor and life expectancy research group","volume":"148","author":"Trevisan","year":"1998","journal-title":"Am J Epidemiol"},{"key":"2025101009015397800_nuaf078-B4","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.2337\/diabetes.52.5.1210","article-title":"NCEP-defined metabolic syndrome, diabetes, and prevalence of coronary heart disease among NHANES III participants age 50 years and older","volume":"52","author":"Alexander","year":"2003","journal-title":"Diabetes"},{"key":"2025101009015397800_nuaf078-B5","doi-asserted-by":"publisher","first-page":"2709","DOI":"10.1001\/jama.288.21.2709","article-title":"The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men","volume":"288","author":"Lakka","year":"2002","journal-title":"JAMA"},{"key":"2025101009015397800_nuaf078-B6","doi-asserted-by":"publisher","first-page":"683","DOI":"10.2337\/diacare.24.4.683","article-title":"Cardiovascular morbidity and mortality associated with the metabolic syndrome","volume":"24","author":"Isomaa","year":"2001","journal-title":"Diabetes Care"},{"key":"2025101009015397800_nuaf078-B7","first-page":"124","article-title":"Epidemiologie und assoziierte Risikofaktoren der Hyperlipoprotein\u00e4mie","volume":"32","author":"Haller","year":"1977","journal-title":"Z Gesamte Inn Med"},{"key":"2025101009015397800_nuaf078-B8","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1111\/j.1463-1326.2004.00409.x","article-title":"The prevalence of the metabolic syndrome in Greece: the MetS-Greece Multicenter Study","volume":"7","author":"Athyros","year":"2005","journal-title":"Diabetes Obes Metab"},{"key":"2025101009015397800_nuaf078-B9","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1038\/sj.jhh.1001445","article-title":"The effect of the combination of Mediterranean diet and leisure time physical activity on the risk of developing acute coronary syndromes, in hypertensive subjects","volume":"16","author":"Pitsavos","year":"2002","journal-title":"J Hum Hypertens"},{"key":"2025101009015397800_nuaf078-B10","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.numecd.2009.07.006","article-title":"Moderate consumption of red wine, but not gin, decreases erythrocyte superoxide dismutase activity: a randomized crossover trial","volume":"21","author":"Estruch","year":"2011","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"2025101009015397800_nuaf078-B11","doi-asserted-by":"publisher","first-page":"2785","DOI":"10.2337\/diacare.26.10.2785","article-title":"Alcohol consumption and the incidence of type 2 diabetes: a 20-year follow-up of the Finnish twin cohort study","volume":"26","author":"Carlsson","year":"2003","journal-title":"Diabetes Care"},{"key":"2025101009015397800_nuaf078-B12","doi-asserted-by":"publisher","first-page":"2954","DOI":"10.2337\/diacare.27.12.2954","article-title":"Third National Health and Nutrition Examination Survey. Alcohol consumption and the prevalence of the Metabolic Syndrome in the US.: a cross-sectional analysis of data from the Third National Health and Nutrition Examination Survey","volume":"27","author":"Freiberg","year":"2004","journal-title":"Diabetes Care"},{"key":"2025101009015397800_nuaf078-B13","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1093\/aje\/155.4.332","article-title":"Alcohol consumption and risk of peripheral arterial disease: the Rotterdam study","volume":"155","author":"Vliegenthart","year":"2002","journal-title":"Am J Epidemiol"},{"key":"2025101009015397800_nuaf078-B14","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1177\/0003319707306146","article-title":"Association of drinking pattern and alcohol beverage type with the prevalence of metabolic syndrome, diabetes, coronary heart disease, stroke, and peripheral arterial disease in a Mediterranean cohort","volume":"58","author":"Athyros","year":"2007","journal-title":"Angiology"},{"key":"2025101009015397800_nuaf078-B15","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0963-9969(00)00037-5","article-title":"Wine and cardiovascular disease","volume":"33","author":"Estruch","year":"2000","journal-title":"Food Res Int"},{"key":"2025101009015397800_nuaf078-B16","doi-asserted-by":"publisher","first-page":"3626","DOI":"10.3390\/molecules24193626","article-title":"Red wine consumption and cardiovascular health","volume":"24","author":"Castaldo","year":"2019","journal-title":"Molecules"},{"key":"2025101009015397800_nuaf078-B17","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1016\/S0735-1097(96)00280-X","article-title":"Effect of a Mediterranean type of diet on the rate of cardiovascular complications in patients with coronary artery disease. Insights into the cardioprotective effect of certain nutriments","volume":"28","author":"De Lorgeril","year":"1996","journal-title":"J Am Coll Cardiol"},{"key":"2025101009015397800_nuaf078-B18","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/0140-6736(93)90206-v","article-title":"Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine","volume":"341","author":"Frankel","year":"1993","journal-title":"Lancet"},{"key":"2025101009015397800_nuaf078-B19","doi-asserted-by":"publisher","first-page":"603","DOI":"10.3109\/09637486.2015.1077796","article-title":"Resveratrol and anti-atherogenic effects","volume":"66","author":"Riccioni","year":"2015","journal-title":"Int J Food Sci Nutr"},{"key":"2025101009015397800_nuaf078-B20","doi-asserted-by":"publisher","first-page":"e15771","DOI":"10.1097\/MD.0000000000015771","article-title":"Effects of wine on blood pressure, glucose parameters, and lipid profile in type 2 diabetes mellitus: a meta-analysis of randomized interventional trials (PRISMA Compliant)","volume":"98","author":"Ye","year":"2019","journal-title":"Medicine (Baltimore)"},{"key":"2025101009015397800_nuaf078-B21","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1016\/j.jclinepi.2009.06.005","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"62","author":"Moher","year":"2009","journal-title":"J Clin Epidemiol"},{"key":"2025101009015397800_nuaf078-B22","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0.","author":"Higgins","year":"2011"},{"key":"2025101009015397800_nuaf078-B23","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s13643-020-01542-z","article-title":"PRISMA-S: an extension to the PRISMA statement for reporting literature searches in systematic reviews","volume":"10","author":"Rethlefsen","year":"2021","journal-title":"Syst Rev"},{"key":"2025101009015397800_nuaf078-B24","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.5114\/aoms\/152921","article-title":"Metabolic syndrome\u2014a new definition and management guidelines: a joint position paper by the Polish Society of Hypertension, Polish Society for the Treatment of Obesity, Polish Lipid Association, Polish Association for Study of Liver, Polish Society of Family Medicine, Polish Society of Lifestyle Medicine, Division of Prevention and Epidemiology Polish Cardiac Society, \u201cClub 30\u201d Polish Cardiac Society, and Division of Metabolic and Bariatric Surgery Society of Polish Surgeons","volume":"18","author":"Dobrowolski","year":"2022","journal-title":"Arch Med Sci"},{"key":"2025101009015397800_nuaf078-B25","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1016\/j.mayocp.2013.11.005","article-title":"Alcohol and cardiovascular health: the dose makes the poison\u2026or the remedy","volume":"89","author":"O\u2019Keefe","year":"2014","journal-title":"Mayo Clin Proc"},{"key":"2025101009015397800_nuaf078-B26","doi-asserted-by":"publisher","first-page":"l4898","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: a revised tool for assessing risk of bias in randomized trials","volume":"366","author":"Sterne","year":"2019","journal-title":"BMJ"},{"key":"2025101009015397800_nuaf078-B27","doi-asserted-by":"publisher","first-page":"i4919","DOI":"10.1136\/bmj.i4919","article-title":"ROBINS-I: a tool for assessing risk of bias in nonrandomized studies of interventions","volume":"355","author":"Sterne","year":"2016","journal-title":"BMJ"},{"key":"2025101009015397800_nuaf078-B28","volume-title":"GRADE Handbook for Grading Quality of Evidence and Strength of Recommendations","author":"Sch\u00fcnemann","year":"2013"},{"key":"2025101009015397800_nuaf078-B29","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.cct.2006.04.004","article-title":"Random-effects model for meta-analysis of clinical trials: an update","volume":"28","author":"DerSimonian","year":"2007","journal-title":"Contemp Clin Trials"},{"key":"2025101009015397800_nuaf078-B30","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Stat Med"},{"key":"2025101009015397800_nuaf078-B31","doi-asserted-by":"publisher","first-page":"a1331","DOI":"10.1136\/bmj.a1331","article-title":"Drug eluting and bare metal stents in people with and without diabetes: collaborative network meta-analysis","volume":"337","author":"Stettler","year":"2008","journal-title":"BMJ"},{"key":"2025101009015397800_nuaf078-B32","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1136\/bmj.323.7304.101","article-title":"Systematic reviews in health care: investigating and dealing with publication and other biases in meta-analysis","volume":"323","author":"Sterne","year":"2001","journal-title":"BMJ"},{"key":"2025101009015397800_nuaf078-B33","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1159\/000177823","article-title":"Effect of dietary supplementation of red or white wine on human blood chemistry, hematology and coagulation: favorable effect of red wine on plasma high-density lipoprotein","volume":"38","author":"Lavy","year":"1994","journal-title":"Ann Nutr Metab"},{"key":"2025101009015397800_nuaf078-B34","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1053\/meta.2000.17672","article-title":"Influence of moderate chronic wine consumption on insulin sensitivity and other correlates of syndrome X in moderately obese women","volume":"49","author":"Cordain","year":"2000","journal-title":"Metabolism"},{"key":"2025101009015397800_nuaf078-B35","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1038\/sj.ijo.0802786","article-title":"Effects of moderate consumption of white wine on weight loss in overweight and obese subjects","volume":"28","author":"Flechtner-Mors","year":"2004","journal-title":"Int J Obes Relat Metab Disord"},{"key":"2025101009015397800_nuaf078-B36","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/sj.ejcn.1602265","article-title":"Effects of moderate Sicilian red wine consumption on inflammatory biomarkers of atherosclerosis","volume":"60","author":"Avellone","year":"2006","journal-title":"Eur J Clin Nutr"},{"key":"2025101009015397800_nuaf078-B37","doi-asserted-by":"publisher","first-page":"203","DOI":"10.33549\/physiolres.930936","article-title":"Effect of white wine consumption on oxidative stress markers and homocysteine levels","volume":"56","author":"Rajdl","year":"2007","journal-title":"Physiol Res"},{"key":"2025101009015397800_nuaf078-B38","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1007\/s00125-008-1031-y","article-title":"Moderate alcohol consumption increases insulin sensitivity and ADIPOQ expression in postmenopausal women: a randomized, crossover trial","volume":"51","author":"Joosten","year":"2008","journal-title":"Diabetologia"},{"key":"2025101009015397800_nuaf078-B39","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.thromres.2011.03.015","article-title":"Moderate consumption of red wine and human platelet responsiveness","volume":"128","author":"Tozzi Ciancarelli","year":"2011","journal-title":"Thromb Res"},{"key":"2025101009015397800_nuaf078-B40","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1556\/OH.2012.29389","article-title":"Pintes feh\u00e9rbor hat\u00e1sa az anyagcsere-param\u00e9terekre metabolikus szindr\u00f3m\u00e1s betegekben [Effect of \u201cPintes\u201d white wine on metabolic parameters in patients with metabolic syndrome]","volume":"153","author":"Abel","year":"2012","journal-title":"Orv Hetil"},{"key":"2025101009015397800_nuaf078-B41","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1002\/ptr.5537","article-title":"Cardioprotective efficacy of red wine extract of onion in healthy hypercholesterolemic subjects","volume":"30","author":"Chiu","year":"2016","journal-title":"Phytother Res"},{"key":"2025101009015397800_nuaf078-B42","doi-asserted-by":"publisher","first-page":"292","DOI":"10.4149\/BLL_2017_072","article-title":"Red or white wine consumption effect on atherosclerosis in healthy individuals (In Vino Veritas study)","volume":"118","author":"Taborsky","year":"2017","journal-title":"Bratisl Lek Listy"},{"key":"2025101009015397800_nuaf078-B43","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1038\/sj.ejcn.1602107","article-title":"Effect of red wine and red grape extract on blood lipids, hemostatic factors, and other risk factors for cardiovascular disease","volume":"59","author":"Hansen","year":"2005","journal-title":"Eur J Clin Nutr"},{"key":"2025101009015397800_nuaf078-B44","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.atherosclerosis.2005.06.027","article-title":"The effect of chronic consumption of red wine on cardiovascular disease risk factors in postmenopausal women","volume":"185","author":"Naissides","year":"2006","journal-title":"Atherosclerosis"},{"key":"2025101009015397800_nuaf078-B45","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.metabol.2004.09.010","article-title":"Red wine consumption improves insulin resistance but not endothelial function in type 2 diabetic patients","volume":"54","author":"Napoli","year":"2005","journal-title":"Metabolism"},{"key":"2025101009015397800_nuaf078-B46","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1016\/j.nut.2006.08.012","article-title":"Muscadine grape products intake, diet and blood constituents of nondiabetic and type 2 diabetic subjects","volume":"22","author":"Banini","year":"2006","journal-title":"Nutrition"},{"key":"2025101009015397800_nuaf078-B47","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1111\/j.1464-5491.2006.01886.x","article-title":"Effect of moderate red wine intake on cardiac prognosis after recent acute myocardial infarction of subjects with type 2 diabetes mellitus","volume":"23","author":"Marfella","year":"2006","journal-title":"Diabet Med"},{"key":"2025101009015397800_nuaf078-B48","doi-asserted-by":"publisher","first-page":"3011","DOI":"10.2337\/dc07-1103","article-title":"Glycemic effects of moderate alcohol intake among patients with type 2 diabetes: a multicenter, randomized, clinical intervention trial","volume":"30","author":"Shai","year":"2007","journal-title":"Diabetes Care"},{"key":"2025101009015397800_nuaf078-B49","doi-asserted-by":"publisher","first-page":"545","DOI":"10.3109\/07853890.2011.588246","article-title":"Effects of moderate red wine consumption on liver fat and blood lipids: a prospective randomized study","volume":"43","author":"Kechagias","year":"2011","journal-title":"Ann Med"},{"key":"2025101009015397800_nuaf078-B50","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1186\/1475-2891-12-147","article-title":"A daily glass of red wine associated with lifestyle changes independently improves blood lipids in patients with carotid arteriosclerosis: results from a randomized controlled trial","volume":"12","author":"Droste","year":"2013","journal-title":"Nutr J"},{"key":"2025101009015397800_nuaf078-B51","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.numecd.2008.10.007","article-title":"Adherence to the Mediterranean diet and risk of metabolic syndrome and its components","volume":"19","author":"Babio","year":"2009","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"2025101009015397800_nuaf078-B52","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1001\/jama.287.3.356cord","article-title":"Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey","volume":"287","author":"Ford","year":"2002","journal-title":"JAMA"},{"key":"2025101009015397800_nuaf078-B53","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1089\/met.2008.0070","article-title":"Health care utilization and costs by metabolic syndrome risk factors","volume":"7","author":"Boudreau","year":"2009","journal-title":"Metab Syndr Relat Disord"},{"key":"2025101009015397800_nuaf078-B54","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1038\/clpt.2011.92","article-title":"Dietary management of the metabolic syndrome","volume":"90","author":"Kimokoti","year":"2011","journal-title":"Clin Pharmacol Ther"},{"key":"2025101009015397800_nuaf078-B55","author":"Ministry of Health","year":"2020"},{"key":"2025101009015397800_nuaf078-B56","doi-asserted-by":"publisher","first-page":"e1001492","DOI":"10.1371\/journal.pmed.1001492","article-title":"Risk prediction for breast, endometrial, and ovarian cancer in white women aged 50 y or older: derivation and validation from population-based cohort studies","volume":"10","author":"Pfeiffer","year":"2013","journal-title":"PLoS Med"},{"key":"2025101009015397800_nuaf078-B57","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1016\/j.numecd.2020.03.018","article-title":"Race- and sex-specific association between alcohol consumption and hypertension in 22 cohort studies: a systematic review and meta-analysis","volume":"30","author":"Liu","year":"2020","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"2025101009015397800_nuaf078-B58","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1038\/hr.2016.46","article-title":"Does the flushing response modify the relationship between alcohol intake and hypertension in the Japanese population? NIPPON DATA2010","volume":"39","author":"Kogure","year":"2016","journal-title":"Hypertens Res"},{"key":"2025101009015397800_nuaf078-B59","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1111\/jch.12455","article-title":"Psychological distress and the development of hypertension over 5 years in black South Africans","volume":"17","author":"Schutte","year":"2015","journal-title":"J Clin Hypertens (Greenwich)"},{"key":"2025101009015397800_nuaf078-B60","first-page":"769","article-title":"Alcohol sensitivity in Taiwanese men with different alcohol and aldehyde dehydrogenase genotypes","volume":"101","author":"Peng","year":"2002","journal-title":"J Formos Med Assoc"},{"key":"2025101009015397800_nuaf078-B61","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1038\/hr.2013.23","article-title":"Effect of alcohol and aldehyde dehydrogenase gene polymorphisms on alcohol-associated hypertension: the Guangzhou Biobank Cohort Study","volume":"36","author":"Zhang","year":"2013","journal-title":"Hypertens Res"},{"key":"2025101009015397800_nuaf078-B62","doi-asserted-by":"publisher","first-page":"2559","DOI":"10.1001\/jama.287.19.2559","article-title":"Effects of moderate alcohol intake on fasting insulin and glucose concentrations and insulin sensitivity in postmenopausal women: a randomized controlled trial","volume":"287","author":"Davies","year":"2002","journal-title":"JAMA"},{"issue":"suppl 2","key":"2025101009015397800_nuaf078-B63","doi-asserted-by":"publisher","first-page":"S121","DOI":"10.1017\/S0007114514003262","article-title":"Moderate red wine consumption is associated with a lower prevalence of the metabolic syndrome in the PREDIMED population","volume":"113","author":"Tresserra-Rimbau","year":"2015","journal-title":"Br J Nutr."},{"key":"2025101009015397800_nuaf078-B64","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0889-8529(18)30220-2","article-title":"Type II diabetes and syndrome X. Pathogenesis and glycemic management","volume":"21","author":"Karam","year":"1992","journal-title":"Endocrinol Metab Clin North Am"},{"key":"2025101009015397800_nuaf078-B65","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1016\/s0026-0495(99)90135-x","article-title":"Effects of red wine, tannic acid, or ethanol on glucose tolerance in non-insulin-dependent diabetic patients and on starch digestibility in vitro","volume":"48","author":"Gin","year":"1999","journal-title":"Metabolism"},{"key":"2025101009015397800_nuaf078-B66","first-page":"151","article-title":"World Health Organization\u2013International Society of Hypertension guidelines for the management of hypertension","volume":"17","author":"Guidelines Subcommittee","year":"1999","journal-title":"J Hypertens"},{"key":"2025101009015397800_nuaf078-B67","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1001\/jama.2013.184182","article-title":"Prevalence, awareness, treatment, and control of hypertension in rural and urban communities in high-, middle-, and low-income countries","volume":"310","author":"Chow","year":"2013","journal-title":"JAMA"},{"key":"2025101009015397800_nuaf078-B68","doi-asserted-by":"publisher","first-page":"3021","DOI":"10.1093\/eurheartj\/ehy339","article-title":"2018 ESC\/ESH Guidelines for the management of arterial hypertension [published correction appears in Eur Heart J. 2019 Feb 1;40(5):475. doi: 10.1093\/eurheartj\/ehy686]","volume":"39","author":"Williams","year":"2018","journal-title":"Eur Heart J."},{"key":"2025101009015397800_nuaf078-B69","volume-title":"Directriz Para el Tratamiento Farmacol\u00f3gico de la Hipertensi\u00f3n en Adultos [Guideline for the Pharmacological Treatment of Hypertension in Adults].","author":"Organizaci\u00f3n Mundial de la Salud","year":"2022"},{"key":"2025101009015397800_nuaf078-B70","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1111\/j.1440-1681.1983.tb00188.x","article-title":"Blood pressure and its relationship to low levels of alcohol consumption","volume":"10","author":"Cooke","year":"1983","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"2025101009015397800_nuaf078-B71","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/0026-0495(87)90163-6","article-title":"Effects of moderate alcohol consumption on platelet aggregation, fibrinolysis, and blood lipids","volume":"36","author":"Pikaar","year":"1987","journal-title":"Metabolism"},{"key":"2025101009015397800_nuaf078-B72","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.1016\/j.freeradbiomed.2008.12.023","article-title":"Resveratrol metabolites in urine as a biomarker of wine intake in free-living subjects: the PREDIMED study","volume":"46","author":"Zamora-Ros","year":"2009","journal-title":"Free Radic Biol Med"},{"key":"2025101009015397800_nuaf078-B73","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1016\/0140-6736(92)91277-f","article-title":"Wine, alcohol, platelets, and the French paradox for coronary heart disease","volume":"339","author":"Renaud","year":"1992","journal-title":"Lancet"},{"key":"2025101009015397800_nuaf078-B74","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1159\/000083847","article-title":"The Mediterranean lecture: wine and thrombosis\u2014from epidemiology to physiology and back","volume":"33","author":"de Gaetano","year":"2003","journal-title":"Pathophysiol Haemost Thromb"},{"key":"2025101009015397800_nuaf078-B75","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1001\/jama.2012.39","article-title":"Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010","volume":"307","author":"Flegal","year":"2012","journal-title":"JAMA"},{"key":"2025101009015397800_nuaf078-B76","author":"Global Database on Body Mass Index"},{"key":"2025101009015397800_nuaf078-B77","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1053\/gast.2000.20206","article-title":"Moderate alcohol drinking: effects on the heart and liver","volume":"119","author":"Brenner","year":"2000","journal-title":"Gastroenterology"},{"key":"2025101009015397800_nuaf078-B78","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1079\/bjn19960108","article-title":"Alcohol and the regulation of energy balance: overnight effects on diet-induced thermogenesis and fuel storage","volume":"75","author":"Murgatroyd","year":"1996","journal-title":"Br J Nutr"},{"key":"2025101009015397800_nuaf078-B79","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1093\/ajcn\/69.2.173","article-title":"Alcohol intake and body weight: a paradox","volume":"69","author":"J\u00e9quier","year":"1999","journal-title":"Am J Clin Nutr"},{"key":"2025101009015397800_nuaf078-B80","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.cccn.2005.06.018","article-title":"Resveratrol, a polyphenolic compound in red wine, protects against oxidized LDL-induced cytotoxicity in endothelial cells","volume":"364","author":"Ou","year":"2006","journal-title":"Clin Chim Acta"},{"key":"2025101009015397800_nuaf078-B81","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1093\/jn\/131.5.1401","article-title":"Alcohol, red wine and cardiovascular disease","volume":"131","author":"Wollin","year":"2001","journal-title":"J Nutr"},{"key":"2025101009015397800_nuaf078-B82","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/B978-0-08-102067-8.00012-9","volume-title":"Managing Wine Quality","author":"Reynolds","year":"2022","edition":"2nd ed"},{"key":"2025101009015397800_nuaf078-B83","doi-asserted-by":"publisher","first-page":"175","DOI":"10.3390\/nu15010175","article-title":"Moderate wine consumption and health: a narrative review","volume":"15","author":"Hrelia","year":"2022","journal-title":"Nutrients"},{"key":"2025101009015397800_nuaf078-B84","doi-asserted-by":"publisher","first-page":"3110","DOI":"10.3390\/ijerph19053110","article-title":"On health effects of resveratrol in wine","volume":"19","author":"Haunschild","year":"2022","journal-title":"Int J Environ Res Public Health"},{"key":"2025101009015397800_nuaf078-B85","doi-asserted-by":"publisher","first-page":"340","DOI":"10.3390\/foods9030340","article-title":"Health benefits and molecular mechanisms of resveratrol: a narrative review","volume":"9","author":"Meng","year":"2020","journal-title":"Foods"},{"key":"2025101009015397800_nuaf078-B86","doi-asserted-by":"publisher","first-page":"R771","DOI":"10.1152\/ajpregu.00147.2005","article-title":"Antihypertensive and cognitive effects of grape polyphenols in estrogen-depleted, female, spontaneously hypertensive rats","volume":"289","author":"Peng","year":"2005","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2025101009015397800_nuaf078-B87","doi-asserted-by":"publisher","first-page":"128091","DOI":"10.1016\/j.foodchem.2020.128091","article-title":"Simultaneous determination of melatonin and trans-resveratrol in wine by dispersive liquid\u2013liquid microextraction followed by HPLC-FLD","volume":"339","author":"Viegas","year":"2021","journal-title":"Food Chem"},{"key":"2025101009015397800_nuaf078-B88","doi-asserted-by":"publisher","first-page":"4105","DOI":"10.3390\/molecules25184105","article-title":"Wine\u2019s phenolic compounds and health: a Pythagorean view","volume":"25","author":"Visioli","year":"2020","journal-title":"Molecules"},{"key":"2025101009015397800_nuaf078-B89","doi-asserted-by":"publisher","first-page":"1900","DOI":"10.1038\/mp.2017.168","article-title":"Methylomic profiling and replication implicates deregulation of PCSK9 in alcohol use disorder","volume":"23","author":"Lohoff","year":"2018","journal-title":"Mol Psychiatry"},{"key":"2025101009015397800_nuaf078-B90","volume-title":"Global Status Report on Alcohol and Health 2018.","author":"WHO","year":"2018"}],"container-title":["Nutrition Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/nutritionreviews\/article-pdf\/83\/11\/2055\/63616162\/nuaf078.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nutritionreviews\/article-pdf\/83\/11\/2055\/63616162\/nuaf078.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:01:59Z","timestamp":1760101319000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nutritionreviews\/article\/83\/11\/2055\/8177174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,28]]},"references-count":90,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,6,28]]},"published-print":{"date-parts":[[2025,11,1]]}},"URL":"https:\/\/doi.org\/10.1093\/nutrit\/nuaf078","relation":{},"ISSN":["0029-6643","1753-4887"],"issn-type":[{"value":"0029-6643","type":"print"},{"value":"1753-4887","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,11]]},"published":{"date-parts":[[2025,6,28]]}}}