{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T19:42:08Z","timestamp":1773430928298,"version":"3.50.1"},"reference-count":106,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Autism spectrum disorder (ASD) is characterized as a neurodevelopmental disorder in which oxidative stress is a strong hypothesis for the pathophysiology. Treatment usually involves complementary therapies and psychotropic medication. However, despite their benefits, these drugs also cause adverse effects. Thus, substances such as vitamins, minerals, antioxidants, and fatty acids have been the subject of studies due to their possible benefits. This scoping review aimed to map the literature on substances that can reduce symptoms associated with ASD. The review followed the PRISMA guidelines and the Joanna Briggs Institute Manual for Evidence Synthesis. The studied substances were folic acid, l-carnitine, l-carnosine, melatonin, methylcobalamin, sulforaphane, beta-glucan, and ubiquinol. The interventions reduced some symptoms, with improvements in sociability, cognition, language, the Childhood Autism Rating Scale (CARS) score, the Clinical Global Impression Scale (CGI-I) score, and sleep disorders, with mild or no adverse effects. Although further research is necessary, the substances described in the literature have potential for use in clinical practice and could be options for reducing symptoms of autism or those related to comorbidities, with a view to improving the quality of life in this population.<\/jats:p>\n                  <jats:p>Scoping Review Registration: The protocol was prospectively registered on the Open Science Framework on June 30, 2022 (https:\/\/osf.io\/2ejhk).<\/jats:p>","DOI":"10.1093\/nutrit\/nuaf085","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T07:32:46Z","timestamp":1746689566000},"page":"2439-2455","source":"Crossref","is-referenced-by-count":3,"title":["Dietary Supplements in the Management of Symptoms Associated With Autism Spectrum Disorder: A Scoping Review"],"prefix":"10.1093","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1696-7905","authenticated-orcid":false,"given":"Sabrina dos Santos","family":"Serafim","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, Graduate Program in Pharmaceutical Services, Federal University of Santa Catarina , Florian\u00f3polis, Santa Catarina 88040-900,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6810-9133","authenticated-orcid":false,"given":"La\u00eds Moraes","family":"Sant\u2032Anna","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Federal University of Santa Catarina , Florian\u00f3polis, Santa Catarina 88040-900,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2123-4493","authenticated-orcid":false,"given":"Marina Raijche Mattozo","family":"Rover","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Graduate Program in Pharmaceutical Services, Federal University of Santa Catarina , Florian\u00f3polis, Santa Catarina 88040-900,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,6,23]]},"reference":[{"key":"2025111102514706600_nuaf085-B1","doi-asserted-by":"publisher","first-page":"4000","DOI":"10.2174\/092986712802002572","article-title":"Glutathione-related factors and oxidative stress in autism, a review","volume":"19","author":"Ghanizadeh","year":"2012","journal-title":"Curr Med Chem"},{"key":"2025111102514706600_nuaf085-B2","volume-title":"Manual Diagn\u00f3stico e Estat\u00edstico de Transtornos Mentais: DSM-V.","author":"Cordioli","year":"2014","edition":"5th ed"},{"key":"2025111102514706600_nuaf085-B3","doi-asserted-by":"publisher","first-page":"150","DOI":"10.3389\/fphys.2014.00150","article-title":"Evidence linking oxidative stress, mitochondrial dysfunction, and inflammation in the brain of individuals with autism","volume":"5","author":"Rossignol","year":"2014","journal-title":"Front Physiol"},{"key":"2025111102514706600_nuaf085-B4","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1096\/fj.201601004R","article-title":"Mitochondrial and redox abnormalities in autism lymphoblastoid cells: a sibling control study","volume":"31","author":"Rose","year":"2017","journal-title":"FASEB J"},{"key":"2025111102514706600_nuaf085-B5","doi-asserted-by":"publisher","first-page":"2314","DOI":"10.1007\/s12035-019-01742-2","article-title":"Oxidative stress in autism spectrum disorder","volume":"57","author":"Bj\u00f8rklund","year":"2020","journal-title":"Mol Neurobiol"},{"key":"2025111102514706600_nuaf085-B6","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1001\/jamapediatrics.2022.1846","article-title":"Prevalence of autism spectrum disorder among children and adolescents in the United States from 2019 to 2020","volume":"176","author":"Li","year":"2022","journal-title":"JAMA Pediatr"},{"key":"2025111102514706600_nuaf085-B7","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.jaac.2017.03.013","article-title":"What is the male-to-female ratio in autism spectrum disorder? 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