{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:58:53Z","timestamp":1791464333374,"version":"4.3.4"},"reference-count":102,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Vitamin\u2009D deficiency is highly prevalent in chronic liver disease. Although international societies recommend vitamin D supplementation in cases of proven deficiency, the impact of vitamin D on chronic liver disease remains uncertain.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Our aim was to evaluate the effects of vitamin D supplementation in patients with chronic liver disease by conducting a systematic review and meta-analysis of randomized controlled trials (RCTs).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Data Sources<\/jats:title>\n                  <jats:p>We systematically searched PubMed, EMBASE and the Cochrane Library on July 2, 2024.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Data Extraction<\/jats:title>\n                  <jats:p>Our primary outcomes involved survival, controlled attenuation parameter (CAP), liver stiffness measurement (LSM), and effects on changes in liver enzymes. Secondary outcomes included lipid profile and homeostasis model assessment of insulin resistance (HOMA-IR), among others. The pooled risk ratio (RR), mean difference (MD), and corresponding 95% CIs were calculated using the random-effects model.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Data Analysis<\/jats:title>\n                  <jats:p>Forty-six RCTs were included, comprising 4084 patients. When we compared the vitamin D group with the control, the RR for overall survival was 1.14 (95% CI, 0.85-1.54; 4 RCTs) at 6\u2009months and 0.99 (95% CI, 0.83-1.17; 4 RCTs) at the 12-month follow-up. Vitamin D supplementation did not result in a lower CAP (MD, \u221223.50\u2009dB\/m; 95% CI, \u221281.72 to 34.72; 3 RCTs) and LSM (MD, \u22120.65\u2009kPa; 95% CI, \u22121.98 to 0.68; 3 RCTs). A significant reduction in HOMA-IR was observed in the vitamin D group (MD, \u22120.31; 95% CI, \u22120.62 to \u22120.01; 15 RCTs). Alanine aminotransferase (ALT) (MD, \u22124.98\u2009IU\/L; 95% CI, \u22128.28 to \u22121.68; 24 RCTs), aspartate aminotransferase (AST) (MD, \u22123.33\u2009IU\/L; 95% CI, \u22126.25 to \u22120.40; 23 RCTs), gamma-glutamyl transferase (GGT) (MD, \u22125.14\u2009IU\/L; \u22126.40; \u22123.88; 11 RCTs), triglycerides (MD, \u22127.59\u2009mg\/dL; 95% CI, \u221215.09 to \u22120.81), and insulin (MD \u22120.79 \u03bcIU\/L; 95% CI, \u22121.36 to \u22120.21) were significantly reduced in the patients with vitamin D supplementation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Our results showed significantly reduced ALT, AST, GGT, triglycerides, insulin, and HOMA-IR in the vitamin D\u2013supplemented group; however, the effect was modest. In addition, there were no differences in survival, CAP, or LSM. Further RCTs with adequate power are warranted to clarify the results.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Systematic Review Registration<\/jats:title>\n                  <jats:p>PROSPERO registration No. CRD42022370312<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/nutrit\/nuaf117","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T17:40:42Z","timestamp":1752255642000},"page":"2043-2054","source":"Crossref","is-referenced-by-count":8,"title":["Role of Vitamin D Supplementation in Chronic Liver Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials"],"prefix":"10.1093","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2007-1112","authenticated-orcid":false,"given":"Petrana","family":"Martinekova","sequence":"first","affiliation":[{"name":"Centre for Translational Medicine, Semmelweis University , Budapest 1085,","place":["Hungary"]},{"name":"Institute for Clinical and Experimental Medicine , Prague 140 21,","place":["Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Obeidat","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine, Semmelweis University , Budapest 1085,","place":["Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela","family":"Topala","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine, Semmelweis University , Budapest 1085,","place":["Hungary"]},{"name":"Carol Davila University of Medicine and Pharmacy , Bucharest 050474,","place":["Romania"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szil\u00e1rd","family":"V\u00e1ncsa","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine, Semmelweis University , Budapest 1085,","place":["Hungary"]},{"name":"Institute of Pancreatic Diseases, Semmelweis University , Budapest 1083,","place":["Hungary"]},{"name":"Institute for Translational Medicine, University of P\u00e9cs, Medical School , P\u00e9cs 7623,","place":["Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e1niel S\u00e1ndor","family":"Veres","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine, Semmelweis University , Budapest 1085,","place":["Hungary"]},{"name":"Department of Biophysics and Radiation Biology, Semmelweis University , Budapest 1094,","place":["Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1d\u00e1m","family":"Zolcs\u00e1k","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine, Semmelweis University , Budapest 1085,","place":["Hungary"]},{"name":"Department of Biophysics and Radiation Biology, Semmelweis University , Budapest 1094,","place":["Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miheller","family":"P\u00e1l","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine, Semmelweis University , Budapest 1085,","place":["Hungary"]},{"name":"Department of Surgery, Transplantation and Gastroenterology, Semmelweis University , Budapest 1082,","place":["Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"F\u00f6ldv\u00e1ri-Nagy","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine, Semmelweis University , Budapest 1085,","place":["Hungary"]},{"name":"Department of Morphology and Physiology, Faculty of Health Sciences, Semmelweis University , Budapest 1088,","place":["Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Banovcin","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine, Semmelweis University , Budapest 1085,","place":["Hungary"]},{"name":"Gastroenterology Clinic, University Hospital in Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava , Martin 036 59,","place":["Slovak Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1lint","family":"Er\u0151ss","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine, Semmelweis University , Budapest 1085,","place":["Hungary"]},{"name":"Institute of Pancreatic Diseases, Semmelweis University , Budapest 1083,","place":["Hungary"]},{"name":"Institute for Translational Medicine, University of P\u00e9cs, Medical School , P\u00e9cs 7623,","place":["Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Hegyi","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine, Semmelweis University , Budapest 1085,","place":["Hungary"]},{"name":"Institute of Pancreatic Diseases, Semmelweis University , Budapest 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