{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:35:01Z","timestamp":1792798501724,"version":"4.5.0"},"reference-count":187,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Noncommunicable Chronic Diseases-National Science and Technology Major Project","award":["2023ZD0507302"],"award-info":[{"award-number":["2023ZD0507302"]}]},{"name":"Noncommunicable Chronic Diseases-National Science and Technology Major Project","award":["2024ZD0531400"],"award-info":[{"award-number":["2024ZD0531400"]}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2022YFA0806101"],"award-info":[{"award-number":["2022YFA0806101"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Type 1 diabetes (T1D) stems from the autoimmune attack on insulin-producing pancreatic islet \u03b2 cells. Progression of T1D is fundamentally dictated by genetic predisposition and modified by environmental and dietary factors. Although patients with T1D are typically characterized by weight loss, overweight and obesity have become more prevalent in recent years. This phenomenon is related to the intake of fat beyond the recommended limit, and a high-fat diet (HFD) is speculated to elevate the risk of T1D along with the development of diabetic complications. By contrast, results of studies in animal models are somehow contradictory: some suggest an HFD has a detrimental effect, others support a protective role. Herein these findings are summarized, and contradictory findings are termed the \u201cfat paradox.\u201d The paradoxical roles of an HFD in the T1D setting are discusses, and the potential mechanistic explanations are delved into from the perspectives of immune regulation, \u03b2-cell fitness, gut microbiota remodeling, and HFD composition. The opposite effects of saturated fatty acids (SFAs) and unsaturated fatty acids, especially n-3 polyunsaturated fatty acids (PUFAs), are particularly emphasized. Specifically, SFAs instigate pro-inflammatory responses and reduce the abundance of bacterial that produced short-chain fatty acids (SCFAs), whereas n-3 PUFAs have anti-inflammatory properties and facilitate the enrichment of SCFA-producing bacteria. Altogether, the multifaceted roles of fat uptake under T1D setting indicate a potential dietary intervention strategy with tailored fat types and optimized intake levels.<\/jats:p>","DOI":"10.1093\/nutrit\/nuaf184","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T12:13:20Z","timestamp":1758888800000},"source":"Crossref","is-referenced-by-count":2,"title":["High-Fat Diet: A Paradoxical Factor in the Setting of Type 1 Diabetes"],"prefix":"10.1093","author":[{"given":"Wan-Ying","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, the Center for Biomedical Research, NHC Key Laboratory of Respiratory Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan-Jie","family":"Rong","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, the Center for Biomedical Research, NHC Key Laboratory of Respiratory Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Shanxi Bethune Hospital, Shanxi Academy of Medical Science, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, the Key Laboratory of Endocrine and Metabolic Diseases of Shanxi Province , Taiyuan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Liang","family":"Yang","sequence":"additional","affiliation":[{"name":"Diabetes Research Center, Qatar Biomedical Research Institute, Hamad Bin Khalifa University , Doha, 34110,","place":["Qatar"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue-Chen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, the Center for Biomedical Research, NHC Key Laboratory of Respiratory Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan,","place":["China"]},{"name":"Diabetes Research Center, Qatar Biomedical Research Institute, Hamad Bin Khalifa University , Doha, 34110,","place":["Qatar"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba H","family":"Al-Siddiqi","sequence":"additional","affiliation":[{"name":"Diabetes Research Center, Qatar Biomedical Research Institute, Hamad Bin Khalifa University , Doha, 34110,","place":["Qatar"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8184-6718","authenticated-orcid":false,"given":"Fei","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, the Center for Biomedical Research, NHC Key Laboratory of Respiratory Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan,","place":["China"]},{"name":"Diabetes Research Center, Qatar Biomedical Research Institute, Hamad Bin Khalifa University , Doha, 34110,","place":["Qatar"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong-Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanxi Bethune Hospital, Shanxi Academy of Medical Science, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, the Key Laboratory of Endocrine and Metabolic Diseases of Shanxi Province , Taiyuan,","place":["China"]},{"name":"Diabetes Research Center, Qatar Biomedical Research Institute, Hamad Bin Khalifa University , Doha, 34110,","place":["Qatar"]},{"name":"The Center for Biomedical Research, Tongji Hospital Research Building, Tongji Hospital , Wuhan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,10,28]]},"reference":[{"key":"2025102902212194500_nuaf184-B1","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.3389\/fimmu.2020.01510","article-title":"The AHR signaling attenuates autoimmune responses during the development of type 1 diabetes","volume":"11","author":"Yue","year":"2020","journal-title":"Front Immunol"},{"key":"2025102902212194500_nuaf184-B2","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/s13578-023-01110-7","article-title":"Pancreatic draining lymph nodes (PLNs) serve as a pathogenic hub contributing to the development of type 1 diabetes","volume":"13","author":"Sun","year":"2023","journal-title":"Cell Biosci"},{"key":"2025102902212194500_nuaf184-B3","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1084\/jem.187.10.1549","article-title":"Cross-tolerance: a pathway for inducing tolerance to peripheral tissue antigens","volume":"187","author":"Heath","year":"1998","journal-title":"J Exp Med"},{"key":"2025102902212194500_nuaf184-B4","doi-asserted-by":"crossref","first-page":"828","DOI":"10.4239\/wjd.v6.i6.828","article-title":"Enterovirus and type 1 diabetes: what is the matter?","volume":"6","author":"Bergamin","year":"2015","journal-title":"World J Diabetes"},{"key":"2025102902212194500_nuaf184-B5","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1084\/jem.20030966","article-title":"Physiological beta cell death triggers priming of self-reactive T cells by dendritic cells in a type-1 diabetes model","volume":"198","author":"Turley","year":"2003","journal-title":"J Exp Med"},{"key":"2025102902212194500_nuaf184-B6","doi-asserted-by":"crossref","first-page":"690783","DOI":"10.3389\/fimmu.2021.690783","article-title":"Revisiting the antigen-presenting function of \u03b2 cells in T1D pathogenesis","volume":"12","author":"Li","year":"2021","journal-title":"Front Immunol"},{"key":"2025102902212194500_nuaf184-B7","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.it.2013.08.005","article-title":"Immune mechanisms in type 1 diabetes","volume":"34","author":"W\u00e5llberg","year":"2013","journal-title":"Trends Immunol"},{"key":"2025102902212194500_nuaf184-B8","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/s41574-019-0254-y","article-title":"The heterogeneous pathogenesis of type 1 diabetes mellitus","volume":"15","author":"Ilonen","year":"2019","journal-title":"Nat Rev Endocrinol"},{"key":"2025102902212194500_nuaf184-B9","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1016\/S0140-6736(23)00223-4","article-title":"Type 1 diabetes","volume":"401","author":"Quattrin","year":"2023","journal-title":"Lancet"},{"key":"2025102902212194500_nuaf184-B10","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/s41574-023-00853-0","article-title":"Heterogeneity and endotypes in type 1 diabetes mellitus","volume":"19","author":"Redondo","year":"2023","journal-title":"Nat Rev Endocrinol"},{"key":"2025102902212194500_nuaf184-B11","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1007\/s00125-023-05955-y","article-title":"Utility of genetic risk scores in type 1 diabetes","volume":"66","author":"Luckett","year":"2023","journal-title":"Diabetologia"},{"key":"2025102902212194500_nuaf184-B12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms21010036","article-title":"Epigenetic regulation in etiology of type 1 diabetes mellitus","volume":"21","author":"Cerna","year":"2019","journal-title":"Int J Mol Sci"},{"key":"2025102902212194500_nuaf184-B13","doi-asserted-by":"crossref","first-page":"e1002300","DOI":"10.1371\/journal.pgen.1002300","article-title":"Identification of type 1 diabetes-associated DNA methylation variable positions that precede disease diagnosis","volume":"7","author":"Rakyan","year":"2011","journal-title":"PLoS Genet"},{"key":"2025102902212194500_nuaf184-B14","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1002\/med.21878","article-title":"Epigenetic modifications in pancreas development, diabetes, and therapeutics","volume":"42","author":"Kaimala","year":"2022","journal-title":"Med Res Rev"},{"key":"2025102902212194500_nuaf184-B15","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/s41418-021-00852-6","article-title":"MBD2 acts as a repressor to maintain the homeostasis of the Th1 program in type 1 diabetes by regulating the STAT1-IFN-\u03b3 axis","volume":"29","author":"Yue","year":"2022","journal-title":"Cell Death Differ"},{"key":"2025102902212194500_nuaf184-B16","doi-asserted-by":"crossref","first-page":"e3075","DOI":"10.1002\/dmrr.3075","article-title":"Incidence and trend of type 1 diabetes and the underlying environmental determinants","volume":"35","author":"Xia","year":"2019","journal-title":"Diabetes Metab Res Rev"},{"key":"2025102902212194500_nuaf184-B17","doi-asserted-by":"crossref","first-page":"9171","DOI":"10.3390\/nu7115461","article-title":"Diet, microbiota and immune system in type 1 diabetes development and evolution","volume":"7","author":"Mej\u00eda-Le\u00f3n","year":"2015","journal-title":"Nutrients"},{"key":"2025102902212194500_nuaf184-B18","first-page":"1","article-title":"Fats and fatty acids in human nutrition. Report of an expert consultation","volume":"91","year":"2010","journal-title":"FAO Food Nutr Pap"},{"key":"2025102902212194500_nuaf184-B19","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.cellimm.2017.03.001","article-title":"Role of immune cells in obesity induced low grade inflammation and insulin resistance","volume":"315","author":"Asghar","year":"2017","journal-title":"Cell Immunol"},{"key":"2025102902212194500_nuaf184-B20","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s10753-012-9557-z","article-title":"A high-fat diet increases IL-1, IL-6, and TNF-\u03b1 production by increasing NF-\u03baB and attenuating PPAR-\u03b3 expression in bone marrow mesenchymal stem cells","volume":"36","author":"Cortez","year":"2013","journal-title":"Inflammation"},{"key":"2025102902212194500_nuaf184-B21","doi-asserted-by":"crossref","first-page":"e825","DOI":"10.1152\/ajpendo.00147.2011","article-title":"A minor role for lipocalin 2 in high-fat diet-induced glucose intolerance","volume":"301","author":"Jun","year":"2011","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2025102902212194500_nuaf184-B22","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1172\/JCI200319246","article-title":"Obesity is associated with macrophage accumulation in adipose tissue","volume":"112","author":"Weisberg","year":"2003","journal-title":"J Clin Invest"},{"key":"2025102902212194500_nuaf184-B23","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1172\/JCI26498","article-title":"MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity","volume":"116","author":"Kanda","year":"2006","journal-title":"J Clin Invest"},{"key":"2025102902212194500_nuaf184-B24","doi-asserted-by":"crossref","first-page":"e12747","DOI":"10.1111\/sji.12747","article-title":"An update on immune dysregulation in obesity-related insulin resistance","volume":"89","author":"Daryabor","year":"2019","journal-title":"Scand J Immunol"},{"key":"2025102902212194500_nuaf184-B25","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1128\/MCB.00951-12","article-title":"Selective inhibition of hypoxia-inducible factor 1\u03b1 ameliorates adipose tissue dysfunction","volume":"33","author":"Sun","year":"2013","journal-title":"Mol Cell Biol"},{"key":"2025102902212194500_nuaf184-B26","doi-asserted-by":"crossref","first-page":"8775","DOI":"10.1074\/jbc.RA117.001526","article-title":"TLR4, TRIF, and MyD88 are essential for myelopoiesis and CD11c(+) adipose tissue macrophage production in obese mice","volume":"293","author":"Griffin","year":"2018","journal-title":"J Biol Chem"},{"key":"2025102902212194500_nuaf184-B27","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/ijo.2015.145","article-title":"Large adipocytes function as antigen-presenting cells to activate CD4(+) T cells via upregulating MHCII in obesity","volume":"40","author":"Xiao","year":"2016","journal-title":"Int J Obes (Lond)"},{"key":"2025102902212194500_nuaf184-B28","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1038\/nm.2885","article-title":"Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase","volume":"18","author":"Talukdar","year":"2012","journal-title":"Nat Med"},{"key":"2025102902212194500_nuaf184-B29","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1172\/JCI29881","article-title":"Obesity induces a phenotypic switch in adipose tissue macrophage polarization","volume":"117","author":"Lumeng","year":"2007","journal-title":"J Clin Invest"},{"key":"2025102902212194500_nuaf184-B30","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1002\/mnfr.201200058","article-title":"Dietary saturated fatty acids prime the NLRP3 inflammasome via TLR4 in dendritic cells-implications for diet-induced insulin resistance","volume":"56","author":"Reynolds","year":"2012","journal-title":"Mol Nutr Food Res"},{"key":"2025102902212194500_nuaf184-B31","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/ni.3120","article-title":"NK cells link obesity-induced adipose stress to inflammation and insulin resistance","volume":"16","author":"Wensveen","year":"2015","journal-title":"Nat Immunol"},{"key":"2025102902212194500_nuaf184-B32","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1038\/nm.1994","article-title":"Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice","volume":"15","author":"Liu","year":"2009","journal-title":"Nat Med"},{"key":"2025102902212194500_nuaf184-B33","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.immuni.2016.06.016","article-title":"Adipose-resident group 1 innate lymphoid cells promote obesity-associated insulin resistance","volume":"45","author":"O'Sullivan","year":"2016","journal-title":"Immunity"},{"key":"2025102902212194500_nuaf184-B34","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1189\/jlb.3A0414-211RR","article-title":"\u03b3\u03b4 T cells promote inflammation and insulin resistance during high fat diet-induced obesity in mice","volume":"97","author":"Mehta","year":"2015","journal-title":"J Leukoc Biol"},{"key":"2025102902212194500_nuaf184-B35","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1084\/jem.20121964","article-title":"Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages","volume":"210","author":"Molofsky","year":"2013","journal-title":"J Exp Med"},{"key":"2025102902212194500_nuaf184-B36","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.molmet.2017.12.004","article-title":"Elevating adipose eosinophils in obese mice to physiologically normal levels does not rescue metabolic impairments","volume":"8","author":"Bolus","year":"2018","journal-title":"Mol Metab"},{"key":"2025102902212194500_nuaf184-B37","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1161\/ATVBAHA.113.302077","article-title":"Essential role of CD11a in CD8+ T-cell accumulation and activation in adipose tissue","volume":"34","author":"Jiang","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2025102902212194500_nuaf184-B38","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.2337\/db12-1404","article-title":"Adipose tissue macrophages function as antigen-presenting cells and regulate adipose tissue CD4+ T cells in mice","volume":"62","author":"Morris","year":"2013","journal-title":"Diabetes"},{"key":"2025102902212194500_nuaf184-B39","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/nm.1964","article-title":"CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity","volume":"15","author":"Nishimura","year":"2009","journal-title":"Nat Med"},{"key":"2025102902212194500_nuaf184-B40","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.2337\/db11-1274","article-title":"Identification of adipose tissue dendritic cells correlated with obesity-associated insulin-resistance and inducing Th17 responses in mice and patients","volume":"61","author":"Bertola","year":"2012","journal-title":"Diabetes"},{"key":"2025102902212194500_nuaf184-B41","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1172\/JCI90350","article-title":"Adipose tissue B2 cells promote insulin resistance through leukotriene LTB4\/LTB4R1 signaling","volume":"127","author":"Ying","year":"2017","journal-title":"J Clin Invest"},{"key":"2025102902212194500_nuaf184-B42","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.cmet.2013.09.017","article-title":"Adipose natural regulatory B cells negatively control adipose tissue inflammation","volume":"18","author":"Nishimura","year":"2013","journal-title":"Cell Metab"},{"key":"2025102902212194500_nuaf184-B43","doi-asserted-by":"crossref","first-page":"13561","DOI":"10.1074\/jbc.M112.350066","article-title":"Activation of natural killer T cells promotes M2 macrophage polarization in adipose tissue and improves systemic glucose tolerance via interleukin-4 (IL-4)\/STAT6 protein signaling axis in obesity","volume":"287","author":"Ji","year":"2012","journal-title":"J Biol Chem"},{"key":"2025102902212194500_nuaf184-B44","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/imm.12269","article-title":"Adipose invariant natural killer T cells","volume":"142","author":"Lynch","year":"2014","journal-title":"Immunology"},{"key":"2025102902212194500_nuaf184-B45","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/s41385-022-00547-2","article-title":"Regulation of intestinal immunity by dietary fatty acids","volume":"15","author":"Qiu","year":"2022","journal-title":"Mucosal Immunol"},{"key":"2025102902212194500_nuaf184-B46","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/advances\/nmz061","article-title":"Negative effects of a high-fat diet on intestinal permeability: a review","volume":"11","author":"Rohr","year":"2020","journal-title":"Adv Nutr"},{"key":"2025102902212194500_nuaf184-B47","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.2337\/db06-1491","article-title":"Metabolic endotoxemia initiates obesity and insulin resistance","volume":"56","author":"Cani","year":"2007","journal-title":"Diabetes"},{"key":"2025102902212194500_nuaf184-B48","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s10753-020-01309-7","article-title":"The combinatorial effect of acetate and propionate on high-fat diet induced diabetic inflammation or metaflammation and T cell polarization","volume":"44","author":"Mandaliya","year":"2021","journal-title":"Inflammation"},{"key":"2025102902212194500_nuaf184-B49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cells10113164","article-title":"High-fat, Western-style diet, systemic inflammation, and gut microbiota: a narrative review","volume":"10","author":"Malesza","year":"2021","journal-title":"Cells"},{"key":"2025102902212194500_nuaf184-B50","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.cmet.2013.03.005","article-title":"Imbalance between neutrophil elastase and its inhibitor \u03b11-antitrypsin in obesity alters insulin sensitivity, inflammation, and energy expenditure","volume":"17","author":"Mansuy-Aubert","year":"2013","journal-title":"Cell Metab"},{"key":"2025102902212194500_nuaf184-B51","doi-asserted-by":"crossref","first-page":"103193","DOI":"10.1016\/j.redox.2024.103193","article-title":"The absence of thioredoxin-interacting protein in alveolar cells exacerbates asthma during obesity","volume":"73","author":"Jeong","year":"2024","journal-title":"Redox Biol"},{"key":"2025102902212194500_nuaf184-B52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms25116170","article-title":"Obesity enhances non-Th2 airway inflammation in a murine model of allergic asthma","volume":"25","author":"Mohamed","year":"2024","journal-title":"Int J Mol Sci"},{"key":"2025102902212194500_nuaf184-B53","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jaci.2019.01.043","article-title":"High dietary fat intake induces a microbiota signature that promotes food allergy","volume":"144","author":"Hussain","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"2025102902212194500_nuaf184-B54","doi-asserted-by":"crossref","first-page":"21240","DOI":"10.1021\/acs.jafc.4c05373","article-title":"Maternal high-fat diet exacerbates epicutaneous sensitization and oral challenge-induced food allergy to ovalbumin in offspring mice","volume":"72","author":"Bai","year":"2024","journal-title":"J Agric Food Chem"},{"key":"2025102902212194500_nuaf184-B55","doi-asserted-by":"crossref","first-page":"132762","DOI":"10.1016\/j.foodchem.2022.132762","article-title":"Role of the dietary components in food allergy: a comprehensive review","volume":"386","author":"Yang","year":"2022","journal-title":"Food Chem"},{"key":"2025102902212194500_nuaf184-B56","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1159\/000517866","article-title":"High-fat diet-induced obesity aggravates food allergy by intestinal barrier destruction and inflammation","volume":"183","author":"Gu","year":"2022","journal-title":"Int Arch Allergy Immunol"},{"key":"2025102902212194500_nuaf184-B57","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/cod.14088","article-title":"Obesity aggravates contact hypersensitivity reaction in mice","volume":"87","author":"Majewska-Szczepanik","year":"2022","journal-title":"Contact Dermatitis"},{"key":"2025102902212194500_nuaf184-B58","doi-asserted-by":"crossref","first-page":"14076","DOI":"10.1038\/s41598-017-14292-1","article-title":"High fat diet exacerbates murine psoriatic dermatitis by increasing the number of IL-17-producing \u03b3\u03b4 T cells","volume":"7","author":"Nakamizo","year":"2017","journal-title":"Sci Rep"},{"key":"2025102902212194500_nuaf184-B59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/lupus-2023-000898","article-title":"Lupus pathogenesis and autoimmunity are exacerbated by high fat diet-induced obesity in MRL\/lpr mice","volume":"10","author":"Zhang","year":"2023","journal-title":"Lupus Sci Med"},{"key":"2025102902212194500_nuaf184-B60","doi-asserted-by":"crossref","first-page":"18532","DOI":"10.1038\/s41598-022-21381-3","article-title":"Effects of high fat diet-induced obesity on pathophysiology, immune cells, and therapeutic efficacy in systemic lupus erythematosus","volume":"12","author":"Choi","year":"2022","journal-title":"Sci Rep"},{"key":"2025102902212194500_nuaf184-B61","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.3389\/fimmu.2019.01881","article-title":"Obesity promotes EAE through IL-6 and CCL-2-mediated T cells infiltration","volume":"10","author":"Ji","year":"2019","journal-title":"Front Immunol"},{"key":"2025102902212194500_nuaf184-B62","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s11481-013-9502-4","article-title":"High fat diet exacerbates neuroinflammation in an animal model of multiple sclerosis by activation of the renin angiotensin system","volume":"9","author":"Timmermans","year":"2014","journal-title":"J Neuroimmune Pharmacol"},{"key":"2025102902212194500_nuaf184-B63","doi-asserted-by":"crossref","first-page":"701626","DOI":"10.3389\/fimmu.2021.701626","article-title":"Propionic acid rescues high-fat diet enhanced immunopathology in autoimmunity via effects on Th17 responses","volume":"12","author":"Haase","year":"2021","journal-title":"Front Immunol"},{"key":"2025102902212194500_nuaf184-B64","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.ajpath.2016.12.023","article-title":"Th17 and IL-17 cause acceleration of inflammation and fat loss by inducing \u03b1(2)-glycoprotein 1 (AZGP1) in rheumatoid arthritis with high-fat diet","volume":"187","author":"Na","year":"2017","journal-title":"Am J Pathol"},{"key":"2025102902212194500_nuaf184-B65","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1136\/annrheumdis-2016-209206","article-title":"Differential impact of obesity on the pathogenesis of RA or preclinical models is contingent on the disease status","volume":"76","author":"Kim","year":"2017","journal-title":"Ann Rheum Dis"},{"key":"2025102902212194500_nuaf184-B66","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1146\/annurev-food-111317-095850","article-title":"Omega-3 polyunsaturated fatty acids and their health benefits","volume":"9","author":"Shahidi","year":"2018","journal-title":"Annu Rev Food Sci Technol"},{"key":"2025102902212194500_nuaf184-B67","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/j.immuni.2013.05.015","article-title":"Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation","volume":"38","author":"Yan","year":"2013","journal-title":"Immunity"},{"key":"2025102902212194500_nuaf184-B68","doi-asserted-by":"crossref","first-page":"116509","DOI":"10.1016\/j.biopha.2024.116509","article-title":"Free fatty acid receptor 4 (FFA4) activation attenuates obese asthma by suppressing adiposity and resolving metaflammation","volume":"174","author":"Son","year":"2024","journal-title":"Biomed Pharmacother"},{"key":"2025102902212194500_nuaf184-B69","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1126\/science.abh1654","article-title":"Immunotherapy: building a bridge to a cure for type 1 diabetes","volume":"373","author":"Bluestone","year":"2021","journal-title":"Science"},{"key":"2025102902212194500_nuaf184-B70","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3109\/07853890.2010.530682","article-title":"Energy and nutrient intakes and adherence to dietary guidelines among Finnish adults with type 1 diabetes","volume":"44","author":"Ahola","year":"2012","journal-title":"Ann Med"},{"key":"2025102902212194500_nuaf184-B71","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41387-018-0021-5","article-title":"An audit of the dietary intake of Australian children with type 1 diabetes","volume":"8","author":"Gilbertson","year":"2018","journal-title":"Nutr Diabetes"},{"key":"2025102902212194500_nuaf184-B72","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s00125-006-0540-9","article-title":"Children and adolescents with type 1 diabetes eat a more atherosclerosis-prone diet than healthy control subjects","volume":"50","author":"Overby","year":"2007","journal-title":"Diabetologia"},{"key":"2025102902212194500_nuaf184-B73","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.tem.2014.02.003","article-title":"Lipotoxic endoplasmic reticulum stress, \u03b2 cell failure, and type 2 diabetes mellitus","volume":"25","author":"Biden","year":"2014","journal-title":"Trends Endocrinol Metab"},{"key":"2025102902212194500_nuaf184-B74","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1016\/j.jmb.2019.09.016","article-title":"Recent insights into mechanisms of \u03b2-cell lipo- and glucolipotoxicity in type 2 diabetes","volume":"432","author":"Lytrivi","year":"2020","journal-title":"J Mol Biol"},{"key":"2025102902212194500_nuaf184-B75","first-page":"E1055","article-title":"Acute enhancement of insulin secretion by FFA in humans is lost with prolonged FFA elevation","volume":"276","author":"Carpentier","year":"1999","journal-title":"Am J Physiol"},{"key":"2025102902212194500_nuaf184-B76","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cells10123328","article-title":"Lipotoxicity and \u03b2-cell failure in type 2 diabetes: oxidative stress linked to NADPH oxidase and ER stress","volume":"10","author":"Vilas-Boas","year":"2021","journal-title":"Cells"},{"key":"2025102902212194500_nuaf184-B77","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1007\/s11892-014-0492-2","article-title":"Lipotoxicity in the pancreatic beta cell: not just survival and function, but proliferation as well?","volume":"14","author":"Sharma","year":"2014","journal-title":"Curr Diab Rep"},{"key":"2025102902212194500_nuaf184-B78","doi-asserted-by":"crossref","first-page":"3489","DOI":"10.1172\/JCI71981","article-title":"Autophagy defends pancreatic \u03b2 cells from human islet amyloid polypeptide-induced toxicity","volume":"124","author":"Rivera","year":"2014","journal-title":"J Clin Invest"},{"key":"2025102902212194500_nuaf184-B79","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.3892\/ijmm.2013.1530","article-title":"Palmitate induces autophagy in pancreatic \u03b2-cells via endoplasmic reticulum stress and its downstream JNK pathway","volume":"32","author":"Chen","year":"2013","journal-title":"Int J Mol Med"},{"key":"2025102902212194500_nuaf184-B80","doi-asserted-by":"crossref","first-page":"44746","DOI":"10.1038\/srep44746","article-title":"The endoplasmic reticulum stress\/autophagy pathway is involved in cholesterol-induced pancreatic \u03b2-cell injury","volume":"7","author":"Kong","year":"2017","journal-title":"Sci Rep"},{"key":"2025102902212194500_nuaf184-B81","doi-asserted-by":"crossref","first-page":"e1801511","DOI":"10.1002\/adhm.201801511","article-title":"Degradable nanoparticles restore lysosomal pH and autophagic flux in lipotoxic pancreatic beta cells","volume":"8","author":"Zeng","year":"2019","journal-title":"Adv Healthc Mater"},{"key":"2025102902212194500_nuaf184-B82","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1083\/jcb.201511042","article-title":"Lysosome acidification by photoactivated nanoparticles restores autophagy under lipotoxicity","volume":"214","author":"Trudeau","year":"2016","journal-title":"J Cell Biol"},{"key":"2025102902212194500_nuaf184-B83","doi-asserted-by":"crossref","first-page":"6071","DOI":"10.1074\/jbc.M114.605345","article-title":"Inhibition of autophagic turnover in \u03b2-cells by fatty acids and glucose leads to apoptotic cell death","volume":"290","author":"Mir","year":"2015","journal-title":"J Biol Chem"},{"key":"2025102902212194500_nuaf184-B84","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms21197161","article-title":"MKP-5 relieves lipotoxicity-induced islet \u03b2-cell dysfunction and apoptosis via regulation of autophagy","volume":"21","author":"Zhao","year":"2020","journal-title":"Int J Mol Sci"},{"key":"2025102902212194500_nuaf184-B85","doi-asserted-by":"crossref","first-page":"42534","DOI":"10.1074\/jbc.M111.242412","article-title":"Fatty acids suppress autophagic turnover in \u03b2-cells","volume":"286","author":"Las","year":"2011","journal-title":"J Biol Chem"},{"key":"2025102902212194500_nuaf184-B86","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1007\/s00125-009-1347-2","article-title":"Autophagy in human type 2 diabetes pancreatic beta cells","volume":"52","author":"Masini","year":"2009","journal-title":"Diabetologia"},{"key":"2025102902212194500_nuaf184-B87","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.2337\/db13-1383","article-title":"RNA sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate","volume":"63","author":"Cnop","year":"2014","journal-title":"Diabetes"},{"key":"2025102902212194500_nuaf184-B88","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1530\/JME-19-0096","article-title":"Differential effects of saturated and unsaturated fatty acids on autophagy in pancreatic \u03b2-cells","volume":"63","author":"Dhayal","year":"2019","journal-title":"J Mol Endocrinol"},{"key":"2025102902212194500_nuaf184-B89","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1080\/15548627.2015.1091141","article-title":"ER stress: autophagy induction, inhibition and selection","volume":"11","author":"Rashid","year":"2015","journal-title":"Autophagy"},{"key":"2025102902212194500_nuaf184-B90","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1126\/science.1209038","article-title":"The unfolded protein response: from stress pathway to homeostatic regulation","volume":"334","author":"Walter","year":"2011","journal-title":"Science"},{"key":"2025102902212194500_nuaf184-B91","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1111\/febs.13598","article-title":"Cell death induced by endoplasmic reticulum stress","volume":"283","author":"Iurlaro","year":"2016","journal-title":"Febs J"},{"key":"2025102902212194500_nuaf184-B92","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1463-1326.2010.01279.x","article-title":"Causes and cures for endoplasmic reticulum stress in lipotoxic \u03b2-cell dysfunction","volume":"12 suppl 2","author":"Cnop","year":"2010","journal-title":"Diabetes Obes Metab"},{"key":"2025102902212194500_nuaf184-B93","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1242\/jcs.026062","article-title":"Initiation and execution of lipotoxic ER stress in pancreatic beta-cells","volume":"121","author":"Cunha","year":"2008","journal-title":"J Cell Sci"},{"key":"2025102902212194500_nuaf184-B94","doi-asserted-by":"crossref","first-page":"e1390","DOI":"10.1152\/ajpendo.00519.2011","article-title":"A role for aberrant protein palmitoylation in FFA-induced ER stress and \u03b2-cell death","volume":"302","author":"Baldwin","year":"2012","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2025102902212194500_nuaf184-B95","doi-asserted-by":"crossref","first-page":"26569","DOI":"10.1074\/jbc.M113.489310","article-title":"Alteration of endoplasmic reticulum lipid rafts contributes to lipotoxicity in pancreatic \u03b2-cells","volume":"288","author":"Boslem","year":"2013","journal-title":"J Biol Chem"},{"key":"2025102902212194500_nuaf184-B96","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1007\/s00125-009-1506-5","article-title":"Reduced endoplasmic reticulum (ER)-to-Golgi protein trafficking contributes to ER stress in lipotoxic mouse beta cells by promoting protein overload","volume":"52","author":"Preston","year":"2009","journal-title":"Diabetologia"},{"key":"2025102902212194500_nuaf184-B97","doi-asserted-by":"crossref","first-page":"32236","DOI":"10.1074\/jbc.M112.362160","article-title":"Cellular inhibitor of apoptosis protein-1 (cIAP1) plays a critical role in \u03b2-cell survival under endoplasmic reticulum stress: promoting ubiquitination and degradation of C\/EBP homologous protein (CHOP)","volume":"287","author":"Qi","year":"2012","journal-title":"J Biol Chem"},{"key":"2025102902212194500_nuaf184-B98","doi-asserted-by":"crossref","first-page":"213","DOI":"10.4161\/isl.3.5.15935","article-title":"Regulation of insulin secretion and reactive oxygen species production by free fatty acids in pancreatic islets","volume":"3","author":"Graciano","year":"2011","journal-title":"Islets"},{"key":"2025102902212194500_nuaf184-B99","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.freeradbiomed.2008.04.029","article-title":"Fatty acids as modulators of the cellular production of reactive oxygen species","volume":"45","author":"Sch\u00f6nfeld","year":"2008","journal-title":"Free Radic Biol Med"},{"key":"2025102902212194500_nuaf184-B100","doi-asserted-by":"crossref","first-page":"e 291","DOI":"10.1038\/emm.2016.157","article-title":"Oxidative stress and calcium dysregulation by palmitate in type 2 diabetes","volume":"49","author":"Ly","year":"2017","journal-title":"Exp Mol Med"},{"key":"2025102902212194500_nuaf184-B101","doi-asserted-by":"crossref","first-page":"200","DOI":"10.2337\/db09-1401","article-title":"Peroxisome-generated hydrogen peroxide as important mediator of lipotoxicity in insulin-producing cells","volume":"60","author":"Elsner","year":"2011","journal-title":"Diabetes"},{"key":"2025102902212194500_nuaf184-B102","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2020.11.023","article-title":"Transient NADPH oxidase 2-dependent H(2)O(2) production drives early palmitate-induced lipotoxicity in pancreatic islets","volume":"162","author":"Vilas-Boas","year":"2021","journal-title":"Free Radic Biol Med"},{"key":"2025102902212194500_nuaf184-B103","doi-asserted-by":"crossref","first-page":"e15726","DOI":"10.1371\/journal.pone.0015726","article-title":"NADPH oxidase 2-derived reactive oxygen species mediate FFAs-induced dysfunction and apoptosis of \u03b2-cells via JNK, p38 MAPK and p53 pathways","volume":"5","author":"Yuan","year":"2010","journal-title":"PLoS One"},{"key":"2025102902212194500_nuaf184-B104","doi-asserted-by":"crossref","first-page":"e0204271","DOI":"10.1371\/journal.pone.0204271","article-title":"The novel NADPH oxidase 4 selective inhibitor GLX7013114 counteracts human islet cell death in vitro","volume":"13","author":"Wang","year":"2018","journal-title":"PLoS One"},{"key":"2025102902212194500_nuaf184-B105","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1042\/CS20100282","article-title":"Arachidonic acid actions on functional integrity and attenuation of the negative effects of palmitic acid in a clonal pancreatic \u03b2-cell line","volume":"120","author":"Keane","year":"2011","journal-title":"Clin Sci (Lond)"},{"key":"2025102902212194500_nuaf184-B106","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.cmet.2012.01.023","article-title":"Saturated fatty acid and TLR signaling link \u03b2 cell dysfunction and islet inflammation","volume":"15","author":"Eguchi","year":"2012","journal-title":"Cell Metab"},{"key":"2025102902212194500_nuaf184-B107","doi-asserted-by":"crossref","first-page":"5934","DOI":"10.1074\/jbc.M117.809228","article-title":"Signaling between pancreatic \u03b2 cells and macrophages via S100 calcium-binding protein A8 exacerbates \u03b2-cell apoptosis and islet inflammation","volume":"293","author":"Inoue","year":"2018","journal-title":"J Biol Chem"},{"key":"2025102902212194500_nuaf184-B108","doi-asserted-by":"crossref","first-page":"110890","DOI":"10.1016\/j.mce.2020.110890","article-title":"The STING-IRF3 pathway is involved in lipotoxic injury of pancreatic \u03b2 cells in type 2 diabetes","volume":"518","author":"Hu","year":"2020","journal-title":"Mol Cell Endocrinol"},{"key":"2025102902212194500_nuaf184-B109","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1042\/CS20180836","article-title":"GPR120 protects lipotoxicity-induced pancreatic \u03b2-cell dysfunction through regulation of PDX1 expression and inhibition of islet inflammation","volume":"133","author":"Wang","year":"2019","journal-title":"Clin Sci (Lond)"},{"key":"2025102902212194500_nuaf184-B110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/nu12103039","article-title":"Microbiota and diabetes mellitus: role of lipid mediators","volume":"12","author":"Salazar","year":"2020","journal-title":"Nutrients"},{"key":"2025102902212194500_nuaf184-B111","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/nature11552","article-title":"Functional interactions between the gut microbiota and host metabolism","volume":"489","author":"Tremaroli","year":"2012","journal-title":"Nature"},{"key":"2025102902212194500_nuaf184-B112","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s40168-017-0258-6","article-title":"High-fat feeding rather than obesity drives taxonomical and functional changes in the gut microbiota in mice","volume":"5","author":"Xiao","year":"2017","journal-title":"Microbiome"},{"key":"2025102902212194500_nuaf184-B113","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1038\/4441022a","article-title":"Microbial ecology: human gut microbes associated with obesity","volume":"444","author":"Ley","year":"2006","journal-title":"Nature"},{"key":"2025102902212194500_nuaf184-B114","doi-asserted-by":"crossref","first-page":"9421","DOI":"10.1021\/acs.jafc.2c03574","article-title":"Neohesperidin dihydrochalcone ameliorates high-fat diet-induced glycolipid metabolism disorder in rats","volume":"70","author":"Xiao","year":"2022","journal-title":"J Agric Food Chem"},{"key":"2025102902212194500_nuaf184-B115","doi-asserted-by":"crossref","first-page":"6356","DOI":"10.1038\/s41467-022-33656-4","article-title":"Functional and metabolic alterations of gut microbiota in children with new-onset type 1 diabetes","volume":"13","author":"Yuan","year":"2022","journal-title":"Nat Commun"},{"key":"2025102902212194500_nuaf184-B116","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1080\/19490976.2016.1270811","article-title":"Western diets, gut dysbiosis, and metabolic diseases: are they linked?","volume":"8","author":"Martinez","year":"2017","journal-title":"Gut Microbes"},{"key":"2025102902212194500_nuaf184-B117","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/microorganisms8111715","article-title":"The influence of probiotics on the Firmicutes\/Bacteroidetes ratio in the treatment of obesity and inflammatory bowel disease","volume":"8","author":"Stojanov","year":"2020","journal-title":"Microorganisms"},{"key":"2025102902212194500_nuaf184-B118","doi-asserted-by":"crossref","first-page":"101546","DOI":"10.1016\/j.molmet.2022.101546","article-title":"Mitochondrial function in intestinal epithelium homeostasis and modulation in diet-induced obesity","volume":"63","author":"Guerbette","year":"2022","journal-title":"Mol Metab"},{"key":"2025102902212194500_nuaf184-B119","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1126\/science.aba3683","article-title":"High-fat diet-induced colonocyte dysfunction escalates microbiota-derived trimethylamine N-oxide","volume":"373","author":"Yoo","year":"2021","journal-title":"Science"},{"key":"2025102902212194500_nuaf184-B120","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s12275-024-00123-2","article-title":"Metabolic interaction between host and the gut microbiota during high-fat diet-induced colorectal cancer","volume":"62","author":"Lee","year":"2024","journal-title":"J Microbiol"},{"key":"2025102902212194500_nuaf184-B121","doi-asserted-by":"crossref","first-page":"e69","DOI":"10.1002\/imt2.69","article-title":"New insights into the mechanisms of high-fat diet mediated gut microbiota in chronic diseases","volume":"2","author":"Chen","year":"2023","journal-title":"Imeta"},{"key":"2025102902212194500_nuaf184-B122","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/nu12030859","article-title":"Dietary fiber, gut microbiota, and metabolic regulation-current status in human randomized trials","volume":"12","author":"Myhrstad","year":"2020","journal-title":"Nutrients"},{"key":"2025102902212194500_nuaf184-B123","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms22063061","article-title":"Butyrate and the fine-tuning of colonic homeostasis: implication for inflammatory bowel diseases","volume":"22","author":"Gasaly","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2025102902212194500_nuaf184-B124","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/1574-6941.12228","article-title":"A gut microbiota-targeted dietary intervention for amelioration of chronic inflammation underlying metabolic syndrome","volume":"87","author":"Xiao","year":"2014","journal-title":"FEMS Microbiol Ecol"},{"key":"2025102902212194500_nuaf184-B125","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1194\/jlr.M800156-JLR200","article-title":"Chylomicrons promote intestinal absorption of lipopolysaccharides","volume":"50","author":"Ghoshal","year":"2009","journal-title":"J Lipid Res"},{"key":"2025102902212194500_nuaf184-B126","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nature11225","article-title":"Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-\/- mice","volume":"487","author":"Devkota","year":"2012","journal-title":"Nature"},{"key":"2025102902212194500_nuaf184-B127","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1038\/ismej.2012.27","article-title":"Structural resilience of the gut microbiota in adult mice under high-fat dietary perturbations","volume":"6","author":"Zhang","year":"2012","journal-title":"Isme J"},{"key":"2025102902212194500_nuaf184-B128","doi-asserted-by":"crossref","first-page":"2802","DOI":"10.1038\/s41467-018-05249-7","article-title":"Bilophila wadsworthia aggravates high fat diet induced metabolic dysfunctions in mice","volume":"9","author":"Natividad","year":"2018","journal-title":"Nat Commun"},{"key":"2025102902212194500_nuaf184-B129","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.taap.2015.04.006","article-title":"Multiple mechanisms involved in diabetes protection by lipopolysaccharide in non-obese diabetic mice","volume":"285","author":"Wang","year":"2015","journal-title":"Toxicol Appl Pharmacol"},{"key":"2025102902212194500_nuaf184-B130","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.cell.2016.04.007","article-title":"Variation in microbiome LPS immunogenicity contributes to autoimmunity in humans","volume":"165","author":"Vatanen","year":"2016","journal-title":"Cell"},{"key":"2025102902212194500_nuaf184-B131","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/imm.13253","article-title":"The role of hydrogen sulphide signalling in macrophage activation","volume":"162","author":"Sun","year":"2021","journal-title":"Immunology"},{"key":"2025102902212194500_nuaf184-B132","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1089\/ars.2021.0004","article-title":"Effects of hydrogen sulfide on the microbiome: from toxicity to therapy","volume":"36","author":"Buret","year":"2022","journal-title":"Antioxid Redox Signal"},{"key":"2025102902212194500_nuaf184-B133","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/mBio.00579-21","article-title":"Reframing nutritional microbiota studies to reflect an inherent metabolic flexibility of the human gut: a narrative review focusing on high-fat diets","volume":"12","author":"Sholl","year":"2021","journal-title":"mBio"},{"key":"2025102902212194500_nuaf184-B134","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms21114093","article-title":"Fatty acid diets: regulation of gut microbiota composition and obesity and its related metabolic dysbiosis","volume":"21","author":"Machate","year":"2020","journal-title":"Int J Mol Sci"},{"key":"2025102902212194500_nuaf184-B135","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.clnu.2019.05.003","article-title":"Interactions of dietary fat with the gut microbiota: evaluation of mechanisms and metabolic consequences","volume":"39","author":"Mokkala","year":"2020","journal-title":"Clin Nutr"},{"key":"2025102902212194500_nuaf184-B136","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1080\/09637486.2017.1343286","article-title":"Impact of dietary fat on gut microbiota and low-grade systemic inflammation: mechanisms and clinical implications on obesity","volume":"69","author":"C\u00e2ndido","year":"2018","journal-title":"Int J Food Sci Nutr"},{"key":"2025102902212194500_nuaf184-B137","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1743-7075-10-6","article-title":"Dietary oil composition differentially modulates intestinal endotoxin transport and postprandial endotoxemia","volume":"10","author":"Mani","year":"2013","journal-title":"Nutr Metab (Lond)"},{"key":"2025102902212194500_nuaf184-B138","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1186\/s12944-016-0357-6","article-title":"Postprandial serum endotoxin in healthy humans is modulated by dietary fat in a randomized, controlled, cross-over study","volume":"15","author":"Lyte","year":"2016","journal-title":"Lipids Health Dis"},{"key":"2025102902212194500_nuaf184-B139","doi-asserted-by":"crossref","first-page":"5977","DOI":"10.1038\/s41467-023-41534-w","article-title":"Myo9b mutations are associated with altered dendritic cell functions and increased susceptibility to autoimmune diabetes onset","volume":"14","author":"Zhang","year":"2023","journal-title":"Nat Commun"},{"key":"2025102902212194500_nuaf184-B140","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1111\/dom.14486","article-title":"High-fat diet prevents the development of autoimmune diabetes in NOD mice","volume":"23","author":"Clark","year":"2021","journal-title":"Diabetes Obes Metab"},{"key":"2025102902212194500_nuaf184-B141","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1136\/gutjnl-2017-314508","article-title":"Akkermansia muciniphila induces gut microbiota remodelling and controls islet autoimmunity in NOD mice","volume":"67","author":"H\u00e4nninen","year":"2018","journal-title":"Gut"},{"key":"2025102902212194500_nuaf184-B142","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1016\/j.immuni.2024.04.017","article-title":"CXCL16-dependent scavenging of oxidized lipids by islet macrophages promotes differentiation of pathogenic CD8(+) T cells in diabetic autoimmunity","volume":"57","author":"Srivastava","year":"2024","journal-title":"Immunity"},{"key":"2025102902212194500_nuaf184-B143","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/dmrr.1207","article-title":"High-fat diet protects BB\/OK rats from developing type 1 diabetes","volume":"27","author":"Bahr","year":"2011","journal-title":"Diabetes Metab Res Rev"},{"key":"2025102902212194500_nuaf184-B144","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1002\/jcp.26062","article-title":"High fat diet attenuates hyperglycemia, body composition changes, and bone loss in male streptozotocin-induced type 1 diabetic mice","volume":"233","author":"Carvalho","year":"2018","journal-title":"J Cell Physiol"},{"key":"2025102902212194500_nuaf184-B145","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1111\/dom.15522","article-title":"Accelerated onset of diabetes in non-obese diabetic mice fed a refined high-fat diet","volume":"26","author":"Batdorf","year":"2024","journal-title":"Diabetes Obes Metab"},{"key":"2025102902212194500_nuaf184-B146","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1530\/REP-13-0614","article-title":"Maternal obesity exacerbates insulitis and type 1 diabetes in non-obese diabetic mice","volume":"148","author":"Wang","year":"2014","journal-title":"Reproduction"},{"key":"2025102902212194500_nuaf184-B147","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.metabol.2018.09.005","article-title":"The epidemiology of obesity","volume":"92","author":"Chooi","year":"2019","journal-title":"Metabolism"},{"key":"2025102902212194500_nuaf184-B148","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1399-5448.2009.00519.x","article-title":"Prevalence of overweight and obesity in youth with diabetes in USA: the SEARCH for Diabetes in Youth study","volume":"11","author":"Liu","year":"2010","journal-title":"Pediatr Diabetes"},{"key":"2025102902212194500_nuaf184-B149","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/dmrr.2565","article-title":"Prevalence of overweight, obesity and metabolic syndrome components in children, adolescents and young adults with type 1 diabetes mellitus","volume":"31","author":"Pinhas-Hamiel","year":"2015","journal-title":"Diabetes Metab Res Rev"},{"key":"2025102902212194500_nuaf184-B150","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s00508-018-1434-9","article-title":"Overweight and obesity in type 1 diabetes equal those of the general population","volume":"131","author":"Fellinger","year":"2019","journal-title":"Wien Klin Wochenschr"},{"key":"2025102902212194500_nuaf184-B151","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s11892-017-0918-8","article-title":"Weight management in patients with type 1 diabetes and obesity","volume":"17","author":"Mottalib","year":"2017","journal-title":"Curr Diab Rep"},{"key":"2025102902212194500_nuaf184-B152","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s11892-015-0641-2","article-title":"Management of severe insulin resistance in patients with type 1 diabetes","volume":"15","author":"Schechter","year":"2015","journal-title":"Curr Diab Rep"},{"key":"2025102902212194500_nuaf184-B153","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/nu11051022","article-title":"Carbohydrate restriction in type 1 diabetes: a realistic therapy for improved glycaemic control and athletic performance?","volume":"11","author":"Scott","year":"2019","journal-title":"Nutrients"},{"key":"2025102902212194500_nuaf184-B154","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/s00125-017-4481-2","article-title":"Maternal obesity as a risk factor for early childhood type 1 diabetes: a nationwide, prospective, population-based case-control study","volume":"61","author":"Lindell","year":"2018","journal-title":"Diabetologia"},{"key":"2025102902212194500_nuaf184-B155","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.2337\/dc09-0663","article-title":"Maternal BMI before pregnancy, maternal weight gain during pregnancy, and risk of persistent positivity for multiple diabetes-associated autoantibodies in children with the high-risk HLA genotype: the MIDIA study","volume":"32","author":"Rasmussen","year":"2009","journal-title":"Diabetes Care"},{"key":"2025102902212194500_nuaf184-B156","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1007\/s00125-022-05722-5","article-title":"Obesity in late adolescence and incident type 1 diabetes in young adulthood","volume":"65","author":"Zucker","year":"2022","journal-title":"Diabetologia"},{"key":"2025102902212194500_nuaf184-B157","doi-asserted-by":"crossref","first-page":"4596","DOI":"10.1210\/jc.2017-01490","article-title":"The role of age and excess body mass index in progression to type 1 diabetes in at-risk adults","volume":"102","author":"Ferrara","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"key":"2025102902212194500_nuaf184-B158","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/j.1464-5491.2004.01368.x","article-title":"Increasing body weight predicts the earlier onset of insulin-dependant [sic] diabetes in childhood: testing the \u2018accelerator hypothesis\u2019 (2)","volume":"22","author":"Betts","year":"2005","journal-title":"Diabet Med"},{"key":"2025102902212194500_nuaf184-B159","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1007\/s00125-005-0033-2","article-title":"The \u2018accelerator hypothesis\u2019: relationship between weight, height, body mass index and age at diagnosis in a large cohort of 9248 German and Austrian children with type 1 diabetes mellitus","volume":"48","author":"Knerr","year":"2005","journal-title":"Diabetologia"},{"key":"2025102902212194500_nuaf184-B160","doi-asserted-by":"crossref","first-page":"580","DOI":"10.2337\/dc19-1167","article-title":"Excess BMI accelerates islet autoimmunity in older children and adolescents","volume":"43","author":"Ferrara-Cook","year":"2020","journal-title":"Diabetes Care"},{"key":"2025102902212194500_nuaf184-B161","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.2337\/dc18-1446","article-title":"BMI, mortality, and cardiovascular outcomes in type 1 diabetes: findings against an obesity paradox","volume":"42","author":"Edqvist","year":"2019","journal-title":"Diabetes Care"},{"key":"2025102902212194500_nuaf184-B162","doi-asserted-by":"crossref","first-page":"e82","DOI":"10.1210\/jc.2014-2340","article-title":"Obesity, islet cell autoimmunity, and cardiovascular risk factors in youth at onset of type 1 autoimmune diabetes","volume":"100","author":"Cedillo","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"2025102902212194500_nuaf184-B163","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1743-7075-11-28","article-title":"Patients with type 1 diabetes show signs of vascular dysfunction in response to multiple high-fat meals","volume":"11","author":"Lassenius","year":"2014","journal-title":"Nutr Metab (Lond)"},{"key":"2025102902212194500_nuaf184-B164","doi-asserted-by":"crossref","first-page":"e14529","DOI":"10.1111\/dme.14529","article-title":"Body mass index, estimated glucose disposal rate and vascular complications in type 1 diabetes: beyond glycated haemoglobin","volume":"38","author":"Helliwell","year":"2021","journal-title":"Diabet Med"},{"key":"2025102902212194500_nuaf184-B165","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/pedi.13189","article-title":"Serum fatty acids and risk of developing islet autoimmunity: a nested case-control study within the TRIGR birth cohort","volume":"22","author":"Hakola","year":"2021","journal-title":"Pediatr Diabetes"},{"key":"2025102902212194500_nuaf184-B166","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.1038\/s41598-021-82200-9","article-title":"Children\u2019s erythrocyte fatty acids are associated with the risk of islet autoimmunity","volume":"11","author":"Niinist\u00f6","year":"2021","journal-title":"Sci Rep"},{"key":"2025102902212194500_nuaf184-B167","first-page":"847","article-title":"Dietary fatty acid intake in childhood and the risk of islet autoimmunity and type 1 diabetes: the DIPP birth cohort study","volume":"62","author":"Hakola","year":"2023","journal-title":"Eur J Nutr"},{"key":"2025102902212194500_nuaf184-B168","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1093\/aje\/kwp065","article-title":"Birth weight, early weight gain, and subsequent risk of type 1 diabetes: systematic review and meta-analysis","volume":"169","author":"Harder","year":"2009","journal-title":"Am J Epidemiol"},{"key":"2025102902212194500_nuaf184-B169","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s00125-009-1648-5","article-title":"Birthweight and the risk of childhood-onset type 1 diabetes: a meta-analysis of observational studies using individual patient data","volume":"53","author":"Cardwell","year":"2010","journal-title":"Diabetologia"},{"key":"2025102902212194500_nuaf184-B170","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1464-5491.2010.03160.x","article-title":"Association between childhood obesity and subsequent type 1 diabetes: a systematic review and meta-analysis","volume":"28","author":"Verbeeten","year":"2011","journal-title":"Diabet Med"},{"key":"2025102902212194500_nuaf184-B171","doi-asserted-by":"crossref","first-page":"290","DOI":"10.2337\/diacare.29.02.06.dc05-1339","article-title":"Testing the accelerator hypothesis: body size, beta-cell function, and age at onset of type 1 (autoimmune) diabetes","volume":"29","author":"Dabelea","year":"2006","journal-title":"Diabetes Care"},{"key":"2025102902212194500_nuaf184-B172","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.2337\/diacare.26.10.2865","article-title":"Testing the accelerator hypothesis: the relationship between body mass and age at diagnosis of type 1 diabetes","volume":"26","author":"Kibirige","year":"2003","journal-title":"Diabetes Care"},{"key":"2025102902212194500_nuaf184-B173","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1007\/s001250100548","article-title":"The accelerator hypothesis: weight gain as the missing link between type I and type II diabetes","volume":"44","author":"Wilkin","year":"2001","journal-title":"Diabetologia"},{"key":"2025102902212194500_nuaf184-B174","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1530\/EJE-14-0522","article-title":"BMI is an important driver of \u03b2-cell loss in type 1 diabetes upon diagnosis in 10 to 18-year-old children","volume":"172","author":"Lauria","year":"2015","journal-title":"Eur J Endocrinol"},{"key":"2025102902212194500_nuaf184-B175","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2337\/dc14-1861","article-title":"Neuronal T-cell autoreactivity is amplified in overweight children with new-onset insulin-requiring diabetes","volume":"38","author":"Buryk","year":"2015","journal-title":"Diabetes Care"},{"key":"2025102902212194500_nuaf184-B176","doi-asserted-by":"crossref","first-page":"707","DOI":"10.2337\/dc06-1982","article-title":"Insulin resistance, the metabolic syndrome, and complication risk in type 1 diabetes: \u201cdouble diabetes\u201d in the Diabetes Control and Complications Trial","volume":"30","author":"Kilpatrick","year":"2007","journal-title":"Diabetes Care"},{"key":"2025102902212194500_nuaf184-B177","doi-asserted-by":"crossref","first-page":"5094569","DOI":"10.1155\/2018\/5094569","article-title":"Teens with type 1 diabetes: how does their nutrition measure up?","volume":"2018","author":"Mackey","year":"2018","journal-title":"J Diabetes Res"},{"key":"2025102902212194500_nuaf184-B178","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.2337\/dc16-0502","article-title":"Coprogression of cardiovascular risk factors in type 1 diabetes during 30 years of follow-up in the DCCT\/EDIC study","volume":"39","author":"Bebu","year":"2016","journal-title":"Diabetes Care"},{"key":"2025102902212194500_nuaf184-B179","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.2337\/dc18-1613","article-title":"Mediation of the effect of glycemia on the risk of CVD outcomes in type 1 diabetes: the DCCT\/EDIC study","volume":"42","author":"Bebu","year":"2019","journal-title":"Diabetes Care"},{"key":"2025102902212194500_nuaf184-B180","doi-asserted-by":"crossref","first-page":"6003","DOI":"10.1210\/jc.2019-00734","article-title":"Longitudinal phenotypes of type 1 diabetes in youth based on weight and glycemia and their association with complications","volume":"104","author":"Kahkoska","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"key":"2025102902212194500_nuaf184-B181","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1046\/j.1523-1755.2002.00507.x","article-title":"Nephropathy in type 1 diabetes: a manifestation of insulin resistance and multiple genetic susceptibilities? Further evidence from the Pittsburgh Epidemiology of Diabetes Complication Study","volume":"62","author":"Orchard","year":"2002","journal-title":"Kidney Int"},{"key":"2025102902212194500_nuaf184-B182","doi-asserted-by":"crossref","first-page":"284","DOI":"10.2337\/diacare.24.2.284","article-title":"Markers of insulin resistance are strong risk factors for retinopathy incidence in type 1 diabetes","volume":"24","author":"Chaturvedi","year":"2001","journal-title":"Diabetes Care"},{"key":"2025102902212194500_nuaf184-B183","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/nu11122990","article-title":"The influence of dietary fatty acids on immune responses","volume":"11","author":"Radzikowska","year":"2019","journal-title":"Nutrients"},{"key":"2025102902212194500_nuaf184-B184","doi-asserted-by":"crossref","first-page":"e88103","DOI":"10.1371\/journal.pone.0088103","article-title":"Effect of marine-derived n-3 polyunsaturated fatty acids on C-reactive protein, interleukin 6 and tumor necrosis factor \u03b1: a meta-analysis","volume":"9","author":"Li","year":"2014","journal-title":"PLoS One"},{"key":"2025102902212194500_nuaf184-B185","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1001\/jama.298.12.1420","article-title":"Omega-3 polyunsaturated fatty acid intake and islet autoimmunity in children at increased risk for type 1 diabetes","volume":"298","author":"Norris","year":"2007","journal-title":"JAMA"},{"key":"2025102902212194500_nuaf184-B186","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1093\/ajcn\/78.6.1128","article-title":"Use of cod liver oil during the first year of life is associated with lower risk of childhood-onset type 1 diabetes: a large, population-based, case-control study","volume":"78","author":"Stene","year":"2003","journal-title":"Am J Clin Nutr"},{"key":"2025102902212194500_nuaf184-B187","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1007\/s00125-017-4280-9","article-title":"Fatty acid status in infancy is associated with the risk of type 1 diabetes-associated autoimmunity","volume":"60","author":"Niinist\u00f6","year":"2017","journal-title":"Diabetologia"}],"container-title":["Nutrition Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/nutritionreviews\/advance-article-pdf\/doi\/10.1093\/nutrit\/nuaf184\/65017534\/nuaf184.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nutritionreviews\/advance-article-pdf\/doi\/10.1093\/nutrit\/nuaf184\/65017534\/nuaf184.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:21:48Z","timestamp":1761718908000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nutritionreviews\/advance-article\/doi\/10.1093\/nutrit\/nuaf184\/8305527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,28]]},"references-count":187,"URL":"https:\/\/doi.org\/10.1093\/nutrit\/nuaf184","relation":{},"ISSN":["0029-6643","1753-4887"],"issn-type":[{"value":"0029-6643","type":"print"},{"value":"1753-4887","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,28]]},"article-number":"nuaf184"}}