{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T01:07:52Z","timestamp":1785546472807,"version":"3.56.0"},"reference-count":132,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T00:00:00Z","timestamp":1763164800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>With a focus on the hippocampus, in this review we examined the emerging role of the ketogenic diet (KD) in treating neurological disorders. There are multiple pathways through which various versions of the KD influence the hippocampus: energy metabolism shifts, neurotransmitter modulation, neuroinflammation control, and synaptic plasticity and epigenetic regulation modifications. Both animal studies and clinical research, with emphasis on epilepsy and Alzheimer disease, have revealed the therapeutic potential of KDs. By modifying energy metabolism and lowering neuroinflammation, KDs may have therapeutic uses such as treatment of epilepsy and Alzheimer disease. In addition, ketones may stabilize hippocampal neuronal networks and reduce amyloid-beta toxicity. Individualized factors and the duration and timing of KD intervention play critical roles in achieving optimal outcomes, such as enhanced hippocampal function and neuroprotection. While preclinical studies have demonstrated enhanced hippocampal synaptic plasticity and neuroprotection, the long-term neurological and metabolic effects of KDs require further clinical validation. There are still a number of important research gaps, especially with regard to the application of animal findings to humans. Future studies should concentrate on long-term human trials using standardized designs to investigate how KDs can affect the nervous system.<\/jats:p>","DOI":"10.1093\/nutrit\/nuaf210","type":"journal-article","created":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T19:58:56Z","timestamp":1763236736000},"page":"1696-1714","source":"Crossref","is-referenced-by-count":0,"title":["The Ketogenic Diet: A Possible Intervention for Improving Hippocampal Function in Neurological Disorders"],"prefix":"10.1093","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9193-9327","authenticated-orcid":false,"given":"Davood","family":"Jahanmehr","sequence":"first","affiliation":[{"name":"Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran 1461884513,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4601-1293","authenticated-orcid":false,"given":"Alireza","family":"Ahmadi","sequence":"additional","affiliation":[{"name":"Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran 1461884513,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1729-2287","authenticated-orcid":false,"given":"Mohammadmahdi","family":"Fadaei","sequence":"additional","affiliation":[{"name":"Department of Artificial Intelligence in Medical Sciences, School of Medicine, Shiraz University of Medical Sciences, Shiraz 7134814336,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3689-8128","authenticated-orcid":false,"given":"Amirhossein","family":"Sangi Nasab Lahijan","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran 1461884513,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8954-8428","authenticated-orcid":false,"given":"Mahdi","family":"Shafiee Sabet","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran 1461884513,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9333-7523","authenticated-orcid":false,"given":"Hossein","family":"Kalantari Dehaghi","sequence":"additional","affiliation":[{"name":"Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran 1461884513,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1901-7171","authenticated-orcid":false,"given":"Reza","family":"Asadi-Golshan","sequence":"additional","affiliation":[{"name":"Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran 1461884513,","place":["Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,11,15]]},"reference":[{"key":"2026073119520588700_nuaf210-B1","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.bj.2021.11.003","article-title":"Updates on the ketogenic diet therapy for pediatric epilepsy","volume":"45","author":"Ko","year":"2022","journal-title":"Biomed J"},{"key":"2026073119520588700_nuaf210-B2","doi-asserted-by":"publisher","first-page":"3273","DOI":"10.2147\/ndt.S201862","article-title":"Current perspectives on the role of the ketogenic diet in epilepsy management","volume":"15","author":"Goswami","year":"2019","journal-title":"Neuropsychiatr Dis Treat"},{"key":"2026073119520588700_nuaf210-B3","doi-asserted-by":"publisher","first-page":"782657","DOI":"10.3389\/fnut.2021.782657","article-title":"Neuroprotection by the ketogenic diet: evidence and controversies","volume":"8","author":"Gough","year":"2021","journal-title":"Front Nutr"},{"key":"2026073119520588700_nuaf210-B4","doi-asserted-by":"publisher","first-page":"2303","DOI":"10.2174\/1570159x20666220830102628","article-title":"Ketogenic diet: an effective treatment approach for neurodegenerative diseases","volume":"20","author":"Tao","year":"2022","journal-title":"Curr Neuropharmacol"},{"key":"2026073119520588700_nuaf210-B5","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1080\/1028415X.2024.2433257","article-title":"Food additives for the central nervous system, useful or harmful? An evidence-based review","volume":"28","author":"Fadaei","year":"2025","journal-title":"Nutr Neurosci"},{"key":"2026073119520588700_nuaf210-B6","doi-asserted-by":"crossref","first-page":"S301","DOI":"10.1016\/S1995-7645(14)60250-9","article-title":"Curcumin prevents the structural changes induced in the rats\u2019 deep cerebellar nuclei by sodium metabisulfite, a preservative agent","volume":"7S1","author":"Karimfar","year":"2014","journal-title":"Asian Pac J Trop Med."},{"key":"2026073119520588700_nuaf210-B7","first-page":"144","article-title":"Efficacy of curcumin in the modulation of anxiety provoked by sulfite, a food preservative, in rats","volume":"22","author":"Noorafshan","year":"2017","journal-title":"Prev Nutr Food Sci"},{"key":"2026073119520588700_nuaf210-B8","doi-asserted-by":"publisher","first-page":"744398","DOI":"10.3389\/fnut.2021.744398","article-title":"Can ketogenic diet improve Alzheimer\u2019s disease? Association with anxiety, depression, and glutamate system","volume":"8","author":"de la Rubia Ort\u00ed","year":"2021","journal-title":"Front Nutr"},{"key":"2026073119520588700_nuaf210-B9","doi-asserted-by":"publisher","first-page":"e3001275","DOI":"10.1371\/journal.pbio.3001275","article-title":"Intrinsic connectivity reveals functionally distinct cortico-hippocampal networks in the human brain","volume":"19","author":"Barnett","year":"2021","journal-title":"PLoS Biol"},{"key":"2026073119520588700_nuaf210-B10","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1038\/s41586-021-03652-7","article-title":"Geometry of abstract learned knowledge in the hippocampus","volume":"595","author":"Nieh","year":"2021","journal-title":"Nature"},{"key":"2026073119520588700_nuaf210-B11","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/s41593-020-00761-w","article-title":"Vector trace cells in the subiculum of the hippocampal formation","volume":"24","author":"Poulter","year":"2021","journal-title":"Nat Neurosci"},{"key":"2026073119520588700_nuaf210-B12","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/j.stemcr.2021.01.019","article-title":"Adult hippocampal neurogenesis in aging and Alzheimer\u2019s disease","volume":"16","author":"Babcock","year":"2021","journal-title":"Stem Cell Reports"},{"key":"2026073119520588700_nuaf210-B13","doi-asserted-by":"publisher","first-page":"687558","DOI":"10.3389\/fncir.2021.687558","article-title":"Hippocampal somatostatin interneurons, long-term synaptic plasticity and memory","volume":"15","author":"Honor\u00e9","year":"2021","journal-title":"Front Neural Circuits"},{"key":"2026073119520588700_nuaf210-B14","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.2022.36.S1.R5607","article-title":"A low-carbohydrate, ketogenic diet enhances hippocampal mitochondrial bioenergetics and efficiency","volume":"36","author":"Saito","year":"2022","journal-title":"The FASEB Journal"},{"key":"2026073119520588700_nuaf210-B15","doi-asserted-by":"publisher","DOI":"10.3390\/metabo12111019","article-title":"A novel ketone-supplemented diet improves recognition memory and hippocampal mitochondrial efficiency in healthy adult mice","volume":"12","author":"Saito","year":"2022","journal-title":"Metabolites"},{"key":"2026073119520588700_nuaf210-B16","doi-asserted-by":"publisher","DOI":"10.3390\/nu12082379","article-title":"Mechanism of action of ketogenic diet treatment: impact of decanoic acid and beta-hydroxybutyrate on sirtuins and energy metabolism in hippocampal murine neurons","volume":"12","author":"Dabke","year":"2020","journal-title":"Nutrients"},{"key":"2026073119520588700_nuaf210-B17","doi-asserted-by":"publisher","first-page":"263","DOI":"10.3389\/fncel.2018.00263","article-title":"Ketogenic Diet Modulates NAD(+)-Dependent Enzymes and Reduces DNA Damage in Hippocampus","volume":"12","author":"Elamin","year":"2018","journal-title":"Front Cell Neurosci"},{"key":"2026073119520588700_nuaf210-B18","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.eplepsyres.2005.03.008","article-title":"The ketogenic diet influences the levels of excitatory and inhibitory amino acids in the CSF in children with refractory epilepsy","volume":"64","author":"Dahlin","year":"2005","journal-title":"Epilepsy Res"},{"key":"2026073119520588700_nuaf210-B19","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.neuint.2005.04.014","article-title":"Response of brain amino acid metabolism to ketosis","volume":"47","author":"Yudkoff","year":"2005","journal-title":"Neurochem Int"},{"key":"2026073119520588700_nuaf210-B20","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1002\/jnr.1221","article-title":"Brain amino acid metabolism and ketosis","volume":"66","author":"Yudkoff","year":"2001","journal-title":"J Neurosci Res"},{"key":"2026073119520588700_nuaf210-B21","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1111\/lam.12882","article-title":"Shifts in gut microbiota composition in an APP\/PSS1 transgenic mouse model of Alzheimer\u2019s disease during lifespan","volume":"66","author":"Bauerl","year":"2018","journal-title":"Lett Appl Microbiol"},{"key":"2026073119520588700_nuaf210-B22","doi-asserted-by":"publisher","first-page":"2767","DOI":"10.4103\/1673-5374.373715","article-title":"Ketogenic diet alleviates cognitive dysfunction and neuroinflammation in APP\/PS1 mice via the Nrf2\/HO-1 and NF-\u03baB signaling pathways","volume":"18","author":"Jiang","year":"2023","journal-title":"Neural Regen Res"},{"key":"2026073119520588700_nuaf210-B23","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1186\/s13578-021-00611-7","article-title":"The ketogenic diet increases Neuregulin 1 expression via elevating histone acetylation and its anti-seizure effect requires ErbB4 kinase activity","volume":"11","author":"Wang","year":"2021","journal-title":"Cell Biosci"},{"key":"2026073119520588700_nuaf210-B24","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1177\/0271678X241245486","article-title":"Neuroprotective effects of lactate and ketone bodies in acute brain injury","volume":"44","author":"Plourde","year":"2024","journal-title":"J Cereb Blood Flow Metab"},{"key":"2026073119520588700_nuaf210-B25","doi-asserted-by":"publisher","first-page":"eabo7639","DOI":"10.1126\/sciadv.abo7639","article-title":"Ketogenic diet uncovers differential metabolic plasticity of brain cells","volume":"8","author":"D\u00fcking","year":"2022","journal-title":"Sci Adv"},{"key":"2026073119520588700_nuaf210-B26","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1186\/s12974-020-01948-5","article-title":"beta-Hydroxybutyrate inhibits inflammasome activation to attenuate Alzheimer\u2019s disease pathology","volume":"17","author":"Shippy","year":"2020","journal-title":"J Neuroinflammation"},{"key":"2026073119520588700_nuaf210-B27","doi-asserted-by":"publisher","first-page":"1425816","DOI":"10.3389\/fimmu.2024.1425816","article-title":"Exploring the ketogenic diet\u2019s potential in reducing neuroinflammation and modulating immune responses","volume":"15","author":"Monda","year":"2024","journal-title":"Front Immunol"},{"key":"2026073119520588700_nuaf210-B28","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25010124","article-title":"Molecular mechanisms of neuroprotection by ketone bodies and ketogenic diet in cerebral ischemia and neurodegenerative diseases","volume":"25","author":"Jang","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2026073119520588700_nuaf210-B29","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043102","article-title":"The ketogenic diet and neuroinflammation: the action of beta-hydroxybutyrate in a microglial cell line","volume":"24","author":"Polito","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2026073119520588700_nuaf210-B30","doi-asserted-by":"publisher","first-page":"7247","DOI":"10.1039\/d3fo00122a","article-title":"Ketogenic diet attenuates neuroinflammation and induces conversion of M1 microglia to M2 in an EAE model of multiple sclerosis by regulating the NF-\u03baB\/NLRP3 pathway and inhibiting HDAC3 and P2X7R activation","volume":"14","author":"Sun","year":"2023","journal-title":"Food Funct"},{"key":"2026073119520588700_nuaf210-B31","doi-asserted-by":"publisher","first-page":"114891","DOI":"10.1016\/j.celrep.2024.114891","article-title":"A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity","volume":"43","author":"Alexander","year":"2024","journal-title":"Cell Rep"},{"key":"2026073119520588700_nuaf210-B32","doi-asserted-by":"publisher","first-page":"109591","DOI":"10.1016\/j.jnutbio.2024.109591","article-title":"Sex-specific effects of ketogenic diet on anxiety-like behavior and neuroimmune response in C57Bl\/6J mice","volume":"127","author":"Kumar","year":"2024","journal-title":"J Nutr Biochem"},{"key":"2026073119520588700_nuaf210-B33","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1111\/cns.13779","article-title":"Ketogenic diet ameliorates cognitive impairment and neuroinflammation in a mouse model of Alzheimer\u2019s disease","volume":"28","author":"Xu","year":"2022","journal-title":"CNS Neurosci Ther"},{"key":"2026073119520588700_nuaf210-B34","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1038\/s42003-024-05860-z","article-title":"Ketogenic diet and BHB rescue the fall of long-term potentiation in an Alzheimer\u2019s mouse model and stimulates synaptic plasticity pathway enzymes","volume":"7","author":"Di Lucente","year":"2024","journal-title":"Commun Biol"},{"key":"2026073119520588700_nuaf210-B35","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.2147\/ndt.S376979","article-title":"Ketogenic diet alleviates hippocampal neurodegeneration possibly via ASIC1a and the mitochondria-mediated apoptotic pathway in a rat model of temporal lobe epilepsy","volume":"18","author":"Qiao","year":"2022","journal-title":"Neuropsychiatr Dis Treat"},{"key":"2026073119520588700_nuaf210-B36","doi-asserted-by":"publisher","first-page":"101593","DOI":"10.1016\/j.xcrm.2024.101593","article-title":"Ketogenic diet administration later in life improves memory by modifying the synaptic cortical proteome via the PKA signaling pathway in aging mice","volume":"5","author":"Acu\u00f1a-Catal\u00e1n","year":"2024","journal-title":"Cell Rep Med"},{"key":"2026073119520588700_nuaf210-B37","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12411","article-title":"Effects of a ketogenic diet on hippocampal plasticity in freely moving juvenile rats","volume":"3","author":"Blaise","year":"2015","journal-title":"Physiol Rep"},{"key":"2026073119520588700_nuaf210-B38","first-page":"1635","volume-title":"Jasper\u2019s Basic Mechanisms of the Epilepsies","author":"Williams","year":"2024"},{"key":"2026073119520588700_nuaf210-B39","doi-asserted-by":"publisher","author":"Xiang","DOI":"10.1117\/12.2691839"},{"key":"2026073119520588700_nuaf210-B40","doi-asserted-by":"publisher","DOI":"10.1093\/med\/9780197501207.003.0025","article-title":"Ketogenic diet and epigenetic mechanisms of epileptogenesis","author":"Murugan","journal-title":"Ketogenic Diet and Metabolic Therapies: Expanded Roles in Health and Disease"},{"key":"2026073119520588700_nuaf210-B41","doi-asserted-by":"publisher","first-page":"105156","DOI":"10.1016\/j.ebiom.2024.105156","article-title":"Ketogenic diet modifies ribosomal protein dysregulation in KMT2D Kabuki syndrome","volume":"104","author":"Tsang","year":"2024","journal-title":"EBioMedicine"},{"key":"2026073119520588700_nuaf210-B42","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1007\/s00018-022-04673-9","article-title":"Brain histone beta-hydroxybutyrylation couples metabolism with gene expression","volume":"80","author":"Cornuti","year":"2023","journal-title":"Cell Mol Life Sci"},{"key":"2026073119520588700_nuaf210-B43","doi-asserted-by":"publisher","author":"Jaisil","year":"2024","DOI":"10.1016\/B978-0-12-820480-1.00148-0"},{"key":"2026073119520588700_nuaf210-B44","doi-asserted-by":"publisher","DOI":"10.3390\/nu14040782","article-title":"Molecular mechanisms underlying the bioactive properties of a ketogenic diet","volume":"14","author":"Murakami","year":"2022","journal-title":"Nutrients"},{"key":"2026073119520588700_nuaf210-B45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.29245\/2572.942x\/2023\/1.1286","article-title":"Exploring the therapeutic potential of the ketogenic diet on neurological disorders: a comprehensive review","volume":"7","author":"Vallamchetla","year":"2023","journal-title":"J Neurol Neuromed."},{"key":"2026073119520588700_nuaf210-B46","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1089\/neu.2008.0664","article-title":"The effects of a ketogenic diet on behavioral outcome after controlled cortical impact injury in the juvenile and adult rat","volume":"26","author":"Appelberg","year":"2009","journal-title":"J Neurotrauma"},{"key":"2026073119520588700_nuaf210-B47","doi-asserted-by":"publisher","first-page":"e35476","DOI":"10.1371\/journal.pone.0035476","article-title":"Inflammation-mediated memory dysfunction and effects of a ketogenic diet in a murine model of multiple sclerosis","volume":"7","author":"Kim","year":"2012","journal-title":"PLoS One"},{"key":"2026073119520588700_nuaf210-B48","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.brainres.2016.06.029","article-title":"Ketogenic diet attenuates spatial and item memory impairment in pentylenetetrazol-kindled rats","volume":"1646","author":"Jiang","year":"2016","journal-title":"Brain Res"},{"key":"2026073119520588700_nuaf210-B49","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.brainres.2015.06.016","article-title":"Ketogenic diet does not impair spatial ability controlled by the hippocampus in male rats","volume":"1622","author":"Fukushima","year":"2015","journal-title":"Brain Res"},{"key":"2026073119520588700_nuaf210-B50","doi-asserted-by":"publisher","first-page":"2481","DOI":"10.1007\/s11357-023-00769-7","article-title":"Ketogenic diets initiated in late mid-life improved measures of spatial memory in male mice","volume":"45","author":"Zhou","year":"2023","journal-title":"Geroscience"},{"key":"2026073119520588700_nuaf210-B51","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.cmet.2017.08.004","article-title":"Ketogenic diet reduces midlife mortality and improves memory in aging mice","volume":"26","author":"Newman","year":"2017","journal-title":"Cell Metab"},{"key":"2026073119520588700_nuaf210-B52","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1093\/gerona\/glx193","article-title":"The antiepileptic ketogenic diet alters hippocampal transporter levels and reduces adiposity in aged rats","volume":"73","author":"Hernandez","year":"2018","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"2026073119520588700_nuaf210-B53","doi-asserted-by":"publisher","first-page":"188","DOI":"10.3164\/jcbn.19-87","article-title":"Ketone production by ketogenic diet and by intermittent fasting has different effects on the gut microbiota and disease progression in an Alzheimer\u2019s disease rat model","volume":"67","author":"Park","year":"2020","journal-title":"J Clin Biochem Nutr"},{"key":"2026073119520588700_nuaf210-B54","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1111\/j.1528-1157.1997.tb01461.x","article-title":"Ketogenic diet: effects on expression of kindled seizures and behavior in adult rats","volume":"38","author":"Hori","year":"1997","journal-title":"Epilepsia"},{"key":"2026073119520588700_nuaf210-B55","doi-asserted-by":"publisher","first-page":"108974","DOI":"10.1016\/j.jnutbio.2022.108974","article-title":"Effects of ketogenic diet on cognitive functions of mice fed high-fat-high-cholesterol diet","volume":"104","author":"Lin","year":"2022","journal-title":"J Nutr Biochem"},{"key":"2026073119520588700_nuaf210-B56","doi-asserted-by":"publisher","first-page":"e0174477","DOI":"10.1371\/journal.pone.0174477","article-title":"Ketogenic diet improves the spatial memory impairment caused by exposure to hypobaric hypoxia through increased acetylation of histones in rats","volume":"12","author":"Zhao","year":"2017","journal-title":"PLoS One"},{"key":"2026073119520588700_nuaf210-B57","doi-asserted-by":"crossref","first-page":"223","DOI":"10.3233\/NUA-140044","article-title":"Enhanced cerebral bioenergetics with dietary ketosis in mild cognitive impairment","volume":"2","author":"Krikorian","year":"2014","journal-title":"Nutr Aging"},{"key":"2026073119520588700_nuaf210-B58","doi-asserted-by":"publisher","first-page":"e75713","DOI":"10.1371\/journal.pone.0075713","article-title":"Ketogenic diet improves motor performance but not cognition in two mouse models of Alzheimer\u2019s pathology","volume":"8","author":"Brownlow","year":"2013","journal-title":"PLoS One"},{"key":"2026073119520588700_nuaf210-B59","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s13195-020-00615-4","article-title":"Are ketogenic diets promising for Alzheimer\u2019s disease? A translational review","volume":"12","author":"Lilamand","year":"2020","journal-title":"Alzheimers Res Ther"},{"key":"2026073119520588700_nuaf210-B60","doi-asserted-by":"publisher","first-page":"148404","DOI":"10.1016\/j.brainres.2023.148404","article-title":"Ketogenic diet alleviates brain iron deposition and cognitive dysfunction via Nrf2-mediated ferroptosis pathway in APP\/PS1 mouse","volume":"1812","author":"Qin","year":"2023","journal-title":"Brain Res"},{"key":"2026073119520588700_nuaf210-B61","doi-asserted-by":"publisher","first-page":"4961","DOI":"10.1007\/s12035-020-02065-3","article-title":"Emerging therapeutic promise of ketogenic diet to attenuate neuropathological alterations in Alzheimer\u2019s disease","volume":"57","author":"Uddin","year":"2020","journal-title":"Mol Neurobiol"},{"key":"2026073119520588700_nuaf210-B62","doi-asserted-by":"publisher","first-page":"e177","DOI":"10.1111\/epi.17688","article-title":"Intermittent vs continuous ketogenic diet: impact on seizures, gut microbiota, and mitochondrial metabolism","volume":"64","author":"Shearer","year":"2023","journal-title":"Epilepsia"},{"key":"2026073119520588700_nuaf210-B63","doi-asserted-by":"publisher","first-page":"e44","DOI":"10.1111\/epi.12603","article-title":"In vivo ketogenic diet treatment attenuates pathologic sharp waves and high frequency oscillations in in vitro hippocampal slices from epileptic Kv 1.1alpha knockout mice","volume":"55","author":"Simeone","year":"2014","journal-title":"Epilepsia"},{"key":"2026073119520588700_nuaf210-B64","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1203\/01.Pdr.0000112032.47575.D1","article-title":"Detrimental effects of the ketogenic diet on cognitive function in rats","volume":"55","author":"Zhao","year":"2004","journal-title":"Pediatr Res"},{"key":"2026073119520588700_nuaf210-B65","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.3233\/jad-230002","article-title":"Ketogenic diet as a promising non-drug intervention for Alzheimer\u2019s disease: mechanisms and clinical implications","volume":"92","author":"Xu","year":"2023","journal-title":"J Alzheimers Dis"},{"key":"2026073119520588700_nuaf210-B66","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.physbeh.2011.04.001","article-title":"A ketogenic diet delays weight loss and does not impair working memory or motor function in the R6\/2 1J mouse model of Huntington\u2019s disease","volume":"103","author":"Ruskin","year":"2011","journal-title":"Physiol Behav"},{"key":"2026073119520588700_nuaf210-B67","doi-asserted-by":"publisher","first-page":"e01246","DOI":"10.1002\/brb3.1246","article-title":"The effect of ketogenic diet on behaviors and synaptic functions of naive mice","volume":"9","author":"Huang","year":"2019","journal-title":"Brain Behav"},{"key":"2026073119520588700_nuaf210-B68","doi-asserted-by":"publisher","first-page":"146697","DOI":"10.1016\/j.brainres.2020.146697","article-title":"Male mice placed on a ketogenic diet from postnatal day (P) 21 through adulthood have reduced growth, are hypoactive, show increased freezing in a conditioned fear paradigm, and have spatial learning deficits","volume":"1734","author":"Miles","year":"2020","journal-title":"Brain Res"},{"key":"2026073119520588700_nuaf210-B69","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/s0165-3806(00)00130-9","article-title":"Timing of ketogenic diet initiation in an experimental epilepsy model","volume":"125","author":"Su","year":"2000","journal-title":"Brain Res Dev Brain Res"},{"key":"2026073119520588700_nuaf210-B70","doi-asserted-by":"publisher","first-page":"5811","DOI":"10.18632\/aging.205741","article-title":"The impact of continuous and intermittent ketogenic diets on cognitive behavior, motor function, and blood lipids in TgF344-AD rats","volume":"16","author":"Rutkowsky","year":"2024","journal-title":"Aging (Albany NY)"},{"key":"2026073119520588700_nuaf210-B71","doi-asserted-by":"publisher","first-page":"23559","DOI":"10.1038\/s41598-021-02849-0","article-title":"Ketogenic Diet as a potential treatment for traumatic brain injury in mice","volume":"11","author":"Har-Even","year":"2021","journal-title":"Sci Rep"},{"key":"2026073119520588700_nuaf210-B72","doi-asserted-by":"publisher","DOI":"10.3390\/metabo14010025","article-title":"A potential role for the ketogenic diet in Alzheimer\u2019s disease treatment: exploring pre-clinical and clinical evidence","volume":"14","author":"Oliveira","year":"2023","journal-title":"Metabolites"},{"key":"2026073119520588700_nuaf210-B73","doi-asserted-by":"publisher","first-page":"290","DOI":"10.2174\/15672050112099990128","article-title":"Triheptanoin supplementation to ketogenic diet curbs cognitive impairment in APP\/PS1 mice used as a model of familial Alzheimer\u2019s disease","volume":"10","author":"Aso","year":"2013","journal-title":"Curr Alzheimer Res"},{"key":"2026073119520588700_nuaf210-B74","doi-asserted-by":"publisher","first-page":"e0160159","DOI":"10.1371\/journal.pone.0160159","article-title":"Cognition and synaptic-plasticity related changes in aged rats supplemented with 8- and 10-carbon medium chain triglycerides","volume":"11","author":"Wang","year":"2016","journal-title":"PLoS One"},{"key":"2026073119520588700_nuaf210-B75","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1111\/epi.13950","article-title":"Inhibition of monoacylglycerol lipase terminates diazepam-resistant status epilepticus in mice and its effects are potentiated by a ketogenic diet","volume":"59","author":"Terrone","year":"2018","journal-title":"Epilepsia"},{"key":"2026073119520588700_nuaf210-B76","doi-asserted-by":"publisher","first-page":"3797","DOI":"10.1007\/s00213-016-4414-7","article-title":"Effect of a ketogenic meal on cognitive function in elderly adults: potential for cognitive enhancement","volume":"233","author":"Ota","year":"2016","journal-title":"Psychopharmacology (Berl.)"},{"key":"2026073119520588700_nuaf210-B77","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.neulet.2018.10.048","article-title":"Effects of a medium-chain triglyceride-based ketogenic formula on cognitive function in patients with mild-to-moderate Alzheimer\u2019s disease","volume":"690","author":"Ota","year":"2019","journal-title":"Neurosci Lett"},{"key":"2026073119520588700_nuaf210-B78","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1002\/alz.12206","article-title":"A ketogenic drink improves cognition in mild cognitive impairment: results of a 6-month RCT","volume":"17","author":"Fortier","year":"2021","journal-title":"Alzheimers Dement"},{"key":"2026073119520588700_nuaf210-B79","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.nbd.2016.08.002","article-title":"Ketone ester supplementation attenuates seizure activity, and improves behavior and hippocampal synaptic plasticity in an Angelman syndrome mouse model","volume":"96","author":"Ciarlone","year":"2016","journal-title":"Neurobiol Dis"},{"key":"2026073119520588700_nuaf210-B80","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.neuroscience.2013.08.044","article-title":"Inter-relationships among diet, obesity and hippocampal-dependent cognitive function","volume":"253","author":"Davidson","year":"2013","journal-title":"Neuroscience"},{"key":"2026073119520588700_nuaf210-B81","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.neurobiolaging.2019.09.015","article-title":"Modified ketogenic diet is associated with improved cerebrospinal fluid biomarker profile, cerebral perfusion, and cerebral ketone body uptake in older adults at risk for Alzheimer\u2019s disease: a pilot study","volume":"86","author":"Neth","year":"2020","journal-title":"Neurobiol Aging"},{"key":"2026073119520588700_nuaf210-B82","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.exger.2008.01.008","article-title":"Manipulation of caloric content but not diet composition, attenuates the deficit in learning and memory of senescence-accelerated mouse strain P8","volume":"43","author":"Komatsu","year":"2008","journal-title":"Exp Gerontol"},{"key":"2026073119520588700_nuaf210-B83","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1073\/pnas.1611431114","article-title":"A ketogenic diet rescues hippocampal memory defects in a mouse model of Kabuki syndrome","volume":"114","author":"Benjamin","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026073119520588700_nuaf210-B84","doi-asserted-by":"publisher","first-page":"239","DOI":"10.3389\/fnagi.2019.00239","article-title":"Age and ketogenic diet have dissociable effects on synapse-related gene expression between hippocampal subregions","volume":"11","author":"Hernandez","year":"2019","journal-title":"Front Aging Neurosci"},{"key":"2026073119520588700_nuaf210-B85","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1097\/WNR.0b013e32830a7109","article-title":"Ketogenic diet does not disturb neurogenesis in the dentate gyrus in rats","volume":"19","author":"Strandberg","year":"2008","journal-title":"Neuroreport"},{"key":"2026073119520588700_nuaf210-B86","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s12576-020-00786-7","article-title":"The effect of ketogenic diets on neurogenesis and apoptosis in the dentate gyrus of the male rat hippocampus","volume":"71","author":"Irfannuddin","year":"2021","journal-title":"J Physiol Sci"},{"key":"2026073119520588700_nuaf210-B87","doi-asserted-by":"publisher","first-page":"2106","DOI":"10.52768\/2379-1039\/2106","article-title":"A 4:1 ketogenic diet to acute stroke patients is safe and feasible: a randomized controlled trial","volume":"9","author":"Mortensen","year":"2023","journal-title":"Open J Clin Med Case Rep"},{"key":"2026073119520588700_nuaf210-B88","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1111\/jnc.15852","article-title":"Modulation of the autophagy-lysosomal pathway and endoplasmic reticulum stress by ketone bodies in experimental models of stroke","volume":"166","author":"Montiel","year":"2023","journal-title":"J Neurochem"},{"key":"2026073119520588700_nuaf210-B89","doi-asserted-by":"publisher","first-page":"86","DOI":"10.3389\/fnmol.2018.00086","article-title":"Ketogenic diet improves brain ischemic tolerance and inhibits NLRP3 inflammasome activation by preventing Drp1-mediated mitochondrial fission and endoplasmic reticulum stress","volume":"11","author":"Guo","year":"2018","journal-title":"Front Mol Neurosci"},{"key":"2026073119520588700_nuaf210-B90","doi-asserted-by":"publisher","first-page":"175933","DOI":"10.1016\/j.ejphar.2023.175933","article-title":"Ketogenic diet and beta-Hydroxybutyrate alleviate ischemic brain injury in mice via an IRAKM-dependent pathway","volume":"955","author":"Lin","year":"2023","journal-title":"Eur J Pharmacol"},{"key":"2026073119520588700_nuaf210-B91","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1038\/s41430-021-01060-8","article-title":"Ketogenic diet for epilepsy: an overview of systematic review and meta-analysis","volume":"76","author":"Ruan","year":"2022","journal-title":"Eur J Clin Nutr"},{"key":"2026073119520588700_nuaf210-B92","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1007\/s00381-020-04578-7","article-title":"Ketogenic diet for the treatment of pediatric epilepsy: review and meta-analysis","volume":"36","author":"Sourbron","year":"2020","journal-title":"Childs Nerv Syst"},{"key":"2026073119520588700_nuaf210-B93","doi-asserted-by":"publisher","first-page":"e123","DOI":"10.1111\/epi.16983","article-title":"Ketogenic diet-mediated seizure reduction preserves CA1 cell numbers in epileptic Kcna1-null mice: an unbiased stereological assessment","volume":"62","author":"Simeone","year":"2021","journal-title":"Epilepsia"},{"key":"2026073119520588700_nuaf210-B94","doi-asserted-by":"publisher","first-page":"Cd001903","DOI":"10.1002\/14651858.CD001903.pub4","article-title":"Ketogenic diets for drug-resistant epilepsy","volume":"11","author":"Martin-McGill","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"2026073119520588700_nuaf210-B95","doi-asserted-by":"publisher","first-page":"2249","DOI":"10.1007\/s12035-023-03659-3","article-title":"A ketogenic diet may improve cognitive function in rats with temporal lobe epilepsy by regulating endoplasmic reticulum stress and synaptic plasticity","volume":"61","author":"Qiao","year":"2024","journal-title":"Mol Neurobiol"},{"key":"2026073119520588700_nuaf210-B96","doi-asserted-by":"publisher","first-page":"147345","DOI":"10.1016\/j.brainres.2021.147345","article-title":"Alkaline brain pH shift in rodent lithium-pilocarpine model of epilepsy with chronic seizures","volume":"1758","author":"Lu","year":"2021","journal-title":"Brain Res"},{"key":"2026073119520588700_nuaf210-B97","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1001\/jamapediatrics.2022.5648","article-title":"Efficacy and safety of dietary therapies for childhood drug-resistant epilepsy: a systematic review and network meta-analysis","volume":"177","author":"Devi","year":"2023","journal-title":"JAMA Pediatr"},{"key":"2026073119520588700_nuaf210-B98","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1080\/14737175.2022.2030220","article-title":"Ketogenic diet in pediatric seizures: a randomized controlled trial review and meta-analysis","volume":"22","author":"Pizzo","year":"2022","journal-title":"Expert Rev Neurother"},{"key":"2026073119520588700_nuaf210-B99","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1186\/s13023-021-01927-w","article-title":"Ketogenic diet for mitochondrial disease: a systematic review on efficacy and safety","volume":"16","author":"Zweers","year":"2021","journal-title":"Orphanet J Rare Dis"},{"key":"2026073119520588700_nuaf210-B100","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s13195-021-00783-x","article-title":"Randomized crossover trial of a modified ketogenic diet in Alzheimer\u2019s disease","volume":"13","author":"Phillips","year":"2021","journal-title":"Alzheimers Res Ther"},{"key":"2026073119520588700_nuaf210-B101","doi-asserted-by":"publisher","first-page":"100306","DOI":"10.1016\/j.jnha.2024.100306","article-title":"Effects of ketogenic diet on cognitive function of patients with Alzheimer\u2019s disease: a systematic review and meta-analysis","volume":"28","author":"Rong","year":"2024","journal-title":"J Nutr Health Aging"},{"key":"2026073119520588700_nuaf210-B102","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.exger.2018.07.009","article-title":"Changes in regional cerebral blood flow associated with a 45\u202fday course of the ketogenic agent, caprylidene, in patients with mild to moderate Alzheimer\u2019s disease: results of a randomized, double-blinded, pilot study","volume":"111","author":"Torosyan","year":"2018","journal-title":"Exp Gerontol"},{"key":"2026073119520588700_nuaf210-B103","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1093\/advances\/nmaa073","article-title":"To Keto or Not to Keto? A systematic review of randomized controlled trials assessing the effects of ketogenic therapy on Alzheimer disease","volume":"11","author":"Grammatikopoulou","year":"2020","journal-title":"Adv Nutr"},{"key":"2026073119520588700_nuaf210-B104","doi-asserted-by":"publisher","first-page":"1015837","DOI":"10.3389\/fnagi.2022.1015837","article-title":"Regulation of gut microbiome by ketogenic diet in neurodegenerative diseases: a molecular crosstalk","volume":"14","author":"Kaviyarasan","year":"2022","journal-title":"Front Aging Neurosci"},{"key":"2026073119520588700_nuaf210-B105","doi-asserted-by":"publisher","first-page":"110","DOI":"10.14283\/jpad.2020.40","article-title":"Nutrition to prevent or treat cognitive impairment in older adults: a GRADE recommendation","volume":"8","author":"Buckinx","year":"2021","journal-title":"J Prev Alzheimers Dis"},{"key":"2026073119520588700_nuaf210-B106","doi-asserted-by":"publisher","first-page":"102236","DOI":"10.1016\/j.plefa.2020.102236","article-title":"The effect of a 6-month ketogenic medium-chain triglyceride supplement on plasma cardiometabolic and inflammatory markers in mild cognitive impairment","volume":"169","author":"Myette-Cote","year":"2021","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"2026073119520588700_nuaf210-B107","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1093\/nutrit\/nuaa113","article-title":"Ketogenic diet and cognition in neurological diseases: a systematic review","volume":"79","author":"Pav\u00f3n","year":"2021","journal-title":"Nutr Rev"},{"key":"2026073119520588700_nuaf210-B108","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/08039488.2020.1795924","article-title":"Use of ketogenic diets in the treatment of central nervous system diseases: a systematic review","volume":"75","author":"Christensen","year":"2021","journal-title":"Nord J Psychiatry"},{"key":"2026073119520588700_nuaf210-B109","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1126\/science.aag2590","article-title":"How neuroinflammation contributes to neurodegeneration","volume":"353","author":"Ransohoff","year":"2016","journal-title":"Science (1979)"},{"key":"2026073119520588700_nuaf210-B110","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/j.jalz.2016.02.010","article-title":"Neuroinflammation in Alzheimer\u2019s disease: current evidence and future directions","volume":"12","author":"Calsolaro","year":"2016","journal-title":"Alzheimers Dement"},{"key":"2026073119520588700_nuaf210-B111","doi-asserted-by":"publisher","first-page":"e13832","DOI":"10.1111\/jsr.13832","article-title":"The effect of a 2 week ketogenic diet, versus a carbohydrate-based diet, on cognitive performance, mood and subjective sleepiness during 36\u2009h of extended wakefulness in military personnel: an exploratory study","volume":"32","author":"Henderson","year":"2023","journal-title":"J Sleep Res"},{"key":"2026073119520588700_nuaf210-B112","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1093\/ajcn\/nqz073","article-title":"Three consecutive weeks of nutritional ketosis has no effect on cognitive function, sleep, and mood compared with a high-carbohydrate, low-fat diet in healthy individuals: a randomized, crossover, controlled trial","volume":"110","author":"Iacovides","year":"2019","journal-title":"Am J Clin Nutr"},{"key":"2026073119520588700_nuaf210-B113","doi-asserted-by":"publisher","first-page":"1868","DOI":"10.1002\/oby.22934","article-title":"Ketonemia and glycemia affect appetite levels and executive functions in overweight females during two ketogenic diets","volume":"28","author":"Lodi","year":"2020","journal-title":"Obesity (Silver Spring)"},{"key":"2026073119520588700_nuaf210-B114","doi-asserted-by":"publisher","first-page":"e14323","DOI":"10.15252\/emmm.202114323","article-title":"Very-low-carbohydrate diet enhances human T-cell immunity through immunometabolic reprogramming","volume":"13","author":"Hirschberger","year":"2021","journal-title":"EMBO Mol Med"},{"key":"2026073119520588700_nuaf210-B115","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/j.dsx.2018.04.031","article-title":"Ketogenic diet, high intensity interval training (HIIT) and memory training in the treatment of mild cognitive impairment: a case study","volume":"12","author":"Dahlgren","year":"2018","journal-title":"Diabetes Metab Syndr"},{"key":"2026073119520588700_nuaf210-B116","doi-asserted-by":"publisher","first-page":"1182519","DOI":"10.3389\/fendo.2024.1182519","article-title":"A randomized feasibility trial of the modified Atkins diet in older adults with mild cognitive impairment due to Alzheimer\u2019s disease","volume":"15","author":"Buchholz","year":"2024","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2026073119520588700_nuaf210-B117","doi-asserted-by":"publisher","DOI":"10.3390\/nu15102329","article-title":"Improving adherence to a mediterranean ketogenic nutrition program for high-risk older adults: a pilot randomized trial","volume":"15","author":"Sheffler","year":"2023","journal-title":"Nutrients"},{"key":"2026073119520588700_nuaf210-B118","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.2147\/jpr.S451236","article-title":"Addressing pain using a mediterranean ketogenic nutrition program in older adults with mild cognitive impairment","volume":"17","author":"Klejc","year":"2024","journal-title":"J Pain Res"},{"key":"2026073119520588700_nuaf210-B119","doi-asserted-by":"publisher","first-page":"e5604","DOI":"10.7759\/cureus.5604","article-title":"Carbohydrate-restricted diet and exercise increase brain-derived neurotrophic factor and cognitive function: a randomized crossover trial","volume":"11","author":"Gyorkos","year":"2019","journal-title":"Cureus"},{"key":"2026073119520588700_nuaf210-B120","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1080\/1028415x.2022.2143609","article-title":"Effects of the ketogenic diet on cognition: a systematic review","volume":"26","author":"Chinna-Meyyappan","year":"2023","journal-title":"Nutr Neurosci"},{"key":"2026073119520588700_nuaf210-B121","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.cmet.2017.08.005","article-title":"A ketogenic diet extends longevity and healthspan in adult mice","volume":"26","author":"Roberts","year":"2017","journal-title":"Cell Metab"},{"key":"2026073119520588700_nuaf210-B122","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1038\/s41598-018-19615-4","article-title":"Role of METTL20 in regulating \u03b2-oxidation and heat production in mice under fasting or ketogenic conditions","volume":"8","author":"Shimazu","year":"2018","journal-title":"Sci Rep"},{"key":"2026073119520588700_nuaf210-B123","doi-asserted-by":"publisher","first-page":"1530","DOI":"10.1016\/j.neurobiolaging.2012.11.023","article-title":"A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer\u2019s disease","volume":"34","author":"Kashiwaya","year":"2013","journal-title":"Neurobiol Aging"},{"key":"2026073119520588700_nuaf210-B124","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1111\/jnc.13958","article-title":"Effects of a dietary ketone ester on hippocampal glycolytic and tricarboxylic acid cycle intermediates and amino acids in a 3xTgAD mouse model of Alzheimer\u2019s disease","volume":"141","author":"Pawlosky","year":"2017","journal-title":"J Neurochem"},{"key":"2026073119520588700_nuaf210-B125","doi-asserted-by":"publisher","first-page":"114432","DOI":"10.1016\/j.expneurol.2023.114432","article-title":"Ketogenic diet ameliorates autism spectrum disorders-like behaviors via reduced inflammatory factors and microbiota remodeling in BTBR T(+) Itpr3(tf)\/J mice","volume":"366","author":"Olivito","year":"2023","journal-title":"Exp Neurol"},{"key":"2026073119520588700_nuaf210-B126","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1210\/en.2016-1816","article-title":"Sex-specific life course changes in the neuro-metabolic phenotype of glut3 null heterozygous mice: ketogenic diet ameliorates electroencephalographic seizures and improves sociability","volume":"158","author":"Dai","year":"2017","journal-title":"Endocrinology"},{"key":"2026073119520588700_nuaf210-B127","doi-asserted-by":"publisher","first-page":"11215","DOI":"10.1021\/acs.jafc.0c04604","article-title":"Cuprizone-induced demyelination in mouse hippocampus is alleviated by ketogenic diet","volume":"68","author":"Liu","year":"2020","journal-title":"J Agric Food Chem"},{"key":"2026073119520588700_nuaf210-B128","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s13578-021-00536-1","article-title":"Neuregulin 1\/ErbB4 signaling contributes to the anti-epileptic effects of the ketogenic diet","volume":"11","author":"Wang","year":"2021","journal-title":"Cell Biosci"},{"key":"2026073119520588700_nuaf210-B129","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1007\/s12031-016-0777-9","article-title":"Erratum to: environmental enrichment mitigates detrimental cognitive effects of ketogenic diet in weanling rats","volume":"60","author":"Scichilone","year":"2016","journal-title":"J Mol Neurosci"},{"key":"2026073119520588700_nuaf210-B130","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.physbeh.2017.06.007","article-title":"The ketogenic diet affects the social behavior of young male rats","volume":"179","author":"Kasprowska-Li\u015bkiewicz","year":"2017","journal-title":"Physiol Behav"},{"key":"2026073119520588700_nuaf210-B131","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.jpain.2012.12.015","article-title":"Ketogenic diets and thermal pain: dissociation of hypoalgesia, elevated ketones, and lowered glucose in rats","volume":"14","author":"Ruskin","year":"2013","journal-title":"J Pain"},{"key":"2026073119520588700_nuaf210-B132","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.eplepsyres.2015.08.005","article-title":"\u03b2-Hydroxybutyrate attenuates NMDA-induced spasms in rats with evidence of neuronal stabilization on MR spectroscopy","volume":"117","author":"Yum","year":"2015","journal-title":"Epilepsy Res"}],"container-title":["Nutrition Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/nutritionreviews\/article-pdf\/84\/8\/1696\/65314330\/nuaf210.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nutritionreviews\/article-pdf\/84\/8\/1696\/65314330\/nuaf210.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T23:52:16Z","timestamp":1785541936000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nutritionreviews\/article\/84\/8\/1696\/8324505"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,15]]},"references-count":132,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,11,15]]},"published-print":{"date-parts":[[2026,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/nutrit\/nuaf210","relation":{},"ISSN":["0029-6643","1753-4887"],"issn-type":[{"value":"0029-6643","type":"print"},{"value":"1753-4887","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,8]]},"published":{"date-parts":[[2025,11,15]]}}}