{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:16:54Z","timestamp":1789726614341,"version":"4.0.1"},"reference-count":100,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,11,23]],"date-time":"2025-11-23T00:00:00Z","timestamp":1763856000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Scientific Research Foundation for Scholars of HZNU","award":["2022QDL004"],"award-info":[{"award-number":["2022QDL004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Taurine, a sulfur-containing amino acid vital for cardiovascular health, is suggested as a promising intervention for reducing cardiometabolic disease risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>In this meta-analysis of randomized controlled trials (RCTs) we sought to evaluate the effects of taurine on cardiometabolic risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data sources<\/jats:title>\n                    <jats:p>We systematically searched PubMed\/MEDLINE, Web of Science, EMBASE, Cochrane Library, and Google Scholar for articles reporting RCTs that investigated the effects of taurine on cardiometabolic risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data extraction<\/jats:title>\n                    <jats:p>Data extraction was performed in accordance with the Cochrane and PRISMA guidelines. A random-effects model or a common-effect model was used to calculate mean differences (MDs) or standardized mean differences (SMDs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data analyses<\/jats:title>\n                    <jats:p>Thirty-four eligible RCTs were analyzed. Taurine supplementation resulted in significant reductions in fasting blood glucose (MD, \u22125.90\u2009mg\/dL; 95% CI, \u22129.65 to \u22122.15), glycated hemoglobin A1c (MD, \u22120.21%; 95% CI, \u22120.37 to \u22120.05), fasting insulin (SMD, \u22120.55; 95% CI, \u22120.78 to \u22120.32), homeostatic model assessment for insulin resistance index (MD, \u22120.57; 95% CI, \u22120.74 to \u22120.40), triglycerides (MD, \u221214.42\u2009mg\/dL; 95% CI, \u221223.60 to \u22125.25), total cholesterol (MD, \u221212.41\u2009mg\/dL; 95% CI, \u221219.10 to \u22125.71), low-density lipoprotein cholesterol (MD, \u22125.08\u2009mg\/dL; 95% CI, \u22128.35 to \u22121.81), systolic blood pressure (MD, \u22124.38\u2009mmHg; 95% CI, \u22127.26 to \u22121.50), diastolic blood pressure (MD, \u22122.54\u2009mmHg; 95% CI, \u22123.97 to \u22121.11), aspartate aminotransferase (MD, \u22129.65 U\/L; 95% CI, \u221217.39 to \u22121.90), alanine aminotransferase (MD, \u22128.26 U\/L; 95% CI, \u221214.81 to \u22121.70), C-reactive protein (SMD, \u22121.26; 95% CI, \u22122.01 to \u22120.52), tumor necrosis factor-\u03b1 (MD, \u22120.35\u2009pg\/mL; 95% CI, \u22120.56 to \u22120.14), and malondialdehyde (SMD, \u22121.16; 95% CI, \u22121.81 to \u22120.52). Subgroup and dose\u2013response analyses indicated that a daily taurine dose of 1.5-3.0\u2009g was more effective in improving these cardiometabolic risk factors. Specifically, taurine intervention for \u22658\u2009weeks yielded greater improvements in glucose and lipid metabolism, while durations &amp;lt;8\u2009weeks were optimal for managing blood pressure and inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Taurine supplementation may effectively improve cardiometabolic risk factors in adults, underscoring its potential to reduce the incidence of cardiometabolic diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic Review Registration<\/jats:title>\n                    <jats:p>PROSPERO registration No. CRD42024577852.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/nutrit\/nuaf220","type":"journal-article","created":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T13:13:44Z","timestamp":1760361224000},"page":"2028-2051","source":"Crossref","is-referenced-by-count":9,"title":["Effects of Oral Taurine Supplementation on Cardiometabolic Risk Factors: A Meta-analysis and Systematic Review of Randomized Clinical Trials"],"prefix":"10.1093","volume":"84","author":[{"given":"Zizheng","family":"Nie","sequence":"first","affiliation":[{"name":"Department of Nutrition and Toxicology, School of Public Health, Hangzhou Normal University , Hangzhou, Zhejiang 311121,","place":["P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Toxicology, School of Public Health, Hangzhou Normal University , Hangzhou, Zhejiang 311121,","place":["P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Toxicology, School of Public Health, Hangzhou Normal University , Hangzhou, Zhejiang 311121,","place":["P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Toxicology, School of Public Health, Hangzhou Normal University , Hangzhou, Zhejiang 311121,","place":["P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinglong","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Toxicology, School of Public Health, Hangzhou Normal University , Hangzhou, Zhejiang 311121,","place":["P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaoyang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Toxicology, School of Public Health, Hangzhou Normal University , Hangzhou, Zhejiang 311121,","place":["P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiren","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Toxicology, School of Public Health, Hangzhou Normal University , Hangzhou, Zhejiang 311121,","place":["P.R. 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