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Nutritional interventions, particularly polyunsaturated fatty acids (PUFAs), have gained attention as potential therapeutic options.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This Mendelian randomization (MR) meta-analysis aimed to evaluate the potential causal relationship between PUFAs and MDs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources<\/jats:title>\n                    <jats:p>Genome-wide association study data were utilized to analyze the association between PUFAs (including omega-3, omega-3 percentage [omega-3%], omega-6, omega-6 percentage [omega-6%], and omega-6 to omega-3 ratio) and 12 major MDs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Extraction<\/jats:title>\n                    <jats:p>Two-sample MR technology was used to assess the role of PUFAs in MDs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Analysis<\/jats:title>\n                    <jats:p>The MR analysis revealed that genetically predicted omega-3 was causally linked to MDs, such as obsessive-compulsive disorder, bipolar disorder, schizophrenia, and major depressive disorder. Omega-3% exhibited protective effects against emotional personality disorder. Conversely, omega-6 was inversely correlated with attention-deficit\/hyperactivity disorder risk, while a high omega-6 to omega-3 ratio was associated with an increased risk of depression and other mood disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>High omega-3 levels and omega-3% may reduce the risk of MDs, whereas a high omega-6:omega-3 ratio may elevate the risk. These findings highlight the potential of PUFAs, particularly omega-3, in MD prevention and treatment, while underscoring the need for further research into the complex interactions between omega-3 and omega-6. The study provides a scientific foundation for future clinical trials and dietary intervention strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic Review Registration<\/jats:title>\n                    <jats:p>PROSPERO no. CRD42024598472.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/nutrit\/nuaf225","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T13:54:25Z","timestamp":1760450065000},"page":"1973-1983","source":"Crossref","is-referenced-by-count":0,"title":["Causal Relationship of Polyunsaturated Fatty Acids With Mental Disorders: A Systematic Review and Meta-analysis"],"prefix":"10.1093","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2669-0122","authenticated-orcid":false,"given":"Yiying","family":"Yao","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Shaoxing Seventh People\u2019s Hospital (Affiliated Mental Health Center of Shaoxing University) , Shaoxing, Zhejiang 312000,","place":["China"]},{"name":"Department of Behavioral Neurosciences, Science Research Center of Medical School, Shaoxing University , Shaoxing, Zhejiang 312000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaopeng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Behavioral Neurosciences, Science Research Center of Medical School, Shaoxing University , Shaoxing, Zhejiang 312000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1749-1693","authenticated-orcid":false,"given":"Junwei","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion, Affiliated Hospital of Shaoxing University , Shaoxing, Zhejiang 312000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongran","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Behavioral Neurosciences, Science Research Center of Medical School, Shaoxing University , Shaoxing, Zhejiang 312000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Nursing, School of Medicine, Shaoxing University , Shaoxing, Zhejiang 312000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayao","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Behavioral Neurosciences, Science Research Center of Medical School, Shaoxing University , Shaoxing, Zhejiang 312000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuqin","family":"Lin","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Shaoxing Seventh People\u2019s Hospital , Shaoxing, Zhejiang 312000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Shaoxing Seventh People\u2019s Hospital (Affiliated Mental Health Center of Shaoxing University) , Shaoxing, Zhejiang 312000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huafang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Behavioral Neurosciences, Science Research Center of Medical School, Shaoxing University , Shaoxing, Zhejiang 312000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1473-0640","authenticated-orcid":false,"given":"Zheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Behavioral Neurosciences, Science Research Center of Medical School, Shaoxing University , Shaoxing, Zhejiang 312000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengfei","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Shaoxing Seventh People\u2019s Hospital (Affiliated Mental Health Center of Shaoxing University) , Shaoxing, Zhejiang 312000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"key":"2026090214265575500_nuaf225-B1","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1017\/S0033291721001185","article-title":"What is a mental disorder? 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