{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T16:15:01Z","timestamp":1767197701760,"version":"3.48.0"},"reference-count":81,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:00:00Z","timestamp":1767139200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100012669","name":"Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission","doi-asserted-by":"publisher","award":["CSTB2022NSCQ-MSX1001"],"award-info":[{"award-number":["CSTB2022NSCQ-MSX1001"]}],"id":[{"id":"10.13039\/501100012669","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Youth Innovation in Future Medicine, Chongqing Medical University","award":["W0109"],"award-info":[{"award-number":["W0109"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Cumulative evidence suggests an association between vitamin\u2009D and nocturnal lower urinary tract symptoms (nLUTS), but results remain inconclusive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To systematically assess the relationship between vitamin\u2009D status or intake and nLUTS via a systematic review and meta-analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources<\/jats:title>\n                    <jats:p>The PubMed, Scopus, Embase, and Web of Science databases were searched through July 2025 without language restrictions. Case-control, cross-sectional, cohort, and randomized controlled trials (RCTs) evaluating the effects of vitamin\u2009D status or intake on nLUTS were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Extraction<\/jats:title>\n                    <jats:p>A total of 2725 articles were identified through the literature search, of which 17 met the inclusion criteria for the systematic review. These comprised 5 RCTs, 2 cohort studies, 4 cross-sectional studies, and 6 case-control studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Analysis<\/jats:title>\n                    <jats:p>Vitamin\u2009D deficiency (&amp;lt;20\u202fng mL\u20131) was associated with a 4.86-fold increase in the odds of nLUTS, and mean serum 25-hydroxyvitamin D levels were 7.75\u202fng mL\u20131 lower in individuals with nLUTS than in control participants. Vitamin\u2009D supplementation correlated with an 86% relative risk reduction for nLUTS and a decrease of 0.23 nocturnal voids per night. Stronger associations were observed in pediatric populations and patients with nocturnal polyuria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Vitamin\u2009D deficiency is a significant risk factor for nLUTS; supplementation may offer therapeutic benefits. Assessing vitamin\u2009D status could guide nLUTS management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic Review Registration<\/jats:title>\n                    <jats:p>PROSPERO registration no. CRD420251004940.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/nutrit\/nuaf260","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T13:19:24Z","timestamp":1761830364000},"source":"Crossref","is-referenced-by-count":0,"title":["Association Between Vitamin D Status and Nocturnal Lower Urinary Tract Symptoms: A Pooled Analysis"],"prefix":"10.1093","author":[{"given":"Zihan","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Urology, Children\u2019s Hospital of Chongqing Medical University , Chongqing, 401122,","place":["China"]},{"name":"Ministry of Education Key Laboratory of Child Development and Disorders , Chongqing, 401122,","place":["China"]},{"name":"National Clinical Research Center for Child Health and Disorders , Chongqing, 401122,","place":["China"]},{"name":"China International Science and Technology Cooperation Base of Child Development and Critical Disorders , Chongqing, 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