{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:34:11Z","timestamp":1791988451502,"version":"4.4.0"},"reference-count":59,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Selenium plays a crucial role in maintaining metabolic health, providing antioxidant protection, and modulating inflammation. Further clarification of the physiological functions and pathological relevance of selenium is necessary to increase understanding of its therapeutic potential through supplementation and to determine the most effective strategies across different populations and metabolic conditions. We sought to systematically map and synthesize existing evidence on the effects of selenium supplementation on inflammation, oxidative stress, and glucose-lipid metabolism in adult populations, and to identify knowledge gaps that hinder the establishment of safe and effective selenium dosing guidelines. A scoping review was conducted based on the Preferred Reporting Items for Systematic reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) guidelines, in which we searched for the major electronic databases to identify clinical trials that evaluated the effects of selenium supplementation on standard features of metabolic disease among diverse adult population groups. Improvements in metabolic markers were observed, particularly in studies addressing diabetes and insulin resistance (up to a 26% reduction in Homeostatic Model Assessment of Insulin Resistance [HOMA-IR])), and inflammation (with up to a 62.4% reduction in high-sensitivity C-reactive protein [hs-CRP]). The benefits were seen in reported studies with intervention durations of 12\u2009weeks or longer. In limited studies, selenium had neutral effects in a trial of polycystic ovary syndrome (PCOS) and an adverse effect in 1 postmenopausal trial, indicating that results in these groups remain inconclusive. Co-supplementation with probiotics or antioxidants had beneficial effects in some studies. Selenium supplementation has been observed to improve insulin sensitivity, lower hs-CRP, and enhance antioxidant defenses, particularly in adults with diabetes or insulin resistance, while effects in PCOS and postmenopausal women remain equivocal. Because both deficiency and excess of selenium can be harmful, dosing must be guided by baseline selenium status. Harnessing this narrow therapeutic window could enhance metabolic care, but long-term, well-controlled trials are still needed to define optimal regimens and clarify who stands to benefit most.<\/jats:p>","DOI":"10.1093\/nutrit\/nuag005","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T12:51:35Z","timestamp":1767963095000},"source":"Crossref","is-referenced-by-count":1,"title":["Current Insights and Research Gaps in Selenium Supplementation for Metabolic Health: A Scoping Review"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1028-2465","authenticated-orcid":false,"given":"Linda","family":"Morales-Ju\u00e1rez","sequence":"first","affiliation":[{"name":"Tecnol\u00f3gico de Monterrey, Institute for Obesity Research , Monterrey, NL 64849,","place":["M\u00e9xico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2516-8267","authenticated-orcid":false,"given":"Astrid","family":"Dom\u00ednguez-Uscanga","sequence":"additional","affiliation":[{"name":"Tecnol\u00f3gico de Monterrey, School of Engineering and Sciences , Monterrey, NL 64849,","place":["M\u00e9xico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1056-7126","authenticated-orcid":false,"given":"Janet A","family":"Guti\u00e9rrez-Uribe","sequence":"additional","affiliation":[{"name":"Tecnol\u00f3gico de Monterrey, School of Engineering and Sciences , Monterrey, NL 64849,","place":["M\u00e9xico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego A","family":"Luna-Vital","sequence":"additional","affiliation":[{"name":"Tecnol\u00f3gico de Monterrey, School of Engineering and Sciences , Monterrey, NL 64849,","place":["M\u00e9xico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6781-5154","authenticated-orcid":false,"given":"Anayansi","family":"Escalante-Aburto","sequence":"additional","affiliation":[{"name":"Tecnol\u00f3gico de Monterrey, Institute for Obesity Research , Monterrey, NL 64849,","place":["M\u00e9xico"]},{"name":"Tecnol\u00f3gico de Monterrey, School of Engineering and Sciences , Monterrey, NL 64849,","place":["M\u00e9xico"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,2,28]]},"reference":[{"key":"2026022813345430600_nuag005-B1","doi-asserted-by":"publisher","first-page":"1790","DOI":"10.3390\/nu12061790","article-title":"The role of selenium mineral trace element in exercise: antioxidant defense system, muscle performance, hormone response, and athletic performance. A systematic review","volume":"12","author":"Fern\u00e1ndez-L\u00e1zaro","year":"2020","journal-title":"Nutrients"},{"key":"2026022813345430600_nuag005-B2","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1079\/phn2001143","article-title":"Selenium, selenoproteins and human health: a review","volume":"4","author":"Brown","year":"2001","journal-title":"Public Health Nutr"},{"key":"2026022813345430600_nuag005-B3","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1007\/s42000-019-00143-3","article-title":"Effect of selenium supplementation on antioxidant markers: a systematic review and meta-analysis of randomized controlled trials","volume":"18","author":"Hasani","year":"2019","journal-title":"Hormones"},{"key":"2026022813345430600_nuag005-B4","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1016\/j.beem.2009.08.002","article-title":"Selenium and thyroid","volume":"23","author":"K\u00f6hrle","year":"2009","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"2026022813345430600_nuag005-B5","doi-asserted-by":"publisher","first-page":"1027629","DOI":"10.3389\/fnut.2022.1027629","article-title":"Emerging roles of selenium on metabolism and type 2 diabetes","volume":"9","author":"Zhao","year":"2022","journal-title":"Front Nutr"},{"key":"2026022813345430600_nuag005-B6","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.jtemb.2015.07.009","article-title":"High levels of plasma selenium are associated with metabolic syndrome and elevated fasting plasma glucose in a Chinese population: a case-control study","volume":"32","author":"Yuan","year":"2015","journal-title":"J Trace Elem Med Biol"},{"key":"2026022813345430600_nuag005-B7","doi-asserted-by":"publisher","first-page":"80","DOI":"10.3390\/nu8020080","article-title":"Selenium and metabolic disorders: an emphasis on type 2 diabetes risk","volume":"8","author":"Ogawa-Wong","year":"2016","journal-title":"Nutrients"},{"key":"2026022813345430600_nuag005-B8","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/s42000-019-00125-5","article-title":"Selenium intake, status, and health: a complex relationship","volume":"19","author":"Rayman","year":"2020","journal-title":"Hormones"},{"key":"2026022813345430600_nuag005-B9","doi-asserted-by":"publisher","first-page":"658","DOI":"10.3390\/biom10040658","article-title":"Selenium and selenoproteins in adipose tissue physiology and obesity","volume":"10","author":"Tinkov","year":"2020","journal-title":"Biomolecules"},{"key":"2026022813345430600_nuag005-B10","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.jtemb.2017.04.009","article-title":"The effect of selenium supplementation on coronary heart disease: a systematic review and meta-analysis of randomized controlled trials","volume":"44","author":"Ju","year":"2017","journal-title":"J Trace Elem Med Biol"},{"key":"2026022813345430600_nuag005-B11","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.clnesp.2021.11.022","article-title":"The effects of selenium administration on carotid intima-media thickness and metabolic status in diabetic hemodialysis patients: a randomized, double-blind, placebo-controlled trial","volume":"47","author":"Salimian","year":"2022","journal-title":"Clin Nutr ESPEN"},{"key":"2026022813345430600_nuag005-B12","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1017\/S0007114518001253","article-title":"Selenium supplementation lowers insulin resistance and markers of cardio-metabolic risk in patients with congestive heart failure: a randomised, double-blind, placebo-controlled trial","volume":"120","author":"Raygan","year":"2018","journal-title":"Br J Nutr"},{"key":"2026022813345430600_nuag005-B13","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1097\/MJT.0b013e318269175f","article-title":"A randomized, placebo-controlled trial of selenium supplementation in patients with type 2 diabetes: effects on glucose homeostasis, oxidative stress, and lipid profile","volume":"21","author":"Faghihi","year":"2014","journal-title":"Am J Ther"},{"key":"2026022813345430600_nuag005-B14","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1016\/j.nut.2015.04.014","article-title":"Effects of selenium supplementation on glucose homeostasis, inflammation, and oxidative stress in gestational diabetes: randomized, double-blind, placebo-controlled trial","volume":"31","author":"Asemi","year":"2015","journal-title":"Nutrition"},{"key":"2026022813345430600_nuag005-B15","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.clnesp.2022.07.017","article-title":"The effects of selenium supplementation on glycemic control, serum lipoproteins and biomarkers of oxidative stress in infertile women diagnosed with polycystic ovary syndrome undergoing in vitro fertilization: a randomized, double-blind, placebo-controlled trial","volume":"51","author":"Zadeh Modarres","year":"2022","journal-title":"Clin Nutr ESPEN"},{"key":"2026022813345430600_nuag005-B16","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.jtemb.2016.01.002","article-title":"Effects of selenium supplementation on glucose homeostasis and free androgen index in women with polycystic ovary syndrome: a randomized, double blinded, placebo controlled clinical trial","volume":"34","author":"Mohammad Hosseinzadeh","year":"2016","journal-title":"J Trace Elem Med Biol"},{"key":"2026022813345430600_nuag005-B17","doi-asserted-by":"publisher","first-page":"983","DOI":"10.20960\/nh.03613","article-title":"Effects of the intake of dairy products naturally enriched with selenium and omega-3 polyunsaturated fatty acids in a sample of postmenopausal women with metabolic syndrome: a randomized, triple-blind, placebo-controlled clinical trial","volume":"38","author":"P\u00e9rez Fern\u00e1ndez","year":"2021","journal-title":"Nutr Hosp"},{"key":"2026022813345430600_nuag005-B18","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1007\/s12011-016-0911-0","article-title":"Clinical and metabolic response to selenium supplementation in pregnant women at risk for intrauterine growth restriction: randomized, double-blind, placebo-controlled trial","volume":"178","author":"Mesdaghinia","year":"2017","journal-title":"Biol Trace Elem Res"},{"key":"2026022813345430600_nuag005-B19","doi-asserted-by":"publisher","first-page":"3005","DOI":"10.3390\/nu14153005","article-title":"Selenium intake and its interaction with iron intake are associated with cognitive functions in Chinese adults: a longitudinal study","volume":"14","author":"Jiang","year":"2022","journal-title":"Nutrients"},{"key":"2026022813345430600_nuag005-B20","doi-asserted-by":"publisher","first-page":"584","DOI":"10.3390\/nu10050584","article-title":"Zinc, magnesium, selenium and depression: a review of the evidence, potential mechanisms and implications","volume":"10","author":"Wang","year":"2018","journal-title":"Nutrients"},{"key":"2026022813345430600_nuag005-B21","doi-asserted-by":"publisher","first-page":"2569","DOI":"10.1016\/j.clnu.2018.11.034","article-title":"Probiotic and selenium co-supplementation, and the effects on clinical, metabolic and genetic status in Alzheimer\u2019s disease: a randomized, double-blind, controlled trial","volume":"38","author":"Tamtaji","year":"2019","journal-title":"Clin Nutr"},{"key":"2026022813345430600_nuag005-B22","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1186\/s12883-024-03800-2","article-title":"The relationship between micronutrients and cognitive ability in an elderly population with mild cognitive impairment and Alzheimer\u2019s disease: a cross-sectional study","volume":"24","author":"Akhgarjand","year":"2024","journal-title":"BMC Neurol"},{"key":"2026022813345430600_nuag005-B23","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.3390\/nu13041344","article-title":"Dietary supplementation with selenium and coenzyme Q10 prevents increase in plasma D-dimer while lowering cardiovascular mortality in an elderly Swedish population","volume":"13","author":"Alehagen","year":"2021","journal-title":"Nutrients"},{"key":"2026022813345430600_nuag005-B24","doi-asserted-by":"publisher","first-page":"3135","DOI":"10.1007\/s00394-022-02876-1","article-title":"Improved cardiovascular health by supplementation with selenium and coenzyme Q10: applying structural equation modelling (SEM) to clinical outcomes and biomarkers to explore underlying mechanisms in a prospective randomized double-blind placebo-controlled intervention project in Sweden","volume":"61","author":"Alehagen","year":"2022","journal-title":"Eur J Nutr"},{"key":"2026022813345430600_nuag005-B25","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1007\/s12011-019-1636-7","article-title":"Effects of selenium supplementation on metabolic status in patients undergoing for coronary artery bypass grafting (CABG) surgery: a randomized, double-blind, placebo-controlled trial","volume":"191","author":"Kamali","year":"2019","journal-title":"Biol Trace Elem Res"},{"key":"2026022813345430600_nuag005-B26","doi-asserted-by":"publisher","first-page":"2116","DOI":"10.3390\/nu14102116","article-title":"Comparison of ferric sodium EDTA in combination with vitamin C, folic acid, copper gluconate, zinc gluconate, and selenomethionine as therapeutic option for chronic kidney disease patients with improvement in inflammatory status","volume":"14","author":"Giliberti","year":"2022","journal-title":"Nutrients"},{"key":"2026022813345430600_nuag005-B27","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1152\/japplphysiol.00018.2018","article-title":"A nutrient cocktail prevents lipid metabolism alterations induced by 20 days of daily steps reduction and fructose overfeeding: result from a randomized study","volume":"126","author":"Damiot","year":"2019","journal-title":"J Appl Physiol"},{"key":"2026022813345430600_nuag005-B28","doi-asserted-by":"publisher","first-page":"3133","DOI":"10.3390\/nu15143133","article-title":"The effects of zinc and selenium co-supplementation on resting metabolic rate, thyroid function, physical fitness, and functional capacity in overweight and obese people under a hypocaloric diet: a randomized, double-blind, and placebo-controlled trial","volume":"15","author":"Zavros","year":"2023","journal-title":"Nutrients"},{"key":"2026022813345430600_nuag005-B29","doi-asserted-by":"publisher","first-page":"240","DOI":"10.18502\/cjn.v23i4.18767","article-title":"Nano-selenium and the SRC family kinases pathway: redefining gene expression dynamics in major depressive disorder based on a randomized controlled trial","volume":"23","author":"Noormohammadi","year":"2024","journal-title":"Curr J Neurol"},{"key":"2026022813345430600_nuag005-B30","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1158\/1055-9965.EPI-05-0950","article-title":"Effects of chemical form of selenium on plasma biomarkers in a high-dose human supplementation trial","volume":"15","author":"Burk","year":"2006","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2026022813345430600_nuag005-B31","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1079\/bjn2000227","article-title":"Selenium absorption and retention from a selenite-or selenate-fortified milk-based formula in men measured by a stable-isotope technique","volume":"85","author":"Van Dael","year":"2001","journal-title":"Br J Nutr"},{"key":"2026022813345430600_nuag005-B32","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/j.foodchem.2011.07.102","article-title":"Current knowledge in species-related bioavailability of selenium in food","volume":"130","author":"Thiry","year":"2012","journal-title":"Food Chem"},{"key":"2026022813345430600_nuag005-B33","doi-asserted-by":"publisher","first-page":"696024","DOI":"10.3389\/fnut.2021.696024","article-title":"Selenium status is associated with insulin resistance markers in adults: findings from the 2013 to 2018 National Health and Nutrition Examination Survey (NHANES)","volume":"8","author":"Cardoso","year":"2021","journal-title":"Front Nutr"},{"key":"2026022813345430600_nuag005-B34","doi-asserted-by":"publisher","first-page":"4430","DOI":"10.1007\/s12011-020-02572-3","article-title":"The effects of probiotic and selenium co-supplementation on clinical and metabolic scales in chronic schizophrenia: a randomized, double-blind, placebo-controlled trial","volume":"199","author":"Jamilian","year":"2021","journal-title":"Biol Trace Elem Res"},{"key":"2026022813345430600_nuag005-B35","doi-asserted-by":"publisher","first-page":"7009863","DOI":"10.1155\/2022\/7009863","article-title":"Selenium status and its antioxidant role in metabolic diseases. Moreira H, ed","volume":"2022","author":"Huang","year":"2022","journal-title":"Oxid Med Cell Longev"},{"key":"2026022813345430600_nuag005-B36","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.freeradbiomed.2017.10.353","article-title":"Selenium intake and status in health & disease","volume":"112","author":"Rayman","year":"2017","journal-title":"Free Radic Biol Med"},{"key":"2026022813345430600_nuag005-B37","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1055\/a-0890-6823","article-title":"Selenium and polycystic ovary syndrome; current knowledge and future directions: a systematic review","volume":"51","author":"Hajizadeh-Sharafabad","year":"2019","journal-title":"Horm Metab Res"},{"key":"2026022813345430600_nuag005-B38","author":"Walsh","year":"2021"},{"key":"2026022813345430600_nuag005-B39","doi-asserted-by":"publisher","first-page":"4933","DOI":"10.3390\/nu14224933","article-title":"Potential benefits of selenium supplementation in reducing insulin resistance in patients with cardiometabolic diseases: a systematic review and meta-analysis","volume":"14","author":"Ouyang","year":"2022","journal-title":"Nutrients"},{"key":"2026022813345430600_nuag005-B40","doi-asserted-by":"publisher","first-page":"106888","DOI":"10.1016\/j.phrs.2023.106888","article-title":"Selenium supplementation effect on glycemic control: a GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials","volume":"195","author":"Vajdi","year":"2023","journal-title":"Pharmacol Res"},{"key":"2026022813345430600_nuag005-B41","doi-asserted-by":"publisher","first-page":"e000613","DOI":"10.1136\/bmjdrc-2018-000613","article-title":"Selenium supplementation and insulin resistance in a randomized, clinical trial","volume":"7","author":"Jacobs","year":"2019","journal-title":"BMJ Open Diabetes Res Care"},{"key":"2026022813345430600_nuag005-B42","first-page":"57","article-title":"Effects of selenium supplementation on glucose homeostasis in women with gestational diabetes mellitus: a randomized, controlled trial","volume":"18","author":"Najib","year":"2020","journal-title":"Int J Reprod Biomed"},{"key":"2026022813345430600_nuag005-B43","doi-asserted-by":"publisher","first-page":"e0174149","DOI":"10.1371\/journal.pone.0174149","article-title":"High dietary selenium intake is associated with less insulin resistance in the Newfoundland population","volume":"12","author":"Wang","year":"2017","journal-title":"PLoS One"},{"key":"2026022813345430600_nuag005-B44","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1111\/jhn.12670","article-title":"Effectiveness and safety of selenium supplementation for type 2 diabetes mellitus in adults: a systematic review of randomised controlled trials","volume":"32","author":"Str\u00f3\u017cyk","year":"2019","journal-title":"J Human Nutrition Diet"},{"key":"2026022813345430600_nuag005-B45","doi-asserted-by":"publisher","first-page":"1011850","DOI":"10.3389\/fnut.2022.1011850","article-title":"Selenium supplementation and pregnancy outcomes","volume":"9","author":"Dahlen","year":"2022","journal-title":"Front Nutr"},{"key":"2026022813345430600_nuag005-B46","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1016\/j.placenta.2015.06.010","article-title":"Selenium supplementation induces mitochondrial biogenesis in trophoblasts","volume":"36","author":"Khera","year":"2015","journal-title":"Placenta"},{"key":"2026022813345430600_nuag005-B47","doi-asserted-by":"publisher","first-page":"127599","DOI":"10.1016\/j.jtemb.2025.127599","article-title":"Selenium ameliorates cognitive impairment through activating BDNF\/TrkB pathway","volume":"88","author":"Liu","year":"2025","journal-title":"J Trace Elem Med Biol"},{"key":"2026022813345430600_nuag005-B48","doi-asserted-by":"publisher","first-page":"3205","DOI":"10.3390\/nu14153205","article-title":"Effects of selenium supplementation in patients with mild cognitive impairment or Alzheimer\u2019s disease: a systematic review and meta-analysis","volume":"14","author":"Pereira","year":"2022","journal-title":"Nutrients"},{"key":"2026022813345430600_nuag005-B49","doi-asserted-by":"publisher","first-page":"7276","DOI":"10.3390\/ijms25137276","article-title":"Exploring the link between oxidative stress, selenium levels, and obesity in youth","volume":"25","author":"Bizerea-Moga","year":"2024","journal-title":"Int J Mol Sci"},{"key":"2026022813345430600_nuag005-B50","doi-asserted-by":"publisher","first-page":"2283","DOI":"10.1080\/87559129.2023.2272946","article-title":"Advances and perspectives of selenocompounds as dietary supplements to ameliorate obesity biomarkers: from field to market","volume":"40","author":"De La Luz Lim\u00f3n Aguilera","year":"2024","journal-title":"Food Reviews International"},{"key":"2026022813345430600_nuag005-B51","doi-asserted-by":"publisher","first-page":"2877","DOI":"10.21873\/invivo.13406","article-title":"The relationship between oxidative stress, selenium, and cumulative risk in metabolic syndrome","volume":"37","author":"Danciu","year":"2023","journal-title":"In Vivo"},{"key":"2026022813345430600_nuag005-B52","doi-asserted-by":"publisher","first-page":"1811","DOI":"10.1177\/0960327111401049","article-title":"Influence of selenium and\/or magnesium on alleviation alcohol induced oxidative stress in rats, normalization function of liver and changes in serum lipid parameters","volume":"30","author":"Markiewicz-G\u00f3rka","year":"2011","journal-title":"Hum Exp Toxicol"},{"key":"2026022813345430600_nuag005-B53","doi-asserted-by":"publisher","first-page":"1722","DOI":"10.1080\/10942912.2020.1825483","article-title":"Review on selected potential nutritional intervention for treatment and prevention of viral infections: possibility of recommending these for Coronavirus 2019","volume":"23","author":"Shirani","year":"2020","journal-title":"Int J Food Prop"},{"key":"2026022813345430600_nuag005-B54","doi-asserted-by":"publisher","first-page":"929","DOI":"10.3390\/nu2090929","article-title":"Reexamination of a meta-analysis of the effect of antioxidant supplementation on mortality and health in randomized trials","volume":"2","author":"Biesalski","year":"2010","journal-title":"Nutrients"},{"key":"2026022813345430600_nuag005-B55","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.fbp.2025.04.011","article-title":"Techno-economic assessment and modeling of large-scale process for biofortified selenized chickpea flour production (Cicer arietinum L.) as a functional ingredient","volume":"152","author":"Ordaz","year":"2025","journal-title":"Food Bioprod. Process"},{"key":"2026022813345430600_nuag005-B56","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.3390\/nu7042209","article-title":"Biomarkers of selenium status","volume":"7","author":"Combs","year":"2015","journal-title":"Nutrients"},{"key":"2026022813345430600_nuag005-B57","author":"NIH-Office of Dietary Supplements. Selenium. Accessed","year":"2025"},{"key":"2026022813345430600_nuag005-B58","doi-asserted-by":"publisher","first-page":"311","DOI":"10.3390\/nu17020311","article-title":"The inhibitory effects of NCT503 and exogenous serine on high-selenium induced insulin resistance in mice","volume":"17","author":"Zhan","year":"2025","journal-title":"Nutrients"},{"key":"2026022813345430600_nuag005-B59","doi-asserted-by":"publisher","first-page":"2410","DOI":"10.3390\/nu14122410","article-title":"Protective effect of mitophagy regulated by mTOR signaling pathway in liver fibrosis associated with selenium","volume":"14","author":"Qiao","year":"2022","journal-title":"Nutrients"}],"container-title":["Nutrition Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/nutritionreviews\/advance-article-pdf\/doi\/10.1093\/nutrit\/nuag005\/67175380\/nuag005.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nutritionreviews\/advance-article-pdf\/doi\/10.1093\/nutrit\/nuag005\/67175380\/nuag005.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T18:35:01Z","timestamp":1772303701000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nutritionreviews\/advance-article\/doi\/10.1093\/nutrit\/nuag005\/8502235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,28]]},"references-count":59,"URL":"https:\/\/doi.org\/10.1093\/nutrit\/nuag005","relation":{},"ISSN":["0029-6643","1753-4887"],"issn-type":[{"value":"0029-6643","type":"print"},{"value":"1753-4887","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,28]]},"article-number":"nuag005"}}